Antigen challenge inhibits thymic emigration

Journal of Immunology

Volumn 176, Issue 8, 2006, Pages 4553-4561

  Uldrich, Adam P ^a,b,d   Berzins, Stuart P ^a   Malin, Mark A ^b   Bouillet, Philippe ^c   Strasser, Andreas ^c   Smyth, Mark J ^d   Boyd, Richard L ^b   Godfrey, Dale I ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE; THYMOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 33645783441     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4553     Document Type: Article

References (55)

1. Michie, A. M., and J. C. Zuniga-Pflucker. 2002. Regulation of thymocyte differentiation: pre-TCR signals and β-selection. Semin. Immunol. 14: 311-323.
2. Irving, B. A., F. W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280: 905-908.
3. Starr, T. K., S. C. Jameson, and K. A. Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21: 139-176.
4. Palmer, E. 2003. Negative selection: clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3: 383-391.
5. Egerton, M., R. Scollay, and K. Shortman. 1990. Kinetics of mature T-cell development in the thymus. Proc. Natl. Acad. Sci. USA 87: 2579-2582.
6. Scollay, R., and D. I. Godfrey. 1995. Thymic emigration: conveyor belts or lucky dips? Immunol. Today 16: 268-273.
7. Lucas, B., F. Vasseur, and C. Penit. 1994. Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153: 53-62.
8. Gabor, M. J., D. I. Godfrey, and R. Scollay. 1997. Recent thymic emigrants are distinct from most medullary thymocytes. Eur. J. Immunol. 27: 2010-2015.
9. Ueno, T., K. Hara, M. S. Willis, M. A. Malin, U. E. Hopken, D. H. Gray, K. Matsushima, M. Lipp, T. A. Springer, R. L. Boyd, et al. 2002. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 16: 205-218.
10. Poznansky, M. C., I. T. Olszak, R. H. Evans, Z. Wang, R. B. Foxall, D. P. Olson, K. Weibrecht, A. D. Luster, and D. T. Scadden. 2002. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J. Clin. Invest. 109: 1101-1110.
11. Cyster, J. G. 2002. Chemorepulsion and thymocyte emigration. J. Clin. Invest. 109: 1011-1012.
12. Vianello, F., P. Kraft, Y. T. Mok, W. K. Hart, N. White, and M. C. Poznansky. 2005. A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus. J. Immunol. 175: 5115-5125.
13. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360.
14. Rosen, H., C. Alfonso, C. D. Surh, and M. G. McHeyzer-Williams. 2003. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist. Proc. Natl. Acad. Sci. USA 100: 10907-10912.
15. Allende, M. L., J. L. Dreier, S. Mandala, and R. L. Proia. 2004. Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279: 15396-15401.
16. Kelly, K. A., and R. Scollay. 1990. Analysis of recent thymic emigrants with subset- and maturity-related markers. Int. Immunol. 2: 419-425.
17. Lee, C. K., K. Kim, L. A. Welniak, W. J. Murphy, K. Muegge, and S. K. Durum. 2001. Thymic emigrants isolated by a new method possess unique phenotypic and functional properties. Blood 97: 1360-1369.
18. Scollay, R., W. F. Chen, and K. Shortman. 1984. The functional capabilities of cells leaving the thymus. J. Immunol. 132: 25-30.
19. Kishimoto, H., and J. Sprent. 1997. Negative selection in the thymus includes semimature T cells. J. Exp. Med. 185: 263-271.
20. Boursalian, T. E., J. Golob, D. M. Soper, C. J. Cooper, and P. J. Fink. 2004. Continued maturation of thymic emigrants in the periphery. Nat. Immunol. 5: 418-425.
21. Penit, C., and F. Vasseur. 1997. Expansion of mature thymocyte subsets before emigration to the periphery. J. Immunol. 159: 4848-4856.
22. Le Campion, A., F. Vasseur, and C. Penit. 2000. Regulation and kinetics of premigrant thymocyte expansion. Eur. J. Immunol. 30: 738-746.
23. Le Campion, A., B. Lucas, N. Dautigny, S. Leaument, F. Vasseur, and C. Penit. 2002. Quantitative and qualitative adjustment of thymic T cell production by clonal expansion of premigrant thymocytes. J. Immunol. 168: 1664-1671.
24. Bouillet, P., D. Metcalf, D. C. Huang, D. M. Tarlinton, T. W. Kay, F. Kontgen, J. M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738.
25. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
26. Korner, H., M. Cook, D. S. Riminton, F. A. Lemckert, R. M. Hoek, B. Ledermann, F. Kontgen, B. Fazekas de St Groth, and J. D. Sedgwick. 1997. Distinct roles for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol. 27: 2600-2609.
