Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling

Cellular Signalling

Volumn 26, Issue 7, 2014, Pages 1576-1588

  Gatfield, John ^a   Monnier, Lucile ^a   Studer, Rolf ^a   Bolli, Martin H ^a   Steiner, Beat ^a   Nayler, Oliver ^a  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

G protein coupled receptors; Receptor recycling; S1P lyase; S1P1 desensitization; Signal transduction; Sphingosine 1 phosphate

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BETA ARRESTIN; CELL SURFACE RECEPTOR; ENZYME INHIBITOR; FINGOLIMOD; GT 11; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LYASE; PERTUSSIS TOXIN; PONESIMOD; RECOMBINANT PROTEIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; SPHINGOSINE 1 PHOSPHATE LYASE BLOCKER; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE TYPE 1 RECEPTOR; SPHINGOSINE 1 PHOSPHATE TYPE 1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; W 146; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHOLIPID; MEMBRANE PROTEIN; PHOSPHATASE; RETINA S ANTIGEN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE-1-PHOSPHATE PHOSPHATASE; THIAZOLE DERIVATIVE;

ARTICLE; AUTOIMMUNE DISEASE; BIOACCUMULATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; ENZYME SUBSTRATE; GOLGI COMPLEX; HUMAN; HUMAN CELL; PHARMACODYNAMICS; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; RECEPTOR RECYCLING; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; HELA CELL LINE; IMMUNOLOGY; METABOLISM; T LYMPHOCYTE; TUMOR CELL LINE;

ARRESTINS; AUTOIMMUNE DISEASES; CELL LINE, TUMOR; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HELA CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LYSOPHOSPHOLIPIDS; MEMBRANE PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN TRANSPORT; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; T-LYMPHOCYTES; THIAZOLES;

EID: 84898655296     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.03.029     Document Type: Article

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