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Volumn 213, Issue 12, 2016, Pages 2773-2791

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress

Author keywords

[No Author keywords available]

Indexed keywords

LYASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; UNCLASSIFIED DRUG; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE);

EID: 84999885128     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20160287     Document Type: Article
Times cited : (44)

References (50)
  • 1
    • 78650381368 scopus 로고    scopus 로고
    • Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1 H-i mi daz ol-4-yl) bu tan e-1,2,3,4-tetraol (LX2932)
    • Bagdanoff, J.T., M.S. Donoviel, A. Nouraldeen, M. Carlsen, T.C. Jessop, J. Tarver, S. Aleem, L. Dong, H. Zhang, L. Boteju, et al. 2010. Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1 H-i mi daz ol-4-yl) bu tan e-1,2,3,4-tetraol (LX2932). J. Med. Chem. 53:8650-8662. http://dx.doi.org/10.1021/jm101183p
    • (2010) J. Med. Chem , vol.53 , pp. 8650-8662
    • Bagdanoff, J.T.1    Donoviel, M.S.2    Nouraldeen, A.3    Carlsen, M.4    Jessop, T.C.5    Tarver, J.6    Aleem, S.7    Dong, L.8    Zhang, H.9    Boteju, L.10
  • 2
    • 0033578325 scopus 로고    scopus 로고
    • A central role for thymic emigrants in peripheral T cell homeostasis
    • Berzins, S.P., D.I. Godfrey, J.F. Miller, and R.L. Boyd. 1999. A central role for thymic emigrants in peripheral T cell homeostasis. Proc. Natl. Acad. Sci. USA. 96:9787-9791. http://dx.doi.org/10.1073/pnas.96.17.9787
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9787-9791
    • Berzins, S.P.1    Godfrey, D.I.2    Miller, J.F.3    Boyd, R.L.4
  • 3
    • 33746271951 scopus 로고    scopus 로고
    • Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry
    • Bielawski, J., Z.M. Szulc, Y.A. Hannun, and A. Bielawska. 2006. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods. 39:82-91. http://dx.doi.org/10.1016/j.ymeth.2006.05.004
    • (2006) Methods , vol.39 , pp. 82-91
    • Bielawski, J.1    Szulc, Z.M.2    Hannun, Y.A.3    Bielawska, A.4
  • 4
    • 33748866909 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
    • Bonasio, R., M.L. Scimone, P Schaerli, N. Grabie, A.H. Lichtman, and U.H. von Andrian. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat. Immunol. 7:1092-1100. http://dx.doi.org/10.1038/ni1385
    • (2006) Nat. Immunol , vol.7 , pp. 1092-1100
    • Bonasio, R.1    Scimone, M.L.2    Schaerli, P.3    Grabie, N.4    Lichtman, A.H.5    von Andrian, U.H.6
  • 8
    • 34447275920 scopus 로고    scopus 로고
    • Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen
    • Caton, M.L., M.R. Smith-Raska, and B. Reizis. 2007. Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen. J Exp. Med. 204:1653-1664. http://dx.doi.org/10.1084/jem.20062648
    • (2007) J Exp. Med , vol.204 , pp. 1653-1664
    • Caton, M.L.1    Smith-raska, M.R.2    Reizis, B.3
  • 9
    • 3242796768 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
    • Cinamon, G., M. Matloubian, M.J. Lesneski, Y. Xu, C. Low, T. Lu, R.L. Proia, and J.G. Cyster. 2004. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat. Immunol. 5:713-720. http://dx.doi.org/10.1038/ni1083
    • (2004) Nat. Immunol , vol.5 , pp. 713-720
    • Cinamon, G.1    Matloubian, M.2    Lesneski, M.J.3    Xu, Y.4    Low, C.5    Lu, T.6    Proia, R.L.7    Cyster, J.G.8
  • 11
    • 17044387828 scopus 로고    scopus 로고
    • Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice
    • Ferron, M., and J. Vacher. 2005. Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice. Genesis. 41:138-145. http://dx.doi.org/10.1002/gene.20108
    • (2005) Genesis , vol.41 , pp. 138-145
    • Ferron, M.1    Vacher, J.2
  • 12
    • 84859727262 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
    • Fukuhara, S., S. Simmons, S. Kawamura, A. Inoue, Y. Orba, T. Tokudome, Y. Sunden, Y. Arai, K. Moriwaki, J. Ishida, et al. 2012. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122:1416-1426. http://dx.doi.org/10.1172/JCI60746
    • (2012) J. Clin. Invest , vol.122 , pp. 1416-1426
    • Fukuhara, S.1    Simmons, S.2    Kawamura, S.3    Inoue, A.4    Orba, Y.5    Tokudome, T.6    Sunden, Y.7    Arai, Y.8    Moriwaki, K.9    Ishida, J.10
  • 13
