-
1
-
-
55249105923
-
Clostridium difficile – more difficult than ever
-
Kelly CP and LaMont JT (2008) Clostridium difficile – more difficult than ever. N Engl J Med 359, 1932–1940.
-
(2008)
N Engl J Med
, vol.359
, pp. 1932-1940
-
-
Kelly, C.P.1
LaMont, J.T.2
-
2
-
-
28844441314
-
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
-
Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, Bourgault AM, Nguyen T, Frenette C, Kelly M et al. (2005) A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 353, 2442–2449.
-
(2005)
N Engl J Med
, vol.353
, pp. 2442-2449
-
-
Loo, V.G.1
Poirier, L.2
Miller, M.A.3
Oughton, M.4
Libman, M.D.5
Michaud, S.6
Bourgault, A.M.7
Nguyen, T.8
Frenette, C.9
Kelly, M.10
-
3
-
-
28844494086
-
An epidemic, toxin gene-variant strain of Clostridium difficile
-
McDonald LC, Killgore GE, Thompson A, Owens RC Jr, Kazakova SV, Sambol SP, Johnson S and Gerding DN (2005) An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 353, 2433–2441.
-
(2005)
N Engl J Med
, vol.353
, pp. 2433-2441
-
-
McDonald, L.C.1
Killgore, G.E.2
Thompson, A.3
Owens, R.C.4
Kazakova, S.V.5
Sambol, S.P.6
Johnson, S.7
Gerding, D.N.8
-
4
-
-
17444366186
-
Clostridium difficile toxins: mechanism of action and role in disease
-
Voth DE and Ballard JD (2005) Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 18, 247–263.
-
(2005)
Clin Microbiol Rev
, vol.18
, pp. 247-263
-
-
Voth, D.E.1
Ballard, J.D.2
-
5
-
-
79959213985
-
Bacterial protein toxins that modify host regulatory GTPases
-
Aktories K (2011) Bacterial protein toxins that modify host regulatory GTPases. Nat Rev Microbiol 9, 487–498.
-
(2011)
Nat Rev Microbiol
, vol.9
, pp. 487-498
-
-
Aktories, K.1
-
6
-
-
0033787469
-
Microbial toxins and the glycosylation of rho family GTPases
-
Busch C and Aktories K (2000) Microbial toxins and the glycosylation of rho family GTPases. Curr Opin Struct Biol 10, 528–535.
-
(2000)
Curr Opin Struct Biol
, vol.10
, pp. 528-535
-
-
Busch, C.1
Aktories, K.2
-
7
-
-
0029011449
-
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
-
Just I, Wilm M, Selzer J, Rex G, von Eichel-Streiber C, Mann M and Aktories K (1995) The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J Biol Chem 270, 13932–13936.
-
(1995)
J Biol Chem
, vol.270
, pp. 13932-13936
-
-
Just, I.1
Wilm, M.2
Selzer, J.3
Rex, G.4
von Eichel-Streiber, C.5
Mann, M.6
Aktories, K.7
-
8
-
-
0029054398
-
Glucosylation of Rho proteins by Clostridium difficile toxin B
-
Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M and Aktories K (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375, 500–503.
-
(1995)
Nature
, vol.375
, pp. 500-503
-
-
Just, I.1
Selzer, J.2
Wilm, M.3
von Eichel-Streiber, C.4
Mann, M.5
Aktories, K.6
-
10
-
-
0030271882
-
Large clostridial cytotoxins – a family of glycosyltransferases modifying small GTP-binding proteins
-
von Eichel-Streiber C, Boquet P, Sauerborn M and Thelestam M (1996) Large clostridial cytotoxins – a family of glycosyltransferases modifying small GTP-binding proteins. Trends Microbiol 4, 375–382.
-
(1996)
Trends Microbiol
, vol.4
, pp. 375-382
-
-
von Eichel-Streiber, C.1
Boquet, P.2
Sauerborn, M.3
Thelestam, M.4
-
11
-
-
3042568878
-
Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins
-
Schirmer J and Aktories K (2004) Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins. Biochim Biophys Acta 1673, 66–74.
-
(2004)
Biochim Biophys Acta
, vol.1673
, pp. 66-74
-
-
Schirmer, J.1
Aktories, K.2
-
12
-
-
0030891386
-
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin
-
Hofmann F, Busch C, Prepens U, Just I and Aktories K (1997) Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin. J Biol Chem 272, 11074–11078.
