Optimal Fluid Therapy for Traumatic Hemorrhagic Shock

Critical Care Clinics

Volumn 33, Issue 1, 2017, Pages 15-36

  Chang, Ronald ^a   Holcomb, John B ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Damage control resuscitation; Hemorrhagic shock; Massive transfusion protocol

Indexed keywords

FIBRINOGEN CONCENTRATE; ISOTONIC SOLUTION; SODIUM CHLORIDE;

ACUTE LUNG INJURY; BLEEDING; BLOOD TRANSFUSION; CONTINUED HEMORRHAGE; CRYOPRECIPITATE; CRYSTALLOID; ERYTHROCYTE TRANSFUSION; FLUID THERAPY; FRESH WHOLE BLOOD TRANSFUSION; HEMORRHAGIC SHOCK; HUMAN; HYPOTENSION; INJURY; ISOTONIC CRYSTALLOID; MULTICENTER STUDY (TOPIC); NONHUMAN; PATIENT ASSESSMENT; PERMISSIVE HYPOTENSION; PLASMA TRANSFUSION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; THERAPY RESISTANCE; THROMBOCYTE TRANSFUSION; TRAUMATIC HEMORRHAGIC SHOCK; TREATMENT OUTCOME; PRACTICE GUIDELINE; RESUSCITATION; SHOCK, HEMORRHAGIC; STANDARDS;

BLOOD TRANSFUSION; FLUID THERAPY; HUMANS; ISOTONIC SOLUTIONS; PRACTICE GUIDELINES AS TOPIC; RESUSCITATION; SHOCK, HEMORRHAGIC;

EID: 84997611268     PISSN: 07490704     EISSN: 15578232     Source Type: Journal    
DOI: 10.1016/j.ccc.2016.08.007     Document Type: Review

References (131)

