3-D Nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product

Altex

Volumn 34, Issue 1, 2017, Pages 23-48

  Iskandar, Anita R ^a   Mathis, Carole ^a   Martin, Florian ^a   Leroy, Patrice ^a   Sewer, Alain ^a   Majeed, Shoaib ^a   Kuehn, Diana ^a   Trivedi, Keyur ^a   Grandolfo, Davide ^a   Cabanski, Maciej ^a   Guedj, Emmanuel ^a   Merg, Céline ^a   Frentzel, Stefan ^a   Ivanov, Nikolai V ^a   Peitsch, Manuel C ^a   Hoeng, Julia ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

Author keywords

Air liquid interface; Cigarette smoke; Modified risk tobacco product; Organotypic culture; Systems toxicology

Indexed keywords

ADENYLATE KINASE; CIGARETTE SMOKE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; EPIDERMAL GROWTH FACTOR; FOXJ1 PROTEIN; GELATINASE B; GROWTH RELATED ONCOGENE ALPHA PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; KI 67 ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 3A; MEMBRANE PROTEIN; MICRORNA; NICOTINE; PROTEIN P63; SOLUBLE INTERCELLULAR ADHESION MOLECULE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; AEROSOL; SMOKE;

AEROSOL; ANALYTICAL PARAMETERS; CANDIDATE MODIFIED RISK TOBACCO PRODUCT; CELL CULTURE; CILIA BEATING FREQUENCY; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DNA MICROARRAY; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NOSE EPITHELIUM; RISK ASSESSMENT; RNA ISOLATION; TOBACCO; TOXICOLOGICAL ASSESSMENT; TRANSCRIPTOMICS; ADVERSE EFFECTS; ANALYSIS; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; CELL ADHESION; CHEMISTRY; DRUG EFFECTS; EXPOSURE; IN VITRO STUDY; METABOLISM; NOSE MUCOSA; SMOKE; TOXICITY;

AEROSOLS; ANIMAL USE ALTERNATIVES; CELL ADHESION; HUMANS; IN VITRO TECHNIQUES; INHALATION EXPOSURE; MODELS, BIOLOGICAL; NASAL MUCOSA; SMOKE; TOBACCO; TOBACCO PRODUCTS;

EID: 85011977757     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.1605041     Document Type: Conference Paper

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