SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis

PLoS Biology

Volumn 14, Issue 11, 2016, Pages

  Kim, Bo Ram ^a,b   Van de Laar, Emily ^a   Cabanero, Michael ^a   Tarumi, Shintaro ^c   Hasenoeder, Stefan ^a,d   Wang, Dennis ^a   Virtanen, Carl ^a   Suzuki, Takaya ^c   Bandarchi, Bizhan ^a   Sakashita, Shingo ^a   Pham, Nhu An ^a   Lee, Sharon ^a,e   Keshavjee, Shaf ^c   Waddell, Thomas K ^c   Tsao, Ming Sound ^a,b   Moghal, Nadeem ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN; MUCIN 16; PI3K PROTEIN; PROTEIN; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CANCER GROWTH; CANCER STAGING; CANCER STEM CELL; CARCINOGENESIS; CELL ACTIVITY; CELL DAMAGE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL REGENERATION; CILIATED EPITHELIUM; CLINICAL OUTCOME; CONTROLLED STUDY; CORRELATIONAL STUDY; DYSPLASIA; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; MALE; MOUSE; MUC16 GENE; NONHUMAN; P13K GENE; PHENOTYPE; RAT; SIGNAL TRANSDUCTION; SMOKING; SOX2 GENE; SOX9 GENE; SQUAMOUS CELL; SQUAMOUS CELL LUNG CARCINOMA; SQUAMOUS CELL METAPLASIA; ANIMAL; ENZYMOLOGY; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA; TRACHEA;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASTIC STEM CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; TRACHEA;

EID: 85007305936     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002581     Document Type: Article

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