    • 84898655296 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling
    • Gatfield, J., L. Monnier, R. Studer, M.H. Bolli, B. Steiner, and O. Nayler. 2014. Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. Cell. Signal. 26:1576-1588. http://dx.doi.org/10.1016/j.cellsig.2014.03.029
    • (2014) Cell. Signal , vol.26 , pp. 1576-1588
    • Gatfield, J.1    Monnier, L.2    Studer, R.3    Bolli, M.H.4    Steiner, B.5    Nayler, O.6
  • 14
    • 34447104270 scopus 로고    scopus 로고
    • Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus
    • Gordon, J., S. Xiao, B. Hughes III, D.M. Su, S.P Navarre, B.G. Condie, and N. R. Manley. 2007. Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev. Biol. 7:69. http://dx.doi.org/10.1186/1471-213X-7
    • (2007) BMC Dev. Biol , vol.7 , pp. 69
    • Gordon, J.1    Xiao, S.2    Hughes, B.3    Su, D.M.4    Navarre, S.P.5    Condie, B.G.6    Manley, N.R.7
  • 15
    • 13544270248 scopus 로고    scopus 로고
    • Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes
    • Graler, M.H., M.C. Huang, S. Watson, and E.J. Goetzl. 2005. Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes. J. Immunol. 174:19972003. http://dx.doi.org/10.4049/jimmunol.174.4.1997
    • (2005) J. Immunol , vol.174 , pp. 199-72003
    • Graler, M.H.1    Huang, M.C.2    Watson, S.3    Goetzl, E.J.4
  • 16
    • 84857059706 scopus 로고    scopus 로고
    • Differential processing of self-antigens by subsets of thymic stromal cells
    • Guerder, S., C. Viret, H. Luche, L. Ardouin, and B. Malissen. 2012. Differential processing of self-antigens by subsets of thymic stromal cells. Curr. Opin. Immunol. 24:99-104. http://dx.doi.org/10.1016/j.coi.2012.01.008
    • (2012) Curr. Opin. Immunol , vol.24 , pp. 99-104
    • Guerder, S.1    Viret, C.2    Luche, H.3    Ardouin, L.4    Malissen, B.5
  • 19
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kühn, R., F. Schwenk, M. Aguet, and K. Rajewsky. 1995. Inducible gene targeting in mice. Science.269:1427-1429. http://dx.doi.org/10.1126/science.7660125
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kühn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 20
    • 0035041537 scopus 로고    scopus 로고
    • Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
    • Lee, G.R., PE. Fields, and R.A. Flavell. 2001. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity. 14:447-459. http://dx.doi.org/10.1016/S1074-7613(01)00125-X
    • (2001) Immunity , vol.14 , pp. 447-459
    • Lee, G.R.1    Fields, P.E.2    Flavell, R.A.3
  • 21
    • 79951715831 scopus 로고    scopus 로고
    • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
    • Lei, Y, A.M. Ripen, N. Ishimaru, I. Ohigashi, T. Nagasawa, L.T. Jeker, M.R. Bösl, G.A. Holländer, Y. Hayashi, R.W Malefyt, et al. 2011. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J. Exp. Med. 208:383-394. http://dx.doi.org/10.1084/jem.20102327
    • (2011) J. Exp. Med , vol.208 , pp. 383-394
    • Lei, Y.1    Ripen, A.M.2    Ishimaru, N.3    Ohigashi, I.4    Nagasawa, T.5    Jeker, L.T.6    Bösl, M.R.7    Holländer, G.A.8    Hayashi, Y.9    Malefyt, R.W.10
  • 22
    • 63449133991 scopus 로고    scopus 로고
    • Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
    • Li, J., J. Park, D. Foss, and I. Goldschneider. 2009. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J. Exp. Med. 206:607-622. http://dx.doi.org/10.1084/jem.20082232
    • (2009) J. Exp. Med , vol.206 , pp. 607-622
    • Li, J.1    Park, J.2    Foss, D.3    Goldschneider, I.4
  • 23
    • 0032938741 scopus 로고    scopus 로고
    • Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1
    • Liu, C.H., S. Thangada, M.J. Lee, J.R. Van Brocklyn, S. Spiegel, and T. Hla. 1999. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol. Biol. Cell. 10:1179-1190. http://dx.doi.org/10.1091/mbc.10.4.1179
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1179-1190
    • Liu, C.H.1    Thangada, S.2    Lee, M.J.3    Van Brocklyn, J.R.4    Spiegel, S.5    Hla, T.6
  • 24
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M.B., N. Kukutsch, A.L. Ogilvie, S. Rössner, F Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods. 223:77-92. http://dx.doi.org/10.1016/S0022-1759(98)00204-X
