메뉴 건너뛰기




Volumn 11, Issue 12, 2011, Pages 2098-2103

Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats

Author keywords

Acute lung injury; Cytokines; Lipopolysaccharide; Liver X receptors; T0901317

Indexed keywords

CYTOKINE; EOSIN; HEMATOXYLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; MYELOPEROXIDASE; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 81855166664     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.09.002     Document Type: Article
Times cited : (34)

References (26)
  • 1
    • 3242669657 scopus 로고    scopus 로고
    • Inflammation and the acute respiratory distress syndrome
    • DOI 10.1016/j.bpa.2003.12.007, PII S1521689603001216
    • E. Crimi, and A.S. Slutsky Inflammation and the acute respiratory distress syndrome Best Pract Res Clin Anaesthesiol 18 3 2004 477 492 (Pubitemid 38949969)
    • (2004) Best Practice and Research: Clinical Anaesthesiology , vol.18 , Issue.3 , pp. 477-492
    • Crimi, E.1    Slutsky, A.S.2
  • 2
    • 1142299409 scopus 로고    scopus 로고
    • Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    • DOI 10.1002/path.1491
    • M. Bhatia, and S. Moochhala Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome J Pathol 202 2004 145 156 (Pubitemid 38208651)
    • (2004) Journal of Pathology , vol.202 , Issue.2 , pp. 145-156
    • Bhatia, M.1    Moochhala, S.2
  • 3
    • 33746190736 scopus 로고    scopus 로고
    • Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
    • M.F. Osuchowski, K. Welch, J. Siddiqui, and D.G. Remick Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality J Immunol 177 3 2006 1967 1974 (Pubitemid 44092537)
    • (2006) Journal of Immunology , vol.177 , Issue.3 , pp. 1967-1974
    • Osuchowski, M.F.1    Welch, K.2    Siddiqui, J.3    Remick, D.G.4
  • 4
    • 42649131356 scopus 로고    scopus 로고
    • Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and HMGB1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice
    • Q. Gong, H. Yin, M. Fang, Y. Xiang, C.L. Yuan, and G.Y. Zheng Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and HMGB1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice Int Immunopharmacol 8 2008 792 798
    • (2008) Int Immunopharmacol , vol.8 , pp. 792-798
    • Gong, Q.1    Yin, H.2    Fang, M.3    Xiang, Y.4    Yuan, C.L.5    Zheng, G.Y.6
  • 7
    • 17044377563 scopus 로고    scopus 로고
    • Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury
    • K. Fukunaga, P. Kohli, C. Bonnans, L.E. Fredenburgh, and B.D. Levy Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury J Immunol 174 2005 5033 5039
    • (2005) J Immunol , vol.174 , pp. 5033-5039
    • Fukunaga, K.1    Kohli, P.2    Bonnans, C.3    Fredenburgh, L.E.4    Levy, B.D.5
  • 8
    • 55849105651 scopus 로고    scopus 로고
    • Liver X receptors (LXR) as therapeutic targets in dyslipidemia
    • J. Bełtowski Liver X receptors (LXR) as therapeutic targets in dyslipidemia Cardiovasc Ther 26 4 2008 297 316
    • (2008) Cardiovasc Ther , vol.26 , Issue.4 , pp. 297-316
    • Bełtowski, J.1
  • 9
    • 70350244600 scopus 로고    scopus 로고
    • Liver X receptors as potential therapeutic targets in atherosclerosis
    • Y. Zhu, and Y. Li Liver X receptors as potential therapeutic targets in atherosclerosis Clin Invest Med 32 5 2009 E383 E394
    • (2009) Clin Invest Med , vol.32 , Issue.5
    • Zhu, Y.1    Li, Y.2
  • 10
    • 77950461242 scopus 로고    scopus 로고
    • Regulation of cholesterol homeostasis by liver X receptors
    • Y.W. Hu, L. Zheng, and Q. Wang Regulation of cholesterol homeostasis by liver X receptors Clin Chim Acta 411 9-10 2010 617 625
    • (2010) Clin Chim Acta , vol.411 , Issue.910 , pp. 617-625
    • Hu, Y.W.1    Zheng, L.2    Wang, Q.3
  • 11
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • DOI 10.1172/JCI27883
    • N. Zelcer, and P. Tontonoz Liver X receptors as integrators of metabolic and inflammatory signaling J Clin Invest 116 2006 607 614 (Pubitemid 43326865)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 12
    • 67650996739 scopus 로고    scopus 로고
    • Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
    • H. Korf, B.S. Vander, M. Romano, K.R. Steffensen, B. Stijlemans, and J.A. Gustafsson Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice J Clin Invest 119 2009 1626 1637
    • (2009) J Clin Invest , vol.119 , pp. 1626-1637
    • Korf, H.1    Vander, B.S.2    Romano, M.3    Steffensen, K.R.4    Stijlemans, B.5    Gustafsson, J.A.6
  • 13
    • 68949145931 scopus 로고    scopus 로고
    • Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
    • N. Gonzalez, S.J. Bensinger, C. Hong, S. Beceiro, M.N. Bradley, and N. Zelcer Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR Immunity 31 2009 245 258
    • (2009) Immunity , vol.31 , pp. 245-258
    • Gonzalez, N.1    Bensinger, S.J.2    Hong, C.3    Beceiro, S.4    Bradley, M.N.5    Zelcer, N.6
  • 15
    • 79961088146 scopus 로고    scopus 로고
    • Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κb pathway
    • P.D. Solan, G. Piraino, P.W. Hake, A. Denenberg, M. O'Connor, and A. Lentsch Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway Shock 35 4 2011 367 374
    • (2011) Shock , vol.35 , Issue.4 , pp. 367-374
    • Solan, P.D.1    Piraino, G.2    Hake, P.W.3    Denenberg, A.4    O'Connor, M.5    Lentsch, A.6
  • 17
    • 0026787392 scopus 로고
    • High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interkeukin-1, interferon, and elastase, in patients with respiratory distress syndrome after trauma, shock, or sepsis
    • P.M. Suter, S. Suter, E. Girardin, P. Roux-Lombard, G.E. Grau, and J.M. Dayer High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interkeukin-1, interferon, and elastase, in patients with respiratory distress syndrome after trauma, shock, or sepsis Am Rev Respir Dis 145 1992 1016 1022
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1016-1022
    • Suter, P.M.1    Suter, S.2    Girardin, E.3    Roux-Lombard, P.4    Grau, G.E.5    Dayer, J.M.6
  • 18
    • 1542264188 scopus 로고    scopus 로고
    • The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome
    • P. Agouridakis, D. Kyriakou, M.G. Alexandrakis, A. Prekates, K. Perisinakis, and N. Karkavitsas The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome Respir Res 3 2002 25 33
    • (2002) Respir Res , vol.3 , pp. 25-33
    • Agouridakis, P.1    Kyriakou, D.2    Alexandrakis, M.G.3    Prekates, A.4    Perisinakis, K.5    Karkavitsas, N.6
  • 19
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: The leukocyte adhesion cascade updated
    • DOI 10.1038/nri2156, PII NRI2156
    • K. Ley, C. Laudanna, M.I. Cybulsky, and S. Nourshargh Getting to the site of inflammation: the leukocyte adhesion cascade updated Nat Rev Immunol 7 2007 678 689 (Pubitemid 47327397)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.9 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 20
    • 65349157884 scopus 로고    scopus 로고
    • Transepithelial migration of neutrophils: Mechanisms and implications for acute lung injury
    • R.L. Zemans, S.P. Colgan, and G.P. Downey Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Am J Respir Cell Mol Biol 40 5 2009 519 535
    • (2009) Am J Respir Cell Mol Biol , vol.40 , Issue.5 , pp. 519-535
    • Zemans, R.L.1    Colgan, S.P.2    Downey, G.P.3
  • 21
    • 0034536222 scopus 로고    scopus 로고
    • Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury
    • E. Abraham, A. Carmody, R. Shenkar, and J. Arcaroli Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury Am J Physiol Lung Cell Mol Physiol 279 2000 L1137 L1145
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279
    • Abraham, E.1    Carmody, A.2    Shenkar, R.3    Arcaroli, J.4
  • 22
    • 0023552006 scopus 로고
    • Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung
    • G.S. Worthen, C. Haslett, A.J. Rees, R.S. Gumbay, J.E. Henson, and P.M. Henson Neutrophil-mediated pulmonary vascular injury: synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung Am Rev Respir Dis 136 1987 19 28 (Pubitemid 18026428)
    • (1987) American Review of Respiratory Disease , vol.136 , Issue.1 , pp. 19-28
    • Worthen, G.S.1    Haslett, C.2    Rees, A.J.3    Gumbay, R.S.4    Henson, J.E.5    Henson, P.M.6
  • 23
    • 50949130053 scopus 로고    scopus 로고
    • Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins prolongs inflammation
    • D. El-Kebir, L. Jozsef, W. Pan, and J.G. Filep Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins prolongs inflammation Circ Res 103 2008 352 359
    • (2008) Circ Res , vol.103 , pp. 352-359
    • El-Kebir, D.1    Jozsef, L.2    Pan, W.3    Filep, J.G.4
  • 24
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • DOI 10.1038/nm820
    • S.B. Joseph, A. Castrillo, B.A. Laffitte, D.J. Mangelsdorf, and P. Tontonoz Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat Med 9 2003 213 219 (Pubitemid 36227724)
    • (2003) Nature Medicine , vol.9 , Issue.2 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 25
    • 0033827637 scopus 로고    scopus 로고
    • Neutrophil transmigration across human airway epithelial monolayers: Mechanisms and dependence on electrical resistance
    • J.C. Kidney, and D. Proud Neutrophil transmigration across human airway epithelial monolayers: mechanisms and dependence on electrical resistance Am J Respir Cell Mol Biol 23 2000 389 395
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 389-395
    • Kidney, J.C.1    Proud, D.2
  • 26
    • 0026546311 scopus 로고
    • Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms
    • S.K. Lo, J. Everitt, J. Gu, and A.B. Malik Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms J Clin Invest 89 1992 981 988
    • (1992) J Clin Invest , vol.89 , pp. 981-988
    • Lo, S.K.1    Everitt, J.2    Gu, J.3    Malik, A.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.