메뉴 건너뛰기




Volumn 24, Issue 1, 2016, Pages 63-74

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; INSULIN; PLACEBO; SHORT CHAIN FATTY ACID; VANCOMYCIN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; BUTYRIC ACID;

EID: 84992381833     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.06.016     Document Type: Article
Times cited : (269)

References (62)
  • 3
    • 84859104629 scopus 로고    scopus 로고
    • Manipulation of the gut microbiota in C57BL/6 mice changes glucose tolerance without affecting weight development and gut mucosal immunity
    • Bech-Nielsen, G.V., Hansen, C.H., Hufeldt, M.R., Nielsen, D.S., Aasted, B., Vogensen, F.K., Midtvedt, T., Hansen, A.K., Manipulation of the gut microbiota in C57BL/6 mice changes glucose tolerance without affecting weight development and gut mucosal immunity. Res. Vet. Sci. 92 (2012), 501–508.
    • (2012) Res. Vet. Sci. , vol.92 , pp. 501-508
    • Bech-Nielsen, G.V.1    Hansen, C.H.2    Hufeldt, M.R.3    Nielsen, D.S.4    Aasted, B.5    Vogensen, F.K.6    Midtvedt, T.7    Hansen, A.K.8
  • 4
    • 33644746318 scopus 로고    scopus 로고
    • Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle
    • Brehm, A., Krssak, M., Schmid, A.I., Nowotny, P., Waldhäusl, W., Roden, M., Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes 55 (2006), 136–140.
    • (2006) Diabetes , vol.55 , pp. 136-140
    • Brehm, A.1    Krssak, M.2    Schmid, A.I.3    Nowotny, P.4    Waldhäusl, W.5    Roden, M.6
  • 5
    • 84879369738 scopus 로고    scopus 로고
    • Commensal bacteria at the interface of host metabolism and the immune system
    • Brestoff, J.R., Artis, D., Commensal bacteria at the interface of host metabolism and the immune system. Nat. Immunol. 14 (2013), 676–684.
    • (2013) Nat. Immunol. , vol.14 , pp. 676-684
    • Brestoff, J.R.1    Artis, D.2
  • 6
    • 84946071276 scopus 로고    scopus 로고
    • Bile acids trigger GLP-1 release predominantly by accessing basolaterally-located G-protein coupled bile acid receptors
    • Brighton, C.A., Rievaj, J., Kuhre, R.E., Glass, L.L., Schoonjans, K., Holst, J.J., Gribble, F.M., Reimann, F., Bile acids trigger GLP-1 release predominantly by accessing basolaterally-located G-protein coupled bile acid receptors. Endocrinology 156 (2015), 3961–3970.
    • (2015) Endocrinology , vol.156 , pp. 3961-3970
    • Brighton, C.A.1    Rievaj, J.2    Kuhre, R.E.3    Glass, L.L.4    Schoonjans, K.5    Holst, J.J.6    Gribble, F.M.7    Reimann, F.8
  • 7
    • 84941879755 scopus 로고    scopus 로고
    • Short-chain fatty acids in control of body weight and insulin sensitivity
    • Canfora, E.E., Jocken, J.W., Blaak, E.E., Short-chain fatty acids in control of body weight and insulin sensitivity. Nat. Rev. Endocrinol. 11 (2015), 577–591.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 577-591
    • Canfora, E.E.1    Jocken, J.W.2    Blaak, E.E.3
  • 9
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani, P.D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R., Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57 (2008), 1470–1481.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 11
    • 49449085321 scopus 로고    scopus 로고
    • Gut decontamination with norfloxacin and ampicillin enhances insulin sensitivity in mice
    • discussion 137–140
    • Chou, C.J., Membrez, M., Blancher, F., Gut decontamination with norfloxacin and ampicillin enhances insulin sensitivity in mice. Nestle Nutr. Workshop Ser. Pediatr. Program. 62 (2008), 127–137 discussion 137–140.
