메뉴 건너뛰기




Volumn 38, Issue 2, 2017, Pages 128-139

T Cell Development by the Numbers

Author keywords

computational modeling; progenitors; quantitative biology; T cells; thymus

Indexed keywords

CELL MATURATION; DEVELOPMENTAL BIOLOGY; GENETIC MODEL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; QUANTITATIVE STUDY; REGENERATION; REPORTER GENE; STATISTICAL MODEL; STEADY STATE; T LYMPHOCYTE; ANIMAL; CELL DIFFERENTIATION; CELL LINEAGE; GENETICS; HUMAN; IMMUNOASSAY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; PRE T LYMPHOCYTE; THEORETICAL MODEL; THYMUS;

EID: 85006713613     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2016.10.007     Document Type: Review
Times cited : (54)

References (82)
  • 1
    • 80052991999 scopus 로고    scopus 로고
    • Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation
    • 1 Dudakov, J.A., van den Brink, M.R., Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation. Best Pract. Res. Clin. Haematol. 24 (2011), 467–476.
    • (2011) Best Pract. Res. Clin. Haematol. , vol.24 , pp. 467-476
    • Dudakov, J.A.1    van den Brink, M.R.2
  • 2
    • 84963615063 scopus 로고    scopus 로고
    • Hematopoiesis and T-cell specification as a model developmental system
    • 2 Rothenberg, E.V., et al. Hematopoiesis and T-cell specification as a model developmental system. Immunol. Rev. 271 (2016), 72–97.
    • (2016) Immunol. Rev. , vol.271 , pp. 72-97
    • Rothenberg, E.V.1
  • 3
    • 84908125658 scopus 로고    scopus 로고
    • Clonal dynamics of native haematopoiesis
    • 3 Sun, J., et al. Clonal dynamics of native haematopoiesis. Nature 514 (2014), 322–327.
    • (2014) Nature , vol.514 , pp. 322-327
    • Sun, J.1
  • 4
    • 84924038121 scopus 로고    scopus 로고
    • Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
    • 4 Busch, K., et al. Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Nature 518 (2015), 542–546.
    • (2015) Nature , vol.518 , pp. 542-546
    • Busch, K.1
  • 5
    • 0023837389 scopus 로고
    • Number and continuous proliferative pattern of transplanted primitive immunohematopoietic stem cells
    • 5 Harrison, D.E., et al. Number and continuous proliferative pattern of transplanted primitive immunohematopoietic stem cells. Proc. Natl. Acad. Sci. U. S. A. 85 (1988), 822–826.
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 822-826
    • Harrison, D.E.1
  • 6
    • 0025205255 scopus 로고
    • Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy
    • 6 Szilvassy, S.J., et al. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc. Natl. Acad. Sci. U. S. A. 87 (1990), 8736–8740.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 8736-8740
    • Szilvassy, S.J.1
  • 7
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • 7 Wilson, A., et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135 (2008), 1118–1129.
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1
  • 8
    • 80054719497 scopus 로고    scopus 로고
    • Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding
    • 8 Lu, R., et al. Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat. Biotechnol. 29 (2011), 928–933.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 928-933
    • Lu, R.1
  • 9
    • 77950981309 scopus 로고    scopus 로고
    • Cellular barcoding tool for clonal analysis in the hematopoietic system
    • 9 Gerrits, A., et al. Cellular barcoding tool for clonal analysis in the hematopoietic system. Blood 115 (2010), 2610–2618.
    • (2010) Blood , vol.115 , pp. 2610-2618
    • Gerrits, A.1
  • 10
    • 84876297531 scopus 로고    scopus 로고
    • Diverse and heritable lineage imprinting of early haematopoietic progenitors
    • 10 Naik, S.H., et al. Diverse and heritable lineage imprinting of early haematopoietic progenitors. Nature 496 (2013), 229–232.
