-
1
-
-
79952232216
-
Global cancer statistics
-
[PMID: 21296855 DOI: 10.3322/caac.20107]
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90 [PMID: 21296855 DOI: 10.3322/caac.20107]
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
80053088189
-
Hepatocellular carcinoma
-
[PMID: 21992124 DOI: 10.1056/NEJMra1001683]
-
El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011; 365: 1118-1127 [PMID: 21992124 DOI: 10.1056/NEJMra1001683]
-
(2011)
N Engl J Med
, vol.365
, pp. 1118-1127
-
-
El-Serag, H.B.1
-
3
-
-
63049133092
-
Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
-
[PMID: 19224838 DOI: 10.1200/JCO.2008.20.7753]
-
Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009; 27: 1485-1491 [PMID: 19224838 DOI: 10.1200/JCO.2008.20.7753]
-
(2009)
J Clin Oncol
, vol.27
, pp. 1485-1491
-
-
Altekruse, S.F.1
McGlynn, K.A.2
Reichman, M.E.3
-
4
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
[PMID: 17570226 DOI: 10.1053/j.gastro.2007.04.061]
-
El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576 [PMID: 17570226 DOI: 10.1053/j.gastro.2007.04.061]
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
5
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
[PMID: 15164071 DOI: 10.1038/nature02625]
-
Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004; 429: 457-463 [PMID: 15164071 DOI: 10.1038/nature02625]
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
6
-
-
0035839057
-
The role of DNA methylation in mammalian epigenetics
-
[PMID: 11498573 DOI: 10.1126/science.1063852]
-
Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001; 293: 1068-1070 [PMID: 11498573 DOI: 10.1126/science.1063852]
-
(2001)
Science
, vol.293
, pp. 1068-1070
-
-
Jones, P.A.1
Takai, D.2
-
7
-
-
0037068358
-
Reactivating the expression of methylation silenced genes in human cancer
-
[PMID: 12154410 DOI: 10.1038/sj.onc.1205602]
-
Karpf AR, Jones DA. Reactivating the expression of methylation silenced genes in human cancer. Oncogene 2002; 21: 5496-5503 [PMID: 12154410 DOI: 10.1038/sj.onc.1205602]
-
(2002)
Oncogene
, vol.21
, pp. 5496-5503
-
-
Karpf, A.R.1
Jones, D.A.2
-
8
-
-
16544395591
-
DNA methylation and cancer
-
[PMID: 15542813 DOI: 10.1200/ JCO.2004.07.151]
-
Das PM, Singal R. DNA methylation and cancer. J Clin Oncol 2004; 22: 4632-4642 [PMID: 15542813 DOI: 10.1200/ JCO.2004.07.151]
-
(2004)
J Clin Oncol
, vol.22
, pp. 4632-4642
-
-
Das, P.M.1
Singal, R.2
-
9
-
-
79957485296
-
Epigenetic mechanisms in hepatocellular carcinoma: How environmental factors influence the epigenome
-
[PMID: 21514401 DOI: 10.1016/j.mrrev.2011.04.001]
-
Herceg Z, Paliwal A. Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. Mutat Res 2011; 727: 55-61 [PMID: 21514401 DOI: 10.1016/j.mrrev.2011.04.001]
-
(2011)
Mutat Res
, vol.727
, pp. 55-61
-
-
Herceg, Z.1
Paliwal, A.2
-
10
-
-
77957361278
-
Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors
-
[PMID: 20305825 DOI: 10.1371/journal. pone.0009749]
-
Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F, Gouysse G, McKay-Chopin S, Tavtigian SV, Scoazec JY, Herceg Z. Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One 2010; 5: e9749 [PMID: 20305825 DOI: 10.1371/journal. pone.0009749]
-
(2010)
PLoS One
, vol.5
-
-
Hernandez-Vargas, H.1
Lambert, M.P.2
Le Calvez-Kelm, F.3
Gouysse, G.4
McKay-Chopin, S.5
Tavtigian, S.V.6
Scoazec, J.Y.7
Herceg, Z.8
-
11
-
-
84874266463
-
Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma
-
[PMID: 23437062 DOI: 10.1371/journal.pone.0055761]
-
Song MA, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong LL. Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PLoS One 2013; 8: e55761 [PMID: 23437062 DOI: 10.1371/journal.pone.0055761]
-
(2013)
PLoS One
, vol.8
-
-
Song, M.A.1
Tiirikainen, M.2
Kwee, S.3
Okimoto, G.4
Yu, H.5
Wong, L.L.6
-
12
-
-
84861572881
-
Genome-wide DNA methylation profiles in hepatocellular carcinoma
-
[PMID: 22234943 DOI: 10.1002/hep.25569]
-
Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, Wang Q, Jasmine F, Ahsan H, Lee PH, Yu MW, Chen CJ, Santella RM. Genome-wide DNA methylation profiles in hepatocellular carcinoma. Hepatology 2012; 55: 1799-1808 [PMID: 22234943 DOI: 10.1002/hep.25569]
-
(2012)
Hepatology
, vol.55
, pp. 1799-1808
-
-
Shen, J.1
Wang, S.2
Zhang, Y.J.3
Kappil, M.4
Wu, H.C.5
Kibriya, M.G.6
Wang, Q.7
Jasmine, F.8
Ahsan, H.9
Lee, P.H.10
Yu, M.W.11
Chen, C.J.12
Santella, R.M.13
-
13
-
-
84865543987
-
Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
-
[PMID: 22407776 DOI: 10.1002/hep.25706]
-
Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A. Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 2012; 56: 994-1003 [PMID: 22407776 DOI: 10.1002/hep.25706]
-
(2012)
Hepatology
, vol.56
, pp. 994-1003
-
-
Nishida, N.1
Kudo, M.2
Nagasaka, T.3
Ikai, I.4
Goel, A.5
-
14
-
-
84888217454
-
Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma
-
[PMID: 24012984]
-
Revill K, Wang T, Lachenmayer A, Kojima K, Harrington A, Li J, Hoshida Y, Llovet JM, Powers S. Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma. Gastroenterology 2013; 145: 1424-1435. e25 [PMID: 24012984]
-
(2013)
Gastroenterology
, vol.145
-
-
Revill, K.1
Wang, T.2
Lachenmayer, A.3
Kojima, K.4
Harrington, A.5
Li, J.6
Hoshida, Y.7
Llovet, J.M.8
Powers, S.9
-
15
-
-
33644851413
-
Recognition and classification of histones using support vector machine
-
[PMID: 16472024 DOI: 10.1089/ cmb.2006.13.102]
-
Bhasin M, Reinherz EL, Reche PA. Recognition and classification of histones using support vector machine. J Comput Biol 2006; 13: 102-112 [PMID: 16472024 DOI: 10.1089/ cmb.2006.13.102]
-
(2006)
J Comput Biol
, vol.13
, pp. 102-112
-
-
Bhasin, M.1
Reinherz, E.L.2
Reche, P.A.3
-
16
-
-
6044256118
-
Histones and histone modifications
-
[PMID: 15268870 DOI: 10.1016/j.cub.2004.07.007]
-
Peterson CL, Laniel MA. Histones and histone modifications. Curr Biol 2004; 14: R546-R551 [PMID: 15268870 DOI: 10.1016/j.cub.2004.07.007]
-
(2004)
Curr Biol
, vol.14
-
-
Peterson, C.L.1
Laniel, M.A.2
-
17
-
-
67349190247
-
Linking DNA methylation and histone modification: Patterns and paradigms
-
[PMID: 19308066 DOI: 10.1038/nrg2540]
-
Cedar H, Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 2009; 10: 295-304 [PMID: 19308066 DOI: 10.1038/nrg2540]
-
(2009)
Nat Rev Genet
, vol.10
, pp. 295-304
-
-
Cedar, H.1
Bergman, Y.2
-
18
-
-
34547890019
-
Functions of site-specific histone acetylation and deacetylation
-
[PMID: 17362198 DOI: 10.1146/annurev.biochem. 76.052705.162114]
-
Shahbazian MD, Grunstein M. Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem 2007; 76: 75-100 [PMID: 17362198 DOI: 10.1146/annurev.biochem. 76.052705.162114]
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 75-100
-
-
Shahbazian, M.D.1
Grunstein, M.2
-
19
-
-
0036591878
-
The many faces of histone lysine methylation
-
[PMID: 12067650 DOI: 10.1016/S0955-0674(02)00335-6]
-
Lachner M, Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol 2002; 14: 286-298 [PMID: 12067650 DOI: 10.1016/S0955-0674(02)00335-6]
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 286-298
-
-
Lachner, M.1
Jenuwein, T.2
-
20
-
-
0035883954
-
Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails
-
[PMID: 11562345 DOI: 10.1101/gad.927301]
-
Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 2001; 15: 2343-2360 [PMID: 11562345 DOI: 10.1101/gad.927301]
-
(2001)
Genes Dev
, vol.15
, pp. 2343-2360
-
-
Zhang, Y.1
Reinberg, D.2
-
21
-
-
84864280886
-
High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma
-
[PMID: 22406368 DOI: 10.1016/j.humpath.2011.11.003]
-
