Cholesterol-dependent pore formation of Clostridium difficile toxin A

Journal of Biological Chemistry

Volumn 281, Issue 16, 2006, Pages 10808-10815

  Giesemann, Torsten ^a   Jank, Thomas ^a   Gerhard, Ralf ^b   Maier, Elke ^c   Just, Ingo ^b   Benz, Roland ^c   Aktories, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; LIPIDS; POSITIVE IONS; RADIOACTIVE MATERIALS; VIRUSES;

CLOSTRIDIAL CYTOTOXINS; PSEUDOMEMBRANOUS COLITIS; VIRULENCE FACTORS;

TOXIC MATERIALS;

BETA CYCLODEXTRIN; CATION; CHOLESTEROL; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; GLYCOSYLPHOSPHATIDYLINOSITOL; RUBIDIUM;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; INTOXICATION; ION PERMEABILITY; LIPID MEMBRANE; NONHUMAN; PH; PRIORITY JOURNAL;

CLOSTRIDIUM DIFFICILE;

EID: 33744965834     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512720200     Document Type: Article

References (62)

1. Bartlett, J. G., Moon, N., Chang, T. W., Taylor, N., and Onderdonk, A. B. (1978) Gastroenterology 75, 778-782
2. Kelly, C. P., and LaMont, J. T. (1998) Annu. Rev. Med. 49, 375-390
3. Mylonakis, E., Ryan, E. T., and Calderwood, S. B. (2001) Arch. Intern. Med. 161, 525-533
4. Reinert, D. J., Jank, T., Aktories, K., and Schulz, G. E. (2005) J. Mol. Biol. 351, 973-981
5. Just, I., Selzer, J., Wilm, M., Von Eichel-Streiber, C., Mann, M., and Aktories, K. (1995) Nature 375, 500-503
6. Just, I., Wilm, M., Selzer, J., Rex, G., Von Eichel-Streiber, C., Mann, M., and Aktories, K. (1995) J. Biol. Chem. 270, 13932-13936
7. Aktories, K., and Just, I. (2005) Curr. Top. Microbiol. Immunol. 291, 113-145
8. Schirmer, J., and Aktories, K. (2004) Biochim. Biophys. Acta 1673, 66-74
9. Just, I., and Gerhard, R. (2004) Rev. Physiol. Biochem. Pharmacol. 152, 23-47
10. Etienne-Manneville, S., and Hall, A. (2002) Nature 420, 629-635
11. Burridge, K., and Wennerberg, K. (2004) Cell 116, 167-179
12. Wennerberg, K., and Der, C. J. (2004) J. Cell Sci. 117, 1301-1312
13. Gerhard, R., Tatge, H., Genth, H., Thum, T., Borlak, J., Fritz, G., and Just, I. (2005) J. Biol. Chem. 280, 1499-1505
14. Fiorentini, C., and Thelestam, M. (1991) Toxicon 29, 543-567
15. Von Eichel-Streiber, C., Boquet, P., Sauerborn, M., and Thelestam, M. (1996) Trends Microbiol. 4, 375-382
16. Barroso, L. A., Moncrief, J. S., Lyerly, D. M., and Wilkins, T. D. (1994) Microb. Pathog. 16, 297-303
17. Hofmann, F., Busch, C., Prepens, U., Just, I., and Aktories, K. (1997) J. Biol. Chem. 272, 11074-11078
18. Dove, C. H., Wang, S. Z., Price, S. B., Phelps, C. J., Lyerly, D. M., Wilkins, T. D., and Johnson, J. L. (1990) Infect. Immun. 58, 480-488
19. Von Eichel-Streiber, C., Sauerborn, M., and Kuramitsu, H. K. (1992) J. Bacteriol. 174, 6707-6710
20. Florin, I., and Thelestam, M. (1983) Biochim. Biophys. Acta 763, 383-392
21. Thelestam, M., and Chaves-Olarte, E. (2000) Curr. Top. Microbiol. Immunol. 250, 85-96
22. Voth, D. E., and Ballard, J. D. (2005) Clin. Microbiol. Rev. 18, 247-263
23. Krivan, H. C., Clark, G. F., Smith, D. F., and Wilkins, T. D. (1986) Infect. Immun. 53, 573-581
24. Teneberg, S., Lönnroth, I., López, J. F. T., Galili, U., Halvarsson, M. Ö., Ångström, J., and Karlsson, K. A. (1996) Glycobiology 6, 599-609
25. Lencer, W. I. (2004) Int. J. Med. Microbiol. 293, 491-494
26. Lord, J. M., and Roberts, L. M. (1998) J. Cell Biol. 140, 733-736
27. Sandvig, K., Spilsberg, B., Lauvrak, S. U., Torgersen, M. L., Iversen, T. G., and van Deurs, B. (2004) Int. J. Med. Microbiol. 293, 483-490
28. Lord, J. M., Smith, D. C., and Roberts, L. M. (1999) Cell. Microbiol. 1, 85-91