    • (2013) Nature , vol.496 , pp. 229-232
    • Naik, S.H.1
  • 11
    • 84896712623 scopus 로고    scopus 로고
    • Determining lineage pathways from cellular barcoding experiments
    • 11 Perie, L., et al. Determining lineage pathways from cellular barcoding experiments. Cell Rep. 6 (2014), 617–624.
    • (2014) Cell Rep. , vol.6 , pp. 617-624
    • Perie, L.1
  • 12
    • 84861985190 scopus 로고    scopus 로고
    • Counting stem cells: methodological constraints
    • 12 Bystrykh, L.V., et al. Counting stem cells: methodological constraints. Nat. Methods 9 (2012), 567–574.
    • (2012) Nat. Methods , vol.9 , pp. 567-574
    • Bystrykh, L.V.1
  • 13
    • 84982256027 scopus 로고    scopus 로고
    • Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system
    • 13 Hofer, T., et al. Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system. Curr. Opin. Biotechnol. 39 (2016), 150–156.
    • (2016) Curr. Opin. Biotechnol. , vol.39 , pp. 150-156
    • Hofer, T.1
  • 14
    • 84991010662 scopus 로고    scopus 로고
    • Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals
    • 14 Sawai, C.M., et al. Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals. Immunity 45 (2016), 597–609.
    • (2016) Immunity , vol.45 , pp. 597-609
    • Sawai, C.M.1
  • 15
    • 84976878537 scopus 로고    scopus 로고
    • Site-specific recombinatorics: in situ cellular barcoding with the Cre Lox system
    • 15 Weber, T.S., et al. Site-specific recombinatorics: in situ cellular barcoding with the Cre Lox system. BMC Syst. Biol., 10, 2016, 43.
    • (2016) BMC Syst. Biol. , vol.10 , pp. 43
    • Weber, T.S.1
  • 16
    • 34250212481 scopus 로고    scopus 로고
    • Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from
    • 16 Bhandoola, A., et al. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26 (2007), 678–689.
    • (2007) Immunity , vol.26 , pp. 678-689
    • Bhandoola, A.1
  • 17
    • 77955275648 scopus 로고    scopus 로고
    • Early T cell development and the pitfalls of potential
    • 17 Schlenner, S.M., Rodewald, H.R., Early T cell development and the pitfalls of potential. Trends Immunol. 31 (2010), 303–310.
    • (2010) Trends Immunol. , vol.31 , pp. 303-310
    • Schlenner, S.M.1    Rodewald, H.R.2
  • 18
    • 4644329449 scopus 로고    scopus 로고
    • Circulating hematopoietic progenitors with T lineage potential
    • 18 Schwarz, B.A., Bhandoola, A., Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5 (2004), 953–960.
    • (2004) Nat. Immunol. , vol.5 , pp. 953-960
    • Schwarz, B.A.1    Bhandoola, A.2
  • 19
    • 33846240496 scopus 로고    scopus 로고
    • Identification of a T lineage-committed progenitor in adult blood
    • 19 Krueger, A., von Boehmer, H., Identification of a T lineage-committed progenitor in adult blood. Immunity 26 (2007), 105–116.
    • (2007) Immunity , vol.26 , pp. 105-116
    • Krueger, A.1    von Boehmer, H.2
  • 20
    • 33947698011 scopus 로고    scopus 로고
    • The blood contains multiple distinct progenitor populations with clonogenic B and T lineage potential
    • 20 Umland, O., et al. The blood contains multiple distinct progenitor populations with clonogenic B and T lineage potential. J. Immunol. 178 (2007), 4147–4152.
    • (2007) J. Immunol. , vol.178 , pp. 4147-4152
    • Umland, O.1
  • 21
    • 34250159205 scopus 로고    scopus 로고
    • Identification of a bone marrow precursor of the earliest thymocytes in adult mouse
    • 21 Lai, A.Y., Kondo, M., Identification of a bone marrow precursor of the earliest thymocytes in adult mouse. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 6311–6316.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 6311-6316
    • Lai, A.Y.1    Kondo, M.2
  • 22
    • 57249094263 scopus 로고    scopus 로고
    • The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man
    • 22 Zlotoff, D.A., et al. The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man. Semin. Immunopathol. 30 (2008), 371–382.
