Ozone-derived oxysterols affect liver X receptor (LXR) signaling: A potential role for lipid-protein adducts

Journal of Biological Chemistry

Volumn 291, Issue 48, 2016, Pages 25192-25206

  Speen, Adam M ^a   Kim, Hye Young H ^b   Bauer, Rebecca N ^a   Meyer, Megan ^a   Gowdy, Kymberly M ^c   Fessler, Michael B ^d   Duncan, Kelly E ^a   Liu, Wei ^b   Porter, Ned A ^b   Jaspers, Ilona ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CHEMICAL ACTIVATION; CHOLESTEROL; CYTOLOGY; GENE EXPRESSION; OZONE; PROTEINS;

ADVERSE HEALTH EFFECTS; AIRWAY EPITHELIAL CELLS; ATP-BINDING CASSETTE TRANSPORTER 1; BIOCHEMICAL MECHANISMS; BRONCHOALVEOLAR LAVAGE FLUID; CHOLESTEROL EFFLUX; CYTOKINE PRODUCTION; HUMAN BRONCHIAL EPITHELIAL CELLS;

CELLS;

ABC TRANSPORTER A1; ALKYNYL GROUP; ALPHA SECOSTEROL; BETA SECOSTEROL; EPOXYCHOLESTEROL; FATTY ACID SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; OXYSTEROL; OZONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; ABCA1 PROTEIN, HUMAN; FLUORINATED HYDROCARBON; SULFONAMIDE; TO-901317;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOCHEMISTRY; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHUS MUCOSA; CELL LYSATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; INFLAMMATION; KNOCKOUT MOUSE; LIPID OXIDATION; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATOR GENE; SIGNAL TRANSDUCTION; VOLUNTEER; AGONISTS; ANIMAL; CELL LINE; DRUG EFFECTS; MALE; METABOLISM;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; CELL LINE; FEMALE; HUMANS; HYDROCARBONS, FLUORINATED; LIVER X RECEPTORS; MALE; MICE; OXYSTEROLS; OZONE; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 84998911164     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.732362     Document Type: Article

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