Emerging role of intestinal microbiota and microbial metabolites in metabolic control

Diabetologia

Volumn 60, Issue 4, 2017, Pages 613-617

  Herrema, Hilde ^a   IJzerman, Richard G ^b   Nieuwdorp, Max ^a,b,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Gut microbiota; Insulin resistance; Obesity; Short chain fatty acids; Type 2 diabetes

Indexed keywords

BACTERIAL METABOLISM; BIOCHEMICAL COMPOSITION; DIET; EDITORIAL; ENVIRONMENTAL FACTOR; FUTUROLOGY; GENETICS; HOST; HUMAN; INTESTINE FLORA; METABOLIC REGULATION; METABOLISM; METABOLITE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; GASTROINTESTINAL TRACT; INSULIN RESISTANCE; METABOLIC DISORDER; MICROBIOLOGY; MICROFLORA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY;

ANIMALS; DIABETES MELLITUS, TYPE 2; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HUMANS; INSULIN RESISTANCE; METABOLIC DISEASES; MICROBIOTA; OBESITY;

EID: 85007168704     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4192-0     Document Type: Editorial

References (35)

1. Wikoff WR, Anfora AT, Liu J et al (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A 106:3698–3703
2. Khan MT, Nieuwdorp M, Backhed F (2014) Microbial modulation of insulin sensitivity. Cell Metab 20:753–760
3. Ussar S, Griffin NW, Bezy O et al (2015) Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome. Cell Metab 22:516–530
4. Perry RJ, Peng L, Barry NA et al (2016) Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome. Nature 534:213–217
5. Jimenez E, Marin ML, Martin R et al (2008) Is meconium from healthy newborns actually sterile? Res Microbiol 159:187–193
6. Goodrich JK, Waters JL, Poole AC et al (2014) Human genetics shape the gut microbiome. Cell 159:789–799
7. Faith JJ, Colombel JF, Gordon JI (2015) Identifying strains that contribute to complex diseases through the study of microbial inheritance. Proc Natl Acad Sci U S A 112:633–640
8. Tamburini S, Shen N, Wu HC, Clemente JC (2016) The microbiome in early life: implications for health outcomes. Nat Med 22:713–722
9. Charbonneau MR, Blanton LV, DiGiulio DB et al (2016) A microbial perspective of human developmental biology. Nature 535:48–55
10. Bonder MJ, Kurilshikov A, Tigchelaar EF et al (2016) The effect of host genetics on the gut microbiome. Nat Genet 48:1407–1412
11. Zhernakova A, Kurilshikov A, Bonder MJ et al (2016) Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science 352:565–569
12. Cotillard A, Kennedy SP, Kong LC et al (2013) Dietary intervention impact on gut microbial gene richness. Nature 500:585–588
13. Le Chatelier E, Nielsen T, Qin J et al (2013) Richness of human gut microbiome correlates with metabolic markers. Nature 500:541–546
14. Amar J, Serino M, Lange C et al (2011) Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia 54:3055–3061
15. Vrieze A, Van Nood E, Holleman F et al (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:913–916, e917
16. Reijnders D, Goossens GH, Hermes GD et al (2016) Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial. Cell Metab 24:63–74
17. Ridaura VK, Faith JJ, Rey FE et al (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214
18. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031
19. Henao-Mejia J, Elinav E, Jin C et al (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482:179–185
20. Upadhyay V, Poroyko V, Kim TJ et al (2012) Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol 13:947–953
21. Liou AP, Paziuk M, Luevano JM Jr, Machineni S, Turnbaugh PJ, Kaplan LM (2013) Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med 5:178ra141
22. Cox LM, Yamanishi S, Sohn J et al (2014) Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158:705–721
23. Schroeder BO, Backhed F (2016) Signals from the gut microbiota to distant organs in physiology and disease. Nat Med 22:1079–1089
24. Ussar S, Fujisaka S, Kahn CR (2016) Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome. Mol Metab 5:795–803
25. Cho SS, Qi L, Fahey GC Jr, Klurfeld DM (2013) Consumption of cereal fiber, mixtures of whole grains and bran, and whole grains and risk reduction in type 2 diabetes, obesity, and cardiovascular disease. Am J Clin Nutr 98:594–619
26. Karlsson FH, Tremaroli V, Nookaew I et al (2013) Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498:99–103
27. Qin J, Li Y, Cai Z et al (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490:55–60
28. Gao Z, Yin J, Zhang J et al (2009) Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58:1509–1517
29. den Besten G, Bleeker A, Gerding A et al (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398–2408
30. De Vadder F, Kovatcheva-Datchary P, Goncalves D et al (2014) Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156:84–96
31. Frost G, Sleeth ML, Sahuri-Arisoylu M et al (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun 5:3611
32. Jiang L, Gulanski BI, De Feyter HM et al (2013) Increased brain uptake and oxidation of acetate in heavy drinkers. J Clin Invest 123:1605–1614
33. Ostman E, Granfeldt Y, Persson L, Bjorck I (2005) Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr 59:983–988
34. Kondo T, Kishi M, Fushimi T, Ugajin S, Kaga T (2009) Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Biosci Biotechnol Biochem 73:1837–1843
35. Maldonado-Gomez MX, Martinez I, Bottacini F et al (2016) Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host Microbe 20:515–526