Cardiac fibroblasts support cardiac inflammation in heart failure

Basic Research in Cardiology

Volumn 109, Issue 5, 2014, Pages 1-16

  Lindner, Diana ^a,b   Zietsch, Christin ^c   Tank, Juliane ^c   Sossalla, Samuel ^b,d   Fluschnik, Nina ^a   Hinrichs, Svenja ^a   Maier, Lars ^e   Poller, Wolfgang ^c   Blankenberg, Stefan ^a,b   Schultheiss, Heinz Peter ^b,c   Tschöpe, Carsten ^b,c   Westermann, Dirk ^a,b  

^a UNIVERSITY HEART CENTER HAMBURG   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Fibroblast; Fibrosis; Heart failure; Inflammation; Remodeling

Indexed keywords

ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; FIBROBLAST; HEART FAILURE; HEART MUSCLE; HUMAN; IMMUNOLOGY; INFLAMMATION; MECHANICAL STRESS; MOUSE; PATHOLOGY;

ANIMALS; CELLS, CULTURED; FIBROBLASTS; HEART FAILURE; HUMANS; INFLAMMATION; MICE; MICE, INBRED C57BL; MYOCARDIUM; STRESS, MECHANICAL;

EID: 84905292022     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0428-7     Document Type: Article

References (37)

1. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Grone HJ, Schaefer L (2009) Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284:24035–24048. doi:10.1074/jbc.M109.014266
2. Barczyk M, Carracedo S, Gullberg D (2010) Integrins. Cell Tissue Res 339:269–280. doi:10.1007/s00441-009-0834-6
3. Bradley LM, Douglass MF, Chatterjee D, Akira S, Baaten BJ (2012) Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling. PLoS Pathog 8:e1002641. doi:10.1371/journal.ppat.1002641
4. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG (2010) The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol 48:504–511. doi:10.1016/j.yjmcc.2009.07.015
5. Duerrschmid C, Crawford JR, Reineke E, Taffet GE, Trial J, Entman ML, Haudek SB (2013) TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. J Mol Cell Cardiol 57:59–67. doi:10.1016/j.yjmcc.2013.01.006
6. Frangogiannis NG (2012) Regulation of the inflammatory response in cardiac repair. Circ Res 110:159–173. doi:10.1161/CIRCRESAHA.111.243162
7. Fujiu K, Nagai R (2013) Contributions of cardiomyocyte-cardiac fibroblast-immune cell interactions in heart failure development. Basic Res Cardiol 108:357. doi:10.1007/s00395-013-0357-x
8. Gidday JM, Gasche YG, Copin JC, Shah AR, Perez RS, Shapiro SD, Chan PH, Park TS (2005) Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol 289:H558–H568. doi:10.1152/ajpheart.01275.2004
9. Hamilton TA, Ohmori Y, Tebo J (2002) Regulation of chemokine expression by anti-inflammatory cytokines. Immunol Res 25:229–245. doi:10.1385/IR:25:3:229
10. Hawwa RL, Hokenson MA, Wang Y, Huang Z, Sharma S, Sanchez-Esteban J (2011) IL-10 inhibits inflammatory cytokines released by fetal mouse lung fibroblasts exposed to mechanical stretch. Pediatr Pulmonol 46:640–649. doi:10.1002/ppul.21433
11. Hazebroek M, Dennert R, Heymans S (2012) Idiopathic dilated cardiomyopathy: possible triggers and treatment strategies. Neth Heart J 20:332–335. doi:10.1007/s12471-012-0285-7
12. Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G (2013) Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress. J Mol Cell Cardiol 54:73–81. doi:10.1016/j.yjmcc.2012.11.006
13. Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschope C, Van Bilsen M, Zannad F, McMurray J, Shah AM (2009) Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 11:119–129. doi:10.1093/eurjhf/hfn043
14. Hofmann U, Frantz S (2013) How can we cure a heart “in flame”? A translational view on inflammation in heart failure. Basic Res Cardiol 108:356. doi:10.1007/s00395-013-0356-y
15. Husse B, Briest W, Homagk L, Isenberg G, Gekle M (2007) Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts. Am J Physiol Regul Integr Comp Physiol 293:R1898–R1907. doi:10.1152/ajpregu.00804.2006
16. Kasner M, Westermann D, Lopez B, Gaub R, Escher F, Kuhl U, Schultheiss HP, Tschope C (2011) Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction. J Am Coll Cardiol 57:977–985. doi:10.1016/j.jacc.2010.10.024
17. Kindermann I, Kindermann M, Kandolf R, Klingel K, Bultmann B, Muller T, Lindinger A, Bohm M (2008) Predictors of outcome in patients with suspected myocarditis. Circulation 118:639–648. doi:10.1161/CIRCULATIONAHA.108.769489
18. Leitinger B (2011) Transmembrane collagen receptors. Annu Rev Cell Dev Biol 27:265–290. doi:10.1146/annurev-cellbio-092910-154013
19. Lindner D, Zietsch C, Becher PM, Schulze K, Schultheiss HP, Tschope C, Westermann D (2012) Differential expression of matrix metalloproteases in human fibroblasts with different origins. Biochem Res Int 2012:875742. doi:10.1155/2012/875742
20. Liu SF, Ye X, Malik AB (1999) Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes. Circulation 100:1330–1337. doi:10.1161/01.CIR.100.12.1330
21. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) Method. Methods 25:402–408. doi:10.1006/meth.2001.1262
22. Nastase MV, Young MF, Schaefer L (2012) Biglycan: a multivalent proteoglycan providing structure and signals. J Histochem Cytochem 60:963–975. doi:10.1369/0022155412456380
23. Papakrivopoulou J, Lindahl GE, Bishop JE, Laurent GJ (2004) Differential roles of extracellular signal-regulated kinase 1/2 and p38MAPK in mechanical load-induced procollagen alpha1(I) gene expression in cardiac fibroblasts. Cardiovasc Res 61:736–744. doi:10.1016/j.cardiores.2003.12.018
24. Spinale FG, Zile MR (2013) Integrating the myocardial matrix into heart failure recognition and management. Circ Res 113:725–738. doi:10.1161/CIRCRESAHA.113.300309
25. Turner NA (2011) Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways. Future Cardiol 7:673–691. doi:10.2217/fca.11.41
26. Turner NA, Das A, Warburton P, O’Regan DJ, Ball SG, Porter KE (2009) Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts. Am J Physiol Heart Circ Physiol 297:H1117–H1127. doi:10.1152/ajpheart.00372.2009
27. Udelson JE, Konstam MA (2011) Ventricular remodeling fundamental to the progression (and regression) of heart failure. J Am Coll Cardiol 57:1477–1479. doi:10.1016/j.jacc.2011.01.009
28. Valen G (2011) Innate immunity and remodelling. Heart Fail Rev 16:71–78. doi:10.1007/s10741-010-9187-1
29. van den Borne SW, Diez J, Blankesteijn WM, Verjans J, Hofstra L, Narula J (2010) Myocardial remodeling after infarction: the role of myofibroblasts. Nat Rev Cardiol 7:30–37. doi:10.1038/nrcardio.2009.199
30. Wang J, Chen H, Seth A, McCulloch CA (2003) Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts. Am J Physiol Heart Circ Physiol 285:H1871–H1881. doi:10.1152/ajpheart.00387.2003
31. Wang L, Pedroja BS, Meyers EE, Garcia AL, Twining SS, Bernstein AM (2012) Degradation of internalized alphavbeta5 integrin is controlled by uPAR bound uPA: effect on beta1 integrin activity and alpha-SMA stress fiber assembly. PLoS One 7:e33915. doi:10.1371/journal.pone.0033915
32. Westermann D, Becher PM, Lindner D, Savvatis K, Xia Y, Frohlich M, Hoffmann S, Schultheiss HP, Tschope C (2012) Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo. Basic Res Cardiol 107:308. doi:10.1007/s00395-012-0308-y
33. Westermann D, Lindner D, Kasner M, Zietsch C, Savvatis K, Escher F, von Schlippenbach J, Skurk C, Steendijk P, Riad A, Poller W, Schultheiss HP, Tschope C (2011) Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction. Circ Heart Fail 4:44–52. doi:10.1161/CIRCHEARTFAILURE.109.931451
34. Westermann D, Rutschow S, Van Linthout S, Linderer A, Bucker-Gartner C, Sobirey M, Riad A, Pauschinger M, Schultheiss HP, Tschope C (2006) Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Diabetologia 49:2507–2513. doi:10.1007/s00125-006-0385-2
35. Westermann D, Savvatis K, Lindner D, Zietsch C, Becher PM, Hammer E, Heimesaat MM, Bereswill S, Volker U, Escher F, Riad A, Plendl J, Klingel K, Poller W, Schultheiss HP, Tschope C (2011) Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy. Circulation 124:2082–2093. doi:10.1161/CIRCULATIONAHA.111.035964
36. Westermann D, Savvatis K, Schultheiss HP, Tschope C (2010) Immunomodulation and matrix metalloproteinases in viral myocarditis. J Mol Cell Cardiol 48:468–473. doi:10.1016/j.yjmcc.2009.08.019
37. Zhang P, Su J, Mende U (2012) Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences. Am J Physiol Heart Circ Physiol 303:H1385–H1396. doi:10.1152/ajpheart.01167.2011