Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury

Hepatology

Volumn 61, Issue 1, 2015, Pages 326-336

  Lee, Kang Kwang ^a   Imaizumi, Naoki ^a,b   Chamberland, Sally R ^a   Alder, Nathan N ^a   Boelsterli, Urs A ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; CYTOCHROME C; METHYLENE BLUE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; ANALGESIC AGENT; BENZOQUINONE DERIVATIVE; ENZYME INHIBITOR; IMINE; N-ACETYL-4-BENZOQUINONEIMINE; PEROXYNITROUS ACID; SUCCINATE DEHYDROGENASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL MEMBRANE; C57BL 6 MOUSE; CELL CULTURE; CONTROLLED STUDY; DRUG MEGADOSE; EX VIVO STUDY; LIVER CELL; LIVER CELL DAMAGE; LIVER TOXICITY; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY CHAIN; SINGLE DRUG DOSE; TOXIC HEPATITIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL DEATH; DRUG EFFECTS; DRUG SCREENING; DRUG-INDUCED LIVER INJURY; LIVER; LIVER MITOCHONDRION; METABOLISM; NECROSIS; PATHOLOGY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BENZOQUINONES; CELL DEATH; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; DRUG-INDUCED LIVER INJURY; ELECTRON TRANSPORT COMPLEX II; ENZYME INHIBITORS; HEPATOCYTES; IMINES; LIVER; MALE; METHYLENE BLUE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; NECROSIS; PEROXYNITROUS ACID; SUCCINATE DEHYDROGENASE;

EID: 84920954574     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27385     Document Type: Article

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