He C, Xu J, Zhang J, Xie D, Ye H, Xiao Z, Cai M, Xu K, Zeng Y, Li H, Wang J. High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma. Hum Pathol 2012; 43: 1425-1435 [PMID: 22406368 DOI: 10.1016/j.humpath.2011.11.003]
-
(2012)
Hum Pathol
, vol.43
, pp. 1425-1435
-
-
He, C.1
Xu, J.2
Zhang, J.3
Xie, D.4
Ye, H.5
Xiao, Z.6
Cai, M.7
Xu, K.8
Zeng, Y.9
Li, H.10
Wang, J.11
-
22
-
-
78651506355
-
High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients
-
[PMID: 20844838]
-
Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, Lin MC, Guan XY, Kung HF, Zeng YX, Xie D. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med 2011; 17: 12-20 [PMID: 20844838]
-
(2011)
Mol Med
, vol.17
, pp. 12-20
-
-
Cai, M.Y.1
Hou, J.H.2
Rao, H.L.3
Luo, R.Z.4
Li, M.5
Pei, X.Q.6
Lin, M.C.7
Guan, X.Y.8
Kung, H.F.9
Zeng, Y.X.10
Xie, D.11
-
23
-
-
33947301272
-
Epigenetic signatures of stem-cell identity
-
[PMID: 17363975 DOI: 10.1038/nrg2046]
-
Spivakov M, Fisher AG. Epigenetic signatures of stem-cell identity. Nat Rev Genet 2007; 8: 263-271 [PMID: 17363975 DOI: 10.1038/nrg2046]
-
(2007)
Nat Rev Genet
, vol.8
, pp. 263-271
-
-
Spivakov, M.1
Fisher, A.G.2
-
24
-
-
78751662908
-
The Polycomb complex PRC2 and its mark in life
-
[PMID: 21248841 DOI: 10.1038/nature09784]
-
Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011; 469: 343-349 [PMID: 21248841 DOI: 10.1038/nature09784]
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
25
-
-
34248169728
-
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
-
[PMID: 17339329 DOI: 10.1128/MCB.01432-06]
-
Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 2007; 27: 3769-3779 [PMID: 17339329 DOI: 10.1128/MCB.01432-06]
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3769-3779
-
-
Pasini, D.1
Bracken, A.P.2
Hansen, J.B.3
Capillo, M.4
Helin, K.5
-
26
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
[PMID: 14500907 DOI: 10.1073/pnas.1933744100]
-
Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100: 11606-11611 [PMID: 14500907 DOI: 10.1073/pnas.1933744100]
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
Shen, R.4
Ota, I.5
Tomlins, S.A.6
Ghosh, D.7
Sewalt, R.G.8
Otte, A.P.9
Hayes, D.F.10
Sabel, M.S.11
Livant, D.12
Weiss, S.J.13
Rubin, M.A.14
Chinnaiyan, A.M.15
-
27
-
-
33644765912
-
Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
-
[PMID: 16489070 DOI: 10.1158/1078-0432.CCR-05-1533]
-
Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A, Aas T, Otte AP, Akslen LA. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 2006; 12: 1168-1174 [PMID: 16489070 DOI: 10.1158/1078-0432.CCR-05-1533]
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1168-1174
-
-
Collett, K.1
Eide, G.E.2
Arnes, J.3
Stefansson, I.M.4
Eide, J.5
Braaten, A.6
Aas, T.7
Otte, A.P.8
Akslen, L.A.9
-
28
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
[PMID: 12374981 DOI: 10.1038/nature01075]
-
Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419: 624-629 [PMID: 12374981 DOI: 10.1038/nature01075]
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
Barrette, T.R.4
Kumar-Sinha, C.5
Sanda, M.G.6
Ghosh, D.7
Pienta, K.J.8
Sewalt, R.G.9
Otte, A.P.10
Rubin, M.A.11
Chinnaiyan, A.M.12
-
29
-
-
19944397508
-
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma
-
[PMID: 15856046 DOI: 10.1038/sj.bjc.6602531]
-
Sudo T, Utsunomiya T, Mimori K, Nagahara H, Ogawa K, Inoue H, Wakiyama S, Fujita H, Shirouzu K, Mori M. Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma. Br J Cancer 2005; 92: 1754-1758 [PMID: 15856046 DOI: 10.1038/sj.bjc.6602531]
-
(2005)
Br J Cancer
, vol.92
, pp. 1754-1758
-
-
Sudo, T.1
Utsunomiya, T.2
Mimori, K.3
Nagahara, H.4
Ogawa, K.5
Inoue, H.6
Wakiyama, S.7
Fujita, H.8
Shirouzu, K.9
Mori, M.10
-
30
-
-
79958219307
-
EZH2 protein: A promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies
-
[PMID: 21330577 DOI: 10.1136/ gut.2010.231993]
-
Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut 2011; 60: 967-976 [PMID: 21330577 DOI: 10.1136/ gut.2010.231993]
-
(2011)
Gut
, vol.60
, pp. 967-976
-
-
Cai, M.Y.1
Tong, Z.T.2
Zheng, F.3
Liao, Y.J.4
Wang, Y.5
Rao, H.L.6
Chen, Y.C.7
Wu, Q.L.8
Liu, Y.H.9
Guan, X.Y.10
Lin, M.C.11
Zeng, Y.X.12
Kung, H.F.13
Xie, D.14
-
31
-
-
68349150322
-
Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma
-
[PMID: 19386347 DOI: 10.1016/j.humpath.2009.01.017]
-
Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O. Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma. Hum Pathol 2009; 40: 1304-1311 [PMID: 19386347 DOI: 10.1016/j.humpath.2009.01.017]
-
(2009)
Hum Pathol
, vol.40
, pp. 1304-1311
-
-
Yonemitsu, Y.1
Imazeki, F.2
Chiba, T.3
Fukai, K.4
Nagai, Y.5
Miyagi, S.6
Arai, M.7
Aoki, R.8
Miyazaki, M.9
Nakatani, Y.10
Iwama, A.11
Yokosuka, O.12
-
32
-
-
79957912993
-
EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis
-
[PMID: 21512140 DOI: 10.1158/0008-5472.CAN-10-3342]
-
Cheng AS, Lau SS, Chen Y, Kondo Y, Li MS, Feng H, Ching AK, Cheung KF, Wong HK, Tong JH, Jin H, Choy KW, Yu J, To KF, Wong N, Huang TH, Sung JJ. EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis. Cancer Res 2011; 71: 4028-4039 [PMID: 21512140 DOI: 10.1158/0008-5472.CAN-10-3342]
-
(2011)
Cancer Res
, vol.71
, pp. 4028-4039
-
-
Cheng, A.S.1
Lau, S.S.2
Chen, Y.3
Kondo, Y.4
Li, M.S.5
Feng, H.6
Ching, A.K.7
Cheung, K.F.8
Wong, H.K.9
Tong, J.H.10
Jin, H.11
Choy, K.W.12
Yu, J.13
To, K.F.14
Wong, N.15
Huang, T.H.16
Sung, J.J.17
-
33
-
-
84864344679
-
Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
-
[PMID: 22370893 DOI: 10.1002/hep.25679]
-
Au SL, Wong CC, Lee JM, Fan DN, Tsang FH, Ng IO, Wong CM. Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology 2012; 56: 622-631 [PMID: 22370893 DOI: 10.1002/hep.25679]
-
(2012)
Hepatology
, vol.56
, pp. 622-631
-
-
Au, S.L.1
Wong, C.C.2
Lee, J.M.3
Fan, D.N.4
Tsang, F.H.5
Ng, I.O.6
Wong, C.M.7
-
34
-
-
77952430646
-
The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells
-
[PMID: 20395008 DOI: 10.1016/j.jhep.2010.01.027]
-
Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A. The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells. J Hepatol 2010; 52: 854-863 [PMID: 20395008 DOI: 10.1016/j.jhep.2010.01.027]
-
(2010)
J Hepatol
, vol.52
, pp. 854-863
-
-
Aoki, R.1
Chiba, T.2
Miyagi, S.3
Negishi, M.4
Konuma, T.5
Taniguchi, H.6
Ogawa, M.7
Yokosuka, O.8
Iwama, A.9
-
35
-
-
84892848885
-
c-Mycmediated epigenetic silencing of microRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma
-
Epub ahead of print [PMID: 24002871]
-
Wang L, Zhang X, Jia LT, Hu SJ, Zhao J, Yang JD, Wen WH, Wang Z, Wang T, Zhao J, Wang RA, Meng YL, Nie YZ, Dou KF, Chen SY, Yao LB, Fan DM, Zhang R, Yang AG. c-Mycmediated epigenetic silencing of microRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma. Hepatology 2013; Epub ahead of print [PMID: 24002871]
-
(2013)
Hepatology
-
-
Wang, L.1
Zhang, X.2
Jia, L.T.3
Hu, S.J.4
Zhao, J.5
Yang, J.D.6
Wen, W.H.7
Wang, Z.8
Wang, T.9
Zhao, J.10
Wang, R.A.11
Meng, Y.L.12
Nie, Y.Z.13
Dou, K.F.14
Chen, S.Y.15
Yao, L.B.16
Fan, D.M.17
Zhang, R.18
Yang, A.G.19
-
36
-
-
58149239686
-
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
-
[PMID: 19008416 DOI: 10.1126/science.1165395]
-
Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008; 322: 1695-1699 [PMID: 19008416 DOI: 10.1126/science.1165395]
-
(2008)
Science
, vol.322
, pp. 1695-1699
-
-
Varambally, S.1
Cao, Q.2
Mani, R.S.3
Shankar, S.4
Wang, X.5
Ateeq, B.6
Laxman, B.7
Cao, X.8
Jing, X.9
Ramnarayanan, K.10
Brenner, J.C.11
Yu, J.12
Kim, J.H.13
Han, B.14
Tan, P.15
Kumar-Sinha, C.16
Lonigro, R.J.17
Palanisamy, N.18
Maher, C.A.19
Chinnaiyan, A.M.20
more..
