-
1
-
-
78650381368
-
Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1 H-i mi daz ol-4-yl) bu tan e-1,2,3,4-tetraol (LX2932)
-
Bagdanoff, J.T., M.S. Donoviel, A. Nouraldeen, M. Carlsen, T.C. Jessop, J. Tarver, S. Aleem, L. Dong, H. Zhang, L. Boteju, et al. 2010. Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1 H-i mi daz ol-4-yl) bu tan e-1,2,3,4-tetraol (LX2932). J. Med. Chem. 53:8650-8662. http://dx.doi.org/10.1021/jm101183p
-
(2010)
J. Med. Chem
, vol.53
, pp. 8650-8662
-
-
Bagdanoff, J.T.1
Donoviel, M.S.2
Nouraldeen, A.3
Carlsen, M.4
Jessop, T.C.5
Tarver, J.6
Aleem, S.7
Dong, L.8
Zhang, H.9
Boteju, L.10
-
2
-
-
0033578325
-
A central role for thymic emigrants in peripheral T cell homeostasis
-
Berzins, S.P., D.I. Godfrey, J.F. Miller, and R.L. Boyd. 1999. A central role for thymic emigrants in peripheral T cell homeostasis. Proc. Natl. Acad. Sci. USA. 96:9787-9791. http://dx.doi.org/10.1073/pnas.96.17.9787
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9787-9791
-
-
Berzins, S.P.1
Godfrey, D.I.2
Miller, J.F.3
Boyd, R.L.4
-
3
-
-
33746271951
-
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry
-
Bielawski, J., Z.M. Szulc, Y.A. Hannun, and A. Bielawska. 2006. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods. 39:82-91. http://dx.doi.org/10.1016/j.ymeth.2006.05.004
-
(2006)
Methods
, vol.39
, pp. 82-91
-
-
Bielawski, J.1
Szulc, Z.M.2
Hannun, Y.A.3
Bielawska, A.4
-
4
-
-
33748866909
-
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
-
Bonasio, R., M.L. Scimone, P Schaerli, N. Grabie, A.H. Lichtman, and U.H. von Andrian. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat. Immunol. 7:1092-1100. http://dx.doi.org/10.1038/ni1385
-
(2006)
Nat. Immunol
, vol.7
, pp. 1092-1100
-
-
Bonasio, R.1
Scimone, M.L.2
Schaerli, P.3
Grabie, N.4
Lichtman, A.H.5
von Andrian, U.H.6
-
5
-
-
84864863230
-
Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues
-
Borowsky, A.D., P Bandhuvula, A. Kumar,Y.Yoshinaga, M. Nefedov, L.G. Fong, M. Zhang, B. Baridon, L. Dillard, P de Jong, et al. 2012. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J. Lipid Res. 53:1920-1931. http://dx.doi.org/10.1194/jlr.M028084
-
(2012)
J. Lipid Res
, vol.53
, pp. 1920-1931
-
-
Borowsky, A.D.1
Bandhuvula, P.2
Kumar, A.3
Yoshinaga, Y.4
Nefedov, M.5
Fong, L.G.6
Zhang, M.7
Baridon, B.8
Dillard, L.9
de Jong, P.10
-
6
-
-
79958257954
-
Lipid phosphate phosphatase 3 enables efficient thymic egress
-
Breart, B., W.D. Ramos-Perez, A. Mendoza, A.K. Salous, M. Gobert,Y. Huang, R.H. Adams, J.J. Lafaille, D. Escalante-Alcalde, A.J. Morris, and S.R. Schwab. 2011. Lipid phosphate phosphatase 3 enables efficient thymic egress. J. Exp. Med. 208:1267-1278. http://dx.doi.org/10.1084/jem.20102551
-
(2011)
J. Exp. Med
, vol.208
, pp. 1267-1278
-
-
Breart, B.1
Ramos-perez, W.D.2
Mendoza, A.3
Salous, A.K.4
Gobert, M.5
Huang, Y.6
Adams, R.H.7
Lafaille, J.J.8
Escalante-alcalde, D.9
Morris, A.J.10
Schwab, S.R.11
-
7
-
-
33746334804
-
Kruppel-like factor 2 regulates thymocyte and T-cell migration