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rössner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 27
    • 84880177345 scopus 로고    scopus 로고
    • Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development
    • Newbigging, S., M. Zhang, and J.D. Saba. 2013. Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development. Gene Expr. Patterns. 13:21-29. http://dx.doi.org/10.1016/j.gep.2012.09.001
    • (2013) Gene Expr. Patterns , vol.13 , pp. 21-29
    • Newbigging, S.1    Zhang, M.2    Saba, J.D.3
  • 28
    • 84884816674 scopus 로고    scopus 로고
    • Tolerance has its limits: how the thymus copes with infection
    • Nunes-Alves, C., C. Nobrega, S.M. Behar, and M. Correia-Neves. 2013. Tolerance has its limits: how the thymus copes with infection. Trends Immunol. 34:502-510. http://dx.doi.org/10.1016/j.it.2013.06.004
    • (2013) Trends Immunol , vol.34 , pp. 502-510
    • Nunes-alves, C.1    Nobrega, C.2    Behar, S.M.3    Correia-neves, M.4
  • 29
    • 84885801968 scopus 로고    scopus 로고
    • Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection
    • Perera, J., L. Meng, F Meng, and H. Huang. 2013. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection. Proc. Natl. Acad. Sci. USA. 110:17011-17016. http://dx.doi.org/10.1073/pnas.1313001110
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 17011-17016
    • Perera, J.1    Meng, L.2    Meng, F.3    Huang, H.4
  • 31
    • 56949095716 scopus 로고    scopus 로고
    • Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
    • Pyne, S., S.C. Lee, J. Long, and N.J. Pyne. 2009. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell. Signal. 21:14-21. http://dx.doi.org/10.1016/j.cellsig.2008.08.008
    • (2009) Cell. Signal , vol.21 , pp. 14-21
    • Pyne, S.1    Lee, S.C.2    Long, J.3    Pyne, N.J.4
  • 32
    • 80055105592 scopus 로고    scopus 로고
    • Isolation of mouse peritoneal cavity cells
    • Ray, A., and B.N. Dittel. 2010. Isolation of mouse peritoneal cavity cells.J Vis. Exp. 35:1488. http://dx.doi.org/10.3791/1488
    • (2010) Vis. Exp , vol.35 , pp. 1488
    • Ray, A.1    Dittel, B.N.2
  • 33
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific Cre-mediated mutagenesis in mice
    • Rickert, R.C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318. http://dx.doi.org/10.1093/nar/25.6.1317
    • (1997) Nucleic Acids Res , vol.25 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 34
    • 52949108813 scopus 로고    scopus 로고
    • The alliance of sphingosine-1-phosphate and its receptors in immunity
    • Rivera, J., R.L. Proia, and A. Olivera. 2008. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat. Rev. Immunol. 8:753-763. http://dx.doi.org/10.1038/nri2400
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 753-763
    • Rivera, J.1    Proia, R.L.2    Olivera, A.3
  • 35
    • 42649138855 scopus 로고    scopus 로고
    • Thymus organogenesis
    • Rodewald, H.R. 2008. Thymus organogenesis. Annu. Rev. Immunol. 26:355- 388. http://dx.doi.org/10.1146/annurev.immunol.26.021607.090408
    • (2008) Annu. Rev. Immunol , vol.26 , pp. 355-388
    • Rodewald, H.R1
  • 36
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab, S.R., J.P Pereira M. Matloubian Y. Xu Y Huang and J.G. Cyster. 2005. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science.309:1735-1739. http://dx.doi.org/10.1126/science.1113640
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3    Xu, Y.4    Huang, Y.5    Cyster, J.G.6
  • 37
    • 50049106591 scopus 로고    scopus 로고
    • Environmental cues dendritic cells and the programming of tissue-selective lymphocyte trafficking
    • Sigmundsdottir, H., and E.C. Butcher. 2008. Environmental cues dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat. Immunol. 9:981-987. http://dx.doi.org/10.1038/ni.f_208
    • (2008) Nat. Immunol , vol.9 , pp. 981-987
    • Sigmundsdottir, H.1    Butcher, E.C.2
  • 38
    • 77956862615 scopus 로고    scopus 로고
    • Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate
    • Siow, D.L., C.D. Anderson E.V. Berdyshev A. Skobeleva S.M. Pitson and B.W Wattenberg. 2010. Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. J. Lipid Res. 51:2546-2559. http://dx.doi.org/10.1194/jlr.M004374
    • (2010) J. Lipid Res , vol.51 , pp. 2546-2559
