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Volumn 180, Issue 2, 2008, Pages 81-84

The contribution of in vitro toxicity data in hazard and risk assessment: Current limitations and future perspectives

Author keywords

In vitro methods; Integrated strategies; Toxicological risk assessment

Indexed keywords

BIOLOGICAL MARKER; LACTATE DEHYDROGENASE;

EID: 48649099822     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.05.008     Document Type: Article
Times cited : (45)

References (39)
  • 1
    • 0026170520 scopus 로고
    • Physiological modelling of organic compounds
    • Andersen M.E. Physiological modelling of organic compounds. Ann. Occup. Hyg. 35 (1991) 309-321
    • (1991) Ann. Occup. Hyg. , vol.35 , pp. 309-321
    • Andersen, M.E.1
  • 2
    • 0029168416 scopus 로고
    • The role of structure-activity relationships and expert systems in alternative strategies for the determination of skin sensitisation, skin corrosivity and eye irritation
    • Barratt M.D. The role of structure-activity relationships and expert systems in alternative strategies for the determination of skin sensitisation, skin corrosivity and eye irritation. Altern. Lab. Anim. 23 (1995) 111-122
    • (1995) Altern. Lab. Anim. , vol.23 , pp. 111-122
    • Barratt, M.D.1
  • 3
    • 0043198212 scopus 로고    scopus 로고
    • Biokinetic and toxicodynamic modelling and its role in toxicological research and risk assessment
    • Blaauboer B.J. Biokinetic and toxicodynamic modelling and its role in toxicological research and risk assessment. Altern. Lab. Anim. 31 (2003) 277-281
    • (2003) Altern. Lab. Anim. , vol.31 , pp. 277-281
    • Blaauboer, B.J.1
  • 4
    • 34247850820 scopus 로고    scopus 로고
    • The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testin initiative. Letter to the Editor
    • Blaauboer B.J., and Andersen M.E. The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testin initiative. Letter to the Editor. Arch. Toxicol. 81 (2007) 385-387
    • (2007) Arch. Toxicol. , vol.81 , pp. 385-387
    • Blaauboer, B.J.1    Andersen, M.E.2
  • 6
    • 0032916246 scopus 로고    scopus 로고
    • The integrated use of alternative methods in toxicological risk evaluation. ECVAM integrated testing strategies task force report 1
    • Blaauboer B.J., Barratt M.D., and Houston J.B. The integrated use of alternative methods in toxicological risk evaluation. ECVAM integrated testing strategies task force report 1. Altern. Lab. Anim. 27 (1999) 229-237
    • (1999) Altern. Lab. Anim. , vol.27 , pp. 229-237
    • Blaauboer, B.J.1    Barratt, M.D.2    Houston, J.B.3
  • 8
    • 0037230506 scopus 로고    scopus 로고
    • An overall strategy for the testing of chemicals for human hazard and risk assessment under the EU REACH System
    • Combes R., Barratt M., and Balls M. An overall strategy for the testing of chemicals for human hazard and risk assessment under the EU REACH System. Altern. Lab. Anim. 31 (2003) 7-19
    • (2003) Altern. Lab. Anim. , vol.31 , pp. 7-19
    • Combes, R.1    Barratt, M.2    Balls, M.3
  • 11
    • 0033179713 scopus 로고    scopus 로고
    • Estimation of systemic toxicity of acrylamide by integration of in vitro data with kinetic simulations
    • DeJongh J., Nordin-Andersen M., Ploeger B.A., and Forsby A. Estimation of systemic toxicity of acrylamide by integration of in vitro data with kinetic simulations. Toxicol. Appl. Pharmacol. 158 (1999) 261-268
    • (1999) Toxicol. Appl. Pharmacol. , vol.158 , pp. 261-268
    • DeJongh, J.1    Nordin-Andersen, M.2    Ploeger, B.A.3    Forsby, A.4
  • 13
    • 34248328303 scopus 로고    scopus 로고
    • Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation
    • Forsby A., and Blaauboer B.J. Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation. Hum. Exp. Toxicol. 26 (2007) 333-338
    • (2007) Hum. Exp. Toxicol. , vol.26 , pp. 333-338
    • Forsby, A.1    Blaauboer, B.J.2
  • 16
    • 48649092458 scopus 로고    scopus 로고
    • Health Council of the Netherlands, 2001. Toxicity testing: a more efficient approach. Health Council of the Netherlands, The Hague. (www.gr.nl/references; 20 November 2001).
    • Health Council of the Netherlands, 2001. Toxicity testing: a more efficient approach. Health Council of the Netherlands, The Hague. (www.gr.nl/references; 20 November 2001).
  • 17
    • 0027427996 scopus 로고
    • Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy
    • Hurni M.A., Noach A.B., Blom-Roosemalen M.C., de Boer A.G., Nagelkerke J.F., and Breimer D.D. Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy. J. Pharmacol. Exp. Ther. 267 (1993) 942-950
    • (1993) J. Pharmacol. Exp. Ther. , vol.267 , pp. 942-950