    • (2008) Nestle Nutr. Workshop Ser. Pediatr. Program. , vol.62 , pp. 127-137
    • Chou, C.J.1    Membrez, M.2    Blancher, F.3
  • 12
    • 84878810790 scopus 로고    scopus 로고
    • Pathways in microbe-induced obesity
    • Cox, L.M., Blaser, M.J., Pathways in microbe-induced obesity. Cell Metab. 17 (2013), 883–894.
    • (2013) Cell Metab. , vol.17 , pp. 883-894
    • Cox, L.M.1    Blaser, M.J.2
  • 13
    • 84923654518 scopus 로고    scopus 로고
    • Antibiotics in early life and obesity
    • Cox, L.M., Blaser, M.J., Antibiotics in early life and obesity. Nat. Rev. Endocrinol. 11 (2015), 182–190.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 182-190
    • Cox, L.M.1    Blaser, M.J.2
  • 14
    • 0018520840 scopus 로고
    • Glucose clamp technique: a method for quantifying insulin secretion and resistance
    • DeFronzo, R.A., Tobin, J.D., Andres, R., Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237 (1979), E214–E223.
    • (1979) Am. J. Physiol. , vol.237 , pp. E214-E223
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 15
    • 0020576146 scopus 로고
    • Calculation of substrate oxidation rates in vivo from gaseous exchange
    • Frayn, K.N., Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55 (1983), 628–634.
    • (1983) J. Appl. Physiol. , vol.55 , pp. 628-634
    • Frayn, K.N.1
  • 19
    • 67649238355 scopus 로고    scopus 로고
    • Butyrate improves insulin sensitivity and increases energy expenditure in mice
    • Gao, Z., Yin, J., Zhang, J., Ward, R.E., Martin, R.J., Lefevre, M., Cefalu, W.T., Ye, J., Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58 (2009), 1509–1517.
    • (2009) Diabetes , vol.58 , pp. 1509-1517
    • Gao, Z.1    Yin, J.2    Zhang, J.3    Ward, R.E.4    Martin, R.J.5    Lefevre, M.6    Cefalu, W.T.7    Ye, J.8
  • 21
    • 78650593791 scopus 로고    scopus 로고
    • Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infection
    • Gonzales, M., Pepin, J., Frost, E.H., Carrier, J.C., Sirard, S., Fortier, L.C., Valiquette, L., Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infection. BMC Infect. Dis., 10, 2010, 363.
    • (2010) BMC Infect. Dis. , vol.10 , pp. 363
    • Gonzales, M.1    Pepin, J.2    Frost, E.H.3    Carrier, J.C.4    Sirard, S.5    Fortier, L.C.6    Valiquette, L.7
  • 23
    • 84945441502 scopus 로고    scopus 로고
    • Obesity: Gut microbiota, host genetics and diet interact to affect the risk of developing obesity and the metabolic syndrome
    • Greenhill, C., Obesity: Gut microbiota, host genetics and diet interact to affect the risk of developing obesity and the metabolic syndrome. Nat. Rev. Endocrinol., 11, 2015, 630.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 630
    • Greenhill, C.1
  • 24
    • 84920025561 scopus 로고    scopus 로고
    • Insights into the role of the microbiome in obesity and type 2 diabetes
    • Hartstra, A.V., Bouter, K.E., Bäckhed, F., Nieuwdorp, M., Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care 38 (2015), 159–165.
    • (2015) Diabetes Care , vol.38 , pp. 159-165
    • Hartstra, A.V.1    Bouter, K.E.2    Bäckhed, F.3    Nieuwdorp, M.4
  • 26
    • 84933505154 scopus 로고    scopus 로고
    • Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity
    • Hwang, I., Park, Y.J., Kim, Y.R., Kim, Y.N., Ka, S., Lee, H.Y., Seong, J.K., Seok, Y.J., Kim, J.B., Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J. 29 (2015), 2397–2411.