1. 1 Tien, H.C., Spencer, F., Tremblay, L.N., et al. Preventable deaths from hemorrhage at a level I Canadian trauma center. J Trauma 62 (2007), 142–146.
2. 2 Sauaia, A., Moore, F.A., Moore, E.E., et al. Epidemiology of trauma deaths: a reassessment. J Trauma 38 (1995), 185–193.
3. 3 Eastridge, B.J., Malone, D., Holcomb, J.B., Early predictors of transfusion and mortality after injury: a review of the data-based literature. J Trauma 60:6 Suppl (2006), S20–S25.
4. 4 Holcomb, J.B., del Junco, D.J., Fox, E.E., et al. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg 148 (2013), 127–136.
5. 5 Holcomb, J.B., Tilley, B.C., Baraniuk, S., et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA 313 (2015), 471–482.
6. 6 Simmons, R.L., Collins, J.A., Heisterkamp, C.A., et al. Coagulation disorders in combat casualties I. Acute changes after wounding. II. Effects of massive transfusion. 3. Post-resuscitative changes. Ann Surg 169:4 (1969), 455–482.
7. 7 Khan, S., Allard, S., Weaver, A., et al. A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44:5 (2013), 587–592.
8. 8 Cotton, B.A., Au, B.K., Nunez, T.C., et al. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma 66:1 (2009), 41–48.
9. 9 Yücel, N., Lefering, R., Maegele, M., et al. Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma 60:6 (2006), 1228–1236.
10. 10 McLaughlin, D.F., Niles, S.E., Salinas, J., et al. A predictive model for massive transfusion in combat casualty patients. J Trauma 64:2 Suppl (2008), S57–S63.
11. 11 Cotton, B.A., Dossett, L.A., Haut, E.R., et al. Multicenter validation of a simplified score to predict massive transfusion in trauma. J Trauma 69:Suppl 1 (2010), S33–S39.
12. 12 Pommerening, M.J., Goodman, M.D., Holcomb, J.B., et al. Clinical gestalt and the prediction of massive transfusion after trauma. Injury 46:5 (2015), 807–813.
13. 13 Cotton, B.A., Faz, G., Hatch, Q.M., et al. Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. J Trauma 71:2 (2011), 407–414.
14. 14 Davenport, R., Manson, J., De'Ath, H., et al. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med 39:12 (2011), 2652–2658.
15. 15 Mitra, B., Cameron, P.A., Gruen, R.L., et al. The definition of massive transfusion in trauma: a critical variable in examining evidence for resuscitation. Eur J Emerg Med 18 (2011), 137–142.
16. 16 Savage, S.A., Zarzaur, B.L., Croce, M.A., et al. Redefining massive transfusion when every second counts. J Trauma Acute Care Surg 74:2 (2013), 396–400.
17. 17 Savage, S.A., Sumislawski, J.J., Zarzaur, B.L., et al. The new metric to define large-volume hemorrhage: results of a prospective study of the critical administration threshold. J Trauma Acute Care Surg 78:2 (2015), 224–229.
18. 18 Savage, S.A., Sumislawski, J.J., Croce, M.A., et al. Using critical administration thresholds to predict abbreviated laparotomy. J Trauma Acute Care Surg 77:4 (2014), 599–603.
19. 19 U.S. Navy, Surface ship survivability. 1996, Naval War Publications, Washington, DC.
20. 20 Stone, H.H., Strom, P.R., Mullins, R.J., Management of the major coagulopathy with onset during laparotomy. Ann Surg 197:5 (1983), 532–535.
21. 21 Rotondo, M.F., Schwab, C.W., McGonigal, M.D., et al. 'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury. J Trauma 35:3 (1993), 375–382.
22. 22 Miller, R.S., Morris, J.A. Jr., Diaz, J.J. Jr., Complications after 344 damage-control open celiotomies. J Trauma 59:6 (2005), 1365–1371.
23. 23 Shoemaker, W.C., Montgomery, E.S., Kaplan, E., et al. Physiologic patterns in surviving and nonsurviving shock patients: use of sequential cardiorespiratory variables in defining criteria for therapeutic goals and early warning of death. Arch Surg 106:5 (1973), 630–636.
24. 24 Shoemaker, W.C., Appel, P., Bland, R., Use of physiologic monitoring to predict outcome and to assist in clinical decisions in critically ill postoperative patients. Am J Surg 146:1 (1983), 43–50.
25. 25 Shoemaker, W.C., Appel, P.L., Kram, H.B., et al. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 94:6 (1988), 1176–1186.
26. 26 Shah, S.K., Uray, K.S., Stewart, R.H., et al. Resuscitation-induced intestinal edema and related dysfunction: state of the science. J Surg Res 166:1 (2011), 120–130.
27. 27 Balogh, Z., McKinley, B.A., Cocanour, C.S., et al. Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. Arch Surg 138:6 (2003), 637–642.