    • (2008) Semin. Immunopathol. , vol.30 , pp. 371-382
    • Zlotoff, D.A.1
  • 23
    • 33645086366 scopus 로고    scopus 로고
    • Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus-bone marrow feedback loop
    • 23 Goldschneider, I., Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus-bone marrow feedback loop. Immunol. Rev. 209 (2006), 58–75.
    • (2006) Immunol. Rev. , vol.209 , pp. 58-75
    • Goldschneider, I.1
  • 24
    • 0035976526 scopus 로고    scopus 로고
    • Physiological migration of hematopoietic stem and progenitor cells
    • 24 Wright, D.E., et al. Physiological migration of hematopoietic stem and progenitor cells. Science 294 (2001), 1933–1936.
    • (2001) Science , vol.294 , pp. 1933-1936
    • Wright, D.E.1
  • 25
    • 59649094661 scopus 로고    scopus 로고
    • Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
    • 25 Serwold, T., et al. Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood 113 (2009), 807–815.
    • (2009) Blood , vol.113 , pp. 807-815
    • Serwold, T.1
  • 26
    • 77949529736 scopus 로고    scopus 로고
    • Multiple extrathymic precursors contribute to T-cell development with different kinetics
    • 26 Saran, N., et al. Multiple extrathymic precursors contribute to T-cell development with different kinetics. Blood 115 (2010), 1137–1144.
    • (2010) Blood , vol.115 , pp. 1137-1144
    • Saran, N.1
  • 27
    • 77949956058 scopus 로고    scopus 로고
    • Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus
    • 27 Schlenner, S.M., et al. Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity 32 (2010), 426–436.
    • (2010) Immunity , vol.32 , pp. 426-436
    • Schlenner, S.M.1
  • 28
    • 77950418217 scopus 로고    scopus 로고
    • CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus
    • 28 Krueger, A., et al. CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood 115 (2010), 1906–1912.
    • (2010) Blood , vol.115 , pp. 1906-1912
    • Krueger, A.1
  • 29
    • 38149019947 scopus 로고    scopus 로고
    • Involvement of CCR9 at multiple stages of adult T lymphopoiesis
    • 29 Svensson, M., et al. Involvement of CCR9 at multiple stages of adult T lymphopoiesis. J. Leukoc. Biol. 83 (2008), 156–164.
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 156-164
    • Svensson, M.1
  • 30
    • 20644462119 scopus 로고    scopus 로고
    • Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1
    • 30 Rossi, F.M., et al. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat. Immunol. 6 (2005), 626–634.
    • (2005) Nat. Immunol. , vol.6 , pp. 626-634
    • Rossi, F.M.1
  • 31
    • 34247261581 scopus 로고    scopus 로고
    • Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
    • 31 Veerman, K.M., et al. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat. Immunol. 8 (2007), 532–539.
    • (2007) Nat. Immunol. , vol.8 , pp. 532-539
    • Veerman, K.M.1
  • 32
    • 77950407764 scopus 로고    scopus 로고
    • CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus
    • 32 Zlotoff, D.A., et al. CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus. Blood 115 (2010), 1897–1905.
    • (2010) Blood , vol.115 , pp. 1897-1905
    • Zlotoff, D.A.1
  • 33
    • 0022556206 scopus 로고
    • Dynamics of early T cells: prothymocyte migration and proliferation in the adult mouse thymus
    • 33 Scollay, R., et al. Dynamics of early T cells: prothymocyte migration and proliferation in the adult mouse thymus. Immunol. Rev. 91 (1986), 129–157.