    • Siow, D.L.1    Anderson, C.D.2    Berdyshev, E.V.3    Skobeleva, A.4    Pitson, S.M.5    Wattenberg, B.W.6
  • 39
    • 79957610938 scopus 로고    scopus 로고
    • The outs and the ins of sphingosine-1-phosphate in immunity
    • Spiegel, S., and S. Milstien. 2011. The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev Immunol. 11:403-415. http://dx.doi.org/10.1038/nri2974
    • (2011) Nat. Rev Immunol , vol.11 , pp. 403-415
    • Spiegel, S.1    Milstien, S.2
  • 41
    • 46949104885 scopus 로고    scopus 로고
    • Inside-out signaling of sphingosine-1-phosphate: therapeutic targets
    • Takabe, K., S.W. Paugh, S. Milstien, and S. Spiegel. 2008. Inside-out signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol. Rev. 60:181-195.http://dx.doi.org/10.1124/pr.107.07113
    • (2008) Pharmacol. Rev , vol.60 , pp. 181-195
    • Takabe, K.1    Paugh, S.W.2    Milstien, S.3    Spiegel, S.4
  • 43
    • 58149474166 scopus 로고    scopus 로고
    • Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
    • Vogel, P, M.S. Donoviel, R. Read, G.M. Hansen, J. Hazlewood, S.J. Anderson, W Sun, J. Swaffield, and T. Oravecz. 2009. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One. 4:e4112. http://dx.doi.org/10.1371/journal.pone.0004112
    • (2009) PLoS One , vol.4 , pp. e4112
    • Vogel, P.1    Donoviel, M.S.2    Read, R.3    Hansen, G.M.4    Hazlewood, J.5    Anderson, S.J.6    Sun, W.7    Swaffield, J.8    Oravecz, T.9
  • 45
    • 70449700288 scopus 로고    scopus 로고
    • Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice
    • Weber, C., A. Krueger, A. Münk, C. Bode, PPVanVeldhoven, and M.H. Gräler. 2009. Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.J. Immunol. 183:4292-4301. http://dx.doi.org/10.4049/jimmunol.0901724
    • (2009) J. Immunol , vol.183 , pp. 4292-4301
    • Weber, C.1    Krueger, A.2    Münk, A.3    Bode, C.4    Van Veldhoven, P.P.5    Gräler, M.H.6
  • 46
    • 84903515236 scopus 로고    scopus 로고
    • Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis
    • Weiler, S., N. Braendlin, C. Beerli, C. Bergsdorf, A. Schubart, H. Srinivas, B. Oberhauser, and A. Billich. 2014. Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J. Med. Chem. 57:5074-5084. http://dx.doi.org/10.1021/jm500338n
    • (2014) J. Med. Chem , vol.57 , pp. 5074-5084
    • Weiler, S.1    Braendlin, N.2    Beerli, C.3    Bergsdorf, C.4    Schubart, A.5    Srinivas, H.6    Oberhauser, B.7    Billich, A.8
  • 47
    • 84929950085 scopus 로고    scopus 로고
    • Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigenbearing dendritic cells and feedback competition
    • Weist, B.M., N. Kurd, J. Boussier, S.W Chan, and E.A. Robey. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigenbearing dendritic cells and feedback competition. Nat. Immunol. 16:635641. http://dx.doi.org/10.1038/ni.3171
    • (2015) Nat. Immunol , vol.16 , pp. 635-641
    • Weist, B.M.1    Kurd, N.2    Boussier, J.3    Chan, S.W.4    Robey, E.A.5
  • 48
    • 22144444873 scopus 로고    scopus 로고
    • Heterogeneity of thymic dendritic cells
    • Wu, L., and K. Shortman. 2005. Heterogeneity of thymic dendritic cells. Semin. Immunol. 17:304-312. http://dx.doi.org/10.1016/j.smim.2005.05.001
    • (2005) Semin. Immunol , vol.17 , pp. 304-312
    • Wu, L.1    Shortman, K.2
  • 49
    • 77952961847 scopus 로고    scopus 로고
    • Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction
    • Zachariah, M.A., and J.G. Cyster. 2010. Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science.328:1129-1135. http://dx.doi.org/10.1126/science.1188222
    • (2010) Science , vol.328 , pp. 1129-1135
    • Zachariah, M.A.1    Cyster, J.G.2
  • 50
    • 34347250824 scopus 로고    scopus 로고
    • Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
    • Zhao, Y., S.K. Kalari, P.V. Usatyuk, I. Gorshkova, D. He, T. Watkins, D.N. Brindley, C. Sun, R. Bittman, J.G. Garcia, et al. 2007. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J. Biol. Chem. 282:14165-14177. http://dx.doi.org/10.1074/jbc.M701279200
    • (2007) J. Biol. Chem , vol.282 , pp. 14165-14177
    • Zhao, Y.1    Kalari, S.K.2    Usatyuk, P.V.3    Gorshkova, I.4    He, D.5    Watkins, T.6    Brindley, D.N.7    Sun, C.8    Bittman, R.9    Garcia, J.G.10


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