DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 8, 2011, Pages 948-956

  Van Boerdonk, Robert A A ^a   Sutedja, Thomas G ^a   Snijders, Peter J F ^a   Reinen, Emilie ^a   Wilting, Saskia M ^a   Van De Wiel, Mark A ^a   Thunnissen, F B J M ^a   Duin, Sylvia ^a   Kooi, Clarissa ^a   Ylstra, Bauke ^a   Meijer, Chris J L M ^a   Meijer, Gerrit A ^a   Grünberg, Katrien ^a   Daniels, Johannes M A ^a   Postmus, Pieter E ^a   Smit, Egbert F ^a   Heideman, Daniëlle A M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

3q; Autofluorescence bronchoscopy; Early detection; Follow up studies; Premalignant

Indexed keywords

KI 67 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN; PROTEIN P53; PROTEIN P63; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE BRONCHOSCOPY; AUTOFLUORESCENCE IMAGING; BRONCHOSCOPY; BRONCHUS BIOPSY; BRONCHUS CANCER; CANCER GROWTH; CANCER LOCALIZATION; CANCER RISK; CARCINOMA IN SITU; CASE CONTROL STUDY; CHROMOSOME 11Q; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 1P; CHROMOSOME 3P; CHROMOSOME 3Q; CHROMOSOME 4P; CHROMOSOME 5P; CHROMOSOME 6P; CHROMOSOME 7Q; CHROMOSOME 8Q; CHROMOSOME 9P; CHROMOSOME 9Q; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; ENDOBRONCHIAL SQUAMOUS METAPLASTIC LESION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; LUNG DYSPLASIA; MALE; PREDICTION; PRIORITY JOURNAL; SQUAMOUS CELL METAPLASIA;

AGED; BIOPSY; BRONCHOSCOPY; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; COHORT STUDIES; DNA COPY NUMBER VARIATIONS; FEMALE; GENETIC MARKERS; HUMANS; LUNG NEOPLASMS; MALE; METAPLASIA; MIDDLE AGED; RISK;

EID: 80054701735     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201102-0218OC     Document Type: Article

References (51)