-
Carlson, C.M., B.T. Endrizzi, J. Wu, X. Ding, M.A. Weinreich, E.R. Walsh, M. A. Wani, J.B. Lingrel, K.A. Hogquist, and S.C. Jameson. 2006. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature. 442:299-302. http://dx.doi.org/10.1038/nature04882
-
(2006)
Nature
, vol.442
, pp. 299-302
-
-
Carlson, C.M.1
Endrizzi, B.T.2
Wu, J.3
Ding, X.4
Weinreich, M.A.5
Walsh, E.R.6
Wani, M.A.7
Lingrel, J.B.8
Hogquist, K.A.9
Jameson, S.C.10
-
8
-
-
34447275920
-
Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen
-
Caton, M.L., M.R. Smith-Raska, and B. Reizis. 2007. Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen. J Exp. Med. 204:1653-1664. http://dx.doi.org/10.1084/jem.20062648
-
(2007)
J Exp. Med
, vol.204
, pp. 1653-1664
-
-
Caton, M.L.1
Smith-raska, M.R.2
Reizis, B.3
-
9
-
-
3242796768
-
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
-
Cinamon, G., M. Matloubian, M.J. Lesneski, Y. Xu, C. Low, T. Lu, R.L. Proia, and J.G. Cyster. 2004. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat. Immunol. 5:713-720. http://dx.doi.org/10.1038/ni1083
-
(2004)
Nat. Immunol
, vol.5
, pp. 713-720
-
-
Cinamon, G.1
Matloubian, M.2
Lesneski, M.J.3
Xu, Y.4
Low, C.5
Lu, T.6
Proia, R.L.7
Cyster, J.G.8
-
10
-
-
84915748800
-
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs
-
Degagne, E., A. Pandurangan, P. Bandhuvula, A. Kumar, A. Eltanawy, M. Zhang, Y. Yoshinaga, M. Nefedov, P.J. de Jong, L.G. Fong, et al. 2014. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J. Clin. Invest. 124:5368-5384. http://dx.doi.org/10.1172/JCI74188
-
(2014)
J. Clin. Invest
, vol.124
, pp. 5368-5384
-
-
Degagne, E.1
Pandurangan, A.2
Bandhuvula, P.3
Kumar, A.4
Eltanawy, A.5
Zhang, M.6
Yoshinaga, Y.7
Nefedov, M.8
de Jong, P.J.9
Fong, L.G.10
-
11
-
-
17044387828
-
Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice
-
Ferron, M., and J. Vacher. 2005. Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice. Genesis. 41:138-145. http://dx.doi.org/10.1002/gene.20108
-
(2005)
Genesis
, vol.41
, pp. 138-145
-
-
Ferron, M.1
Vacher, J.2
-
12
-
-
84859727262
-
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
-
Fukuhara, S., S. Simmons, S. Kawamura, A. Inoue, Y. Orba, T. Tokudome, Y. Sunden, Y. Arai, K. Moriwaki, J. Ishida, et al. 2012. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122:1416-1426. http://dx.doi.org/10.1172/JCI60746
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1416-1426
-
-
Fukuhara, S.1
Simmons, S.2
Kawamura, S.3
Inoue, A.4
Orba, Y.5
Tokudome, T.6
Sunden, Y.7
Arai, Y.8
Moriwaki, K.9
Ishida, J.10
-
13
-
-
84898655296
-
Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling
-
Gatfield, J., L. Monnier, R. Studer, M.H. Bolli, B. Steiner, and O. Nayler. 2014. Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. Cell. Signal. 26:1576-1588. http://dx.doi.org/10.1016/j.cellsig.2014.03.029
-
(2014)
Cell. Signal
, vol.26
, pp. 1576-1588
-
-
Gatfield, J.1
Monnier, L.2
Studer, R.3
Bolli, M.H.4
Steiner, B.5
Nayler, O.6
-
14
-
-
34447104270
-
Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus
-
Gordon, J., S. Xiao, B. Hughes III, D.M. Su, S.P Navarre, B.G. Condie, and N. R. Manley. 2007. Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev. Biol. 7:69. http://dx.doi.org/10.1186/1471-213X-7
-
(2007)
BMC Dev. Biol
, vol.7
, pp. 69
-
-
Gordon, J.1
Xiao, S.2
Hughes, B.3
Su, D.M.4
Navarre, S.P.5
Condie, B.G.6
Manley, N.R.7
-
15
-
-
13544270248
-
Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes
-
Graler, M.H., M.C. Huang, S. Watson, and E.J. Goetzl. 2005. Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes. J. Immunol. 174:19972003. http://dx.doi.org/10.4049/jimmunol.174.4.1997
-
(2005)
J. Immunol
, vol.174
, pp. 199-72003
-
-
Graler, M.H.1
Huang, M.C.2
Watson, S.3
Goetzl, E.J.4
-
16
-
-
84857059706
-
Differential processing of self-antigens by subsets of thymic stromal cells
-
Guerder, S., C. Viret, H. Luche, L. Ardouin, and B. Malissen. 2012. Differential processing of self-antigens by subsets of thymic stromal cells. Curr. Opin. Immunol. 24:99-104. http://dx.doi.org/10.1016/j.coi.2012.01.008
-
(2012)
Curr. Opin. Immunol
, vol.24
, pp. 99-104
-
-
Guerder, S.1
Viret, C.2
Luche, H.3
Ardouin, L.4
Malissen, B.5
-
17
-
-
80052423824
-
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
-
Hubert, F.X., S.A. Kinkel, G.M. Davey, B. Phipson, S.N. Mueller, A. Liston, A.I. Proietto, PZ. Cannon, S. Forehan, G.K. Smyth, et al. 2011. Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood. 118:2462-2472. http://dx.doi.org
-
(2011)
Blood
, vol.118
, pp. 2462-2472
-
-
Hubert, F.X.1
Kinkel, S.A.2
Davey, G.M.3
Phipson, B.4
Mueller, S.N.5
Liston, A.6
Proietto, A.I.7
Cannon, P.Z.8
Forehan, S.9
Smyth, G.K.10
-
18
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
Kappos, L., J. Antel, G. Comi, X. Montalban, P O'Connor, C.H. Polman, T. Haas, A.A. Korn, G. Karlsson, and E.W Radue. FTY720 D2201 Study Group. 2006. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N. Engl. J. Med. 355:1124-1140. http://dx.doi.org/10.1056/NEJMoa052643
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
Montalban, X.4
O'Connor, P.5
Polman, C.H.6
Haas, T.7
Korn, A.A.8
Karlsson, G.9
Radue, E.W.10
-
19
-
-
0029155706
-
Inducible gene targeting in mice
-
Kühn, R., F. Schwenk, M. Aguet, and K. Rajewsky. 1995. Inducible gene targeting in mice. Science.269:1427-1429. http://dx.doi.org/10.1126/science.7660125
-
(1995)
Science
, vol.269
, pp. 1427-1429
-
-
Kühn, R.1
Schwenk, F.2
Aguet, M.3
Rajewsky, K.4
-
20
-
-
0035041537
-
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
-
Lee, G.R., PE. Fields, and R.A. Flavell. 2001. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity. 14:447-459. http://dx.doi.org/10.1016/S1074-7613(01)00125-X
-
(2001)
Immunity
, vol.14
, pp. 447-459
-
-
Lee, G.R.1
Fields, P.E.2
Flavell, R.A.3
-
21
-
-
79951715831
-
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
-
Lei, Y, A.M. Ripen, N. Ishimaru, I. Ohigashi, T. Nagasawa, L.T. Jeker, M.R. Bösl, G.A. Holländer, Y. Hayashi, R.W Malefyt, et al. 2011. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J. Exp. Med. 208:383-394. http://dx.doi.org/10.1084/jem.20102327