-
37
-
-
0031035764
-
The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice
-
[PMID: 9053836 DOI: 10.1038/ sj.onc.1200850]
-
Terradillos O, Billet O, Renard CA, Levy R, Molina T, Briand P, Buendia MA. The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene 1997; 14: 395-404 [PMID: 9053836 DOI: 10.1038/ sj.onc.1200850]
-
(1997)
Oncogene
, vol.14
, pp. 395-404
-
-
Terradillos, O.1
Billet, O.2
Renard, C.A.3
Levy, R.4
Molina, T.5
Briand, P.6
Buendia, M.A.7
-
38
-
-
0035084167
-
Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions
-
[PMID: 11264374 DOI: 10.1128/JVI.75.8.3851-3858.2001]
-
Madden CR, Finegold MJ, Slagle BL. Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol 2001; 75: 3851-3858 [PMID: 11264374 DOI: 10.1128/JVI.75.8.3851-3858.2001]
-
(2001)
J Virol
, vol.75
, pp. 3851-3858
-
-
Madden, C.R.1
Finegold, M.J.2
Slagle, B.L.3
-
39
-
-
57649116077
-
Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy
-
[PMID: 18693245 DOI: 10.1074/jbc.M802751200]
-
Rakotomalala L, Studach L, Wang WH, Gregori G, Hullinger RL, Andrisani O. Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. J Biol Chem 2008; 283: 28729-28740 [PMID: 18693245 DOI: 10.1074/jbc.M802751200]
-
(2008)
J Biol Chem
, vol.283
, pp. 28729-28740
-
-
Rakotomalala, L.1
Studach, L.2
Wang, W.H.3
Gregori, G.4
Hullinger, R.L.5
Andrisani, O.6
-
40
-
-
77956943757
-
Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy
-
[PMID: 20624918 DOI: 10.1074/jbc.M109.093963]
-
Studach L, Wang WH, Weber G, Tang J, Hullinger RL, Malbrue R, Liu X, Andrisani O. Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy. J Biol Chem 2010; 285: 30282-30293 [PMID: 20624918 DOI: 10.1074/jbc.M109.093963]
-
(2010)
J Biol Chem
, vol.285
, pp. 30282-30293
-
-
Studach, L.1
Wang, W.H.2
Weber, G.3
Tang, J.4
Hullinger, R.L.5
Malbrue, R.6
Liu, X.7
Andrisani, O.8
-
41
-
-
84867181392
-
Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein
-
[PMID: 22505317 DOI: 10.1002/hep.25781]
-
Studach LL, Menne S, Cairo S, Buendia MA, Hullinger RL, Lefrançois L, Merle P, Andrisani OM. Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein. Hepatology 2012; 56: 1240-1251 [PMID: 22505317 DOI: 10.1002/hep.25781]
-
(2012)
Hepatology
, vol.56
, pp. 1240-1251
-
-
Studach, L.L.1
Menne, S.2
Cairo, S.3
Buendia, M.A.4
Hullinger, R.L.5
Lefrançois, L.6
Merle, P.7
Andrisani, O.M.8
-
42
-
-
79953765052
-
Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication
-
[PMID: 21480320 DOI: 10.1002/hep.24163]
-
Wang WH, Studach LL, Andrisani OM. Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. Hepatology 2011; 53: 1137-1147 [PMID: 21480320 DOI: 10.1002/hep.24163]
-
(2011)
Hepatology
, vol.53
, pp. 1137-1147
-
-
Wang, W.H.1
Studach, L.L.2
Andrisani, O.M.3
-
43
-
-
60149088848
-
Origins and Mechanisms of miRNAs and siRNAs
-
[PMID: 19239886 DOI: 10.1016/j.cell.2009.01.035]
-
Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-655 [PMID: 19239886 DOI: 10.1016/j.cell.2009.01.035]
-
(2009)
Cell
, vol.136
, pp. 642-655
-
-
Carthew, R.W.1
Sontheimer, E.J.2
-
44
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
[PMID: 14744438 DOI: 10.1016/S0092-8674(04)00045-5]
-
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297 [PMID: 14744438 DOI: 10.1016/S0092-8674(04)00045-5]
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
45
-
-
33750370444
-
MicroRNA signatures in human cancers
-
[PMID: 17060945 DOI: 10.1038/nrc1997]
-
Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-866 [PMID: 17060945 DOI: 10.1038/nrc1997]
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 857-866
-
-
Calin, G.A.1
Croce, C.M.2
-
46
-
-
35349009932
-
Interferon modulation of cellular microRNAs as an antiviral mechanism
-
[PMID: 17943132 DOI: 10.1038/nature06205]
-
Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 2007; 449: 919-922 [PMID: 17943132 DOI: 10.1038/nature06205]
-
(2007)
Nature
, vol.449
, pp. 919-922
-
-
Pedersen, I.M.1
Cheng, G.2
Wieland, S.3
Volinia, S.4
Croce, C.M.5
Chisari, F.V.6
David, M.7
-
47
-
-
17644363376
-
A cellular microRNA mediates antiviral defense in human cells
-
[PMID: 15845854 DOI: 10.1126/science.1108784]
-
Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, Saïb A, Voinnet O. A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308: 557-560 [PMID: 15845854 DOI: 10.1126/science.1108784]
-
(2005)
Science
, vol.308
, pp. 557-560
-
-
Lecellier, C.H.1
Dunoyer, P.2
Arar, K.3
Lehmann-Che, J.4
Eyquem, S.5
Himber, C.6
Saïb, A.7
Voinnet, O.8
-
48
-
-
84859135566
-
MicroRNA-141 represses HBV replication by targeting PPARA
-
[PMID: 22479552 DOI: 10.1371/journal.pone.0034165]
-
Hu W, Wang X, Ding X, Li Y, Zhang X, Xie P, Yang J, Wang S. MicroRNA-141 represses HBV replication by targeting PPARA. PLoS One 2012; 7: e34165 [PMID: 22479552 DOI: 10.1371/journal.pone.0034165]
-
(2012)
PLoS One
, vol.7
-
-
Hu, W.1
Wang, X.2
Ding, X.3
Li, Y.4
Zhang, X.5
Xie, P.6
Yang, J.7
Wang, S.8
-
49
-
-
0037197803
-
Identification of tissue-specific microRNAs from mouse
-
[PMID: 12007417 DOI: 10.1016/S0960-9822(02)00809-6]
-
Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol 2002; 12: 735-739 [PMID: 12007417 DOI: 10.1016/S0960-9822(02)00809-6]
-
(2002)
Curr Biol
, vol.12
, pp. 735-739
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Yalcin, A.3
Meyer, J.4
Lendeckel, W.5
Tuschl, T.6
-
50
-
-
82655181501
-
A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication
-
[PMID: 21903935 DOI: 10.1096/fj.11-187781]
-
Chen Y, Shen A, Rider PJ, Yu Y, Wu K, Mu Y, Hao Q, Liu Y, Gong H, Zhu Y, Liu F, Wu J. A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J 2011; 25: 4511-4521 [PMID: 21903935 DOI: 10.1096/fj.11-187781]
-
(2011)
FASEB J
, vol.25
, pp. 4511-4521
-
-
Chen, Y.1
Shen, A.2
Rider, P.J.3
Yu, Y.4
Wu, K.5
Mu, Y.6
Hao, Q.7
Liu, Y.8
Gong, H.9
Zhu, Y.10
Liu, F.11
Wu, J.12
-
51
-
-
84856367312
-
Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
-
[PMID: 22215596 DOI: 10.1073/pnas.1112263109]
-
Shimakami T, Yamane D, Jangra RK, Kempf BJ, Spaniel C, Barton DJ, Lemon SM. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci USA 2012; 109: 941-946 [PMID: 22215596 DOI: 10.1073/pnas.1112263109]
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 941-946
-
-
Shimakami, T.1
Yamane, D.2
Jangra, R.K.3
Kempf, B.J.4
Spaniel, C.5
Barton, D.J.6
Lemon, S.M.7
-
52
-
-
84877258007
-
Treatment of HCV infection by targeting microRNA
-
[PMID: 23534542 DOI: 10.1056/NEJMoa1209026]
-
Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR. Treatment of HCV infection by targeting microRNA. N Engl J Med 2013; 368: 1685-1694 [PMID: 23534542 DOI: 10.1056/NEJMoa1209026]
-
(2013)
N Engl J Med
, vol.368
, pp. 1685-1694
-
-
Janssen, H.L.1
Reesink, H.W.2
Lawitz, E.J.3
Zeuzem, S.4
Rodriguez-Torres, M.5
Patel, K.6
van der Meer, A.J.7
Patick, A.K.8
Chen, A.9
Zhou, Y.10
Persson, R.11
King, B.D.12
Kauppinen, S.13
Levin, A.A.14
Hodges, M.R.15
-
53
-
-
33749479908
-
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
-
[PMID: 16924677 DOI: 10.1002/jcb.20982]
-
Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, Frankel W, Jacob ST, Ghoshal K. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 2006; 99: 671-678 [PMID: 16924677 DOI: 10.1002/jcb.20982]
-
(2006)
J Cell Biochem
, vol.99
, pp. 671-678
-
-
Kutay, H.1
Bai, S.2
Datta, J.3
Motiwala, T.4
Pogribny, I.5
Frankel, W.6
Jacob, S.T.7
Ghoshal, K.8
-
54
-
-
33646157967
-
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
-
[PMID: 16331254 DOI: 10.1038/sj.onc.1209283]
-
Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006; 25: 2537-2545 [PMID: 16331254 DOI: 10.1038/sj.onc.1209283]
-
(2006)
Oncogene
, vol.25
, pp. 2537-2545
-
-
Murakami, Y.1
Yasuda, T.2
Saigo, K.3
Urashima, T.4
Toyoda, H.5
Okanoue, T.6
Shimotohno, K.7
-
55
-
-
66149114383
-
MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
-
[PMID: 19296470 DOI: 10.1002/hep.22806]
-
Tsai WC, Hsu PW, Lai TC, Chau GY, Lin CW, Chen CM, Lin CD, Liao YL, Wang JL, Chau YP, Hsu MT, Hsiao M, Huang HD, Tsou AP. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology 2009; 49: 1571-1582 [PMID: 19296470 DOI: 10.1002/hep.22806]
-
(2009)
Hepatology
, vol.49
, pp. 1571-1582
-
-
Tsai, W.C.1
Hsu, P.W.2
Lai, T.C.3
Chau, G.Y.4
Lin, C.W.5
Chen, C.M.6
Lin, C.D.7
Liao, Y.L.8
Wang, J.L.9
Chau, Y.P.10
Hsu, M.T.11
Hsiao, M.12
Huang, H.D.13
Tsou, A.P.14
-
56
-
-
79955109306
-
Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1
-
[PMID: 21520166 DOI: 10.1002/hep.24195]
-
Zhang X, Zhang E, Ma Z, Pei R, Jiang M, Schlaak JF, Roggendorf M, Lu M. Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1. Hepatology 2011; 53: 1476-1485 [PMID: 21520166 DOI: 10.1002/hep.24195]
-
(2011)
Hepatology
, vol.53
, pp. 1476-1485
-
-
Zhang, X.1
Zhang, E.2
Ma, Z.3
Pei, R.4
Jiang, M.5
Schlaak, J.F.6
Roggendorf, M.7
Lu, M.8
-
57
-
-
84873344263
-
Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis
-
[PMID: 23321675]
-
Xu X, Fan Z, Kang L, Han J, Jiang C, Zheng X, Zhu Z, Jiao H, Lin J, Jiang K, Ding L, Zhang H, Cheng L, Fu H, Song Y, Jiang Y, Liu J, Wang R, Du N, Ye Q. Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest 2013; 123: 630-645 [PMID: 23321675]
-
(2013)
J Clin Invest
, vol.123
, pp. 630-645
-
-
Xu, X.1
Fan, Z.2
Kang, L.3
Han, J.4
Jiang, C.5
Zheng, X.6
Zhu, Z.7
Jiao, H.8
Lin, J.9
Jiang, K.10
Ding, L.11
Zhang, H.12
Cheng, L.13
Fu, H.14
Song, Y.15
Jiang, Y.16
Liu, J.17
Wang, R.18
Du, N.19
Ye, Q.20
more..