    • Hurni, M.A.1    Noach, A.B.2    Blom-Roosemalen, M.C.3    de Boer, A.G.4    Nagelkerke, J.F.5    Breimer, D.D.6
  • 18
    • 0021213116 scopus 로고
    • General toxicity testing: sense and non-sense, science and policy
    • Kroes R., and Feron V.J. General toxicity testing: sense and non-sense, science and policy. Fundam. Appl. Toxicol. 4 (1984) 298-308
    • (1984) Fundam. Appl. Toxicol. , vol.4 , pp. 298-308
    • Kroes, R.1    Feron, V.J.2
  • 19
    • 0001880943 scopus 로고
    • Toxicity testing: strategies and conduct
    • Clayson D.B., Munro I.C., Shubik P., and Seenberg J.A. (Eds), Elsevier, Amsterdam
    • Kroes R., and Feron V.J. Toxicity testing: strategies and conduct. In: Clayson D.B., Munro I.C., Shubik P., and Seenberg J.A. (Eds). Progress in Predictive Toxicology (1990), Elsevier, Amsterdam 15-39
    • (1990) Progress in Predictive Toxicology , pp. 15-39
    • Kroes, R.1    Feron, V.J.2
  • 20
    • 26444572796 scopus 로고    scopus 로고
    • The threshold of toxicological concern concept in risk assessment
    • Kroes R., Kleiner J., and Renwick A. The threshold of toxicological concern concept in risk assessment. Toxicol. Sci. 86 (2005) 226-230
    • (2005) Toxicol. Sci. , vol.86 , pp. 226-230
    • Kroes, R.1    Kleiner, J.2    Renwick, A.3
  • 22
    • 0033655573 scopus 로고    scopus 로고
    • Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes
    • LeCluyse E., Madan A., Hamilton G., Carroll K., and DeHaan R.P.A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J. Biochem. Mol. Toxicol. 14 (2000) 177-188
    • (2000) J. Biochem. Mol. Toxicol. , vol.14 , pp. 177-188
    • LeCluyse, E.1    Madan, A.2    Hamilton, G.3    Carroll, K.4    DeHaan, R.P.A.5
  • 23
    • 0037186867 scopus 로고    scopus 로고
    • Currently available in vitro methods used in the regulatory toxicology
    • Liebsch M., and Spielmann H. Currently available in vitro methods used in the regulatory toxicology. Toxicol. Lett. 127 (2002) 127-134
    • (2002) Toxicol. Lett. , vol.127 , pp. 127-134
    • Liebsch, M.1    Spielmann, H.2
  • 24
    • 48649084839 scopus 로고    scopus 로고
    • NAS, 2007. Toxicity testing in the 21st century. A vision and a strategy. Report of the Committee on Toxicity Testing and Assessment of Environmental Agents. National Research Council of The National Academies. The National Academies Press, Washington, DC. (www.nap.edu/catalog/11970.html).
    • NAS, 2007. Toxicity testing in the 21st century. A vision and a strategy. Report of the Committee on Toxicity Testing and Assessment of Environmental Agents. National Research Council of The National Academies. The National Academies Press, Washington, DC. (www.nap.edu/catalog/11970.html).
  • 26
    • 48649106206 scopus 로고    scopus 로고
    • OECD, 2004. OECD Guidelines for the Testing of Chemicals Test No. 432: In Vitro 3T3 NRU Phototoxicity Test.
    • OECD, 2004. OECD Guidelines for the Testing of Chemicals Test No. 432: In Vitro 3T3 NRU Phototoxicity Test.
  • 31
    • 0019083071 scopus 로고
    • Evaluating the mutagenic potential of chemicals. The minimal battery and extrapolation problems
    • Sobels F.H. Evaluating the mutagenic potential of chemicals. The minimal battery and extrapolation problems. Arch. Toxicol. 46 (1980) 21-30
    • (1980) Arch. Toxicol. , vol.46 , pp. 21-30
    • Sobels, F.H.1
  • 33
    • 23944490116 scopus 로고    scopus 로고
    • The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin
    • Treijtel N., van Helvoort H., Barendregt A., Blaauboer B.J., and van Eijkeren J.C.H. The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin. Drug Metab. Dispos. 33 (2005) 1325-1332
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 1325-1332
    • Treijtel, N.1    van Helvoort, H.2    Barendregt, A.3    Blaauboer, B.J.4    van Eijkeren, J.C.H.5
  • 35
    • 33744995562 scopus 로고    scopus 로고
    • Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
    • Verwei M., van Burgsteden J.A., Krul C.A.M., van de Sandt J.J.M., and Freidig A.P. Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling. Toxicol. Lett. 165 (2006) 79-87
    • (2006) Toxicol. Lett. , vol.165 , pp. 79-87
    • Verwei, M.1    van Burgsteden, J.A.2    Krul, C.A.M.3    van de Sandt, J.J.M.4    Freidig, A.P.5
  • 37
    • 0027367950 scopus 로고
    • Cellular methods for identification of neurotoxic chemicals and estimation of neurotoxicological risk
    • Walum E., Nordin M., Beckman M., and Odland L. Cellular methods for identification of neurotoxic chemicals and estimation of neurotoxicological risk. Toxicol. In Vitro 7 (1993) 321-326
    • (1993) Toxicol. In Vitro , vol.7 , pp. 321-326
    • Walum, E.1    Nordin, M.2    Beckman, M.3    Odland, L.4


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