Vitamin D signaling through induction of paneth cell defensins maintains gut microbiota and improves metabolic disorders and hepatic steatosis in animal models

Frontiers in Physiology

Volumn 7, Issue NOV, 2016, Pages

  Su, Danmei ^a   Nie, Yuanyang ^a   Zhu, Airu ^a   Chen, Zishuo ^a   Wu, Pengfei ^a   Zhang, Li ^a   Luo, Mei ^a,b   Sun, Qun ^a   Cai, Linbi ^a   Lai, Yuchen ^a   Xiao, Zhixiong ^a   Duan, Zhongping ^c   Zheng, Sujun ^c   Wu, Guihui ^b   Hu, Richard ^d   Tsukamoto, Hidekazu ^e   Lugea, Aurelia ^f   Liu, Zhenqui ^f   Pandol, Stephen J ^f   Han, Yuan Ping ^a,f  

^a SICHUAN UNIVERSITY   (China)

^b Public Health Clinical Center of Chengdu   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Akkermansia muciniphila; Defensins; Gut microbiota; Helicobacter; Metabolic syndrome; Non alcoholic fatty liver disease (NAFLD); Non alcoholic steatohepatitis (NASH); Vitamin D

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 5; MATRILYSIN; MUCIN 2; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

AKKERMANSIA MUCINIPHILA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL OVERGROWTH; BACTERIUM; CONTROLLED STUDY; DEFA5 GENE; DISEASE EXACERBATION; DOWN REGULATION; DYSBIOSIS; ENDOTOXEMIA; ENZYME ACTIVATION; FATTY LIVER; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HELICOBACTER HEPATICUS; HOMEOSTASIS; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTESTINE EPITHELIUM; INTESTINE FLORA; LIPID DIET; MALE; METABOLIC DISORDER; MMP7 GENE; MOUSE; MUC2 GENE; NONHUMAN; PANETH CELL; PERMEABILITY; PHENOTYPE; SIGNAL TRANSDUCTION; TIGHT JUNCTION; VITAMIN D DEFICIENCY;

EID: 85006373468     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2016.00498     Document Type: Article

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