-
(1997)
J Biol Chem
, vol.272
, pp. 11074-11078
-
-
Hofmann, F.1
Busch, C.2
Prepens, U.3
Just, I.4
Aktories, K.5
-
13
-
-
0032831781
-
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling
-
Genth H, Aktories K and Just I (1999) Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. J Biol Chem 274, 29050–29056.
-
(1999)
J Biol Chem
, vol.274
, pp. 29050-29056
-
-
Genth, H.1
Aktories, K.2
Just, I.3
-
14
-
-
0032584665
-
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins
-
Busch C, Hofmann F, Selzer J, Munro S, Jeckel D and Aktories K (1998) A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem 273, 19566–19572.
-
(1998)
J Biol Chem
, vol.273
, pp. 19566-19572
-
-
Busch, C.1
Hofmann, F.2
Selzer, J.3
Munro, S.4
Jeckel, D.5
Aktories, K.6
-
15
-
-
36849050145
-
Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding
-
Jank T, Giesemann T and Aktories K (2007) Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding. J Biol Chem 282, 35222–35231.
-
(2007)
J Biol Chem
, vol.282
, pp. 35222-35231
-
-
Jank, T.1
Giesemann, T.2
Aktories, K.3
-
16
-
-
23644460027
-
Structural basis for the function of Clostridium difficile toxin B
-
Reinert DJ, Jank T, Aktories K and Schulz GE (2005) Structural basis for the function of Clostridium difficile toxin B. J Mol Biol 351, 973–981.
-
(2005)
J Mol Biol
, vol.351
, pp. 973-981
-
-
Reinert, D.J.1
Jank, T.2
Aktories, K.3
Schulz, G.E.4
-
17
-
-
33947502604
-
Autocatalytic cleavage of Clostridium difficile toxin B
-
Reineke J, Tenzer S, Rupnik M, Koschinski A, Hasselmayer O, Schrattenholz A, Schild H and von Eichel-Streiber C (2007) Autocatalytic cleavage of Clostridium difficile toxin B. Nature 446, 415–419.
-
(2007)
Nature
, vol.446
, pp. 415-419
-
-
Reineke, J.1
Tenzer, S.2
Rupnik, M.3
Koschinski, A.4
Hasselmayer, O.5
Schrattenholz, A.6
Schild, H.7
von Eichel-Streiber, C.8
-
18
-
-
34548472183
-
Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity
-
Egerer M, Giesemann T, Jank T, Satchell KJ and Aktories K (2007) Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity. J Biol Chem 282, 25314–25321.
-
(2007)
J Biol Chem
, vol.282
, pp. 25314-25321
-
-
Egerer, M.1
Giesemann, T.2
Jank, T.3
Satchell, K.J.4
Aktories, K.5
-
19
-
-
69249090956
-
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A
-
Pruitt RN, Chagot B, Cover M, Chazin WJ, Spiller B and Lacy DB (2009) Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. J Biol Chem 284, 21934–21940.
-
(2009)
J Biol Chem
, vol.284
, pp. 21934-21940
-
-
Pruitt, R.N.1
Chagot, B.2
Cover, M.3
Chazin, W.J.4
Spiller, B.5
Lacy, D.B.6
-
20
-
-
79952418425
-
Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B
-
Genisyuerek S, Papatheodorou P, Guttenberg G, Schubert R, Benz R and Aktories K (2011) Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B. Mol Microbiol 79, 1643–1654.
-
(2011)
Mol Microbiol
, vol.79
, pp. 1643-1654
-
-
Genisyuerek, S.1
Papatheodorou, P.2
Guttenberg, G.3
Schubert, R.4
Benz, R.5
Aktories, K.6
-
21
-
-
63649106579
-
Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate
-
Egerer M, Giesemann T, Herrmann C and Aktories K (2009) Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate. J Biol Chem 284, 3389–3395.
-
(2009)
J Biol Chem
, vol.284
, pp. 3389-3395
-
-
Egerer, M.1
Giesemann, T.2
Herrmann, C.3
Aktories, K.4
-
22
-
-
0035815642
-
Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells
-
Barth H, Pfeifer G, Hofmann F, Maier E, Benz R and Aktories K (2001) Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells. J Biol Chem 276, 10670–10676.
-
(2001)
J Biol Chem
, vol.276
, pp. 10670-10676
-
-
Barth, H.1
Pfeifer, G.2
Hofmann, F.3
Maier, E.4
Benz, R.5
Aktories, K.6
-
23
-
-
0034114105
-
pH-induced conformational changes in Clostridium difficile toxin B
-
Qa'Dan M, Spyres LM and Ballard JD (2000) pH-induced conformational changes in Clostridium difficile toxin B. Infect Immun 68, 2470–2474.