-
58
-
-
84861619812
-
MicroRNAs in liver disease
-
[PMID: 22504185]
-
Wang XW, Heegaard NH, Orum H. MicroRNAs in liver disease. Gastroenterology 2012; 142: 1431-1443 [PMID: 22504185]
-
(2012)
Gastroenterology
, vol.142
, pp. 1431-1443
-
-
Wang, X.W.1
Heegaard, N.H.2
Orum, H.3
-
59
-
-
84979256697
-
Role of microRNAs in hepatocellular carcinoma: A clinical perspective
-
[PMID: 24039437]
-
Callegari E, Elamin BK, Sabbioni S, Gramantieri L, Negrini M. Role of microRNAs in hepatocellular carcinoma: a clinical perspective. Onco Targets Ther 2013; 6: 1167-1178 [PMID: 24039437]
-
(2013)
Onco Targets Ther
, vol.6
, pp. 1167-1178
-
-
Callegari, E.1
Elamin, B.K.2
Sabbioni, S.3
Gramantieri, L.4
Negrini, M.5
-
60
-
-
84873907356
-
Identification of deregulated miRNAs and their targets in hepatitis B virusassociated hepatocellular carcinoma
-
[PMID: 23082062 DOI: 10.3748/wjg.v18.i38.5442]
-
Wang W, Zhao LJ, Tan YX, Ren H, Qi ZT. Identification of deregulated miRNAs and their targets in hepatitis B virusassociated hepatocellular carcinoma. World J Gastroenterol 2012; 18: 5442-5453 [PMID: 23082062 DOI: 10.3748/wjg.v18.i38.5442]
-
(2012)
World J Gastroenterol
, vol.18
, pp. 5442-5453
-
-
Wang, W.1
Zhao, L.J.2
Tan, Y.X.3
Ren, H.4
Qi, Z.T.5
-
61
-
-
84860485917
-
MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma
-
[PMID: 22362728 DOI: 10.1093/carcin/bgs113]
-
Wang W, Zhao LJ, Tan YX, Ren H, Qi ZT. MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. Carcinogenesis 2012; 33: 1113-1120 [PMID: 22362728 DOI: 10.1093/carcin/bgs113]
-
(2012)
Carcinogenesis
, vol.33
, pp. 1113-1120
-
-
Wang, W.1
Zhao, L.J.2
Tan, Y.X.3
Ren, H.4
Qi, Z.T.5
-
62
-
-
77955970127
-
Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion
-
[PMID: 20799954 DOI: 10.1186/1476-4598-9-227]
-
Shen Q, Cicinnati VR, Zhang X, Iacob S, Weber F, Sotiropoulos GC, Radtke A, Lu M, Paul A, Gerken G, Beckebaum S. Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer 2010; 9: 227 [PMID: 20799954 DOI: 10.1186/1476-4598-9-227]
-
(2010)
Mol Cancer
, vol.9
, pp. 227
-
-
Shen, Q.1
Cicinnati, V.R.2
Zhang, X.3
Iacob, S.4
Weber, F.5
Sotiropoulos, G.C.6
Radtke, A.7
Lu, M.8
Paul, A.9
Gerken, G.10
Beckebaum, S.11
-
63
-
-
38949184246
-
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
-
[PMID: 18223217 DOI: 10.1158/1078-0432. CCR-07-0523]
-
Jiang J, Gusev Y, Aderca I, Mettler TA, Nagorney DM, Brackett DJ, Roberts LR, Schmittgen TD. Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 2008; 14: 419-427 [PMID: 18223217 DOI: 10.1158/1078-0432. CCR-07-0523]
-
(2008)
Clin Cancer Res
, vol.14
, pp. 419-427
-
-
Jiang, J.1
Gusev, Y.2
Aderca, I.3
Mettler, T.A.4
Nagorney, D.M.5
Brackett, D.J.6
Roberts, L.R.7
Schmittgen, T.D.8
-
64
-
-
70349871321
-
MicroRNA expression, survival, and response to interferon in liver cancer
-
[PMID: 19812400 DOI: 10.1056/NEJMoa0901282]
-
Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med 2009; 361: 1437-1447 [PMID: 19812400 DOI: 10.1056/NEJMoa0901282]
-
(2009)
N Engl J Med
, vol.361
, pp. 1437-1447
-
-
Ji, J.1
Shi, J.2
Budhu, A.3
Yu, Z.4
Forgues, M.5
Roessler, S.6
Ambs, S.7
Chen, Y.8
Meltzer, P.S.9
Croce, C.M.10
Qin, L.X.11
Man, K.12
Lo, C.M.13
Lee, J.14
Ng, I.O.15
Fan, J.16
Tang, Z.Y.17
Sun, H.C.18
Wang, X.W.19
-
65
-
-
78049521995
-
MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2
-
[PMID: 20827722 DOI: 10.1002/hep.23904]
-
Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology 2010; 52: 1731-1740 [PMID: 20827722 DOI: 10.1002/hep.23904]
-
(2010)
Hepatology
, vol.52
, pp. 1731-1740
-
-
Liang, L.1
Wong, C.M.2
Ying, Q.3
Fan, D.N.4
Huang, S.5
Ding, J.6
Yao, J.7
Yan, M.8
Li, J.9
Yao, M.10
Ng, I.O.11
He, X.12
-
66
-
-
84879607251
-
MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma
-
[PMID: 23401231 DOI: 10.1002/hep.26315]
-
Yang H, Fang F, Chang R, Yang L. MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology 2013; 58: 205-217 [PMID: 23401231 DOI: 10.1002/hep.26315]
-
(2013)
Hepatology
, vol.58
, pp. 205-217
-
-
Yang, H.1
Fang, F.2
Chang, R.3
Yang, L.4
-
67
-
-
84879104968
-
Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling
-
[PMID: 23315977 DOI: 10.1002/hep.26252]
-
Wei W, Hou J, Alder O, Ye X, Lee S, Cullum R, Chu A, Zhao Y, Warner SM, Knight DA, Yang D, Jones SJ, Marra MA, Hoodless PA. Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling. Hepatology 2013; 57: 2491-2501 [PMID: 23315977 DOI: 10.1002/hep.26252]
-
(2013)
Hepatology
, vol.57
, pp. 2491-2501
-
-
Wei, W.1
Hou, J.2
Alder, O.3
Ye, X.4
Lee, S.5
Cullum, R.6
Chu, A.7
Zhao, Y.8
Warner, S.M.9
Knight, D.A.10
Yang, D.11
Jones, S.J.12
Marra, M.A.13
Hoodless, P.A.14
-
68
-
-
84864773072
-
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
-
[PMID: 22820290 DOI: 10.1172/ JCI63455]
-
Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, Hsu MT, Wu JC, Huang HD, Shiao MS, Hsiao M, Tsou AP. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest 2012; 122: 2884-2897 [PMID: 22820290 DOI: 10.1172/ JCI63455]
-
(2012)
J Clin Invest
, vol.122
, pp. 2884-2897
-
-
Tsai, W.C.1
Hsu, S.D.2
Hsu, C.S.3
Lai, T.C.4
Chen, S.J.5
Shen, R.6
Huang, Y.7
Chen, H.C.8
Lee, C.H.9
Tsai, T.F.10
Hsu, M.T.11
Wu, J.C.12
Huang, H.D.13
Shiao, M.S.14
Hsiao, M.15
Tsou, A.P.16
-
69
-
-
70349976819
-
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
-
[PMID: 19617899 DOI: 10.1038/onc.2009.211]
-
Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 2009; 28: 3526-3536 [PMID: 19617899 DOI: 10.1038/onc.2009.211]
-
(2009)
Oncogene
, vol.28
, pp. 3526-3536
-
-
Coulouarn, C.1
Factor, V.M.2
Andersen, J.B.3
Durkin, M.E.4
Thorgeirsson, S.S.5
-
70
-
-
45549084904
-
Liver cancer stem cells
-
[PMID: 18539957 DOI: 10.1200/JCO.2007.15.5945]
-
Sell S, Leffert HL. Liver cancer stem cells. J Clin Oncol 2008; 26: 2800-2805 [PMID: 18539957 DOI: 10.1200/JCO.2007.15.5945]
-
(2008)
J Clin Oncol
, vol.26
, pp. 2800-2805
-
-
Sell, S.1
Leffert, H.L.2
-
71
-
-
84255168800
-
Stem cells in liver diseases and cancer: Recent advances on the path to new therapies
-
[PMID: 22030746 DOI: 10.1002/hep.24762]
-
Rountree CB, Mishra L, Willenbring H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology 2012; 55: 298-306 [PMID: 22030746 DOI: 10.1002/hep.24762]
-
(2012)
Hepatology
, vol.55
, pp. 298-306
-
-
Rountree, C.B.1
Mishra, L.2
Willenbring, H.3
-
72
-
-
60449087921
-
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/ progenitor cell features
-
[PMID: 19150350 DOI: 10.1053/j.gastro.2008.12.004]
-
Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E, Reid LM, Minato H, Honda M, Kaneko S, Tang ZY, Wang XW. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/ progenitor cell features. Gastroenterology 2009; 136: 1012-1024 [PMID: 19150350 DOI: 10.1053/j.gastro.2008.12.004]
-
(2009)
Gastroenterology
