From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders

Psychopharmacology

Volumn 234, Issue 9-10, 2017, Pages 1347-1355

  Acri, Jane B ^a   Cross, Alan J ^b   Skolnick, Phil ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Animal models; Athina Markou; Cocaine; Cue induced reinstatement; Glutamate; mGluR2; Nicotine; Self administration; Smoking cessation

Indexed keywords

ACETAZOLAMIDE; AZD 8529; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR ANTAGONIST; RISPERIDONE; UNCLASSIFIED DRUG; AZD8529; INDOLE DERIVATIVE; METABOTROPIC RECEPTOR; NICOTINE; NICOTINE GUM; OXADIAZOLE DERIVATIVE;

CUE INDUCED REINSTATEMENT; DRUG BLOOD LEVEL; DRUG CRAVING; DRUG DEPENDENCE; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SEEKING BEHAVIOR; EXPERIMENTAL BEHAVIORAL TEST; FEEDBACK SYSTEM; HUMAN; INCUBATION TIME; LIMIT OF QUANTITATION; NICOTINE SELF-ADMINISTRATION TEST; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); RELAPSE; REVIEW; SCHIZOPHRENIA; SELF REPORT; SMOKING CESSATION; AGONISTS; ALLOSTERISM; ANIMAL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; DRUG SELF ADMINISTRATION; MALE; METABOLISM; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ALLOSTERIC REGULATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MALE; NICOTINE; OXADIAZOLES; RECEPTORS, METABOTROPIC GLUTAMATE; SELF ADMINISTRATION; SUBSTANCE-RELATED DISORDERS; TOBACCO USE CESSATION PRODUCTS; TREATMENT OUTCOME;

EID: 85006379775     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-016-4501-9     Document Type: Review

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