-
(2011)
J. Exp. Med
, vol.208
, pp. 383-394
-
-
Lei, Y.1
Ripen, A.M.2
Ishimaru, N.3
Ohigashi, I.4
Nagasawa, T.5
Jeker, L.T.6
Bösl, M.R.7
Holländer, G.A.8
Hayashi, Y.9
Malefyt, R.W.10
-
22
-
-
63449133991
-
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
-
Li, J., J. Park, D. Foss, and I. Goldschneider. 2009. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J. Exp. Med. 206:607-622. http://dx.doi.org/10.1084/jem.20082232
-
(2009)
J. Exp. Med
, vol.206
, pp. 607-622
-
-
Li, J.1
Park, J.2
Foss, D.3
Goldschneider, I.4
-
23
-
-
0032938741
-
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1
-
Liu, C.H., S. Thangada, M.J. Lee, J.R. Van Brocklyn, S. Spiegel, and T. Hla. 1999. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol. Biol. Cell. 10:1179-1190. http://dx.doi.org/10.1091/mbc.10.4.1179
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 1179-1190
-
-
Liu, C.H.1
Thangada, S.2
Lee, M.J.3
Van Brocklyn, J.R.4
Spiegel, S.5
Hla, T.6
-
24
-
-
0033012030
-
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
-
Lutz, M.B., N. Kukutsch, A.L. Ogilvie, S. Rössner, F Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods. 223:77-92. http://dx.doi.org/10.1016/S0022-1759(98)00204-X
-
(1999)
J. Immunol. Methods
, vol.223
, pp. 77-92
-
-
Lutz, M.B.1
Kukutsch, N.2
Ogilvie, A.L.3
Rössner, S.4
Koch, F.5
Romani, N.6
Schuler, G.7
-
25
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian, M., C.G. Lo, G. Cinamon, M.J. Lesneski, Y Xu, V Brinkmann, M.L. Allende, R.L. Proia, and J.G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 427:355-360. http://dx.doi.org/10.1038/nature02284
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
Lesneski, M.J.4
Xu, Y.5
Brinkmann, V.6
Allende, M.L.7
Proia, R.L.8
Cyster, J.G.9
-
26
-
-
0038264036
-
Selective imprinting of guthoming T cells by Peyer's patch dendritic cells
-
Mora, J.R., M.R. Bono, N. Manjunath, W Weninger, L.L. Cavanagh, M. Rosemblatt, and U.H. Von Andrian. 2003. Selective imprinting of guthoming T cells by Peyer's patch dendritic cells. Nature. 424:88-93. http://dx.doi.org/10.1038/nature01726
-
(2003)
Nature
, vol.424
, pp. 88-93
-
-
Mora, J.R.1
Bono, M.R.2
Manjunath, N.3
Weninger, W.4
Cavanagh, L.L.5
Rosemblatt, M.6
Von Andrian, U.H.7
-
27
-
-
84880177345
-
Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development
-
Newbigging, S., M. Zhang, and J.D. Saba. 2013. Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development. Gene Expr. Patterns. 13:21-29. http://dx.doi.org/10.1016/j.gep.2012.09.001
-
(2013)
Gene Expr. Patterns
, vol.13
, pp. 21-29
-
-
Newbigging, S.1
Zhang, M.2
Saba, J.D.3
-
28
-
-
84884816674
-
Tolerance has its limits: how the thymus copes with infection
-
Nunes-Alves, C., C. Nobrega, S.M. Behar, and M. Correia-Neves. 2013. Tolerance has its limits: how the thymus copes with infection. Trends Immunol. 34:502-510. http://dx.doi.org/10.1016/j.it.2013.06.004
