Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1- yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis

Journal of Medicinal Chemistry

Volumn 57, Issue 12, 2014, Pages 5074-5084

  Weiler, Sven ^a   Braendlin, Nadine ^a   Beerli, Christian ^a   Bergsdorf, Christian ^a   Schubart, Anna ^a   Srinivas, Honnappa ^a   Oberhauser, Berndt ^a   Billich, Andreas ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 (4 BENZYL 7 CHLOROPHTHALAZIN 1 YL) 2 METHYLPIPERAZIN 1 YL]NICOTINONITRILE; ENZYME INHIBITOR; LYASE; SPHINGOSINE 1 PHOSPHATE LYASE; SPHINGOSINE 1 PHOSPHATE LYASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INDICATION; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; INFLAMMATORY DISEASE; MALE; MULTIPLE SCLEROSIS; NONHUMAN; RAT; SINGLE DRUG DOSE; T LYMPHOCYTE;

ADMINISTRATION, ORAL; ALDEHYDE-LYASES; ANIMALS; CATALYTIC DOMAIN; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; MALE; MODELS, MOLECULAR; MULTIPLE SCLEROSIS; MUTATION; PHTHALAZINES; PROTEIN CONFORMATION; PYRIDINES; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903515236     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500338n     Document Type: Article

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