27. Herrmann, T., and H. R. MacDonald. 1993. The CD8 T cell response to staphylococcal enterotoxins. Semin. Immunol. 5: 33-39.
28. Miethke, T., C. Wahl, K. Heeg, B. Echtenacher, P. H. Krammer, and H. Wagner. 1992. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 175: 91-98.
29. + cells to bacterial superantigens. Eur. J. Immunol. 22: 1935-1938.
30. MacDonald, H. R., R. K. Lees, S. Baschieri, T. Herrmann, and A. R. Lussow. 1993. Peripheral T-cell reactivity to bacterial superantigens in vivo: the response/anergy paradox. Immunol. Rev. 133: 105-117.
31. Kanegane, H., and G. Tosato. 1996. Activation of naive and memory T cells by interleukin-15. Blood 88: 230-235.
32. Tough, D. F., S. Sun, and J. Sprent. 1997. T cell stimulation in vivo by lipopolysaccharide (LPS). J. Exp. Med. 185: 2089-2094.
33. Renno, T., A. Attinger, S. Locatelli, T. Bakker, S. Vacheron, and H. R. MacDonald. 1999. Cutting edge: apoptosis of superantigen-activated T cells occurs preferentially after a discrete number of cell divisions in vivo. J. Immunol. 162: 6312-6315.
34. Hildeman, D. A., Y. Zhu, T. C. Mitchell, P. Bouillet, A. Strasser, J. Kappler, and P. Marrack. 2002. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity 16: 759-767.
35. Gonzalo, J. A., C. Martinez, T. A. Springer, and J. C. Gutierrez-Ramos. 1995. ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo. Int. Immunol. 7: 1691-1698.
36. Goettelfinger, P., R. Roussin, F. Lecerf, S. Berrih-Aknin, and M. Fattal-German. 2000. T cell deletion and unresponsiveness induced by intrathymic injection of staphylococcal enterotoxin B. Transplant Immunol. 8: 39-48.
37. Martin, S., and M. J. Bevan. 1997. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur. J. Immunol. 27: 2726-2736.
38. Grech, A. P., D. S. Riminton, M. J. Gabor, C. L. Hardy, J. D. Sedgwick, and D. I. Godfrey. 2000. Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-α and TNF gene-targeted mice. Dev. Immunol. 8: 61-74.
39. Hubbe, M., and P. Altevogt. 1994. Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur. J. Immunol. 24: 731-737.
40. Bouillet, P., J. F. Purton, D. I. Godfrey, L. C. Zhang, L. Coultas, H. Puthalakath, M. Pellegrini, S. Cory, J. M. Adams, and A. Strasser. 2002. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926.
41. Pellegrini, M., G. Belz, P. Bouillet, and A. Strasser. 2003. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc. Natl. Acad. Sci. USA 100: 14175-14180.
42. + thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc. Natl. Acad. Sci. USA 101: 7052-7057.
43. Li, M., G. M. Davey, R. M. Sutherland, C. Kurts, A. M. Lew, C. Hirst, F. R. Carbone, and W. R. Heath. 2001. Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J. Immunol. 166: 6099-6103.
44. Mintem, J. D., M. M. Maurice, H. L. Ploegh, and E. Schott. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J. Immunol. 172: 699-708.
45. Barnden, M. J., W. R. Heath, S. Rodda, and F. R. Carbone. 1994. Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion. Eur. J. Immunol. 24: 2452-2456.
46. Berzins, S. P., R. L. Boyd, and J. F. Miller. 1998. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187: 1839-1848.
47. Scollay, R. G., E. C. Butcher, and I. L. Weissman. 1980. Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 10: 210-218.
48. Scollay, R., and K. Shortman. 1984. Contribution of thymus lymphocytes to the peripheral lymphoid tissues and the effect of antigen on the rate of cell exit from the thymus. Am. J. Anat. 170: 331-338.
49. Kelly, K. A., and R. Scollay. 1991. The effect of peripheral immunization with Mis-1a on the emigration of antigen-specific cells from the thymus. Eur. J. Immunol. 21: 43-47.
50. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
51. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
52. + regulatory T cells. Nat. Immunol. 4: 330-336.
53. Graeler, M., and E. J. Goetzl. 2002. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J. 16: 1874-1878.
54. Nakayama, T., D. J. Kasprowicz, M. Yamashita, L. A. Schubert, G. Gillard, M. Kimura, A. Didierlaurent, H. Koseki, and S. F. Ziegler. 2002. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168: 87-94.
55. Feng, C., K. J. Woodside, B. A. Vance, D. El-Khoury, M. Canelles, J. Lee, R. Gress, B. J. Fowlkes, E. W. Shores, and P. E. Love. 2002. A potential role for CD69 in thymocyte emigration. Int. Immunol. 14: 535-544.