Using biological performance similarity to inform disaccharide library design

Journal of the American Chemical Society

Volumn 131, Issue 14, 2009, Pages 5075-5083

  Tanikawa, Tetsuya ^a,b,c   Fridman, Micha ^a,b,c,d   Zhu, Wenjiang ^a,b,c   Faulk, Brian ^a,b,c   Joseph, Isaac C ^a,b   Kahne, Daniel ^a,b,c   Wagner, Bridget K ^a,b   Clemons, Paul A ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD UNIVERSITY   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYSIS APPROACH; BIOLOGICAL ASSAYS; BIOLOGICAL EFFECTS; BIOLOGICAL PERFORMANCE; BIOLOGICAL PROCESS; CHEMICAL DESCRIPTORS; LIBRARY DESIGNS; SMALL MOLECULES; STEREOCHEMICAL VARIATION; STRUCTURAL FEATURE; SYNTHETIC METHODS;

CELL MEMBRANES; STEREOCHEMISTRY;

POLYSACCHARIDES;

DISACCHARIDE; MOLECULAR LIBRARY;

ARTICLE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE SYNTHESIS; CELL ASSAY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DATA ANALYSIS; MOLECULAR LIBRARY; MOLECULAR SIZE; STEREOCHEMISTRY; STRUCTURE ANALYSIS; ADIPOCYTE; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; COMBINATORIAL CHEMISTRY; CYTOLOGY; GLYCOSYLATION; KNOCKOUT MOUSE; METABOLISM; MOUSE; PROCEDURES; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COMBINATORIAL CHEMISTRY TECHNIQUES; DISACCHARIDES; GLYCOSYLATION; MICE; MICE, KNOCKOUT; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67849128975     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja806583y     Document Type: Article

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