Expression of CD44 Isoforms Is Increased in the Airway Epithelium of Asthmatic Subjects

American Journal of Respiratory Cell and Molecular Biology

Volumn 16, Issue 1, 1997, Pages 14-22

  Lackie, Peter M ^a   Baker, Janice E ^b   Günthert, Ursula ^b   Holgate, Stephen T ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHUS;

HERMES ANTIGEN;

ARTICLE; ASTHMA; BRONCHUS; CELL JUNCTION; CELL MEMBRANE; CHEMISTRY; EPITHELIUM; HUMAN; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; ULTRASTRUCTURE;

ANTIGENS, CD44; ASTHMA; BRONCHI; CELL MEMBRANE; EPITHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR JUNCTIONS; MICROSCOPY, IMMUNOELECTRON;

EID: 0030638424     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.16.1.8998074     Document Type: Article

References (39)

1. Stadnyk, A. W. 1994. Cytokine production by epithelial cells. FASEB J. 8:1041-1047.
2. Raeburn, D., and S. E. Webber. 1994. Proinflammatory potential of the airway epithelium in bronchial asthma. Eur. Respir. J. 7:2226-2233.
3. Marini, M., M. Soloperto, Y. Zheng, M. Mezzetti, and S. Mattoli. 1992. Protective effect of nedocromil sodium on the IL1-induced release of GMCSF from cultured human bronchial epithelial cells. Pulm. Pharmacol. 5:61-65.
4. Wegner, C. D., R. H. Gundel, P Reilly, N. Haynes, L G. Letts, and R. Rothlein. 1990. Intercellular adhesion molecule-1 (ICAM-1) inthepathogenesis of asthma. Science 247:456-459.
5. Look, D. C., S. R. Rapp, B. T. Keller, and M. J. Hollzman. 1992. Selective induction of intercellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells. Am. J. Physiol. 263:L79-L87.
6. Bloemen, P. G., M. C. van-den-Tweel, P. A. Henricks, F. Engels, S. S Wagenaar, A. A. Rutten, and F. P. Nijkamp. 1993. Expression and mod ulation of adhesion molecules on human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 9:586-593.
7. Tosi, M. F., J. M. Stark, C. W. Smith, A. Hamedani, D. C. Gruenert, and M. D. Infeld. 1992. Induction of ICAM-1 expression on airway epithelial cells by inflammatory cytokines: effects on neutrophil-epithelial cell adhesion. Am. J. Respir. Cell Mol. Biol. 7:214-221.
8. Montefort, S., J. A. Roberts, R. Beasley, S. T. Holgate, and W. R. Roche. 1992. The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax 47:499-503.
9. Laitinen, L. A., M. Heino, A. Laitinen, T. Kava, and T. Haahtela. 1985. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am. Rev. Respir. Dis. 131:599-606.
10. Dunhill, M. S. 1960. The pathology of asthma with specific reference to changes in the bronchial mucosa. J. Clin. Pathol. 12:27-33.
11. Naylor, B. 1962. The shedding of the mucosa of the bronchial tree in asthma. Thorax 17:69-72.
12. Terpe, H.-J., H. Stark, P. Prehm, and U. Günthert. 1994. CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues. Histochemistry 101:79-89.
13. Lesley, J., R. Hyman, and P. W. Kincade. 1993. CD44 and its interaction with the extracellular matrix. Adv. Immunol. 54:271-335.
14. Hua, Q., C. B. Knudson, and W. Knudson. 1993. Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis. J. Cell Sci. 106:365-375.
15. Bennett, K. L., D. G. Jackson, J. C. Simon, E. Tanczos, R. Peach, B. Modrell, I. Stamenkovic, G. Plowman, and A. Aruffo. 1995. CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor. J. Cell Biol. 128:687-698.
16. Tanaka, Y., D. H. Adams, S. Hubscher, H. Hirano, U. Siebenlist, and S. Shaw. 1993. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β. Nature 361:79-82.
17. Tanaka, Y., D. H. Adams, and S. Shaw. 1993. Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes. Immunol. Today 14:111-115.
18. Günthert, U., M. Hofmann, W. Rudy, S. Reber, M. Zoller, I. Haussmann, S. Matzku, A. Wenzel, H. Ponta, and P. Herrlich. 1991. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65:13-24.
