Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

Chinese Journal of Natural Medicines

Volumn 14, Issue 11, 2016, Pages 856-864

  FENG, Li Xing ^a   SUN, Peng ^a   MI, Tian ^a   LIU, Miao ^a   LIU, Wang ^a   YAO, Si ^a   CAO, Yi Min ^a   YU, Xiao Lu ^a   WU, Wan Ying ^a   JIANG, Bao Hong ^a   YANG, Min ^a   GUO, De An ^a   LIU, Xuan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Agglutinin; Apoptosis; Arisaema heterophyllum Blume; Autophagy; Human non small cell lung cancer A549 cell line

Indexed keywords

AGGLUTININ; ARISEMA HETEROPHYLLUM AGGLUTININ; CASPASE 3; CASPASE 9; ENZYME; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1 ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

A549 CELL LINE; APOPTOSIS; ARISEMA HETEROPHYLLUM; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL ORGANELLE; CHINESE MEDICINE; CLINICAL EVALUATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG PURIFICATION; DRUG PURITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; MEDICINAL PLANT; NON SMALL CELL LUNG CANCER; A-549 CELL LINE; ARISAEMA; CARCINOMA, NON-SMALL-CELL LUNG; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

A549 CELLS; AGGLUTININS; APOPTOSIS; ARISAEMA; AUTOPHAGY; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DRUGS, CHINESE HERBAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84998698801     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(16)30102-9     Document Type: Article

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