28. 28 Cotton, B.A., Guy, J.S., Morris, J.A. Jr., et al. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock 26:2 (2006), 115–121.
29. 29 Lang, F., Busch, G.L., Ritter, M., et al. Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:1 (1998), 247–306.
30. 30 Häussinger, D., Schliess, F., Warskulat, U., et al. Liver cell hydration. Cell Biol Toxicol 13:4–5 (1997), 275–287.
31. 31 Tseng, G.N., Cell swelling increases membrane conductance of canine cardiac cells: evidence for a volume-sensitive Cl channel. Am J Physiol 262:4 Pt 1 (1992), C1056–C1068.
32. 32 Velmahos, G.C., Demetriades, D., Shoemaker, W.C., et al. Endpoints of resuscitation of critically injured patients: normal or supranormal? A prospective randomized trial. Ann Surg 232:3 (2000), 409–418.
33. 33 Lobo, D.N., Bostock, K.A., Neal, K.R., et al. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial. Lancet 359:9320 (2002), 1812–1818.
34. 34 Brandstrup, B., Tønnesen, H., Beier-Holgersen, R., et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg 238:5 (2003), 641–648.
35. 35 Biffl, W.L., Moore, E.E., Burch, J.M., et al. Secondary abdominal compartment syndrome is a highly lethal event. Am J Surg 182:6 (2001), 645–648.
36. 36 Kasotakis, G., Sideris, A., Yang, Y., et al. Aggressive early crystalloid resuscitation adversely affects outcomes in adult blunt trauma patients: an analysis of the Glue Grant database. J Trauma Acute Care Surg 74:5 (2013), 1215–1222.
37. 37 Robinson, B.R., Cotton, B.A., Pritts, T.A., et al. Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia. J Trauma Acute Care Surg 75:1 Suppl 1 (2013), S61–S67.
38. 38 Ley, E.J., Clond, M.A., Srour, M.K., et al. Emergency department crystalloid resuscitation of 1.5 L or more is associated with increased mortality in elderly and nonelderly trauma patients. J Trauma 70:2 (2011), 398–400.
39. 39 Brown, J.B., Cohen, M.J., Minei, J.P., et al. Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis. J Trauma Acute Care Surg 74:5 (2013), 1207–1212.
40. 40 Velasco, I.T., Pontieri, V., Rocha e Silva, M. Jr., et al. Hyperosmotic NaCl and severe hemorrhagic shock. Am J Physiol 239:5 (1980), H664–H673.
41. 41 Mazzoni, M.C., Borgstrom, P., Arfors, K.E., et al. Dynamic fluid redistribution in hyperosmotic resuscitation of hypovolemic hemorrhage. Am J Physiol 255:3 Pt 2 (1988), H629–H637.
42. 42 Junger, W.G., Rhind, S.G., Rizoli, S.B., et al. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock 38:4 (2012), 341–350.
43. 43 Pascual, J.L., Ferri, L.E., Seely, A.J., et al. Hypertonic saline resuscitation of hemorrhagic shock diminishes neutrophil rolling and adherence to endothelium and reduces in vivo vascular leakage. Ann Surg 236:5 (2002), 634–642.
44. 44 Rizoli, S.B., Rhind, S.G., Shek, P.N., et al. The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock: a randomized, controlled, double-blinded trial. Ann Surg 243:1 (2006), 47–57.
45. 45 Bulger, E.M., Cuschieri, J., Warner, K., et al. Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock. Ann Surg 245:4 (2007), 635–641.
46. 46 Bulger, E.M., May, S., Kerby, J.D., et al. Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial. Ann Surg 253:3 (2011), 431–441.
47. 47 Delano, M.J., Rizoli, S.B., Rhind, S.G., et al. Prehospital resuscitation of traumatic hemorrhagic shock with hypertonic solutions worsens hypocoagulation and hyperfibrinolysis. Shock 44:1 (2015), 25–31.
48. 48 Cannon, W.B., Fraser, J., Cowell, E.B., The preventive treatment of wound shock. JAMA 70:9 (1918), 618–621.
49. 49 Sondeen, J.L., Coppes, V.G., Holcomb, J.B., Blood pressure at which rebleeding occurs after resuscitation in swine with aortic injury. J Trauma 54:5 Suppl (2003), S110–S117.
50. 50 Mapstone, J., Roberts, I., Evans, P., Fluid resuscitation strategies: a systematic review of animal trials. J Trauma 55:3 (2003), 571–589.
51. 51 Bickell, W.H., Wall, M.J., Pepe, P.E., et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 331:17 (1994), 1105–1109.
52. 52 Dutton, R.P., Mackenzie, C.F., Scalea, T.M., Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality. J Trauma 52:6 (2002), 1141–1146.
53. 53 Schreiber, M.A., Meier, E.N., Tisherman, S.A., et al. A controlled resuscitation strategy is feasible and safe in hypotensive trauma patients: results of a prospective randomized pilot trial. J Trauma Acute Care Surg 78:4 (2015), 687–695.
54. 54 Chesnut, R.M., Marshall, L.F., Klauber, M.R., et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 34:2 (1993), 216–222.
