Steatotic rat hepatocytes in primary culture are more susceptible to the acute toxic effect of acetaminophen

Physiological Research

Volumn 61, Issue SUPPL.2, 2012, Pages

  Kucera O ^a   Al Dury, S ^a   Lotkova H ^a   Rouar T ^a,b   Rychtrmoc, D ^a   Cervinkova Z ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

Author keywords

Acetaminophen; Fatty liver; Glutathione; Hepatocytes in vitro; Hepatotoxicity

Indexed keywords

ANALGESIC AGENT; GLUTATHIONE; LACTATE DEHYDROGENASE; PARACETAMOL; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; FATTY LIVER; LIVER CELL; MALE; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE; RAT; WISTAR RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; DISEASE MODELS, ANIMAL; FATTY LIVER; GLUTATHIONE; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MALE; PRIMARY CELL CULTURE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84873148322     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. BAJT ML, KNIGHT TR, LEMASTERS JJ, JAESCHKE H Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci 80: 343-349, 2004.
2. BEDOGNI G, MIGLIOLI L, MASUTTI F, TIRIBELLI C, MARCHESINI G, BELLENTANI S: Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 42: 44-52, 2005.
3. BERRY MN, EDWARDS AM, BARRITT GJ High-yield preparation of isolated hepatocytes from rat liver. In: Isolated Hepatocytes Preparation, Properties and Application. BURDON RH, VAN KNIPPENBERG PH (eds), Elsevier, New York, 1991, pp 15-81.
4. BRAUNERSREUTHER V, VIVIANI GL, MACH F, MONTECUCCO F Role of cytokines and chemokines in nonalcoholic fatty liver disease. World J Gastroenterol 18: 727-735, 2012.
5. CHARLTON M, SREEKUMAR R, RASMUSSEN D, LINDOR K, NAIR KS Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 35: 898-904, 2002.
6. DAHLIN DC, MIWA GT, LU AY, NELSON SD N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci U S A 81: 1327-1331, 1984
7. DE FEO P, GAISANO MG, HAYMOND MW Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J Clin Invest 88: 833-840, 1991.
8. DECKER K: Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 192: 245-261, 1990.
9. GAMBINO R, MUSSO G, CASSADER M Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities. Antioxid Redox Signal 15: 1325-1365, 2011.
10. GUILLOUZO A Liver cell models in in vitro toxicology. Environ Health Perspect 106 (Suppl 2): 511-532, 1998.
11. HINSON JA, ROBERTS DW, JAMES LP Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol 196: 369-405, 2010.
12. JAMES RC, HARBISON RD, ROBERTS SM Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mechanism. Toxicol Appl Pharmacol 118: 159-168, 1993.
13. JEFFERSON LS, LIAO WS, PEAVY DE, MILLER TB, APPEL MC, TAYLOR JM Diabetes-induced alterations in liver protein synthesis. Changes in the relative abundance of mRNAs for albumin and other plasma proteins. J Biol Chem 258: 1369-1375, 1983.
14. JU C, REILLY TP, BOURDI M, RADONOVICH MF, BRADY JN, GEORGE JW, POHL LR: Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem Res Toxicol 15: 1504-1513, 2002.
15. KMIEĆ Z Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol 161: 1-151, 2001.
16. KOHJIMA M, ENJOJI M, HIGUCHI N, KATO M, KOTOH K, YOSHIMOTO T, FUJINO T, YADA M, YADA R, HARADA N, TAKAYANAGI R, NAKAMUTA M Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med 20: 351-358, 2007.
17. KON K, KIM JS, JAESCHKE H, LEMASTERS JJ Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40: 1170-1179, 2004.
