Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: Structure-activity relationships and assessment in a rat model of nicotine dependence

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 9434-9445

  Sidique, Shyama ^a   Dhanya, Raveendra Panickar ^a   Sheffler, Douglas J ^b   Nickols, Hilary Highfield ^b   Yang, Li ^a   Dahl, Russell ^a   Mangravita Novo, Arianna ^a   Smith, Layton H ^a   D'Souza, Manoranjan S ^c   Semenova, Svetlana ^c   Conn, P Jeffrey ^b   Markou, Athina ^c   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BENZISOTHIAZOLIN 3 ONE; ISOINDOLE DERIVATIVE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 2 POSITIVE ALLOSTERIC MODULATOR; METABOTROPIC RECEPTOR AGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TOBACCO DEPENDENCE;

ADMINISTRATION, ORAL; ALLOSTERIC REGULATION; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; GLUTAMIC ACID; HEK293 CELLS; HUMANS; INDOLES; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NICOTINE; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TOBACCO USE DISORDER;

EID: 84870020714     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3005306     Document Type: Article

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