55. 55 Learoyd, P., The history of blood transfusion prior to the 20th century–part 1. Transfus Med 22:5 (2012), 308–314.
56. 56 Learoyd, P., The history of blood transfusion prior to the 20th century–part 2. Transfus Med 22:6 (2012), 372–376.
57. 57 Johansson, P.I., Stensballe, J., Oliveri, R., et al. How I treat patients with massive hemorrhage. Blood 124:20 (2014), 3052–3058.
58. 58 Borgman, M.A., Spinella, P.C., Perkins, J.G., et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 63:4 (2007), 805–813.
59. 59 Johansson, P.I., Stensballe, J., Rosenberg, I., et al. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion 47:4 (2007), 593–598.
60. 60 Holcomb, J.B., Wade, C.E., Michalek, J.E., et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 248:3 (2008), 447–458.
61. 61 Teixeira, P.G., Inaba, K., Shulman, I., et al. Impact of plasma transfusion in massively transfused trauma patients. J Trauma 66:3 (2009), 693–697.
62. 62 Mitra, B., Mori, A., Cameron, P.A., et al. Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury 41:1 (2010), 35–39.
63. 63 Peiniger, S., Nienaber, U., Lefering, R., et al. Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury. Crit Care, 15(1), 2011, R68.
64. 64 Shrestha, B., Holcomb, J.B., Camp, E.A., et al. Damage-control resuscitation increases successful nonoperative management rates and survival after severe blunt liver injury. J Trauma Acute Care Surg 78:2 (2015), 336–341.
65. 65 Langan, N.R., Eckert, M., Martin, M.J., Changing patterns of in-hospital deaths following implementation of damage control resuscitation practices in US forward military treatment facilities. JAMA Surg 149:9 (2014), 904–912.
66. 66 Gonzalez, E., Moore, E.E., Moore, H.B., et al. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg 263:6 (2016), 1051–1059.
67. 67 Moore, H.B., Moore, E.E., Morton, A.P., et al. Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation. J Trauma Acute Care Surg 79:6 (2015), 897–903.
68. 68 Sillesen, M., Johansson, P.I., Rasmussen, L.S., et al. Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma. J Trauma Acute Care Surg 76:4 (2014), 998–1007.
69. 69 Rahbar, E., Cardenas, J.C., Baimukanova, G., et al. Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients. J Transl Med, 13, 2015, 117.
70. 70 Nieuwdorp, M., Mooij, H.L., Kroon, J., et al. Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. Diabetes 55:4 (2006), 1127–1132.
71. 71 Liang, Y., Li, X., Zhang, X., et al. Elevated levels of plasma TNF-α are associated with microvascular endothelial dysfunction in patients with sepsis through activating the NF-κB and p38 mitogen-activated protein kinase in endothelial cells. Shock 41:4 (2014), 275–281.
72. 72 Rehm, M., Bruegger, D., Christ, F., et al. Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation 116:17 (2007), 1896–1906.
73. 73 Haywood-Watson, R.J., Holcomb, J.B., Gonzalez, E.A., et al. Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation. PLoS One, 6(8), 2011, e23530.
74. 74 Wataha, K., Menge, T., Deng, X., et al. Spray-dried plasma and fresh frozen plasma modulate permeability and inflammation in vitro in vascular endothelial cells. Transfusion 53:Suppl 1 (2013), 80S–90S.
75. 75 Peng, Z., Pati, S., Potter, D., et al. Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1. Shock 40:3 (2013), 195–202.
76. 76 Kozar, R.A., Peng, Z., Zhang, R., et al. Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg 112:6 (2011), 1289–1295.
77. 77 Potter, D.R., Baimukanova, G., Keating, S.M., et al. Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock. J Trauma Acute Care Surg 78:6 Suppl 1 (2015), S7–S17.
78. 78 Jin, G., DeMoya, M.A., Duggan, M., et al. Traumatic brain injury and hemorrhagic shock: evaluation of different resuscitation strategies in a large animal model of combined insults. Shock 38:1 (2012), 49–56.
79. 79 Johansson, P.I., Stensballe, J., Rasmussen, L.S., et al. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg 254:2 (2011), 194–200.
80. 80 Ostrowski, S.R., Johansson, P.I., Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg 73:1 (2012), 60–66.
81. 81 Downes, K.A., Wilson, E., Yomtovian, R., et al. Serial measurement of clotting factors in thawed plasma stored for 5 days. Transfusion, 41(4), 2001, 570.
82. 82 Matijevic, N., Wang, Y.W., Cotton, B.A., et al. Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma. J Trauma Acute Care Surg 74:1 (2013), 84–90.