, vol.136
, pp. 1012-1024
-
-
Yamashita, T.1
Ji, J.2
Budhu, A.3
Forgues, M.4
Yang, W.5
Wang, H.Y.6
Jia, H.7
Ye, Q.8
Qin, L.X.9
Wauthier, E.10
Reid, L.M.11
Minato, H.12
Honda, M.13
Kaneko, S.14
Tang, Z.Y.15
Wang, X.W.16
-
73
-
-
67651003100
-
The emerging role of Ep-CAM in cancer and stem cell signaling
-
[PMID: 19584271 DOI: 10.1158/0008-5472. CAN-09-0654]
-
Munz M, Baeuerle PA, Gires O. The emerging role of Ep-CAM in cancer and stem cell signaling. Cancer Res 2009; 69: 5627-5629 [PMID: 19584271 DOI: 10.1158/0008-5472. CAN-09-0654]
-
(2009)
Cancer Res
, vol.69
, pp. 5627-5629
-
-
Munz, M.1
Baeuerle, P.A.2
Gires, O.3
-
74
-
-
34249980343
-
Identification and characterization of tumorigenic liver cancer stem/progenitor cells
-
[PMID: 17570225 DOI: 10.1053/j.gastro.2007.04.025]
-
Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132: 2542-2556 [PMID: 17570225 DOI: 10.1053/j.gastro.2007.04.025]
-
(2007)
Gastroenterology
, vol.132
, pp. 2542-2556
-
-
Ma, S.1
Chan, K.W.2
Hu, L.3
Lee, T.K.4
Wo, J.Y.5
Ng, I.O.6
Zheng, B.J.7
Guan, X.Y.8
-
75
-
-
33750809196
-
Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells
-
[PMID: 17097610 DOI: 10.1016/j.bbrc.2006.10.128]
-
Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T, Moriwaki H. Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun 2006; 351: 820-824 [PMID: 17097610 DOI: 10.1016/j.bbrc.2006.10.128]
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 820-824
-
-
Suetsugu, A.1
Nagaki, M.2
Aoki, H.3
Motohashi, T.4
Kunisada, T.5
Moriwaki, H.6
-
76
-
-
38549139140
-
Significance of CD90+ cancer stem cells in human liver cancer
-
[PMID: 18242515 DOI: 10.1016/j.ccr.2008.01.013]
-
Yang ZF, Ho DW, Ng MN, Lau CK, Yu WC, Ngai P, Chu PW, Lam CT, Poon RT, Fan ST. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 2008; 13: 153-166 [PMID: 18242515 DOI: 10.1016/j.ccr.2008.01.013]
-
(2008)
Cancer Cell
, vol.13
, pp. 153-166
-
-
Yang, Z.F.1
Ho, D.W.2
Ng, M.N.3
Lau, C.K.4
Yu, W.C.5
Ngai, P.6
Chu, P.W.7
Lam, C.T.8
Poon, R.T.9
Fan, S.T.10
-
77
-
-
40949160140
-
Identification of local and circulating cancer stem cells in human liver cancer
-
[PMID: 18275073 DOI: 10.1002/ hep.22082]
-
Yang ZF, Ngai P, Ho DW, Yu WC, Ng MN, Lau CK, Li ML, Tam KH, Lam CT, Poon RT, Fan ST. Identification of local and circulating cancer stem cells in human liver cancer. Hepatology 2008; 47: 919-928 [PMID: 18275073 DOI: 10.1002/ hep.22082]
-
(2008)
Hepatology
, vol.47
, pp. 919-928
-
-
Yang, Z.F.1
Ngai, P.2
Ho, D.W.3
Yu, W.C.4
Ng, M.N.5
Lau, C.K.6
Li, M.L.7
Tam, K.H.8
Lam, C.T.9
Poon, R.T.10
Fan, S.T.11
-
78
-
-
68949170622
-
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
-
[PMID: 19585654 DOI: 10.1002/hep.22989]
-
Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C, Deng C, Wauthier E, Reid LM, Ye QH, Qin LX, Yang W, Wang HY, Tang ZY, Croce CM, Wang XW. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009; 50: 472-480 [PMID: 19585654 DOI: 10.1002/hep.22989]
-
(2009)
Hepatology
, vol.50
, pp. 472-480
-
-
Ji, J.1
Yamashita, T.2
Budhu, A.3
Forgues, M.4
Jia, H.L.5
Li, C.6
Deng, C.7
Wauthier, E.8
Reid, L.M.9
Ye, Q.H.10
Qin, L.X.11
Yang, W.12
Wang, H.Y.13
Tang, Z.Y.14
Croce, C.M.15
Wang, X.W.16
-
79
-
-
79960205154
-
Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
-
[PMID: 21711587 DOI: 10.1186/2045-3701-1-4]
-
Ji J, Yamashita T, Wang XW. Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci 2011; 1: 4 [PMID: 21711587 DOI: 10.1186/2045-3701-1-4]
-
(2011)
Cell Biosci
, vol.1
, pp. 4
-
-
Ji, J.1
Yamashita, T.2
Wang, X.W.3
-
80
-
-
84863124163
-
microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb
-
[PMID: 22025269]
-
Zhang J, Luo N, Luo Y, Peng Z, Zhang T, Li S. microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. Int J Oncol 2012; 40: 747-756 [PMID: 22025269]
-
(2012)
Int J Oncol
, vol.40
, pp. 747-756
-
-
Zhang, J.1
Luo, N.2
Luo, Y.3
Peng, Z.4
Zhang, T.5
Li, S.6
-
81
-
-
84867305743
-
miR-548c-5p inhibits proliferation and migration and promotes apoptosis in CD90(+) HepG2 cells
-
[PMID: 23077462 DOI: 10.2478/v10019-012-0025-z]
-
Fang L, Zhang HB, Li H, Fu Y, Yang GS. miR-548c-5p inhibits proliferation and migration and promotes apoptosis in CD90(+) HepG2 cells. Radiol Oncol 2012; 46: 233-241 [PMID: 23077462 DOI: 10.2478/v10019-012-0025-z]
-
(2012)
Radiol Oncol
, vol.46
, pp. 233-241
-
-
Fang, L.1
Zhang, H.B.2
Li, H.3
Fu, Y.4
Yang, G.S.5
-
82
-
-
84879684791
-
Long noncoding RNAs and the genetics of cancer
-
[PMID: 23660942 DOI: 10.1038/bjc.2013.233]
-
Cheetham SW, Gruhl F, Mattick JS, Dinger ME. Long noncoding RNAs and the genetics of cancer. Br J Cancer 2013; 108: 2419-2425 [PMID: 23660942 DOI: 10.1038/bjc.2013.233]
-
(2013)
Br J Cancer
, vol.108
, pp. 2419-2425
-
-
Cheetham, S.W.1
Gruhl, F.2
Mattick, J.S.3
Dinger, M.E.4
-
83
-
-
82155186923
-
The emergence of lncRNAs in cancer biology
-
[PMID: 22096659 DOI: 10.1158/2159-8290.CD-11-0209]
-
Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology. Cancer Discov 2011; 1: 391-407 [PMID: 22096659 DOI: 10.1158/2159-8290.CD-11-0209]
-
(2011)
Cancer Discov
, vol.1
, pp. 391-407
-
-
Prensner, J.R.1
Chinnaiyan, A.M.2
-
84
-
-
67650921949
-
Many human large intergenic noncoding RNAs associate with chromatinmodifying complexes and affect gene expression
-
[PMID: 19571010 DOI: 10.1073/pnas.0904715106]
-
Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, Regev A, Lander ES, Rinn JL. Many human large intergenic noncoding RNAs associate with chromatinmodifying complexes and affect gene expression. Proc Natl Acad Sci USA 2009; 106: 11667-11672 [PMID: 19571010 DOI: 10.1073/pnas.0904715106]
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 11667-11672
-
-
Khalil, A.M.1
Guttman, M.2
Huarte, M.3
Garber, M.4
Raj, A.5
Rivea Morales, D.6
Thomas, K.7
Presser, A.8
Bernstein, B.E.9
van Oudenaarden, A.10
Regev, A.11
Lander, E.S.12
Rinn, J.L.13
-
85
-
-
77957243987
-
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
-
[PMID: 20460456 DOI: 10.1093/nar/gkq296]
-
Redon S, Reichenbach P, Lingner J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res 2010; 38: 5797-5806 [PMID: 20460456 DOI: 10.1093/nar/gkq296]
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5797-5806
-
-
Redon, S.1
Reichenbach, P.2
Lingner, J.3
-
86
-
-
77953957633
-
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
-
[PMID: 20577206 DOI: 10.1038/nature09144]
-
Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 2010; 465: 1033-1038 [PMID: 20577206 DOI: 10.1038/nature09144]
-
(2010)
Nature
, vol.465
, pp. 1033-1038
-
-
Poliseno, L.1
Salmena, L.2
Zhang, J.3
Carver, B.4
Haveman, W.J.5
Pandolfi, P.P.6
-
87
-
-
33846223294
-
Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA
-
[PMID: 17241883 DOI: 10.1053/j.gastro.2006.08.026]
-
Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M, Zatloukal K. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology 2007; 132: 330-342 [PMID: 17241883 DOI: 10.1053/j.gastro.2006.08.026]
-
(2007)
Gastroenterology
, vol.132
, pp. 330-342
-
-
Panzitt, K.1
Tschernatsch, M.M.2
Guelly, C.3
Moustafa, T.4
Stradner, M.5
Strohmaier, H.M.6
Buck, C.R.7
Denk, H.8
Schroeder, R.9
Trauner, M.10
Zatloukal, K.11
-
88
-
-
84864387239
-
Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18
-
[PMID: 22685290 DOI: 10.1074/jbc.M112.342113]
-
Du Y, Kong G, You X, Zhang S, Zhang T, Gao Y, Ye L, Zhang X. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem 2012; 287: 26302-26311 [PMID: 22685290 DOI: 10.1074/jbc.M112.342113]
-
(2012)
J Biol Chem
, vol.287
, pp. 26302-26311
-
-
Du, Y.1
Kong, G.2
You, X.3
Zhang, S.4
Zhang, T.5
Gao, Y.6
Ye, L.7
Zhang, X.8
-
89
-
-
84876718756
-
Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin
-
[PMID: 23239537 DOI: 10.1002/hep.26195]
-
Huang JF, Guo YJ, Zhao CX, Yuan SX, Wang Y, Tang GN, Zhou WP, Sun SH. Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology 2013; 57: 1882-1892 [PMID: 23239537 DOI: 10.1002/hep.26195]
-
(2013)
Hepatology
, vol.57
, pp. 1882-1892
-
-
Huang, J.F.1
Guo, Y.J.2
Zhao, C.X.3
Yuan, S.X.4
Wang, Y.5
Tang, G.N.6
Zhou, W.P.7
Sun, S.H.8
-
90
-
-
0344429906
-
MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer
-
[PMID: 12970751 DOI: 10.1038/sj.onc.1206928]
-
Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, Thomas M, Berdel WE, Serve H, Müller-Tidow C. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 2003; 22: 8031-8041 [PMID: 12970751 DOI: 10.1038/sj.onc.1206928]
-
(2003)
Oncogene
, vol.22
, pp. 8031-8041
-
-
Ji, P.1
Diederichs, S.2
Wang, W.3
Böing, S.4
Metzger, R.5
Schneider, P.M.6
Tidow, N.7
Brandt, B.8
Buerger, H.9
Bulk, E.10
Thomas, M.11
Berdel, W.E.12
Serve, H.13
Müller-Tidow, C.14
-
91
-
-
84873451950
-
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
-
[PMID: 23243023 DOI: 10.1158/0008-5472.CAN-12-2850]
-
Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 2013; 73: 1180-1189 [PMID: 23243023 DOI: 10.1158/0008-5472.CAN-12-2850]
-
(2013)
Cancer Res
, vol.73
, pp. 1180-1189
-
-
Gutschner, T.1
Hämmerle, M.2
Eissmann, M.3
Hsu, J.4
Kim, Y.5
Hung, G.6
Revenko, A.7
Arun, G.8
Stentrup, M.9
Gross, M.10
Zörnig, M.11
McLeod, A.R.12
Spector, D.L.13
Diederichs, S.14
-
92
-
-
84872825450
-
Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation
-
[PMID: 21678027 DOI: 10.1007/s12032-011-0004-z]
-
Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM, Zheng SS. Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol 2012; 29: 1810-1816 [PMID: 21678027 DOI: 10.1007/s12032-011-0004-z]
-
(2012)
Med Oncol
, vol.29
, pp. 1810-1816
-
-
Lai, M.C.1
Yang, Z.2
Zhou, L.3
Zhu, Q.Q.4
Xie, H.Y.5
Zhang, F.6
Wu, L.M.7
Chen, L.M.8
Zheng, S.S.9
-
93
-
-
79955836034
-
Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
-
[PMID: 21327457 DOI: 10.1245/s10434-011-1581-y]
-
Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, Zheng SS. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol 2011; 18: 1243-1250 [PMID: 21327457 DOI: 10.1245/s10434-011-1581-y]
-
(2011)
Ann Surg Oncol
, vol.18
, pp. 1243-1250
-
-
Yang, Z.1
Zhou, L.2
Wu, L.M.3
Lai, M.C.4
Xie, H.Y.5
Zhang, F.6
Zheng, S.S.7
-
94
-
-
84870530823
-
Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy
-
[PMID: 22706893 DOI: 10.1002/ hep.25895]
-
Yuan SX, Yang F, Yang Y, Tao QF, Zhang J, Huang G, Yang Y, Wang RY, Yang S, Huo XS, Zhang L, Wang F, Sun SH, Zhou WP. Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology 2012; 56: 2231-2241 [PMID: 22706893 DOI: 10.1002/ hep.25895]
-
(2012)
Hepatology
, vol.56
, pp. 2231-2241
-
-
Yuan, S.X.1
Yang, F.2
Yang, Y.3
Tao, Q.F.4
Zhang, J.5
Huang, G.6
Yang, Y.7
Wang, R.Y.8
Yang, S.9
Huo, X.S.10
Zhang, L.11
Wang, F.12
Sun, S.H.13
Zhou, W.P.14
-
95
-
-
80055046798
-
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
-
[PMID: 21769904 DOI: 10.1002/hep.24563]
-
Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, Shang JL, Gao CF, Zhang FR, Wang F, Sun SH. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 2011; 54: 1679-1689 [PMID: 21769904 DOI: 10.1002/hep.24563]
-
(2011)
Hepatology
, vol.54
, pp. 1679-1689
-
-
Yang, F.1
Zhang, L.2
Huo, X.S.3
Yuan, J.H.4
Xu, D.5
Yuan, S.X.6
Zhu, N.7
Zhou, W.P.8
Yang, G.S.9
Wang, Y.Z.10
Shang, J.L.11
Gao, C.F.12
Zhang, F.R.13
Wang, F.14
Sun, S.H.15
-
96
-
-
84873668884
-
Long non-coding RNAs: Challenges for diagnosis and therapies
-
[PMID: 23391415]
-
Sánchez Y, Huarte M. Long non-coding RNAs: challenges for diagnosis and therapies. Nucleic Acid Ther 2013; 23: 15-20 [PMID: 23391415]
-
(2013)
Nucleic Acid Ther
, vol.23
, pp. 15-20
-
-
Sánchez, Y.1
Huarte, M.2
-
97
-
-
33644778515
-
Hepatocellular carcinoma: Overcoming challenges in disease management
-
[PMID: 16527686 DOI: 10.1016/j.cgh.2006.01.001]
-
Gish RG. Hepatocellular carcinoma: overcoming challenges in disease management. Clin Gastroenterol Hepatol 2006; 4: 252-261 [PMID: 16527686 DOI: 10.1016/j.cgh.2006.01.001]
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 252-261
-
-
Gish, R.G.1
-
98
-
-
84869475394
-
Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma
-
[PMID: 23070690 DOI: 10.3322/ caac.21161]
-
Maluccio M, Covey A. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin 2012; 62: 394-399 [PMID: 23070690 DOI: 10.3322/ caac.21161]
-
(2012)
CA Cancer J Clin
, vol.62
, pp. 394-399
-
-
Maluccio, M.1
Covey, A.2
-
99
-
-
77649261266
-
Surgical treatment for liver cancer
-
[PMID: 20180230 DOI: 10.3748/wjg.v16.i8.927]
-
Tsim NC, Frampton AE, Habib NA, Jiao LR. Surgical treatment for liver cancer. World J Gastroenterol 2010; 16: 927-933 [PMID: 20180230 DOI: 10.3748/wjg.v16.i8.927]
-
(2010)
World J Gastroenterol
, vol.16
, pp. 927-933
-
-
Tsim, N.C.1
Frampton, A.E.2
Habib, N.A.3
Jiao, L.R.4
-
100
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
[PMID: 18650514 DOI: 10.1056/NEJMoa0708857]
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-390 [PMID: 18650514 DOI: 10.1056/NEJMoa0708857]
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Häussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
101
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
[PMID: 19095497 DOI: 10.1016/ S1470-2045(08)70285-7]
-
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, Xu J, Sun Y, Liang H, Liu J, Wang J, Tak WY, Pan H, Burock K, Zou J, Voliotis D, Guan Z. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34 [PMID: 19095497 DOI: 10.1016/ S1470-2045(08)70285-7]
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
Luo, R.7
Feng, J.8
Ye, S.9
Yang, T.S.10
Xu, J.11
Sun, Y.12
Liang, H.13
Liu, J.14
Wang, J.15
Tak, W.Y.16
Pan, H.17
Burock, K.18
Zou, J.19
Voliotis, D.20
Guan, Z.21
more..
