Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children

Immunobiology

Volumn 219, Issue 11, 2014, Pages 873-879

  Hamzaoui, Agnes ^a,b   Berraïes, Anissa ^a,b   Hamdi, Besma ^a,b   Kaabachi, Wajih ^b   Ammar, Jamel ^a,b   Hamzaoui, Kamel ^b  

^a ABDERRAHMAN MAMI HOSPITAL   (Tunisia)

^b UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

Asthma; CCR6; IL 23R; RORC; Th17; 25(OH)D3

Indexed keywords

CALCIFEDIOL; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR6; GLUCOCORTICOID; INTERLEUKIN 17; INTERLEUKIN 23 RECEPTOR; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; VITAMIN D;

ADOLESCENT; ANIMAL CELL CULTURE; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL POLARITY; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL LYMPHOCYTE; PRESCHOOL CHILD; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; T LYMPHOCYTE ACTIVATION; TH17 CELL; BLOOD; CASE CONTROL STUDY; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL; PATHOPHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ASTHMA; CALCIFEDIOL; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; DENDRITIC CELLS; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; T-LYMPHOCYTE SUBSETS; TH17 CELLS; VITAMIN D;

EID: 84908258863     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2014.07.009     Document Type: Article

References (41)

1. Al-Ramli W., Préfontaine D., Chouiali F., Martin J.G., Olivenstein R., Lemière C., Hamid Q. TH17-associated cytokines (IL-17A and IL-17F) in severe asthma. J. Allergy Clin. Immunol. 2009, 123:1185-1187.
2. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., Parente E., Filì L., Ferri S., Frosali F., Giudici F., Romagnani P., Parronchi P., Tonelli F., Maggi E., Romagnani S. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204:1849-1861.
3. Arnson Y., Amital H., Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann. Rheum. Dis. 2007, 66:1137-1142.
4. Berraies A., Hamzaoui K., Hamzaoui A. Link between vitamin D and airway remodelling. J. Asthma Allergy 2014, 7:23-30.
5. Brehm J.M., Schuemann B., Fuhlbrigge A.L., Hollis B.W., Strunk R.C., Zeiger R.S., Weiss S.T., Litonjua A.A. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J. Allergy Clin. Immunol. 2010, 126(1):52-58. e5.
6. Chang S.H., Chung Y., Dong C. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J. Biol. Chem. 2010, 285:38751-38755.
7. Chen J., Deng Y., Zhao J., Luo Z., Peng W., Yang J., Ren L., Wang L., Fu Z., Yang X., Liu E. The polymorphism of IL-17G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis. J. Clin. Immunol. 2010, 30:539-545.
8. Chinellato I., Piazza M., Sandri M., Peroni D., Piacentini G., Boner A.L. Vitamin D serum levels and markers of asthma control in Italian children. J. Pediatr. 2011, 158(3):437-441.
9. Cosmi L., Liotta F., Maggi E., Romagnani S., Annunziato F. Th17 cells: new players in asthma pathogenesis. Allergy 2011, 66:989-998.
10. Fauber B.P., Magnuson S. Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc). J. Med. Chem. 2014, (in press). 10.1021/jm401901d.
11. + T cells. Adv. Immunol. 2010, 105:99-130.
12. Galowitz S., Chang C. Immunobiology of critical pediatric asthma. Clin. Rev. Allergy Immunol. 2014, PMID: 24452844 (in press).
13. Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2014, Available from: http://www.ginasthma.org/.
14. Hamid Q., Tulic M. Immunobiology of asthma. Annu. Rev. Pharmacol. 2009, 71:489-507.
15. Hamzaoui A., Ammar J., Hamzaoui K. Regulatory T cells in induced sputum of asthmatic children: association with inflammatory cytokines. Multidiscip. Respir. Med. 2010, 5:22-30.
16. Hamzaoui K., Ben Dhifallah I., Karray E., Sassi F.H., Hamzaoui A. Vitamin D modulates peripheral immunity in patients with Behçet's disease. Clin. Exp. Rheumatol. 2010, 28(4 (Suppl. 60)). S50-7.
17. Hamzaoui A., Maalmi H., Berraïes A., Abid H., Ammar J., Hamzaoui K. Transcriptional characteristics of CD4 T cells in young asthmatic children: RORC and FOXP3 axis. J. Inflamm. Res. 2011, 4:139-146.
18. Hamzaoui A., Berraies A., Kaabachi W., Maalmi H., Ammar J., Hamzaoui K. Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children. J. Asthma 2013, 50(8):803-809.
