Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening

Molecular and Cellular Neuroscience

Volumn 80, Issue , 2017, Pages 198-207

  O'Duibhir, Eoghan ^a,b   Carragher, Neil O ^b   Pollard, Steven M ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CRISPR Cas9; Genome editing; Glioblastoma stem cell; HCS; Neural stem cell; Phenotypic screening

Indexed keywords

ALLELE; BRAIN CANCER; CANCER GROWTH; CELL CULTURE; CELL KINETICS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; DRUG DEVELOPMENT; GENE DISRUPTION; GENE EDITING; GENE TARGETING; GENETIC ENGINEERING; GENETIC MODEL; GENETIC SCREENING; GENOTYPE; GLIOBLASTOMA; HUMAN; MICROSCOPY; MOLECULAR GENETICS; NEURAL STEM CELL; NONHUMAN; ONCOGENE; PHARMACOGENOMICS; PHENOTYPE; REVIEW; ROBOTICS; STEM CELL; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; ANIMAL; BRAIN NEOPLASMS; GENETICS; HUMAN GENOME; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PATHOLOGY; PROCEDURES;

ANTINEOPLASTIC AGENT;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DRUG DISCOVERY; GENE EDITING; GENOME, HUMAN; GLIOBLASTOMA; HUMANS; INDUCED PLURIPOTENT STEM CELLS;

EID: 85006701121     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2016.11.001     Document Type: Review

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