-
102
-
-
84881504440
-
Temsirolimus combined with sorafenib in hepatocellular carcinoma: A phase I dose-finding trial with pharmacokinetic and biomarker correlates
-
[PMID: 23519998 DOI: 10.1093/annonc/mdt109]
-
Kelley RK, Nimeiri HS, Munster PN, Vergo MT, Huang Y, Li CM, Hwang J, Mulcahy MF, Yeh BM, Kuhn P, Luttgen MS, Grabowsky JA, Stucky-Marshall L, Korn WM, Ko AH, Bergsland EK, Benson AB, Venook AP. Temsirolimus combined with sorafenib in hepatocellular carcinoma: a phase I dose-finding trial with pharmacokinetic and biomarker correlates. Ann Oncol 2013; 24: 1900-1907 [PMID: 23519998 DOI: 10.1093/annonc/mdt109]
-
(2013)
Ann Oncol
, vol.24
, pp. 1900-1907
-
-
Kelley, R.K.1
Nimeiri, H.S.2
Munster, P.N.3
Vergo, M.T.4
Huang, Y.5
Li, C.M.6
Hwang, J.7
Mulcahy, M.F.8
Yeh, B.M.9
Kuhn, P.10
Luttgen, M.S.11
Grabowsky, J.A.12
Stucky-Marshall, L.13
Korn, W.M.14
Ko, A.H.15
Bergsland, E.K.16
Benson, A.B.17
Venook, A.P.18
-
103
-
-
84860240078
-
Targeted therapy of hepatocellular carcinoma: Present and future
-
[PMID: 22369685 DOI: 10.1111/j.1440-1746.2012.07096.x]
-
Chan SL, Yeo W. Targeted therapy of hepatocellular carcinoma: present and future. J Gastroenterol Hepatol 2012; 27: 862-872 [PMID: 22369685 DOI: 10.1111/j.1440-1746.2012.07096.x]
-
(2012)
J Gastroenterol Hepatol
, vol.27
, pp. 862-872
-
-
Chan, S.L.1
Yeo, W.2
-
104
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
[PMID: 16485345 DOI: 10.1038/nrd1930]
-
Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 2006; 5: 37-50 [PMID: 16485345 DOI: 10.1038/nrd1930]
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
105
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
[PMID: 19230772 DOI: 10.1016/ S1470-2045(09)70003-8]
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, Schoch R, Gattermann N, Sanz G, List A, Gore SD, Seymour JF, Bennett JM, Byrd J, Backstrom J, Zimmerman L, McKenzie D, Beach C, Silverman LR. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009; 10: 223-232 [PMID: 19230772 DOI: 10.1016/ S1470-2045(09)70003-8]
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
Santini, V.4
Finelli, C.5
Giagounidis, A.6
Schoch, R.7
Gattermann, N.8
Sanz, G.9
List, A.10
Gore, S.D.11
Seymour, J.F.12
Bennett, J.M.13
Byrd, J.14
Backstrom, J.15
Zimmerman, L.16
McKenzie, D.17
Beach, C.18
Silverman, L.R.19
-
106
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies
-
[PMID: 14604977 DOI: 10.1182/blood-2003-03-0687]
-
Issa JP, Garcia-Manero G, Giles FJ, Mannari R, Thomas D, Faderl S, Bayar E, Lyons J, Rosenfeld CS, Cortes J, Kantarjian HM. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004; 103: 1635-1640 [PMID: 14604977 DOI: 10.1182/blood-2003-03-0687]
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
Mannari, R.4
Thomas, D.5
Faderl, S.6
Bayar, E.7
Lyons, J.8
Rosenfeld, C.S.9
Cortes, J.10
Kantarjian, H.M.11
-
107
-
-
21244431605
-
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
-
[PMID: 15883410 DOI: 10.1200/JCO.2005.11.981]
-
Issa JP, Gharibyan V, Cortes J, Jelinek J, Morris G, Verstovsek S, Talpaz M, Garcia-Manero G, Kantarjian HM. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 2005; 23: 3948-3956 [PMID: 15883410 DOI: 10.1200/JCO.2005.11.981]
-
(2005)
J Clin Oncol
, vol.23
, pp. 3948-3956
-
-
Issa, J.P.1
Gharibyan, V.2
Cortes, J.3
Jelinek, J.4
Morris, G.5
Verstovsek, S.6
Talpaz, M.7
Garcia-Manero, G.8
Kantarjian, H.M.9
-
108
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
[PMID: 22439938 DOI: 10.1016/j.ccr.2011.12.029]
-
Tsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E, Harris J, Yen RW, Ahuja N, Brock MV, Stearns V, Feller-Kopman D, Yarmus LB, Lin YC, Welm AL, Issa JP, Minn I, Matsui W, Jang YY, Sharkis SJ, Baylin SB, Zahnow CA. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 2012; 21: 430-446 [PMID: 22439938 DOI: 10.1016/j.ccr.2011.12.029]
-
(2012)
Cancer Cell
, vol.21
, pp. 430-446
-
-
Tsai, H.C.1
Li, H.2
Van Neste, L.3
Cai, Y.4
Robert, C.5
Rassool, F.V.6
Shin, J.J.7
Harbom, K.M.8
Beaty, R.9
Pappou, E.10
Harris, J.11
Yen, R.W.12
Ahuja, N.13
Brock, M.V.14
Stearns, V.15
Feller-Kopman, D.16
Yarmus, L.B.17
Lin, Y.C.18
Welm, A.L.19
Issa, J.P.20
Minn, I.21
Matsui, W.22
Jang, Y.Y.23
Sharkis, S.J.24
Baylin, S.B.25
Zahnow, C.A.26
more..
-
109
-
-
84872183961
-
DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis
-
[PMID: 23320119 DOI: 10.1371/journal.pone.0054036]
-
Nakamura K, Aizawa K, Nakabayashi K, Kato N, Yamauchi J, Hata K, Tanoue A. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. PLoS One 2013; 8: e54036 [PMID: 23320119 DOI: 10.1371/journal.pone.0054036]
-
(2013)
PLoS One
, vol.8
-
-
Nakamura, K.1
Aizawa, K.2
Nakabayashi, K.3
Kato, N.4
Yamauchi, J.5
Hata, K.6
Tanoue, A.7
-
110
-
-
77958610661
-
An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer
-
[PMID: 20962331 DOI: 10.1126/scitranslmed.3001338]
-
Andersen JB, Factor VM, Marquardt JU, Raggi C, Lee YH, Seo D, Conner EA, Thorgeirsson SS. An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer. Sci Transl Med 2010; 2: 54ra77 [PMID: 20962331 DOI: 10.1126/scitranslmed.3001338]
-
(2010)
Sci Transl Med
, vol.2
-
-
Andersen, J.B.1
Factor, V.M.2
Marquardt, J.U.3
Raggi, C.4
Lee, Y.H.5
Seo, D.6
Conner, E.A.7
Thorgeirsson, S.S.8
-
111
-
-
84861747490
-
Anti-tumor effect of 5-aza-2'-deoxycytidine by inhibiting telomerase activity in hepatocellular carcinoma cells
-
[PMID: 22654424 DOI: 10.3748/wjg.v18.i19.2334]
-
Tao SF, Zhang CS, Guo XL, Xu Y, Zhang SS, Song JR, Li R, Wu MC, Wei LX. Anti-tumor effect of 5-aza-2'-deoxycytidine by inhibiting telomerase activity in hepatocellular carcinoma cells. World J Gastroenterol 2012; 18: 2334-2343 [PMID: 22654424 DOI: 10.3748/wjg.v18.i19.2334]
-
(2012)
World J Gastroenterol
, vol.18
, pp. 2334-2343
-
-
Tao, S.F.1
Zhang, C.S.2
Guo, X.L.3
Xu, Y.4
Zhang, S.S.5
Song, J.R.6
Li, R.7
Wu, M.C.8
Wei, L.X.9
-
112
-
-
77952240320
-
The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines
-
[PMID: 19172229 DOI: 10.1007/s10637-009-9219-7]
-
Ma BB, Sung F, Tao Q, Poon FF, Lui VW, Yeo W, Chan SL, Chan AT. The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines. Invest New Drugs 2010; 28: 107-114 [PMID: 19172229 DOI: 10.1007/s10637-009-9219-7]
-
(2010)
Invest New Drugs
, vol.28
, pp. 107-114
-
-
Ma, B.B.1
Sung, F.2
Tao, Q.3
Poon, F.F.4
Lui, V.W.5
Yeo, W.6
Chan, S.L.7
Chan, A.T.8
-
113
-
-
38749130035
-
Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects
-
[PMID: 18097557]
-
Carlisi D, Vassallo B, Lauricella M, Emanuele S, D'Anneo A, Di Leonardo E, Di Fazio P, Vento R, Tesoriere G. Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. Int J Oncol 2008; 32: 177-184 [PMID: 18097557]
-
(2008)
Int J Oncol
, vol.32
, pp. 177-184
-
-
Carlisi, D.1
Vassallo, B.2
Lauricella, M.3
Emanuele, S.4
D'Anneo, A.5
Di Leonardo, E.6
Di Fazio, P.7
Vento, R.8
Tesoriere, G.9
-
114
-
-
68749089762
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation
-
[PMID: 19643600 DOI: 10.1016/j.ejca.2009.06.024]
-
Carlisi D, Lauricella M, D'Anneo A, Emanuele S, Angileri L, Di Fazio P, Santulli A, Vento R, Tesoriere G. The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation. Eur J Cancer 2009; 45: 2425-2438 [PMID: 19643600 DOI: 10.1016/j.ejca.2009.06.024]
-
(2009)
Eur J Cancer
, vol.45
, pp. 2425-2438
-
-
Carlisi, D.1
Lauricella, M.2
D'Anneo, A.3
Emanuele, S.4
Angileri, L.5
Di Fazio, P.6
Santulli, A.7
Vento, R.8
Tesoriere, G.9
-
115
-
-
84866758581
-
Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: A multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group
-
[PMID: 22915658 DOI: 10.1200/ JCO.2011.41.2395]
-
Yeo W, Chung HC, Chan SL, Wang LZ, Lim R, Picus J, Boyer M, Mo FK, Koh J, Rha SY, Hui EP, Jeung HC, Roh JK, Yu SC, To KF, Tao Q, Ma BB, Chan AW, Tong JH, Erlichman C, Chan AT, Goh BC. Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group. J Clin Oncol 2012; 30: 3361-3367 [PMID: 22915658 DOI: 10.1200/ JCO.2011.41.2395]
-
(2012)
J Clin Oncol
, vol.30
, pp. 3361-3367
-
-
Yeo, W.1
Chung, H.C.2
Chan, S.L.3
Wang, L.Z.4
Lim, R.5
Picus, J.6
Boyer, M.7
Mo, F.K.8
Koh, J.9
Rha, S.Y.10
Hui, E.P.11
Jeung, H.C.12
Roh, J.K.13
Yu, S.C.14
To, K.F.15
Tao, Q.16
Ma, B.B.17
Chan, A.W.18
Tong, J.H.19
Erlichman, C.20
Chan, A.T.21
Goh, B.C.22
more..