    • (1986) Immunol. Rev. , vol.91 , pp. 129-157
    • Scollay, R.1
  • 34
    • 0016611505 scopus 로고
    • On the sparse seeding of bone marrow and thymus in radiation chimaeras
    • 34 Wallis, V.J., et al. On the sparse seeding of bone marrow and thymus in radiation chimaeras. Transplantation 19 (1975), 2–11.
    • (1975) Transplantation , vol.19 , pp. 2-11
    • Wallis, V.J.1
  • 35
    • 0035437165 scopus 로고    scopus 로고
    • Characterization of thymus-seeding precursor cells from mouse bone marrow
    • 35 Mori, S., et al. Characterization of thymus-seeding precursor cells from mouse bone marrow. Blood 98 (2001), 696–704.
    • (2001) Blood , vol.98 , pp. 696-704
    • Mori, S.1
  • 36
    • 33646480885 scopus 로고    scopus 로고
    • A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
    • 36 Scimone, M.L., et al. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 7006–7011.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 7006-7011
    • Scimone, M.L.1
  • 37
    • 65549089187 scopus 로고    scopus 로고
    • Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
    • 37 Gossens, K., et al. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J. Exp. Med. 206 (2009), 761–778.
    • (2009) J. Exp. Med. , vol.206 , pp. 761-778
    • Gossens, K.1
  • 38
    • 84961226113 scopus 로고    scopus 로고
    • Multicongenic fate mapping quantification of dynamics of thymus colonization
    • 38 Zietara, N., et al. Multicongenic fate mapping quantification of dynamics of thymus colonization. J. Exp. Med. 212 (2015), 1589–1601.
    • (2015) J. Exp. Med. , vol.212 , pp. 1589-1601
    • Zietara, N.1
  • 39
    • 0035808785 scopus 로고    scopus 로고
    • The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice
    • 39 Foss, D.L., et al. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J. Exp. Med. 193 (2001), 365–374.
    • (2001) J. Exp. Med. , vol.193 , pp. 365-374
    • Foss, D.L.1
  • 40
    • 0036200874 scopus 로고    scopus 로고
    • Functional demonstration of intrathymic binding sites and microvascular gates for prothymocytes in irradiated mice
    • 40 Foss, D.L., et al. Functional demonstration of intrathymic binding sites and microvascular gates for prothymocytes in irradiated mice. Int. Immunol. 14 (2002), 331–338.
    • (2002) Int. Immunol. , vol.14 , pp. 331-338
    • Foss, D.L.1
  • 41
    • 0035898387 scopus 로고    scopus 로고
    • Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
    • 41 Lind, E.F., et al. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 194 (2001), 127–134.
    • (2001) J. Exp. Med. , vol.194 , pp. 127-134
    • Lind, E.F.1
  • 42
    • 0141449952 scopus 로고    scopus 로고
    • Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice
    • 42 Porritt, H.E., et al. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J. Exp. Med. 198 (2003), 957–962.
    • (2003) J. Exp. Med. , vol.198 , pp. 957-962
    • Porritt, H.E.1
  • 43
    • 84989819835 scopus 로고    scopus 로고
    • Lymphotoxin beta receptor controls T cell progenitor entry to the thymus
    • 43 Lucas, B., et al. Lymphotoxin beta receptor controls T cell progenitor entry to the thymus. J. Immunol. 197 (2016), 2665–2672.
    • (2016) J. Immunol. , vol.197 , pp. 2665-2672
    • Lucas, B.1
  • 44
    • 84981237535 scopus 로고    scopus 로고
    • LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration
    • 44 Shi, Y., et al. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat. Commun., 7, 2016, 12369.
    • (2016) Nat. Commun. , vol.7 , pp. 12369
    • Shi, Y.1
  • 45
    • 84956772709 scopus 로고    scopus 로고
    • A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
    • 45 Buono, M., et al. A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors. Nat. Cell Biol. 18 (2016), 157–167.
