Frontline science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

Journal of Leukocyte Biology

Volumn 100, Issue 6, 2016, Pages 1239-1254

  Patera, Andriani C ^a   Drewry, Anne M ^b   Chang, Katherine ^b   Beiter, Evan R ^b   Osborne, Dale ^b   Hotchkiss, Richard S ^b  

^a MEDIMMUNE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunosuppression; Monocytes; Neutrophils; Programmed cell death

Indexed keywords

CD163 ANTIGEN; GAMMA INTERFERON; GRANZYME B; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; CD274 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; DISEASE SEVERITY; EX VIVO STUDY; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; MALE; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CRITICAL ILLNESS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROSPECTIVE STUDY;

ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD274; CD8-POSITIVE T-LYMPHOCYTES; CRITICAL ILLNESS; FEMALE; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONOCYTES; NEUTROPHILS; PHAGOCYTOSIS; PROGRAMMED CELL DEATH 1 RECEPTOR; PROSPECTIVE STUDIES; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85002824021     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.4HI0616-255R     Document Type: Article

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