    • (2015) FASEB J. , vol.29 , pp. 2397-2411
    • Hwang, I.1    Park, Y.J.2    Kim, Y.R.3    Kim, Y.N.4    Ka, S.5    Lee, H.Y.6    Seong, J.K.7    Seok, Y.J.8    Kim, J.B.9
  • 28
    • 84920019418 scopus 로고    scopus 로고
    • Microbiota, antibiotics, and obesity
    • Jess, T., Microbiota, antibiotics, and obesity. N. Engl. J. Med. 371 (2014), 2526–2528.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2526-2528
    • Jess, T.1
  • 29
    • 84896118845 scopus 로고    scopus 로고
    • The human microbiome and bile acid metabolism: dysbiosis, dysmetabolism, disease and intervention
    • Jones, M.L., Martoni, C.J., Ganopolsky, J.G., Labbé, A., Prakash, S., The human microbiome and bile acid metabolism: dysbiosis, dysmetabolism, disease and intervention. Expert Opin. Biol. Ther. 14 (2014), 467–482.
    • (2014) Expert Opin. Biol. Ther. , vol.14 , pp. 467-482
    • Jones, M.L.1    Martoni, C.J.2    Ganopolsky, J.G.3    Labbé, A.4    Prakash, S.5
  • 30
    • 84942315854 scopus 로고    scopus 로고
    • Early life events influence whole-of-life metabolic health via gut microflora and gut permeability
    • Kerr, C.A., Grice, D.M., Tran, C.D., Bauer, D.C., Li, D., Hendry, P., Hannan, G.N., Early life events influence whole-of-life metabolic health via gut microflora and gut permeability. Crit. Rev. Microbiol. 41 (2015), 326–340.
    • (2015) Crit. Rev. Microbiol. , vol.41 , pp. 326-340
    • Kerr, C.A.1    Grice, D.M.2    Tran, C.D.3    Bauer, D.C.4    Li, D.5    Hendry, P.6    Hannan, G.N.7
  • 32
    • 84910131419 scopus 로고    scopus 로고
    • Microbial modulation of insulin sensitivity
    • Khan, M.T., Nieuwdorp, M., Bäckhed, F., Microbial modulation of insulin sensitivity. Cell Metab. 20 (2014), 753–760.
    • (2014) Cell Metab. , vol.20 , pp. 753-760
    • Khan, M.T.1    Nieuwdorp, M.2    Bäckhed, F.3
  • 33
    • 36649027452 scopus 로고    scopus 로고
    • Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome
    • Kotronen, A., Seppälä-Lindroos, A., Bergholm, R., Yki-Järvinen, H., Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia 51 (2008), 130–138.
    • (2008) Diabetologia , vol.51 , pp. 130-138
    • Kotronen, A.1    Seppälä-Lindroos, A.2    Bergholm, R.3    Yki-Järvinen, H.4
  • 34
    • 0345040873 scopus 로고    scopus 로고
    • Classification and Regression by randomForest
    • Liaw, A., Wiener, M., Classification and Regression by randomForest. R News 2 (2002), 18–22.
    • (2002) R News , vol.2 , pp. 18-22
    • Liaw, A.1    Wiener, M.2
  • 37
    • 0004193573 scopus 로고
    • Latent class analysis
    • Sage
    • McCutcheon, A.L., Latent class analysis. 1987, Sage.
    • (1987)
    • McCutcheon, A.L.1
  • 40
  • 41
    • 84886695993 scopus 로고    scopus 로고
    • Lactobacillus reuteri and Escherichia coli in the human gut microbiota may predict weight gain associated with vancomycin treatment
    • Million, M., Thuny, F., Angelakis, E., Casalta, J.P., Giorgi, R., Habib, G., Raoult, D., Lactobacillus reuteri and Escherichia coli in the human gut microbiota may predict weight gain associated with vancomycin treatment. Nutr. Diabetes, 3, 2013, e87.
    • (2013) Nutr. Diabetes , vol.3 , pp. e87
    • Million, M.1    Thuny, F.2    Angelakis, E.3    Casalta, J.P.4    Giorgi, R.5    Habib, G.6    Raoult, D.7
  • 42
    • 84977111942 scopus 로고    scopus 로고
    • Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
    • Published online May 18, 2016. ajcn122937
    • Most, J., Timmers, S., Warnke, I., Jocken, J.W., van Boekschoten, M., de Groot, P., Bendik, I., Schrauwen, P., Goossens, G.H., Blaak, E.E., Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am. J. Clin. Nutr., 2016 Published online May 18, 2016. ajcn122937.