    • (2016) Nat. Cell Biol. , vol.18 , pp. 157-167
    • Buono, M.1
  • 46
    • 3242747324 scopus 로고    scopus 로고
    • Regulation of thymus size by competition for stromal niches among early T cell progenitors
    • 46 Prockop, S.E., Petrie, H.T., Regulation of thymus size by competition for stromal niches among early T cell progenitors. J. Immunol. 173 (2004), 1604–1611.
    • (2004) J. Immunol. , vol.173 , pp. 1604-1611
    • Prockop, S.E.1    Petrie, H.T.2
  • 47
    • 79953095511 scopus 로고    scopus 로고
    • In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors
    • 47 Richie Ehrlich, L.I., et al. In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors. Blood 117 (2011), 2618–2624.
    • (2011) Blood , vol.117 , pp. 2618-2624
    • Richie Ehrlich, L.I.1
  • 48
    • 84922200235 scopus 로고    scopus 로고
    • Limited niche availability suppresses murine intrathymic dendritic-cell development from noncommitted progenitors
    • 48 Lyszkiewicz, M., et al. Limited niche availability suppresses murine intrathymic dendritic-cell development from noncommitted progenitors. Blood 125 (2015), 457–464.
    • (2015) Blood , vol.125 , pp. 457-464
    • Lyszkiewicz, M.1
  • 49
    • 84871284932 scopus 로고    scopus 로고
    • Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence
    • 49 Manesso, E., et al. Computational modelling of T-cell formation kinetics: output regulated by initial proliferation-linked deferral of developmental competence. J. R. Soc. Interface, 10, 2013, 20120774.
    • (2013) J. R. Soc. Interface , vol.10 , pp. 20120774
    • Manesso, E.1
  • 50
    • 77952581999 scopus 로고    scopus 로고
    • hi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria
    • hi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria. Nat. Immunol. 11 (2010), 477–485.
    • (2010) Nat. Immunol. , vol.11 , pp. 477-485
    • Belyaev, N.N.1
  • 51
    • 33846902089 scopus 로고    scopus 로고
    • Selective thymus settling regulated by cytokine and chemokine receptors
    • 51 Schwarz, B.A., et al. Selective thymus settling regulated by cytokine and chemokine receptors. J. Immunol. 178 (2007), 2008–2017.
    • (2007) J. Immunol. , vol.178 , pp. 2008-2017
    • Schwarz, B.A.1
  • 52
    • 84866463556 scopus 로고    scopus 로고
    • Thymocytes may persist and differentiate without any input from bone marrow progenitors
    • 52 Peaudecerf, L., et al. Thymocytes may persist and differentiate without any input from bone marrow progenitors. J. Exp. Med. 209 (2012), 1401–1408.
    • (2012) J. Exp. Med. , vol.209 , pp. 1401-1408
    • Peaudecerf, L.1
  • 53
    • 84873619402 scopus 로고    scopus 로고
    • Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation
    • 53 Manesso, E., et al. Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation. J. R. Soc. Interface, 10, 2013, 20120817.
    • (2013) J. R. Soc. Interface , vol.10 , pp. 20120817
    • Manesso, E.1
  • 54
    • 84055178955 scopus 로고    scopus 로고
    • T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
    • 54 Germar, K., et al. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 20060–20065.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 20060-20065
    • Germar, K.1
  • 55
    • 79961140554 scopus 로고    scopus 로고
    • A critical role for TCF-1 in T-lineage specification and differentiation
    • 55 Weber, B.N., et al. A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476 (2011), 63–68.
    • (2011) Nature , vol.476 , pp. 63-68
    • Weber, B.N.1
  • 56
    • 84958599461 scopus 로고    scopus 로고
    • Responsiveness of developing T cells to IL-7 signals is sustained by miR-17∼92
    • 56 Regelin, M., et al. Responsiveness of developing T cells to IL-7 signals is sustained by miR-17∼92. J. Immunol. 195 (2015), 4832–4840.
