Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1862, Issue 2, 2017, Pages 234-245

  Sokolova, Marina ^a,b   Vinge, Leif Erik ^a,b,c   Alfsnes, Katrine ^a,b   Olsen, Maria Belland ^a,b   Eide, Lars ^a,b   Kaasbøll, Ole Jørgen ^a,b   Attramadal, Håvard ^a,b   Torp, May Kristin ^b   Fosshaug, Linn E ^a,b,c   Rashidi, Azita ^a,b   Lien, Egil ^d,e   Finsen, Alexandra Vanessa ^a,b   Sandanger, Øystein ^a,b   Aukrust, Pål ^a,b   Ranheim, Trine ^a,b   Yndestad, Arne ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c DIAKONHJEMMET HOSPITAL   (Norway)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Cardiac fibroblast; Cellular senescence; Inflammation; NLRP3; Palmitate; TLR4

Indexed keywords

5' ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ACTIVATING TRANSCRIPTION FACTOR 4; ADENOSINE TRIPHOSPHATE; ALPHA SMOOTH MUSCLE ACTIN; ARACHIDONIC ACID; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CRYOPYRIN; CXCL2 CHEMOKINE; GELATINASE B; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LINOLEIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; OLIGOMYCIN; OXYGEN; PALMITIC ACID; PHOSPHATIDYLSERINE; PROTEIN KINASE; ROTENONE; SUPEROXIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIMENTIN; APOPTOSIS REGULATORY PROTEIN; BETA GALACTOSIDASE; PALMITIC ACID DERIVATIVE;

ADULT; ANAEROBIC GLYCOLYSIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COCULTURE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; HEART FIBROBLAST; INFLAMMATION; MACROPHAGE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENESCENCE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL AGING; CHEMICALLY INDUCED; DRUG EFFECTS; FIBROBLAST; HEART; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BETA-GALACTOSIDASE; CELL AGING; CHEMOKINE CXCL2; FIBROBLASTS; HEART; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PALMITATES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 85000844013     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2016.11.003     Document Type: Article

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