29. Barth, H. (2004) Rev. Physiol. Biochem. Pharmacol. 152, 165-182
30. Sandvig, K., and van Deurs, B. (2005) Gene Ther. 12, 865-872
31. Barth, H., Pfeifer, G., Hofmann, F., Maier, E., Benz, R., and Aktories, K. (2001) J. Biol. Chem. 276, 10670-10676
32. Pfeifer, G., Schirmer, J., Leemhuis, J., Busch, C., Meyer, D. K., Aktories, K., and Barth, H. (2003) J. Biol. Chem. 278, 44535-44541
33. Rupnik, M., Pabst, S., Rupnik, M., Von Eichel-Streiber, C., Urlaub, H., and Soling, H. D. (2005) Microbiology 151, 199-208
34. Just, I., Selzer, J., Hofmann, F., and Aktories, K. (1997) in Bacterial toxins: Tools in Cell Biology and Pharmacology (Aktories, K., ed) pp. 159-168, Chapman & Hall, Weinheim, Germany
35. Burger, S., Tatge, H., Hofmann, F., Genth, H., Just, I., and Gerhard, R. (2003) Biochem. Biophys. Res. Commun. 307, 584-588
36. Benz, R., Janko, K., Boos, W., and Lauger, P. (1978) Biochim. Biophys. Acta 511, 305-319
37. Andersen, C., Schiffler, B., Charbit, A., and Benz, R. (2002) J. Biol. Chem. 277, 41318-41325
38. Netzer, A., and Gstraunthaler, G. (1993) Ren. Physiol. Biochem. 16, 299-310
39. Busch, C., Hofmann, F., Selzer, J., Munro, J., Jeckel, D., and Aktories, K. (1998) J. Biol. Chem. 273, 19566-19572
40. Palmer, M. (2004) FEMS Microbiol. Lett. 238, 281-289
41. Yancey, P. G., Rodrigueza, W. V., Kilsdonk, E. P., Stoudt, G. W., Johnson, W. J., Phillips, M. C., and Rothblat, G. H. (1996) J. Biol. Chem. 271, 16026-16034
42. Kilsdonk, E. P., Yancey, P. G., Stoudt, G. W., Bangerter, F. W., Johnson, W. J., Phillips, M. C., and Rothblat, G. H. (1995) J. Biol. Chem. 270, 17250-17256
43. Benz, R., Ishii, J., and Nakae, T. (1980) J. Membr. Biol. 56, 19-29
44. Henriques, B., Florin, I., and Thelestam, M. (1987) Microb. Pathog. 2, 455-463
45. Falnes, P. O., and Sandvig, K. (2000) Curr. Opin. Cell Biol. 12, 407-413
46. Sandvig, K., and Van Deurs, B. (2002) Annu. Rev. Cell Dev. Biol. 18, 1-24
47. Sandvig, K., and Olsnes, S. (1981) J. Biol. Chem. 256, 9068-9076
48. Qa'Dan, M., Spyres, L. M., and Ballard, J. D. (2000) Infect. Immun. 68, 2470-2474
49. Donovan, J. J., Simon, M. I., Draper, R. K., and Montal, M. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 172-176
50. Boquet, P., and Duflot, E. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 7614-7618
51. Eriksen, S., Olsnes, S., Sandvig, K., and Sand, O. (1994) EMBO J. 13, 4433-4439
52. Sandvig, K., and Olsnes, S. (1988) J. Biol. Chem. 263, 12352-12359
53. Blaustein, R. O., Koehler, T. M., Collier, R. J., and Finkelstein, A. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 2209-2213
54. Barth, H., Blöcker, D., Behlke, J., Bergsma-Schutter, W., Brisson, A., Benz, R., and Aktories, K. (2000) J. Biol. Chem. 275, 18704-18711
55. Gerhard, R., Burger, S., Tatge, H., Genth, H., Just, I., and Hofmann, F. (2005) Microb. Pathog. 38, 77-83
56. Just, I., Hofmann, F., and Aktories, K. (2000) Curr. Top. Microbiol. Immunol. 250, 55-83
57. Benz, R. (2001) in Microbial Transport Systems (Winkelmann, G., ed) pp. 227-246, Wiley-VCH Verlag, Weinheim, Germany
58. Barth, H., Aktories, K., Popoff, M. R., and Stiles, B. G. (2004) Microbiol. Mol. Biol. Rev. 68, 373-402
59. Benz, R., Maier, E., Ladant, D., Ullmann, A., and Sebo, P. (1994) J. Biol. Chem. 269, 27231-27239
60. Schmid, A., Benz, R., Just, I., and Aktories, K. (1994) J. Biol. Chem. 269, 16706-16711
61. Hayakawa, E., Naganuma, M., Mukasa, K., Shimozawa, T., and Araiso, T. (1998) Biophys. J. 74, 892-898
62. Giddings, K. S., Johnson, A. E., and Tweten, R. K. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11315-11320