    • (2015) J. Immunol. , vol.195 , pp. 4832-4840
    • Regelin, M.1
  • 57
    • 10944269361 scopus 로고    scopus 로고
    • Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development
    • 57 Benz, C., et al. Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur. J. Immunol. 34 (2004), 3652–3663.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 3652-3663
    • Benz, C.1
  • 58
    • 84859388345 scopus 로고    scopus 로고
    • Selection of self-reactive T cells in the thymus
    • 58 Stritesky, G.L., et al. Selection of self-reactive T cells in the thymus. Annu. Rev. Immunol. 30 (2012), 95–114.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 95-114
    • Stritesky, G.L.1
  • 59
    • 0025320656 scopus 로고
    • Kinetics of mature T-cell development in the thymus
    • 59 Egerton, M., et al. Kinetics of mature T-cell development in the thymus. Proc. Natl. Acad. Sci. U. S. A. 87 (1990), 2579–2582.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 2579-2582
    • Egerton, M.1
  • 60
    • 84875257845 scopus 로고    scopus 로고
    • Murine thymic selection quantified using a unique method to capture deleted T cells
    • 60 Stritesky, G.L., et al. Murine thymic selection quantified using a unique method to capture deleted T cells. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 4679–4684.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 4679-4684
    • Stritesky, G.L.1
  • 61
    • 84895516392 scopus 로고    scopus 로고
    • From pre-DP, post-DP, SP4, and SP8 thymocyte cell counts to a dynamical model of cortical and medullary selection
    • 61 Sawicka, M., et al. From pre-DP, post-DP, SP4, and SP8 thymocyte cell counts to a dynamical model of cortical and medullary selection. Front. Immunol., 5, 2014, 19.
    • (2014) Front. Immunol. , vol.5 , pp. 19
    • Sawicka, M.1
  • 62
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • 62 Surh, C.D., Sprent, J., T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372 (1994), 100–103.
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 63
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
    • 63 Laufer, T.M., et al. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383 (1996), 81–85.
    • (1996) Nature , vol.383 , pp. 81-85
    • Laufer, T.M.1
  • 64
    • 0031048826 scopus 로고    scopus 로고
    • Quantitative impact of thymic clonal deletion on the T cell repertoire
    • 64 van Meerwijk, J.P., et al. Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185 (1997), 377–383.
    • (1997) J. Exp. Med. , vol.185 , pp. 377-383
    • van Meerwijk, J.P.1
  • 65
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • 65 Moran, A.E., et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208 (2011), 1279–1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 66
    • 84881096188 scopus 로고    scopus 로고
    • Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system
    • 66 Sinclair, C., et al. Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), E2905–E2914.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. E2905-E2914
    • Sinclair, C.1
  • 67
    • 0018833714 scopus 로고
    • Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice
    • 67 Scollay, R.G., et al. Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 10 (1980), 210–218.
    • (1980) Eur. J. Immunol. , vol.10 , pp. 210-218
    • Scollay, R.G.1
  • 68
    • 0021810585 scopus 로고
    • Identification of early stages of T lymphocyte development in the thymus cortex and medulla
    • 68 Scollay, R., Shortman, K., Identification of early stages of T lymphocyte development in the thymus cortex and medulla. J. Immunol. 134 (1985), 3632–3642.
    • (1985) J. Immunol. , vol.134 , pp. 3632-3642
    • Scollay, R.1    Shortman, K.2
  • 69
    • 84938937838 scopus 로고    scopus 로고
    • T cell adolescence: maturation events beyond positive selection
    • 69 Hogquist, K.A., et al. T cell adolescence: maturation events beyond positive selection. J. Immunol. 195 (2015), 1351–1357.
    • (2015) J. Immunol. , vol.195 , pp. 1351-1357
    • Hogquist, K.A.1
  • 70
    • 84962068228 scopus 로고    scopus 로고
    • Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling
    • 70 Xing, Y., et al. Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling. Nat. Immunol. 17 (2016), 565–573.