19. Joshi S., Pantalena L.C., Liu X.K., Gaffen S.L., Liu H., Rohowsky-Kochan C., Ichiyama K., Yoshimura A., Steinman L., Christakos S., Youssef S. 1,25-Dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol. Cell. Biol. 2011, 31:3653-3669.
20. Lanzavecchia A., Sallusto F. The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr. Opin. Immunol. 2001, 13:291-298.
21. Li K., Wang Z., Cao Y., Bunjhoo H., Zhu J., Chen Y., Xiong S., Xu Y., Xiong W. The study of the ratio and distribution of Th17 cells and Tc17 cells in asthmatic patients and the mouse model. Asian Pac. J. Allergy Immunol. 2013, 31(2):125-131.
22. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
23. Maalmi H., Beraies A., Charad R., Ammar J., Hamzaoui K., Hamzaoui A. IL-17A and IL-17F genes variants and susceptibility to childhood asthma in Tunisia. J. Asthma 2014, 51(4):348-354.
24. Maalmi H., Berraïes A., Tangour E., Ammar J., Abid H., Hamzaoui K., Hamzaoui A. The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study. J. Asthma Allergy 2012, 5:11-19.
25. Manel N., Unutmaz D., Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 2008, 9:641-649.
26. Manni M.L., Trudeau J.B., Scheller E.V., Mandalapu S., Elloso M.M., Kolls J.K., Wenzel S.E., Alcorn J.F. The complex relationship between inflammation and lung function in severe asthma. Mucosal Immunol. 2014, (in press). 10.1038/mi.2014.8.
27. McKinley L., Alcorn J.F., Peterson A., Dupont R.B., Kapadia S., Logar A., Henry A., Irvin C.G., Piganelli J.D., Ray A., Kolls J.K. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 2008, 181:4089-4097.
28. Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Pagé N., Olivenstein R., Elias J., Chakir J. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 2001, 108(3):430-438.
29. Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., Sekikawa K., Asano M., Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002, 17(3):375-387.
30. Nanzer A.M., Chambers E.S., Ryanna K., Richards D.F., Black C., Timms P.M., Martineau A.R., Griffiths C.J., Corrigan C.J., Hawrylowicz C.M. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J. Allergy Clin. Immunol. 2013, 132(2):297-304. e3.
31. Ouyang X., Zhang R., Yang J., Li Q., Qin L., Zhu C., Liu J., Ning H., Shin M.S., Gupta M., Qi C.F., He J.C., Lira S.A., Morse H.C., Ozato K., Mayer L., Xiong H. Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nat. Commun. 2011, 2:314.
32. Pène J., Chevalier S., Preisser L., Vénéreau E., Guilleux M.H., Ghannam S., Molès J.P., Danger Y., Ravon E., Lesaux S., Yssel H., Gascan H. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol. 2008, 180:7423-7430.
33. Sallusto F., Lanzavecchia A. The instructive role of dendritic cells on T-cell responses. Arthritis Res. 2002, 4(Suppl. 3):S127-S132.
34. Searing D.A., Zhang Y., Murphy J.R., Hauk P.J., Goleva E., Leung D.Y. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J. Allergy Clin. Immunol. 2010, 125(5):995-1000.
35. Silverpil E., Linden A. IL-17 in human asthma. Expert Rev. Respir. Med. 2012, 6:173-186.
36. Tang J., Zhou R., Luger D., Zhu W., Silver P.B., Grajewski R.S., Su S.B., Chan C.C., Adorini L., Caspi R.R. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J. Immunol. 2009, 182:4624-4632.
37. Tian Y., Wang C., Ye Z., Xiao X., Kijlstra A., Yang P. Effect of 1,25-dihydroxyvitamin D3 on Th17 and Th1 response in patients with Behçet's disease. Invest. Ophthalmol. Vis. Sci. 2012, 53(10):6434-6441.
38. Van Weel C., Bateman E.D., Bousquet J., Reid J., Grouse L., Schermer T., Valovirta E., Zhong N. Asthma management pocket reference. Allergy 2008, 63:997-1004.
39. Wahono C.S., Rusmini H., Soelistyoningsih D., Hakim R., Handono K., Endharti A.T., Kalim H., Widjajanto E. Effects of 25(OH)D3in immune response regulation of systemic lupus erithematosus (SLE) patient with hypovitamin D. Int. J. Clin. Exp. Med. 2014, 7(1):22-31.
40. Wang C., Kang S.G., Lee J., Sun Z., Kim C.H. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009, 2:173-183.
41. Yu X., Rollins D., Ruhn K.A., Stubblefield J.J., Green C.B., Kashiwada M., Rothman P.B., Takahashi J.S., Hooper L.V. TH17 cell differentiation is regulated by the circadian clock. Science 2013, 342(6159):727-730.