A network-based approach to quantifying the impact of biologically active substances

Drug Discovery Today

Volumn 17, Issue 9-10, 2012, Pages 413-418

  Hoeng, Julia ^a   Deehan, Renée ^b   Pratt, Dexter ^b   Martin, Florian ^a   Sewer, Alain ^a   Thomson, Ty M ^b   Drubin, David A ^b   Waters, Christina A ^a   De Graaf, David ^b   Peitsch, Manuel C ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

^b Selventa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICALLY ACTIVE SUBSTANCE; DRUG; UNCLASSIFIED DRUG;

BIOLOGICAL IMPACT FACTOR SCORE; CARCINOGENESIS; ENVIRONMENTAL EXPOSURE; HEALTH HAZARD; HIGH THROUGHPUT SCREENING; HUMAN; LONG TERM EXPOSURE; MOLECULAR BIOLOGY; NONHUMAN; NOSE MUCOSA; PREDICTION; REVIEW; RISK ASSESSMENT; SCORING SYSTEM; TRANSLATIONAL RESEARCH;

EID: 84860698978     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.11.008     Document Type: Short Survey

References (12)

1. M.D. Waters, and J.M. Fostel Toxicogenomics and systems toxicology: aims and prospects Nat. Rev. Genet. 5 2004 936 948
2. D. Krewski New directions in toxicity testing Annu. Rev. Public Health 32 2011 19.1 19.18
3. J.D. Pleil, and L.S. Sheldon Adapting concepts from systems biology to develop systems exposure event networks for exposure science research Biomarkers 16 2011 99 105
4. S. Ekins Techniques: application of systems biology to absorption, distribution, metabolism, and toxicity Trends Pharmacol. Sci. 26 2005 202 209
5. N. Kyosawa Practical application of toxicogenomics for profiling toxicant-induced biological perturbations Int. J. Mol. Sci. 11 2010 3397 3412
6. J.J. Smith Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo BMC Syst. Biol. 3 2009 31
7. D. Laifenfeld The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma Toxicol. Sci. 113 2010 254 266
8. R. Kumar Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data BMC Genomics 6 2010 419
9. J.W. Westra Construction of a computable cell proliferation network focused on non-diseased lung cells BMC Syst. Biol. 2 2011 105
10. W.K. Schlage A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue BMC Syst Biol 5 2011 168
11. M.E. Andersen Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound Toxicol. Sci. 118 2010 716 731
12. T.M. Monticello Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells Cancer Res. 56 1996 1012 1022