    • (2016) Nat. Immunol. , vol.17 , pp. 565-573
    • Xing, Y.1
  • 71
    • 9144228777 scopus 로고    scopus 로고
    • Continued maturation of thymic emigrants in the periphery
    • 71 Boursalian, T.E., et al. Continued maturation of thymic emigrants in the periphery. Nat. Immunol. 5 (2004), 418–425.
    • (2004) Nat. Immunol. , vol.5 , pp. 418-425
    • Boursalian, T.E.1
  • 72
    • 84879101247 scopus 로고    scopus 로고
    • Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci
    • 72 Berkley, A.M., et al. Recent thymic emigrants and mature naive T cells exhibit differential DNA methylation at key cytokine loci. J. Immunol. 190 (2013), 6180–6186.
    • (2013) J. Immunol. , vol.190 , pp. 6180-6186
    • Berkley, A.M.1
  • 73
    • 35748979722 scopus 로고    scopus 로고
    • Thymic emigration revisited
    • 73 McCaughtry, T.M., et al. Thymic emigration revisited. J. Exp. Med. 204 (2007), 2513–2520.
    • (2007) J. Exp. Med. , vol.204 , pp. 2513-2520
    • McCaughtry, T.M.1
  • 74
    • 77953955389 scopus 로고    scopus 로고
    • Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial
    • 74 Wang, G.P., et al. Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial. Blood 115 (2010), 4356–4366.
    • (2010) Blood , vol.115 , pp. 4356-4366
    • Wang, G.P.1
  • 75
    • 34547686397 scopus 로고    scopus 로고
    • Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy
    • 75 Aiuti, A., et al. Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy. J. Clin. Invest. 117 (2007), 2233–2240.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2233-2240
    • Aiuti, A.1
  • 76
    • 13544262340 scopus 로고    scopus 로고
    • Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro
    • 76 La Motte-Mohs, R.N., et al. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 105 (2005), 1431–1439.
    • (2005) Blood , vol.105 , pp. 1431-1439
    • La Motte-Mohs, R.N.1
  • 77
    • 84857416171 scopus 로고    scopus 로고
    • Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
    • 77 den Braber, I., et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 36 (2012), 288–297.
    • (2012) Immunity , vol.36 , pp. 288-297
    • den Braber, I.1
  • 78
    • 1342288971 scopus 로고    scopus 로고
    • Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice
    • 78 Rangarajan, A., Weinberg, R.A., Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nat. Rev. Cancer 3 (2003), 952–959.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 79
    • 84884695279 scopus 로고    scopus 로고
    • Telomere dynamics in mice and humans
    • 79 Calado, R.T., Dumitriu, B., Telomere dynamics in mice and humans. Semin. Hematol. 50 (2013), 165–174.
    • (2013) Semin. Hematol. , vol.50 , pp. 165-174
    • Calado, R.T.1    Dumitriu, B.2
  • 80
    • 0021223477 scopus 로고
    • The total marrow mass of the mouse: a simplified method of measurement
    • 80 Boggs, D.R., The total marrow mass of the mouse: a simplified method of measurement. Am. J. Hematol. 16 (1984), 277–286.
    • (1984) Am. J. Hematol. , vol.16 , pp. 277-286
    • Boggs, D.R.1
  • 81
    • 78049517631 scopus 로고    scopus 로고
    • Lunatic fringe enhances competition for Delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte β-selection in vivo
    • 81 Visan, I., et al. Lunatic fringe enhances competition for Delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte β-selection in vivo. J. Immunol. 185 (2010), 4609–4617.
    • (2010) J. Immunol. , vol.185 , pp. 4609-4617
    • Visan, I.1
  • 82
    • 0035134037 scopus 로고    scopus 로고
    • A good practice guide to the administration of substances and removal of blood, including routes and volumes
    • 82 Diehl, K.H., et al. A good practice guide to the administration of substances and removal of blood, including routes and volumes. J. Appl. Toxicol. 21 (2001), 15–23.
    • (2001) J. Appl. Toxicol. , vol.21 , pp. 15-23
    • Diehl, K.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.