1. Hirsch FR, Franklin WA, Gazdar AF, Bunn PA Jr. Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res 2001;7:5-22. (Pubitemid 32110200)
2. Lam S, Kennedy T, Unger M, Miller YE, Gelmont D, Rusch V, Gipe B, Howard D, leRiche JC, Coldman A, et al. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 1998;113:696-702. (Pubitemid 28130944)
3. Kennedy TC, McWilliams A, Edell E, Sutedja T, Downie G, Yung R, Gazdar A, Mathur PN. Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007;132:221S-233S. (Pubitemid 47502809)
4. Bota S, Auliac JB, Paris C, Metayer J, Sesboue R, Nouvet G, Thiberville L. Follow-up of bronchial precancerous lesions and carcinoma in situ using fluorescence endoscopy. Am J Respir Crit Care Med 2001;164:1688-1693. (Pubitemid 33124160)
5. Lam S, Palcic B. Re: Autofluorescence bronchoscopy in the detection of squamous metaplasia and dysplasia in current and former smokers. J Natl Cancer Inst 1999;91:561-562.
6. Loewen G, Natarajan N, Tan D, Nava E, Klippenstein D, Mahoney M, Cummings M, Reid M. Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment. Thorax 2007;62:335-340. (Pubitemid 46580577)
7. Venmans BJ, van Boxem TJ, Smit EF, Postmus PE, Sutedja TG. Outcome of bronchial carcinoma in situ. Chest 2000;117:1572-1576. (Pubitemid 30413346)
8. Breuer RH, Pasic A, Smit EF, van Vliet E, Vonk NA, Risse EJ, Postmus PE, Sutedja TG. The natural course of preneoplastic lesions in bronchial epithelium. Clin Cancer Res 2005;11:537-543. (Pubitemid 40116877)
9. Ishizumi T, McWilliams A, Macaulay C, Gazdar A, Lam S. Natural history of bronchial preinvasive lesions. Cancer Metastasis Rev 2010;29:5-14.
10. Wistuba II. Histologic evaluation of bronchial squamous lesions: any role in lung cancer risk assessment? Clin Cancer Res 2005;11:1358-1360. (Pubitemid 40315213)
11. Jeanmart M, Lantuejoul S, Fievet F, Moro D, Sturm N, Brambilla C, Brambilla E. Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer. Clin Cancer Res 2003;9:2195-2203. (Pubitemid 36687643)
12. Snijders PJ, Breuer RH, Sutedja TG, Egging M, Voorhorst FJ, Steenbergen RD, van der Linden HC, Risse EK, Berkhof J, de Vries EG, et al. Elevated hTERT mRNA levels: a potential determinant of bronchial squamous cell carcinoma (in situ). Int J Cancer 2004;109:412-417. (Pubitemid 38252770)
13. Salaun M, Sesboue R, Moreno-Swirc S, Metayer J, Bota S, Bourguignon J, Thiberville L. Molecular predictive factors for progression of high-grade preinvasive bronchial lesions. Am J Respir Crit Care Med 2008;177:880-886. (Pubitemid 351600666)
14. Rahman SM, Gonzalez AL, Li M, Seeley EH, Zimmerman LJ, Zhang XJ, Manier ML, Olson SJ, Shah RN, Miller AN, et al. Lung cancer diagnosis from proteomic analysis of preinvasive lesions. Cancer Res 2011;71:3009-3017.
15. Sutedja TG, Codrington H, Risse EK, Breuer RH, van Mourik JC, Golding RP, Postmus PE. Autofluorescence bronchoscopy improves staging of radiographically occult lung cancer and has an impact on therapeutic strategy. Chest 2001;120:1327-1332. (Pubitemid 32960111)
16. Pasic A, Brokx HA, Vonk NA, Paul RM, Postmus PE, Sutedja TG. Cost-effectiveness of early intervention: comparison between intraluminal bronchoscopic treatment and surgical resection for T1N0 lung cancer patients. Respiration 2004;71:391-396. (Pubitemid 39179176)
17. Masuda A, Takahashi T. Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis. Oncogene 2002;21:6884-6897. (Pubitemid 35221935)
18. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-649. (Pubitemid 29003936)
19. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-674.
20. van Boerdonk R, Reinen E, Sutedja TG, Wilting S, van de Wiel MA, Thunnissen FB, Kooi C, Ylstra B, Smit EF, Meijer GA, et al. Genomic profiling of autofluorescence bronchoscopy (AFB)-visualized squamous metaplastic lesions to predict endobronchial cancer [abstract]. Eur Respir J 2010;39S.
21. van Boerdonk R, Sutedja TG, Snijders PJ, Reinen E, Wilting S, van de Wiel MA, Thunnissen FB, Duin S, Kooi C, Ylstra B, et al. DNA copy number alterations in endobronchial squamous metaplastic lesions visualized by autofluorescence bronchoscopy predict lung cancer [abstract]. J Thor Oncol 2011;6(Suppl. 2):S295-S296.
22. Terry J, Leung S, Laskin J, Leslie KO, Gown AM, Ionescu DN. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol 2010;34:1805-1811.
23. Kang JU, Koo SH, Kwon KC, Park JW. Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung. Int J Oncol 2010;37:327-335.
24. Kang JU, Koo SH, Kwon KC, Park JW, Kim JM. Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2-q29 in squamous cell carcinoma of the lung. BMC Cancer 2009;9:237.
25. Gallegos Ruiz MI, Floor K, Roepman P, Rodriguez JA, Meijer GA, Mooi WJ, Jassem E, Niklinski J, Muley T, van ZN, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS ONE 2008;3:e0001722.
26. Massion PP, Kuo WL, Stokoe D, Olshen AB, Treseler PA, Chin K, Chen C, Polikoff D, Jain AN, Pinkel D, et al. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. Cancer Res 2002;62:3636-3640. (Pubitemid 34728838)