-
(2000)
Infect Immun
, vol.68
, pp. 2470-2474
-
-
Qa'Dan, M.1
Spyres, L.M.2
Ballard, J.D.3
-
24
-
-
33744965834
-
Cholesterol-dependent pore formation of Clostridium difficile toxin A
-
Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R and Aktories K (2006) Cholesterol-dependent pore formation of Clostridium difficile toxin A. J Biol Chem 281, 10808–10815.
-
(2006)
J Biol Chem
, vol.281
, pp. 10808-10815
-
-
Giesemann, T.1
Jank, T.2
Gerhard, R.3
Maier, E.4
Just, I.5
Benz, R.6
Aktories, K.7
-
25
-
-
0242414631
-
Cellular uptake of Clostridium difficile toxin B. Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells
-
Pfeifer G, Schirmer J, Leemhuis J, Busch C, Meyer DK, Aktories K and Barth H (2003) Cellular uptake of Clostridium difficile toxin B. Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells. J Biol Chem 278, 44535–44541.
-
(2003)
J Biol Chem
, vol.278
, pp. 44535-44541
-
-
Pfeifer, G.1
Schirmer, J.2
Leemhuis, J.3
Busch, C.4
Meyer, D.K.5
Aktories, K.6
Barth, H.7
-
26
-
-
77955782233
-
Structural organization of the functional domains of Clostridium difficile toxins A and B
-
Pruitt RN, Chambers MG, Ng KK, Ohi MD and Lacy DB (2010) Structural organization of the functional domains of Clostridium difficile toxins A and B. Proc Natl Acad Sci USA 107, 13467–13472.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13467-13472
-
-
Pruitt, R.N.1
Chambers, M.G.2
Ng, K.K.3
Ohi, M.D.4
Lacy, D.B.5
-
27
-
-
42749095602
-
Structure and mode of action of clostridial glucosylating toxins: the ABCD model
-
Jank T and Aktories K (2008) Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol 16, 222–229.
-
(2008)
Trends Microbiol
, vol.16
, pp. 222-229
-
-
Jank, T.1
Aktories, K.2
-
28
-
-
0025667927
-
Clostridium difficile toxin A carries a C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferases
-
von Eichel-Streiber C and Sauerborn M (1990) Clostridium difficile toxin A carries a C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferases. Gene 96, 107–113.
-
(1990)
Gene
, vol.96
, pp. 107-113
-
-
von Eichel-Streiber, C.1
Sauerborn, M.2
-
29
-
-
29444439842
-
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A
-
Ho JG, Greco A, Rupnik M and Ng KK (2005) Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci USA 102, 18373–18378.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18373-18378
-
-
Ho, J.G.1
Greco, A.2
Rupnik, M.3
Ng, K.K.4
-
30
-
-
33745086500
-
Carbohydrate recognition by Clostridium difficile toxin A
-
Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M and Ng KK (2006) Carbohydrate recognition by Clostridium difficile toxin A. Nat Struct Mol Biol 13, 460–461.
-
(2006)
Nat Struct Mol Biol
, vol.13
, pp. 460-461
-
-
Greco, A.1
Ho, J.G.2
Lin, S.J.3
Palcic, M.M.4
Rupnik, M.5
Ng, K.K.6
-
31
-
-
77649270019
-
Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS
-
Albesa-Jove D, Bertrand T, Carpenter EP, Swain GV, Lim J, Zhang J, Haire LF, Vasisht N, Braun V, Lange A et al. (2010) Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS. J Mol Biol 396, 1260–1270.
-
(2010)
J Mol Biol
, vol.396
, pp. 1260-1270
-
-
Albesa-Jove, D.1
Bertrand, T.2
Carpenter, E.P.3
Swain, G.V.4
Lim, J.5
Zhang, J.6
Haire, L.F.7
Vasisht, N.8
Braun, V.9
Lange, A.10
-
32
-
-
0022525082
-
Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAc
-
Krivan HC, Clark GF, Smith DF and Wilkins TD (1986) Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAc. Infect Immun 53, 573–581.
-
(1986)
Infect Immun
, vol.53
, pp. 573-581
-
-
Krivan, H.C.1
Clark, G.F.2
Smith, D.F.3
Wilkins, T.D.4
-
33
-
-
46449130378
-
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A
-
Na X, Kim H, Moyer MP, Pothoulakis C and LaMont JT (2008) gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. Infect Immun 76, 2862–2871.