-
(2013)
Trends Immunol
, vol.34
, pp. 502-510
-
-
Nunes-alves, C.1
Nobrega, C.2
Behar, S.M.3
Correia-neves, M.4
-
29
-
-
84885801968
-
Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection
-
Perera, J., L. Meng, F Meng, and H. Huang. 2013. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection. Proc. Natl. Acad. Sci. USA. 110:17011-17016. http://dx.doi.org/10.1073/pnas.1313001110
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 17011-17016
-
-
Perera, J.1
Meng, L.2
Meng, F.3
Huang, H.4
-
30
-
-
58149376454
-
Dendritic cells in the thymus contribute to T-regulatory cell induction
-
Proietto, A.I., S. van Dommelen, P Zhou, A. Rizzitelli, A. D'Amico, RJ. Steptoe, S.H. Naik, M.H. Lahoud, Y. Liu, P Zheng, et al. 2008. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc. Natl. Acad. Sci. USA. 105:19869-19874. http://dx.doi.org/10.1073/pnas.0810268105
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19869-19874
-
-
Proietto, A.I.1
van Dommelen, S.2
Zhou, P.3
Rizzitelli, A.4
D'Amico, A.5
Steptoe, R.J.6
Naik, S.H.7
Lahoud, M.H.8
Liu, Y.9
Zheng, P.10
-
31
-
-
56949095716
-
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
-
Pyne, S., S.C. Lee, J. Long, and N.J. Pyne. 2009. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell. Signal. 21:14-21. http://dx.doi.org/10.1016/j.cellsig.2008.08.008
-
(2009)
Cell. Signal
, vol.21
, pp. 14-21
-
-
Pyne, S.1
Lee, S.C.2
Long, J.3
Pyne, N.J.4
-
32
-
-
80055105592
-
Isolation of mouse peritoneal cavity cells
-
Ray, A., and B.N. Dittel. 2010. Isolation of mouse peritoneal cavity cells.J Vis. Exp. 35:1488. http://dx.doi.org/10.3791/1488
-
(2010)
Vis. Exp
, vol.35
, pp. 1488
-
-
Ray, A.1
Dittel, B.N.2
-
33
-
-
0030818183
-
B lymphocyte-specific Cre-mediated mutagenesis in mice
-
Rickert, R.C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318. http://dx.doi.org/10.1093/nar/25.6.1317
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 1317-1318
-
-
Rickert, R.C.1
Roes, J.2
Rajewsky, K.3
-
34
-
-
52949108813
-
The alliance of sphingosine-1-phosphate and its receptors in immunity
-
Rivera, J., R.L. Proia, and A. Olivera. 2008. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat. Rev. Immunol. 8:753-763. http://dx.doi.org/10.1038/nri2400
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 753-763
-
-
Rivera, J.1
Proia, R.L.2
Olivera, A.3
-
35
-
-
42649138855
-
Thymus organogenesis
-
Rodewald, H.R. 2008. Thymus organogenesis. Annu. Rev. Immunol. 26:355- 388. http://dx.doi.org/10.1146/annurev.immunol.26.021607.090408
-
(2008)
Annu. Rev. Immunol
, vol.26
, pp. 355-388
-
-
Rodewald, H.R1
-
36
-
-
24644469502
-
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
-
Schwab, S.R., J.P Pereira M. Matloubian Y. Xu Y Huang and J.G. Cyster. 2005. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science.309:1735-1739. http://dx.doi.org/10.1126/science.1113640
-
(2005)
Science
, vol.309
, pp. 1735-1739
-
-
Schwab, S.R.1
Pereira, J.P.2
Matloubian, M.3
Xu, Y.4
Huang, Y.5
Cyster, J.G.6
-
37
-
-
