Continual exposure to cigarette smoke extracts induces tumor-like transformation of human nontumor bronchial epithelial cells in a microfluidic chip

Journal of Thoracic Oncology

Volumn 9, Issue 8, 2014, Pages 1091-1100

  Li, Encheng ^a   Xu, Zhiyun ^a   Liu, Fen ^a   Wang, Huiling ^a   Wen, Jiabin ^a   Shao, Shujuan ^a   Zhang, Lichuan ^b   Wang, Lei ^c   Liu, Chong ^c   Lu, Jianxin ^d   Wang, Wenxin ^e   Gao, Zhancheng ^f   Wang, Qi ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY   (China)

^c DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^d BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

^f PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Epithelial cells; Microfluidic chip; Reactive oxygen species; Smoking; Transformation

Indexed keywords

CIGARETTE SMOKE; GLUCOSE REGULATED PROTEIN 78; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; DRUG MIXTURE; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; SMOKE;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BRONCHUS MUCOSA; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CHROMOSOME ANALYSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN TISSUE; LUNG SQUAMOUS CELL CARCINOMA; MALIGNANT TRANSFORMATION; MICROFLUIDIC ANALYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOKING; ADVERSE EFFECTS; APOPTOSIS; BRONCHUS; CARCINOMA, SQUAMOUS CELL; CELL CULTURE; CELL TRANSFORMATION; CHEMISTRY; DRUG EFFECTS; DRUG MIXTURE; EPITHELIUM CELL; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKE; TOBACCO; TOXICITY;

APOPTOSIS; BRONCHI; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOMAL INSTABILITY; COMPLEX MIXTURES; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; HEAT-SHOCK PROTEINS; HUMANS; LUNG NEOPLASMS; MICROFLUIDIC ANALYTICAL TECHNIQUES; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMOKE; SMOKING; TOBACCO;

EID: 84905858181     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0000000000000219     Document Type: Article

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