The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

Archives of Toxicology

Volumn 88, Issue 9, 2014, Pages 1695-1709

  Toledo, Flavia D ^a   Pérez, Leonardo M ^a   Basiglio, Cecilia L ^a   Ochoa, Justina E ^a   Sanchez Pozzi, Enrique J ^a   Roma, Marcelo G ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Apoptosis; Cytochrome c; Mitochondrial permeability transition pore; Oxidative stress; tert Butyl hydroperoxide

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; LIPOCORTIN 5; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE; TRIFLUOPERAZINE; CALMODULIN; CARRIER PROTEIN; OXIDIZING AGENT; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; LIPID PEROXIDATION; LIVER CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; LIVER MITOCHONDRION; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; WISTAR RAT;

RATTUS;

ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; CELLS, CULTURED; HEPATOCYTES; LIPID PEROXIDATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; OXIDANTS; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROPEROXIDE;

EID: 84906250545     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1219-5     Document Type: Article

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