-
(2008)
Infect Immun
, vol.76
, pp. 2862-2871
-
-
Na, X.1
Kim, H.2
Moyer, M.P.3
Pothoulakis, C.4
LaMont, J.T.5
-
34
-
-
10244233005
-
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A
-
Pothoulakis C, Gilbert RJ, Cladaras C, Castagliuolo I, Semenza G, Hitti Y, Montcrief JS, Linevsky J, Kelly CP, Nikulasson S et al. (1996) Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A. J Clin Invest 98, 641–649.
-
(1996)
J Clin Invest
, vol.98
, pp. 641-649
-
-
Pothoulakis, C.1
Gilbert, R.J.2
Cladaras, C.3
Castagliuolo, I.4
Semenza, G.5
Hitti, Y.6
Montcrief, J.S.7
Linevsky, J.8
Kelly, C.P.9
Nikulasson, S.10
-
35
-
-
0026655261
-
Comparative sequence analysis of the Clostridium difficile toxins A and B
-
von Eichel-Streiber C, Laufenberg-Feldmann R, Sartingen S, Schulze J and Sauerborn M (1992) Comparative sequence analysis of the Clostridium difficile toxins A and B. Mol Gen Genet 233, 260–268.
-
(1992)
Mol Gen Genet
, vol.233
, pp. 260-268
-
-
von Eichel-Streiber, C.1
Laufenberg-Feldmann, R.2
Sartingen, S.3
Schulze, J.4
Sauerborn, M.5
-
36
-
-
0025017490
-
Molecular characterization of the Clostridium difficile toxin A gene
-
Dove CH, Wang SZ, Price SB, Phelps CJ, Lyerly DM, Wilkins TD and Johnson JL (1990) Molecular characterization of the Clostridium difficile toxin A gene. Infect Immun 58, 480–488.
-
(1990)
Infect Immun
, vol.58
, pp. 480-488
-
-
Dove, C.H.1
Wang, S.Z.2
Price, S.B.3
Phelps, C.J.4
Lyerly, D.M.5
Wilkins, T.D.6
Johnson, J.L.7
-
37
-
-
79952803707
-
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A
-
Olling A, Goy S, Hoffmann F, Tatge H, Just I and Gerhard R (2011) The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A. PLoS ONE 6, e17623.
-
(2011)
PLoS ONE
, vol.6
-
-
Olling, A.1
Goy, S.2
Hoffmann, F.3
Tatge, H.4
Just, I.5
Gerhard, R.6
-
38
-
-
84881571463
-
Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain
-
Gerhard R, Frenzel E, Goy S and Olling A (2013) Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain. J Med Microbiol 62 (Pt 9), 1414–1422.
-
(2013)
J Med Microbiol
, vol.62
, pp. 1414-1422
-
-
Gerhard, R.1
Frenzel, E.2
Goy, S.3
Olling, A.4
-
39
-
-
34247229774
-
A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C
-
Amimoto K, Noro T, Oishi E and Shimizu M (2007) A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C. Microbiology 153 (Pt 9), 1198–1206.
-
(2007)
Microbiology
, vol.153
, pp. 1198-1206
-
-
Amimoto, K.1
Noro, T.2
Oishi, E.3
Shimizu, M.4
-
40
-
-
84864105928
-
Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells
-
Guttenberg G, Hornei S, Jank T, Schwan C, Lu W, Einsle O, Papatheodorou P and Aktories K (2012) Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells. J Biol Chem 287, 24929–24940.
-
(2012)
J Biol Chem
, vol.287
, pp. 24929-24940
-
-
Guttenberg, G.1
Hornei, S.2
Jank, T.3
Schwan, C.4
Lu, W.5
Einsle, O.6
Papatheodorou, P.7
Aktories, K.8
-
41
-
-
84899641495
-
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins
-
Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P and Aktories K (2014) LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proc Natl Acad Sci USA 111, 6431–6436.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 6431-6436
-
-
Schorch, B.1
Song, S.2
van Diemen, F.R.3
Bock, H.H.4
May, P.5
Herz, J.6
Brummelkamp, T.R.7
Papatheodorou, P.8
Aktories, K.9
-
42
-
-
84930965989
-
Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity
-
LaFrance ME, Farrow MA, Chandrasekaran R, Sheng J, Rubin DH and Lacy DB (2015) Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity. Proc Natl Acad Sci U S A 112, 7073–7078.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 7073-7078
-
-
LaFrance, M.E.1
Farrow, M.A.2
Chandrasekaran, R.3
Sheng, J.4
Rubin, D.H.5
Lacy, D.B.6
-
43
-
-
84992391514
-
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
-
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X et al. (2016) Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature 538, 350–355.