    • (2016) Am. J. Clin. Nutr.
    • Most, J.1    Timmers, S.2    Warnke, I.3    Jocken, J.W.4    van Boekschoten, M.5    de Groot, P.6    Bendik, I.7    Schrauwen, P.8    Goossens, G.H.9    Blaak, E.E.10
  • 45
    • 84992361529 scopus 로고    scopus 로고
    • Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: the R package lcmm.
    • Proust-Lima, C., Philipps, V., and Liquet, B. (2015). Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: the R package lcmm. https://arxiv.org/pdf/1503.00890.pdf.
    • (2015)
    • Proust-Lima, C.1    Philipps, V.2    Liquet, B.3
  • 46
    • 67649945513 scopus 로고    scopus 로고
    • Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults
    • Rajilić-Stojanović, M., Heilig, H.G., Molenaar, D., Kajander, K., Surakka, A., Smidt, H., de Vos, W.M., Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ. Microbiol. 11 (2009), 1736–1751.
    • (2009) Environ. Microbiol. , vol.11 , pp. 1736-1751
    • Rajilić-Stojanović, M.1    Heilig, H.G.2    Molenaar, D.3    Kajander, K.4    Surakka, A.5    Smidt, H.6    de Vos, W.M.7
  • 48
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon, J.M., Kang, D.J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47 (2006), 241–259.
    • (2006) J. Lipid Res. , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 51
    • 0029787450 scopus 로고    scopus 로고
    • Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease
    • Schols, A.M., Buurman, W.A., Staal van den Brekel, A.J., Dentener, M.A., Wouters, E.F., Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 51 (1996), 819–824.
    • (1996) Thorax , vol.51 , pp. 819-824
    • Schols, A.M.1    Buurman, W.A.2    Staal van den Brekel, A.J.3    Dentener, M.A.4    Wouters, E.F.5
  • 52
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Smyth, G.K., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol., 3, 2004, Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3 , pp. Article3
    • Smyth, G.K.1
  • 53
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele, R., Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. N Y Acad. Sci. 82 (1959), 420–430.
    • (1959) Ann. N Y Acad. Sci. , vol.82 , pp. 420-430
    • Steele, R.1
  • 54
    • 77949363140 scopus 로고    scopus 로고
    • Vancomycin treatment of infective endocarditis is linked with recently acquired obesity
    • Thuny, F., Richet, H., Casalta, J.P., Angelakis, E., Habib, G., Raoult, D., Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS ONE, 5, 2010, e9074.
    • (2010) PLoS ONE , vol.5 , pp. e9074
    • Thuny, F.1    Richet, H.2    Casalta, J.P.3    Angelakis, E.4    Habib, G.5    Raoult, D.6
  • 55
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006), 1027–1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 56
  • 57
    • 84875257071 scopus 로고    scopus 로고
    • Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial
    • van Wijck, K., Verlinden, T.J., van Eijk, H.M., Dekker, J., Buurman, W.A., Dejong, C.H., Lenaerts, K., Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial. Clin. Nutr. 32 (2013), 245–251.
    • (2013) Clin. Nutr. , vol.32 , pp. 245-251
    • van Wijck, K.1    Verlinden, T.J.2    van Eijk, H.M.3    Dekker, J.4    Buurman, W.A.5    Dejong, C.H.6    Lenaerts, K.7
  • 58
    • 0037902984 scopus 로고    scopus 로고
    • Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    • Vilsbøll, T., Krarup, T., Sonne, J., Madsbad, S., Vølund, A., Juul, A.G., Holst, J.J., Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 88 (2003), 2706–2713.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2706-2713
    • Vilsbøll, T.1    Krarup, T.2    Sonne, J.3    Madsbad, S.4    Vølund, A.5    Juul, A.G.6    Holst, J.J.7
  • 61
    • 8944256349 scopus 로고
    • New methods for calculating metabolic rate with special reference to protein metabolism
    • Weir, J.B., New methods for calculating metabolic rate with special reference to protein metabolism. J. Physiol. 109 (1949), 1–9.
    • (1949) J. Physiol. , vol.109 , pp. 1-9
    • Weir, J.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.