19. Seiter, S., R. Arch, S. Reber, D. Komitowski, M. Hofmann, H. Ponta, P. Herrlich, S. Matzku, and M. Zoller. 1993. Prevention of tumor metastasis formation by anti-variant CD44. J. Exp. Med. 177:443-455.
20. Gunthert, U., 1993. CD44: a multitude of isoforms with diverse functions. Curr. Top. Microbiol. Immunol. 184:47-63.
21. Screaton, G. R., M. V. Bell, D. G. Jackson, F. B. Cornelis, U. Gerth, and J. I Bell. 1992. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Sci. USA 89:12160-12164.
22. Ruiz, P., C. Schwärzler, and U. Günhert. 1995. CD44 isoforms during differentiation and development Bioessays 17:17-24.
23. Günthert, U., R. Stauder, B. Mayer, H.-J. Terpe, L. Finke, and K. Friedrich. 1995. Are CD44 variant isoforms involved in human tumour progression. Cancer Surveys 24:19-42.
24. Salmi, M., K. Gron-Virta, P. Sointu, R. Grenman, H. Kalimo, and S. Jalkanen. 1993. Regulated expression of exon v6-containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J. Cell Biol. 122:431-442.
25. Lesley, J., N. Howes, A. Perschl, and R. Hyman 1994. Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response. J. Exp. Med. 180:383-387.
26. Stauder, R., and U. Gunthert. 1995. CD44 isoforms impact on lymphocyte activation and differentiation. Immunologist 3:78-83.
27. Isacke, C. M. 1994 The role of the cytoplasmic domain in regulating CD44 function. J. Cell Sci. 107:2353-2359.
28. Droll, A., S. T. Dougherty, R. K. Chiv, J. F. Dirks, W. H. McBride, D. L. Cooper, and G. J. Dougherty. 1995. Adhesive interactions between alternatively spliced CD44 isoforms. J. Biol. Chem. 270:11567-11573.
29. Mackay, C. R., H.-J. Terpe, R. Stauder, W. L. Marston, H. Stark, and U. Günthert. 1994. Expression and modulation of CD44 variant isoforms in humans. J. Cell Biol. 124:71-82.
30. Jalkanen, S., R. F. Bargatze, J. del los Toyos, and E. C. Butcher. 1987. Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of a 85-95kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal or synovial endothelial cells. J. Cell Biol. 105:983-990.
31. Mackay, C. R., J. F. Maddox, G. L. Wijffels, I. R. Mackay, and I. D. Walker. 1988. Characterisation of a 95,000 molecule on sheep leucocytes homologous to murine Pgp-1 and human CD44. Immunology 65:93-99.
32. Britten, K., P. Howarth, and W. R. Roche. 1993. Immunohistochemistry on resin sections; a comparison of resin embedding techniques for small mucosal biopsies. Biotechnol. Histochem. 68:271-280.
33. Tokuyasu, K. T. 1986. Application of cryoultramicrotomy to immunocytochemislry. J. Microsc. (Oxford) 143:139-149.
34. Tokuyasu, K. T. 1989. Use of poly(vinylpyrrolidone) and poly(vinyl alcohol) for cryoultramicrotomy. Histochem. J. 21:163-171.
35. Griffiths, G., K. Simons, G. Warren, and K. T. Tokuyasu. 1983. Immunoelectron microscopy using thin, frozen sections: application to studies of the intracellular transport of semliki forest virus spike glycoproteins. Methods Enzymol. 96:466.
36. Schefler, W. C. 1979. Statistics for the Biological Sciences, 2nd ed. Addison-Wesley, Reading, MA. 145-150.
37. Kasper, M., U. Günthert, P. Dall, K. Kayser, D. Schuh, and M. Müller, 1995. Distinct expression patterns of CD44 isoforms during human lung development and in pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 13:648-656.
38. Peroni, D. J., R. Djukanovic, P. Bradding, I. H. Feather, S. Montefort, P. Howarth, D. B. Jones, and S. T. Holgate. 1997 Comparison of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects. European Respiratory Journal (In press)
39. Lozewicz, S., C. Wells, E. Gomez, H. Ferguson, P. Richman, J. Devalia, and R. J. Davies. 1990. Morphological integrity of the bronchial epithelium in mild asthma. Thorax 45:12-15.