An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice

Cell Reports

Volumn 17, Issue 11, 2016, Pages 3077-3088

  Snouwaert, John N ^a   Nguyen, MyTrang ^a   Repenning, Peter W ^a   Dye, Rebecca ^a   Livingston, Eric W ^c   Kovarova, Martina ^a   Moy, Sheryl S ^a   Brigman, Brian E ^b   Bateman, Ted A ^c   Ting, Jenny P Y ^a   Koller, Beverly H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

arthritis; autoinflammatory; cryopyrinopathies; endotoxic shock; familial cold autoinflammatory syndrome; IL 18; inflammasome; meningitis; Muckle Wells syndrome; NOMID; syntenic replacement

Indexed keywords

CRYOPYRIN; ENDOTOXIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; NLRP3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; EMBRYO; ENZYME INHIBITION; GRANULOCYTE; IN VIVO STUDY; INNATE IMMUNITY; LIMIT OF QUANTITATION; MOUSE; NONHUMAN; OSTEOPOROSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; ARTHROPATHY; DISEASE MODEL; GENETICS; HUMAN; MUTATION; PATHOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMASOMES; JOINT DISEASES; MICE; MUTATION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OSTEOPOROSIS;

EID: 85004010283     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.11.052     Document Type: Article

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