18. KUČERA O, GARNOL T, LOTKOVÁ H, STANKOVÁ P, MAZUROVÁ Y, HROCH M, BOLEHOVSKÁ R, ROUŠAR T, ČERVINKOVÁ Z The effect of rat strain, diet composition and feeding period on the development of a nutritional model of non-alcoholic fatty liver disease in rats. Physiol Res 60: 317-328, 2011a.
19. KUČERA O, LOTKOVÁ H, STANKOVÁ P, PODHOLA M, ROUŠAR T, MEZERA V, ČERVINKOVÁ Z Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide? Int J Exp Pathol 92: 281-289, 2011b
20. KUČERA O, ROUŠAR T, STANKOVÁ P, HANÁČKOVÁ L, LOTKOVÁ H, PODHOLA M, ČERVINKOVÁ Z Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. J Gastroenterol Hepatol 27: 323-330, 2012.
21. LEE WM Acute liver failure in the United States. Semin Liver Dis 23: 217-226, 2003.
22. LICKTEIG AJ, FISHER CD, AUGUSTINE LM, CHERRINGTON NJ Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis. J Biochem Mol Toxicol 21: 216-220, 2007.
23. LIEBER CS, LEO MA, MAK KM, XU Y, CAO Q, REN C, PONOMARENKO A, DECARLI LM Model of nonalcoholic steatohepatitis. Am J Clin Nutr 79: 502-509, 2004.
24. LOTKOVÁ H, KUČERA O, ROUŠAR T, ENDLICHER R, KŘIVÁKOVÁ P, GARNOL T, ČERVINKOVÁ Z Effect of S-adenosylmethionine on Acetaminophen-induced Toxic Injury of Rat Hepatocytes in vitro. Acta Vet Brno 78: 603-613, 2009.
25. MASUBUCHI Y, BOURDI M, REILLY TP, GRAF ML, GEORGE JW, POHL LR Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease. Biochem Biophys Res Commun 304: 207-212, 2003.
26. MITCHELL JR, JOLLOW DJ, POTTER WZ, GILLETTE JR, BRODIE BB Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187: 211-217, 1973.
27. ORELLANA M, RODRIGO R, VARELA N, ARAYA J, PONIACHIK J, CSENDES A, SMOK G, VIDELA LA Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients. Hepatol Res 34: 57-63, 2006.
28. PHUNG N, PERA N, FARRELL G, LECLERCQ I, HOU JY, GEORGE J Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis. Int J Mol Med 24: 171-180, 2009.
29. ROLLINS DE, BUCKPITT AR Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen. Toxicol Appl Pharmacol 47: 331-339, 1979.
30. ROUŠAR T, KUČERA O, KŘIVÁKOVÁ P, LOTKOVÁ H, KANĎÁR R, MUŽÁKOVÁ V, ČERVINKOVÁ Z Evaluation of oxidative status in acetaminophen treated rat hepatocytes in culture. Physiol Res 58: 239-246, 2009.
31. ROUŠAR T, PAŘÍK P, KUČERA O, BARTOŠ M, ČERVINKOVÁ Z Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro. Physiol Res 59: 225-232, 2010.
32. ROUŠAR T, KUČERA O, LOTKOVÁ H, ČERVINKOVÁ Z Assessment of reduced glutathione: comparison of an optimized fluorometric assay with enzymatic recycling method. Anal Biochem 423: 236-240, 2012.
33. VENDEMIALE G, GRATTAGLIANO I, ALTOMARE E, TURTURRO N, GUERRIERI F Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat. Biochem Pharmacol 52: 1147-1154, 1996.
34. VENDEMIALE G, GRATTAGLIANO I, CARACENI P, CARACCIO G, DOMENICALI M, DALL'AGATA M, TREVISANI F, GUERRIERI F, BERNARDI M, ALTOMARE E Mitochondrial oxidative injury and energy metabolism alteration in rat fatty liver: effect of the nutritional status. Hepatology 33: 808-815, 2001.
35. VERNON G, BARANOVA A, YOUNOSSI ZM Systematic review: the epidemiology and natural history of nonalcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34: 274-285, 2011.
36. VIDELA LA, RODRIGO R, ORELLANA M, FERNANDEZ V, TAPIA G, QUIÑONES L, VARELA N, CONTRERAS J, LAZARTE R, CSENDES A, ROJAS J, MALUENDA F, BURDILES P, DIAZ JC, SMOK G, THIELEMANN L, PONIACHIK J Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin Sci (Lond) 106: 261-268, 2004.