SOX2 amplification is a common event in squamous cell carcinomas of different organ sites

Human Pathology

Volumn 42, Issue 8, 2011, Pages 1078-1088

  Maier, Sebastian ^a   Wilbertz, Theresia ^a   Braun, Martin ^a   Scheble, Veit ^a   Reischl, Markus ^b   Mikut, Ralf ^b   Menon, Roopika ^a   Nikolov, Pavel ^a   Petersen, Karen ^a   Beschorner, Christine ^a   Moch, Holger ^c   Kakies, Christoph ^d   Protzel, Chris ^d   Bauer, Jürgen ^a   Soltermann, Alex ^c   Fend, Falko ^a   Staebler, Annette ^a   Lengerke, Claudia ^a   Perner, Sven ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

Penis; Skin; SOX2; Squamous Cell carcinoma; Uterine cervix

Indexed keywords

THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CANCER LOCALIZATION; CARCINOGENESIS; CARCINOID; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DOSAGE; GENE FREQUENCY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; NEUROENDOCRINE TUMOR; PENIS CARCINOMA; PROTEIN EXPRESSION; SKIN CARCINOMA; SMALL CELL CARCINOMA; SQUAMOUS CELL CARCINOMA; TUMOR DIFFERENTIATION; UTERINE CERVIX CARCINOMA;

ADENOCARCINOMA; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; SOXB1 TRANSCRIPTION FACTORS; TISSUE ARRAY ANALYSIS;

EID: 79960022074     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.11.010     Document Type: Article

References (29)

1. Albertson D.G., Collins C., McCormick F., and Gray J.W. Chromosome aberrations in solid tumors Nat Genet 34 2003 369 376 (Pubitemid 36935328)
2. Albertson D.G. Gene amplification in cancer Trends Genet 22 2006 447 455 (Pubitemid 44093770)
3. Masui S., Nakatake Y., and Toyooka Y. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells Nat Cell Biol 9 2007 625 635 (Pubitemid 47214724)
4. Fong H., Hohenstein K.A., and Donovan P.J. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells Stem Cells 26 2008 1931 1938
5. Adachi K., Suemori H., Yasuda S.Y., Nakatsuji N., and Kawase E. Role of SOX2 in maintaining pluripotency of human embryonic stem cells Genes Cells 15 2010 455 470
6. Takahashi K., Tanabe K., and Ohnuki M. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872 (Pubitemid 350138099)
7. Yu J., Vodyanik M.A., and Smuga-Otto K. Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
8. Wernig M., Meissner A., and Foreman R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 448 2007 318 324 (Pubitemid 47080337)
9. Garraway L.A., and Sellers W.R. Lineage dependency and lineage-survival oncogenes in human cancer Nat Rev Cancer 6 2006 593 602 (Pubitemid 44140858)
10. Bass A.J., Watanabe H., and Mermel C.H. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas Nat Genet 41 2009 1238 1242
11. Hussenet T., Dali S., and Exinger J. SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas PLoS One 5 2010 e8960
12. Yuan P., Kadara H., and Behrens C. Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung PLoS One 5 2010 e9112
13. Que J., Okubo T., and Goldenring J.R. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm Development 134 2007 2521 2531 (Pubitemid 47074146)
14. Gontan C., de Munck A., Vermeij M., Grosveld F., Tibboel D., and Rottier R. Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation Dev Biol 317 2008 296 309
15. Que J., Luo X., Schwartz R.J., and Hogan B.L. Multiple roles for Sox2 in the developing and adult mouse trachea Development 136 2009 1899 1907
16. Tompkins D.H., Besnard V., and Lange A.W. Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells PLoS One 4 2009 e8248
17. Favaro R., Valotta M., and Ferri A.L. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh Nat Neurosci 12 2009 1248 1256
18. Kiernan A.E., Pelling A.L., and Leung K.K. Sox2 is required for sensory organ development in the mammalian inner ear Nature 434 2005 1031 1035 (Pubitemid 40586052)
19. Taranova O.V., Magness S.T., and Fagan B.M. SOX2 is a dose-dependent regulator of retinal neural progenitor competence Genes Dev 20 2006 1187 1202
20. Williamson K.A., Hever A.M., and Rainger J. Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome Hum Mol Genet 15 2006 1413 1422
21. Episkopou V. SOX2 functions in adult neural stem cells Trends Neurosci 28 2005 219 221 (Pubitemid 41556906)
22. Freier K., Knoepfle K., and Flechtenmacher C. Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma Genes Chromosomes Cancer 49 2010 9 16
23. Long K.B., and Hornick J.L. SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract Hum Pathol 40 2009 1768 1773
24. Scheble V.J., Braun M., and Wilbertz T. ERG rearrangement in small cell prostatic and lung cancer Histopathology 56 2010 937 943
25. Perner S., Wagner P.L., and Soltermann A. TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival J Pathol 217 2009 65 72
26. Weir B.A., Woo M.S., and Getz G. Characterizing the cancer genome in lung adenocarcinoma Nature 450 2007 893 898 (Pubitemid 350231325)
27. Kwei K.A., Kim Y.H., and Girard L. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer Oncogene 27 2008 3635 3640 (Pubitemid 351793793)
28. Ring B.Z., Seitz R.S., and Beck R.A. A novel five-antibody immunohistochemical test for subclassification of lung carcinoma Mod Pathol 22 2009 1032 1043
29. McCaughan F., Pole J.C., and Bankier A.T. Progressive 3q amplification consistently targets SOX2 in preinvasive squamous cell lung cancer Am J Respir Crit Care Med 182 2010 83 91