SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer

Modern Pathology

Volumn 24, Issue 7, 2011, Pages 944-953

  Wilbertz, Theresia ^a   Wagner, Patrick ^b   Petersen, Karen ^a   Stiedl, Ann Cathrin ^a   Scheble, Veit J ^a   Maier, Sebastian ^a   Reischl, Markus ^c   Mikut, Ralf ^c   Altorki, Nasser K ^b   Moch, Holger ^d   Fend, Falko ^a   Staebler, Annette ^a   Bass, Adam J ^e,f   Meyerson, Matthew ^e,f,g   Rubin, Mark A ^b   Soltermann, Alex ^d   Lengerke, Claudia ^a   Perner, Sven ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b WEILL CORNELL MEDICAL CENTER   (United States)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

amplification; expression; lung cancer; SOX2; squamous cell carcinoma

Indexed keywords

TRANSCRIPTION FACTOR SOX2;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; TUMOR VOLUME; UPREGULATION;

ADENOCARCINOMA; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; NEOPLASM STAGING; PROGNOSIS; SOXB1 TRANSCRIPTION FACTORS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 79959930090     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.49     Document Type: Article

References (31)

1. Frohling S, Dohner H. Chromosomal abnormalities in cancer. N Engl J Med 2008;359:722-734.
2. Albertson DG. Gene amplification in cancer. Trends Genet 2006;22:447-455. (Pubitemid 44093770)
3. Weir BA, Woo MS, Getz G, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007;450:893-898. (Pubitemid 350231325)
4. Kwei KA, Kim YH, Girard L, et al. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene 2008;27:3635-3640. (Pubitemid 351793793)
5. Garraway LA, Sellers WR. Lineage dependency and lineage-survival oncogenes in human cancer. Nat Rev Cancer 2006;6:593-602. (Pubitemid 44140858)
6. Perner S, Wagner PL, Soltermann A, et al. TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival. J Pathol 2009;217:65-72.
7. Barletta JA, Perner S, Iafrate AJ, et al. Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma. J Cell Mol Med 2009;13:1977-1986.
8. Qian J, Massion PP. Role of chromosome 3q amplification in lung cancer. J Thorac Oncol 2008;3:212-215. (Pubitemid 351654319)
9. Bass AJ, Watanabe H, Mermel CH, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009;41:1238-1242.
10. Hussenet T, Dali S, Exinger J, et al. SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS One 2010;5:e8960.
11. Kamachi Y, Uchikawa M, Kondoh H. Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet 2000;16:182-187. (Pubitemid 30169154)
12. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
13. Avilion AA, Nicolis SK, Pevny LH, et al. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 2003;17:126-140. (Pubitemid 36062514)
14. Chew LJ, Gallo V. The Yin and Yang of Sox proteins: activation and repression in development and disease. J Neurosci Res 2009;87:3277-3287.
15. Gontan C, de Munck A, Vermeij M, et al. Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol 2008;317:296-309.
16. Que J, Okubo T, Goldenring JR, et al. Multiple dosedependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 2007;134:2521-2531. (Pubitemid 47074146)
17. Yuan P, Kadara H, Behrens C, et al. Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung. PLoS One 2010;5:e9112.
18. Sholl LM, Long KB, Hornick JL. Sox2 expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol 2010;18:55-61.
19. Sholl LM, Barletta JA, Yeap BY, et al. Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma. Am J Surg Pathol 2010;34:1193-1198.
20. McCaughan F, Pole JC, Bankier AT, et al. Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am J Respir Crit Care Med 2010;182:83-91.
21. Freier K, Knoepfle K, Flechtenmacher C, et al. Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma. Genes Chromosomes Cancer 2010;49:9-16.
22. Long KB, Hornick JL. SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol 2009;40:1768-1773.
23. Maier S, Wilbertz T, Braun M, et al. SOX2 amplification is a common event in squamous cell carcinomas of different organ sites. Hum Pathol 2011 (e-pub ahead of print).
24. Lengerke C, Fehm T, Kurth R, et al. Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma. BMC Cancer 2011;11.
25. Lu Y, Futtner C, Rock JR, et al. Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One 2010;5:e11022.
26. Zhang X, Yu H, Yang Y, et al. SOX2 in gastric carcinoma, but not Hath1, is related to patients' clinicopathological features and prognosis. J Gastrointest Surg 2010;14:1220-1226.
27. Soltermann A, Tischler V, Arbogast S, et al. Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer. Clin Cancer Res 2008;14: 7430-7437.
28. Hussenet T, du Manoir S. SOX2 in squamous cell carcinoma: amplifying a pleiotropic oncogene along carcinogenesis. Cell Cycle 2010;9.
29. Ben-Porath I, Thomson M, Carey V, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507. (Pubitemid 351601215)
30. Jeter C, Badeaux M, Choy G, et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 2009;27:993-1005.
31. Rosen J, Jordan C. The increasing complexity of the cancer stem cell paradigm. Science 2009;324: 1670-1673.