50049106591
-
Environmental cues dendritic cells and the programming of tissue-selective lymphocyte trafficking
-
Sigmundsdottir, H., and E.C. Butcher. 2008. Environmental cues dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat. Immunol. 9:981-987. http://dx.doi.org/10.1038/ni.f_208
-
(2008)
Nat. Immunol
, vol.9
, pp. 981-987
-
-
Sigmundsdottir, H.1
Butcher, E.C.2
-
38
-
-
77956862615
-
Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate
-
Siow, D.L., C.D. Anderson E.V. Berdyshev A. Skobeleva S.M. Pitson and B.W Wattenberg. 2010. Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. J. Lipid Res. 51:2546-2559. http://dx.doi.org/10.1194/jlr.M004374
-
(2010)
J. Lipid Res
, vol.51
, pp. 2546-2559
-
-
Siow, D.L.1
Anderson, C.D.2
Berdyshev, E.V.3
Skobeleva, A.4
Pitson, S.M.5
Wattenberg, B.W.6
-
39
-
-
79957610938
-
The outs and the ins of sphingosine-1-phosphate in immunity
-
Spiegel, S., and S. Milstien. 2011. The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev Immunol. 11:403-415. http://dx.doi.org/10.1038/nri2974
-
(2011)
Nat. Rev Immunol
, vol.11
, pp. 403-415
-
-
Spiegel, S.1
Milstien, S.2
-
40
-
-
34248577055
-
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity
-
Stranges, P.B., J. Watson, C.J. Cooper, C.M. Choisy-Rossi, A.C. Stonebraker, R.A. Beighton, H. Hartig, J.P Sundberg, S. Servick, G. Kaufmann, et al. 2007. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 26:629-641. http://dx.doi.org/10.1016/j.immuni.2007.03.016
-
(2007)
Immunity
, vol.26
, pp. 629-641
-
-
Stranges, P.B.1
Watson, J.2
Cooper, C.J.3
Choisy-rossi, C.M.4
Stonebraker, A.C.5
Beighton, R.A.6
Hartig, H.7
Sundberg, J.P.8
Servick, S.9
Kaufmann, G.10
-
41
-
-
46949104885
-
Inside-out signaling of sphingosine-1-phosphate: therapeutic targets
-
Takabe, K., S.W. Paugh, S. Milstien, and S. Spiegel. 2008. Inside-out signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol. Rev. 60:181-195.http://dx.doi.org/10.1124/pr.107.07113
-
(2008)
Pharmacol. Rev
, vol.60
, pp. 181-195
-
-
Takabe, K.1
Paugh, S.W.2
Milstien, S.3
Spiegel, S.4
-
42
-
-
33645783441
-
Antigen challenge inhibits thymic emigration
-
Uldrich, A.P., S.P Berzins, M.A. Malin, P. Bouillet, A. Strasser, M.J. Smyth, R.L. Boyd, and D.I. Godfrey. 2006. Antigen challenge inhibits thymic emigration. J. Immunol. 176:4553-4561. http://dx.doi.org/10.4049/jimmunol. 176.8.4553
-
(2006)
J. Immunol
, vol.176
, pp. 4553-4561
-
-
Uldrich, A.P.1
Berzins, S.P.2
Malin, M.A.3
Bouillet, P.4
Strasser, A.5
Smyth, M.J.6
Boyd, R.L.7
Godfrey, D.I.8
-
43
-
-
58149474166
-
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
-
Vogel, P, M.S. Donoviel, R. Read, G.M. Hansen, J. Hazlewood, S.J. Anderson, W Sun, J. Swaffield, and T. Oravecz. 2009. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One. 4:e4112. http://dx.doi.org/10.1371/journal.pone.0004112
-
(2009)
PLoS One
, vol.4
, pp. e4112
-
-
Vogel, P.1
Donoviel, M.S.2
Read, R.3
Hansen, G.M.4
Hazlewood, J.5
Anderson, S.J.6
Sun, W.7
Swaffield, J.8
Oravecz, T.9
-
44
-
-
77953029002
-