-
(2016)
Nature
, vol.538
, pp. 350-355
-
-
Tao, L.1
Zhang, J.2
Meraner, P.3
Tovaglieri, A.4
Wu, X.5
Gerhard, R.6
Zhang, X.7
Stallcup, W.B.8
Miao, J.9
He, X.10
-
44
-
-
84922252575
-
Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B
-
Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S et al. (2015) Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res 25, 157–168.
-
(2015)
Cell Res
, vol.25
, pp. 157-168
-
-
Yuan, P.1
Zhang, H.2
Cai, C.3
Zhu, S.4
Zhou, Y.5
Yang, X.6
He, R.7
Li, C.8
Guo, S.9
Li, S.10
-
45
-
-
77957988127
-
The role of toxin A and toxin B in Clostridium difficile infection
-
Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A and Minton NP (2010) The role of toxin A and toxin B in Clostridium difficile infection. Nature 467, 711–713.
-
(2010)
Nature
, vol.467
, pp. 711-713
-
-
Kuehne, S.A.1
Cartman, S.T.2
Heap, J.T.3
Kelly, M.L.4
Cockayne, A.5
Minton, N.P.6
-
46
-
-
0041670743
-
Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system
-
Burger S, Tatge H, Hofmann F, Genth H, Just I and Gerhard R (2003) Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system. Biochem Biophys Res Commun 307, 584–588.
-
(2003)
Biochem Biophys Res Commun
, vol.307
, pp. 584-588
-
-
Burger, S.1
Tatge, H.2
Hofmann, F.3
Genth, H.4
Just, I.5
Gerhard, R.6
-
47
-
-
56649108115
-
Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
-
Yang G, Zhou B, Wang J, He X, Sun X, Nie W, Tzipori S and Feng H (2008) Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiol 8, 192.
-
(2008)
BMC Microbiol
, vol.8
, pp. 192
-
-
Yang, G.1
Zhou, B.2
Wang, J.3
He, X.4
Sun, X.5
Nie, W.6
Tzipori, S.7
Feng, H.8
-
48
-
-
84955254203
-
Binding and entry of Clostridium difficile toxin B is mediated by multiple domains
-
Manse JS and Baldwin MR (2015) Binding and entry of Clostridium difficile toxin B is mediated by multiple domains. FEBS Lett 589 (Pt B), 3945–51.
-
(2015)
FEBS Lett
, vol.589
, pp. 3945-3951
-
-
Manse, J.S.1
Baldwin, M.R.2
-
49
-
-
0347994116
-
On the analysis of membrane protein circular dichroism spectra
-
Sreerama N and Woody RW (2004) On the analysis of membrane protein circular dichroism spectra. Protein Sci 13, 100–112.
-
(2004)
Protein Sci
, vol.13
, pp. 100-112
-
-
Sreerama, N.1
Woody, R.W.2
-
50
-
-
84965009684
-
Crystal structure of Clostridium difficile toxin A
-
Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA and Lacy DB (2016) Crystal structure of Clostridium difficile toxin A. Nat Microbiol 1, 15002.
-
(2016)
Nat Microbiol
, vol.1
, pp. 15002
-
-
Chumbler, N.M.1
Rutherford, S.A.2
Zhang, Z.3
Farrow, M.A.4
Lisher, J.P.5
Farquhar, E.6
Giedroc, D.P.7
Spiller, B.W.8
Melnyk, R.A.9
Lacy, D.B.10
-
51
-
-
84896259912
-
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore
-
Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB and Melnyk RA (2014) Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore. Proc Natl Acad Sci U S A 111, 3721–3726.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 3721-3726
-
-
Zhang, Z.1
Park, M.2
Tam, J.3
Auger, A.4
Beilhartz, G.L.5
Lacy, D.B.6
Melnyk, R.A.7
-
52
-
-
84918515229
-
The combined repetitive oligopeptides of Clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation
-
Olling A, Huls C, Goy S, Muller M, Krooss S, Rudolf I, Tatge H and Gerhard R (2014) The combined repetitive oligopeptides of Clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation. Toxins (Basel) 6, 2162–2176.
-
(2014)
Toxins (Basel)
, vol.6
, pp. 2162-2176
-
-
Olling, A.1
Huls, C.2
Goy, S.3
Muller, M.4
Krooss, S.5
Rudolf, I.6
Tatge, H.7
Gerhard, R.8
|