-
116
-
-
84863004652
-
Histone deacetylase inhibitors facilitate dihydroartemisinininduced apoptosis in liver cancer in vitro and in vivo
-
[PMID: 22761917]
-
Zhang CZ, Pan Y, Cao Y, Lai PB, Liu L, Chen GG, Yun J. Histone deacetylase inhibitors facilitate dihydroartemisinininduced apoptosis in liver cancer in vitro and in vivo. PLoS One 2012; 7: e39870 [PMID: 22761917]
-
(2012)
PLoS One
, vol.7
-
-
Zhang, C.Z.1
Pan, Y.2
Cao, Y.3
Lai, P.B.4
Liu, L.5
Chen, G.G.6
Yun, J.7
-
117
-
-
84865740818
-
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy
-
[PMID: 22811583 DOI: 10.1158/1078-0432.CCR-12-0633]
-
Lin KT, Wang YW, Chen CT, Ho CM, Su WH, Jou YS. HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clin Cancer Res 2012; 18: 4691-4701 [PMID: 22811583 DOI: 10.1158/1078-0432.CCR-12-0633]
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4691-4701
-
-
Lin, K.T.1
Wang, Y.W.2
Chen, C.T.3
Ho, C.M.4
Su, W.H.5
Jou, Y.S.6
-
118
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
[PMID: 22842901 DOI: 10.1038/nature11262]
-
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Shep-pard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012; 488: 404-408 [PMID: 22842901 DOI: 10.1038/nature11262]
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
Bantscheff, M.7
Bountra, C.8
Bridges, A.9
Diallo, H.10
Eberhard, D.11
Hutchinson, S.12
Jones, E.13
Katso, R.14
Leveridge, M.15
Mander, P.K.16
Mosley, J.17
Ramirez-Molina, C.18
Rowland, P.19
Schofield, C.J.20
Sheppard, R.J.21
Smith, J.E.22
Swales, C.23
Tanner, R.24
Thomas, P.25
Tumber, A.26
Drewes, G.27
Oppermann, U.28
Patel, D.J.29
Lee, K.30
Wilson, D.M.31
more..
-
119
-
-
34548644772
-
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
-
[PMID: 17825402 DOI: 10.1016/j.cell.2007.08.019]
-
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007; 130: 1083-1094 [PMID: 17825402 DOI: 10.1016/j.cell.2007.08.019]
-
(2007)
Cell
, vol.130
, pp. 1083-1094
-
-
De Santa, F.1
Totaro, M.G.2
Prosperini, E.3
Notarbartolo, S.4
Testa, G.5
Natoli, G.6
-
120
-
-
34447327216
-
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
-
[PMID: 17615358 DOI: 10.1126/science.1140485]
-
Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-124 [PMID: 17615358 DOI: 10.1126/science.1140485]
-
(2007)
Science
, vol.317
, pp. 121-124
-
-
Naugler, W.E.1
Sakurai, T.2
Kim, S.3
Maeda, S.4
Kim, K.5
Elsharkawy, A.M.6
Karin, M.7
-
121
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
[PMID: 20141834 DOI: 10.1016/j.cell.2009.12.052]
-
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208 [PMID: 20141834 DOI: 10.1016/j.cell.2009.12.052]
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
Lee, J.H.2
Yu, G.Y.3
He, G.4
Ali, S.R.5
Holzer, R.G.6
Osterreicher, C.H.7
Takahashi, H.8
Karin, M.9
-
122
-
-
66449136951
-
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
-
[PMID: 19524505 DOI: 10.1016/j.cell.2009.04.021]
-
Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137: 1005-1017 [PMID: 19524505 DOI: 10.1016/j.cell.2009.04.021]
-
(2009)
Cell
, vol.137
, pp. 1005-1017
-
-
Kota, J.1
Chivukula, R.R.2
O'Donnell, K.A.3
Wentzel, E.A.4
Montgomery, C.L.5
Hwang, H.W.6
Chang, T.C.7
Vivekanandan, P.8
Torbenson, M.9
Clark, K.R.10
Mendell, J.R.11
Mendell, J.T.12
-
123
-
-
83255162659
-
An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis
-
[PMID: 22153071 DOI: 10.1016/j.cell.2011.10.043]
-
Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 2011; 147: 1233-1247 [PMID: 22153071 DOI: 10.1016/j.cell.2011.10.043]
-
(2011)
Cell
, vol.147
, pp. 1233-1247
-
-
Hatziapostolou, M.1
Polytarchou, C.2
Aggelidou, E.3
Drakaki, A.4
Poultsides, G.A.5
Jaeger, S.A.6
Ogata, H.7
Karin, M.8
Struhl, K.9
Hadzopoulou-Cladaras, M.10
Iliopoulos, D.11
-
124
-
-
84861183742
-
Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib
-
[PMID: 22322234 DOI: 10.1016/j.jhep.2012.01.009]
-
Lachenmayer A, Toffanin S, Cabellos L, Alsinet C, Hoshida Y, Villanueva A, Minguez B, Tsai HW, Ward SC, Thung S, Friedman SL, Llovet JM. Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. J Hepatol 2012; 56: 1343-1350 [PMID: 22322234 DOI: 10.1016/j.jhep.2012.01.009]
-
(2012)
J Hepatol
, vol.56
, pp. 1343-1350
-
-
Lachenmayer, A.1
Toffanin, S.2
Cabellos, L.3
Alsinet, C.4
Hoshida, Y.5
Villanueva, A.6
Minguez, B.7
Tsai, H.W.8
Ward, S.C.9
Thung, S.10
Friedman, S.L.11
Llovet, J.M.12
-
125
-
-
31544432509
-
De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model
-
[PMID: 16424047 DOI: 10.1158/0008-5472.CAN-05-3020]
-
Guo ZS, Hong JA, Irvine KR, Chen GA, Spiess PJ, Liu Y, Zeng G, Wunderlich JR, Nguyen DM, Restifo NP, Schrump DS. De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model. Cancer Res 2006; 66: 1105-1113 [PMID: 16424047 DOI: 10.1158/0008-5472.CAN-05-3020]
-
(2006)
Cancer Res
, vol.66
, pp. 1105-1113
-
-
Guo, Z.S.1
Hong, J.A.2
Irvine, K.R.3
Chen, G.A.4
Spiess, P.J.5
Liu, Y.6
Zeng, G.7
Wunderlich, J.R.8
Nguyen, D.M.9
Restifo, N.P.10
Schrump, D.S.11
-
126
-
-
84867685827
-
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
-
[PMID: 23051752 DOI: 10.1038/nature11538]
-
Landsberg J, Kohlmeyer J, Renn M, Bald T, Rogava M, Cron M, Fatho M, Lennerz V, Wölfel T, Hölzel M, Tüting T. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature 2012; 490: 412-416 [PMID: 23051752 DOI: 10.1038/nature11538]
-
(2012)
Nature
, vol.490
, pp. 412-416
-
-
Landsberg, J.1
Kohlmeyer, J.2
Renn, M.3
Bald, T.4
Rogava, M.5
Cron, M.6
Fatho, M.7
Lennerz, V.8
Wölfel, T.9
Hölzel, M.10
Tüting, T.11
-
127
-
-
33644879237
-
Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: Immunotherapeutic implications
-
[PMID: 16252259 DOI: 10.1002/ jcp.20540]
-
Coral S, Sigalotti L, Colizzi F, Spessotto A, Nardi G, Cortini E, Pezzani L, Fratta E, Fonsatti E, Di Giacomo AM, Nicotra MR, Natali PG, Altomonte M, Maio M. Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: immunotherapeutic implications. J Cell Physiol 2006; 207: 58-66 [PMID: 16252259 DOI: 10.1002/ jcp.20540]
-
(2006)
J Cell Physiol
, vol.207
, pp. 58-66
-
-
Coral, S.1
Sigalotti, L.2
Colizzi, F.3
Spessotto, A.4
Nardi, G.5
Cortini, E.6
Pezzani, L.7
Fratta, E.8
Fonsatti, E.9
Di Giacomo, A.M.10
Nicotra, M.R.11
Natali, P.G.12
Altomonte, M.13
Maio, M.14
-
128
-
-
38849106118
-
Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma
-
[PMID: 17962206 DOI: 10.1093/annonc/ mdm448]
-
Porta C, De Amici M, Quaglini S, Paglino C, Tagliani F, Boncimino A, Moratti R, Corazza GR. Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma. Ann Oncol 2008; 19: 353-358 [PMID: 17962206 DOI: 10.1093/annonc/ mdm448]
-
(2008)
Ann Oncol
, vol.19
, pp. 353-358
-
-
Porta, C.1
De Amici, M.2
Quaglini, S.3
Paglino, C.4
Tagliani, F.5
Boncimino, A.6
Moratti, R.7
Corazza, G.R.8
-
129
-
-
84877808348
-
Genetics and epigenetics of liver cancer
-
[PMID: 23392071 DOI: 10.1016/ j.nbt.2013.01.007]
-
Ozen C, Yildiz G, Dagcan AT, Cevik D, Ors A, Keles U, Topel H, Ozturk M. Genetics and epigenetics of liver cancer. N Biotechnol 2013; 30: 381-384 [PMID: 23392071 DOI: 10.1016/ j.nbt.2013.01.007]
-
(2013)
N Biotechnol
, vol.30
, pp. 381-384
-
-
Ozen, C.1
Yildiz, G.2
Dagcan, A.T.3
Cevik, D.4
Ors, A.5
Keles, U.6
Topel, H.7
Ozturk, M.8
|