Acetaminophen toxicity in rat and mouse hepatocytes in vitro

Drug and Chemical Toxicology

Volumn 40, Issue 4, 2017, Pages 448-456

  Kučera, Otto ^a   Endlicher, René ^a   Rychtrmoc, David ^a   Lotková, Halka ^a   Sobotka, Ondřej ^a   Červinková, Zuzana ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Acetaminophen; hepatotoxicity; in vitro; mouse hepatocytes; primary cell culture; rat hepatocytes

Indexed keywords

CASPASE 3; CYTOCHROME C; DIGITONIN; GLUTAMIC ACID; GLUTATHIONE; LACTATE DEHYDROGENASE; MALIC ACID; MALONALDEHYDE; OXIDOREDUCTASE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; ANALGESIC AGENT; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL LYSATE; CELL MEMBRANE; CELL RESPIRATION; CONTROLLED STUDY; CULTURE MEDIUM; IN VITRO STUDY; LIMIT OF DETECTION; LIPID PEROXIDATION; LIVER CELL; LIVER TOXICITY; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OUTER MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIMARY CULTURE; RAT; RESPIROMETRY; AGONISTS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; LIVER MITOCHONDRION; METABOLISM; OXIDATION REDUCTION REACTION; SPECIES DIFFERENCE; WISTAR RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BIOMARKERS; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; GLUTATHIONE; HEPATOCYTES; LIPID PEROXIDATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANES; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SPECIES SPECIFICITY;

EID: 85006117471     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480545.2016.1255953     Document Type: Article

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