27. Dehan E, Ben-Dor A, Liao W, Lipson D, Frimer H, Rienstein S, Simansky D, Krupsky M, Yaron P, Friedman E, et al. Chromosomal aberrations and gene expression profiles in non-small cell lung cancer. Lung Cancer 2007;56:175-184. (Pubitemid 46613918)
28. Choi YW, Choi JS, Zheng LT, Lim YJ, Yoon HK, Kim YH, Wang YP, Lim Y. Comparative genomic hybridization array analysis and real time PCR reveals genomic alterations in squamous cell carcinomas of the lung. Lung Cancer 2007;55:43-51. (Pubitemid 46038877)
29. Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ, et al. Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. PLoS Med 2010;7:e1000315.
30. Weiss J, Sos ML, Seidel D, Peifer M, Zander T, Heuckmann JM, Ullrich RT, Menon R, Maier S, Soltermann A, et al. The identification of focal and recurrent amplification of FGFR1 in squamous-cell lung cancer represents the first therapeutically amendable target in this histological type of lung cancer that is characterized by smoking history and resistance to targeted drugs. Sci Transl Med 2010;2:62ra93.
31. Jonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL, et al. Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer. Am J Respir Crit Care Med 2008;177:342-347. (Pubitemid 351198379)
32. Massion PP, Zou Y, Uner H, Kiatsimkul P, Wolf HJ, Baron AE, Byers T, Jonsson S, Lam S, Hirsch FR, et al. Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS ONE 2009;4:e5611.
33. Helfritzsch H, Junker K, Bartel M, Scheele J. Differentiation of positive autofluorescence bronchoscopy findings by comparative genomic hybridization. Oncol Rep 2002;9:697-701.
34. Ma J, Gao M, Lu Y, Feng X, Zhang J, Lin D, Xiao T, Hu Z, Yuan J, Su K, et al. Gain of 1q25-32, 12q23-24.3, and 17q12-22 facilitates tumorigenesis and progression of human squamous cell lung cancer. J Pathol 2006;210:205-213. (Pubitemid 44463935)
35. Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009;41:1238-1242.
36. Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, et al. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med 20102:26ra25.
37. McCaughan F, Pole JC, Bankier AT, Konfortov BA, Carroll B, Falzon M, Rabbitts TH, George PJ, Dear PH, Rabbitts PH. Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am J Respir Crit Care Med 2010;182:83-91.
38. Qian J, Massion PP. Role of chromosome 3q amplification in lung cancer. J Thorac Oncol 2008;3:212-215. (Pubitemid 351654319)
39. Ikeda S. Atlas of flexible bronchofiberscopy. Baltimore: University Park Press, 1974.
40. Travis WD, Brambilla E, Muller-Hermelink KM. Pathology and genetics: tumours of the lung, pleura, thymus and heart. Lyon: IARC; 2004.
41. Boers JE, Ambergen AW, Thunnissen FB. Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am J Respir Crit Care Med 1998;157:2000-2006.
42. Flake GP, Rivera MP, Funkhouser WK, Maygarden SJ, Meadows KL, Long EH, Stockton PS, Jones TC, Yim HW, Slebos RJ, et al. Detection of pre-invasive lung cancer: technical aspects of the LIFE project. Toxicol Pathol 2007;35:65-74. (Pubitemid 46328408)
43. van Zeeburg HJ, Snijders PJ, Pals G, Hermsen MA, Rooimans MA, Bagby G, Soulier J, Gluckman E, Wennerberg J, Leemans CR, et al. Generation and molecular characterization of head and neck squamous cell lines of Fanconi anemia patients. Cancer Res 2005;65:1271-1276. (Pubitemid 40270153)
44. Buffart TE, Tijssen M, Krugers T, Carvalho B, Smeets SJ, Brakenhoff RH, Grabsch H, Meijer GA, Sadowski HB, Ylstra B. DNA quality assessment for array CGH by isothermal whole genome amplification. Cell Oncol 2007;29:351-359. (Pubitemid 47037249)
45. Buffart TE, Israeli D, Tijssen M, Vosse SJ, Mrsic A, Meijer GA, Ylstra B. Across array comparative genomic hybridization: a strategy to reduce reference channel hybridizations. Genes Chromosomes Cancer 2008;47:994-1004.
46. van de Wiel MA, Brosens R, Eilers PH, Kumps C, Meijer GA, Menten B, Sistermans E, Speleman F, Timmerman ME, Ylstra B. Smoothing waves in array CGH tumor profiles. Bioinformatics 2009;25:1099-1104.
47. van de Wiel MA, Kim KI, Vosse SJ, van Wieringen WN, Wilting SM, Ylstra B. CGHcall: calling aberrations for array CGH tumor profiles. Bioinformatics 2007;23:892-894. (Pubitemid 47049924)
48. van de Wiel MA, van Wieringen WN. CGH regions: dimension reduction for array CGH data with minimal information loss. Cancer Inform 2007;3:55-63.
49. van Wieringen WN, van de Wiel MA, Ylstra B. Weighted clustering of called array CGH data. Biostatistics 2008;9:484-500. (Pubitemid 351882087)
50. Wilting SM, Smeets SJ, Snijders PJ, van Wieringen WN, van de Wiel MA, Meijer GA, Ylstra B, Leemans CR, Meijer CJ, Brakenhoff RH, et al. Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck. BMC Med Genomics 2009;2:32.
51. Kim KI, Roquain E, van de Wiel MA. Spatial clustering of array CGH features in combination with hierarchical multiple testing. Stat Appl Genet Mol Biol 2010;9:40.