A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

Toxicology in Vitro

Volumn 39, Issue , 2017, Pages 29-51

  Iskandar, Anita R ^a   Mathis, Carole ^a   Schlage, Walter K ^b   Frentzel, Stefan ^a   Leroy, Patrice ^a   Xiang, Yang ^a   Sewer, Alain ^a   Majeed, Shoaib ^a   Ortega Torres, Laura ^a   Johne, Stephanie ^a   Guedj, Emmanuel ^a   Trivedi, Keyur ^a   Kratzer, Gilles ^a   Merg, Celine ^a   Elamin, Ashraf ^a   Martin, Florian ^a   Ivanov, Nikolai V ^a   Peitsch, Manuel C ^a   Hoeng, Julia ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

^b Biology Consultant   (Germany)

Author keywords

air liquid interface; causal biological network modelling; product testing; Reconstituted epithelium; transcriptomics

Indexed keywords

CIGARETTE SMOKE; MICRORNA; NICOTINE; AEROSOL; MESSENGER RNA; SMOKE;

ADULT; AEROSOL; ARTICLE; BRONCHUS MUCOSA; CELL FATE; CELL PROLIFERATION; CELL STRESS; COMBUSTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EPITHELIUM CELL; EXPOSURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; SMOKING; TOBACCO; TRANSCRIPTOMICS; YOUNG ADULT; ADVERSE EFFECTS; BRONCHUS; CYTOLOGY; DNA MICROARRAY; DRUG EFFECTS; EUKARYOTIC FLAGELLUM; HEAT; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; RISK; SMOKE; SYSTEMS BIOLOGY;

ADULT; AEROSOLS; BRONCHI; CILIA; EPITHELIAL CELLS; GENE EXPRESSION; HOT TEMPERATURE; HUMANS; MALE; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN CULTURE TECHNIQUES; RISK; RNA, MESSENGER; SMOKE; SYSTEMS BIOLOGY; TOBACCO; TOBACCO PRODUCTS; YOUNG ADULT;

EID: 84999767729     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.11.009     Document Type: Article

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