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
-
Wang, Y, M. Nakayama, M.E. Pitulescu, T.S. Schmidt, M.L. Bochenek, A. Sakakibara, S. Adams, A. Davy, U. Deutsch, U. Lüthi, et al. 2010. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 465:483-486. http://dx.doi.org/10.1038/nature09002
-
(2010)
Nature
, vol.465
, pp. 483-486
-
-
Wang, Y.1
Nakayama, M.2
Pitulescu, M.E.3
Schmidt, T.S.4
Bochenek, M.L.5
Sakakibara, A.6
Adams, S.7
Davy, A.8
Deutsch, U.9
Lüthi, U.10
-
45
-
-
70449700288
-
Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice
-
Weber, C., A. Krueger, A. Münk, C. Bode, PPVanVeldhoven, and M.H. Gräler. 2009. Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.J. Immunol. 183:4292-4301. http://dx.doi.org/10.4049/jimmunol.0901724
-
(2009)
J. Immunol
, vol.183
, pp. 4292-4301
-
-
Weber, C.1
Krueger, A.2
Münk, A.3
Bode, C.4
Van Veldhoven, P.P.5
Gräler, M.H.6
-
46
-
-
84903515236
-
Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis
-
Weiler, S., N. Braendlin, C. Beerli, C. Bergsdorf, A. Schubart, H. Srinivas, B. Oberhauser, and A. Billich. 2014. Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J. Med. Chem. 57:5074-5084. http://dx.doi.org/10.1021/jm500338n
-
(2014)
J. Med. Chem
, vol.57
, pp. 5074-5084
-
-
Weiler, S.1
Braendlin, N.2
Beerli, C.3
Bergsdorf, C.4
Schubart, A.5
Srinivas, H.6
Oberhauser, B.7
Billich, A.8
-
47
-
-
84929950085
-
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigenbearing dendritic cells and feedback competition
-
Weist, B.M., N. Kurd, J. Boussier, S.W Chan, and E.A. Robey. 2015. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigenbearing dendritic cells and feedback competition. Nat. Immunol. 16:635641. http://dx.doi.org/10.1038/ni.3171
-
(2015)
Nat. Immunol
, vol.16
, pp. 635-641
-
-
Weist, B.M.1
Kurd, N.2
Boussier, J.3
Chan, S.W.4
Robey, E.A.5
-
48
-
-
22144444873
-
Heterogeneity of thymic dendritic cells
-
Wu, L., and K. Shortman. 2005. Heterogeneity of thymic dendritic cells. Semin. Immunol. 17:304-312. http://dx.doi.org/10.1016/j.smim.2005.05.001
-
(2005)
Semin. Immunol
, vol.17
, pp. 304-312
-
-
Wu, L.1
Shortman, K.2
-
49
-
-
77952961847
-
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction
-
Zachariah, M.A., and J.G. Cyster. 2010. Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science.328:1129-1135. http://dx.doi.org/10.1126/science.1188222
-
(2010)
Science
, vol.328
, pp. 1129-1135
-
-
Zachariah, M.A.1
Cyster, J.G.2
-
50
-
-
34347250824
-
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
-
Zhao, Y., S.K. Kalari, P.V. Usatyuk, I. Gorshkova, D. He, T. Watkins, D.N. Brindley, C. Sun, R. Bittman, J.G. Garcia, et al. 2007. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J. Biol. Chem. 282:14165-14177. http://dx.doi.org/10.1074/jbc.M701279200
-
(2007)
J. Biol. Chem
, vol.282
, pp. 14165-14177
-
-
Zhao, Y.1
Kalari, S.K.2
Usatyuk, P.V.3
Gorshkova, I.4
He, D.5
Watkins, T.6
Brindley, D.N.7
Sun, C.8
Bittman, R.9
Garcia, J.G.10
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