83. 83 Radwan, Z.A., Bai, Y., Matijevic, N., et al. An emergency department thawed plasma protocol for severely injured patients. JAMA Surg 148:2 (2013), 170–175.
84. 84 Novak, D.J., Bai, Y., Cooke, R.K., et al. Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial. Transfusion 55:6 (2015), 1331–1339.
85. 85 Holcomb, J.B., Donathan, D.P., Cotton, B.A., et al. Prehospital transfusion of plasma and red blood cells in trauma patients. Prehosp Emerg Care 19:1 (2015), 1–9.
86. 86 Moore, E.E., Chin, T.L., Chapman, M.C., et al. Plasma first in the field for postinjury hemorrhagic shock. Shock 41:Suppl 1 (2014), 35–38.
87. 87 Brown, J.B., Guyette, F.X., Neal, M.D., et al. Taking the blood bank to the field: the design and rationale of the Prehospital Air Medical Plasma (PAMPer) trial. Prehosp Emerg Care 19:3 (2015), 343–350.
88. 88 American Red Cross. Blood Types. 2010. Available at. http://givebloodgivelife.org/education/bloodtypes.php. Accessed April 14, 2016.
89. 89 Mair, B., Benson, K., Evaluation of changes in hemoglobin levels associated with ABO-incompatible plasma in apheresis platelets. Transfusion 38 (1998), 51–55.
90. 90 Karafin, M.S., Blagg, L., Tobian, A.A.R., et al. ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions. Transfusion 48 (2012), 2087–2093.
91. 91 Stubbs, J.R., Zielinski, M.D., Berns, K.S., et al. How we provide thawed plasma for trauma patients. Transfusion 55:8 (2015), 1830–1837.
92. 92 Eder, A.F., Dy, B.A., Perez, J.M., et al. The residual risk of transfusion-related acute lung injury at the American Red Cross (2008-2011): limitations of a predominantly male-donor plasma mitigation strategy. Transfusion 53:7 (2013), 1442–1449.
93. 93 Zielinski, M.D., Johnson, P.M., Jenkins, D., et al. Emergency use of prethawed Group A plasma in trauma patients. J Trauma Acute Care Surg 74:1 (2013), 69–74.
94. 94 Zielinski, M.D., Schrager, J.J., Johnson, P., et al. Multicenter comparison of emergency release group A versus AB plasma in blunt-injured trauma patients. Clin Transl Sci 8:1 (2015), 43–47.
95. 95 Chhibber, V., Green, M., Vauthrin, M., et al. Is group A thawed plasma suitable as the first option for emergency release transfusion? (CME). Transfusion 54 (2014), 1751–1755.
96. 96 Dunbar, N.M., Yazer, M.H., Biomedical Excellence for Safer Transfusion (BEST) Collaborative. A possible new paradigm? A survey-based assessment of the use of thawed group A plasma for trauma resuscitation in the United States. Transfusion 56:1 (2016), 125–129.
97. 97 Watson, G.A., Sperry, J.L., Rosengart, M.R., et al. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma 67:2 (2009), 221–227.
98. 98 Johnson, J.L., Moore, E.E., Kashuk, J.L., et al. Effect of blood products transfusion on the development of postinjury multiple organ failure. Arch Surg 145:10 (2010), 973–977.
99. 99 Inaba, K., Branco, B.C., Rhee, P., et al. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg 210:6 (2010), 957–965.
100. 100 Gunter, O.L. Jr., Au, B.K., Isbell, J.M., et al. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma 65:3 (2008), 527–534.
101. 101 Holcomb, J.B., Zarzabal, L.A., Michalek, J.E., et al. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma 71:2 Suppl 3 (2011), S318–S328.
102. 102 Committee on Trauma of the American College of Surgeons. ACS TQIP massive transfusion in trauma guidelines. 2015, American College of Surgeons, Chicago Available at: https://www.facs.org/∼/media/files/quality%20programs/trauma/tqip/massive%20transfusion%20in%20trauma%20guildelines.ashx Accessed April 13, 2016.
103. 103 Spinella, P.C., Reddy, H.L., Jaffe, J.S., et al. Fresh whole blood use for hemorrhagic shock: preserving benefit while avoiding complications. Anesth Analg 115:4 (2012), 751–758.
104. 104 Kauvar, D.S., Holcomb, J.B., Norris, G.C., et al. Fresh whole blood transfusion: a controversial military practice. J Trauma 61:1 (2006), 181–184.
105. 105 Ponschab, M., Schöchl, H., Gabriel, C., et al. Haemostatic profile of reconstituted blood in a proposed 1:1:1 ratio of packed red blood cells, platelet concentrate and four different plasma preparations. Anaesthesia 70:5 (2015), 528–536.
106. 106 Kiraly, L.N., Underwood, S., Differding, J.A., et al. Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients. J Trauma 67:1 (2009), 29–32.
107. 107 Arslan, E., Sierko, E., Waters, J.H., et al. Microcirculatory hemodynamics after acute blood loss followed by fresh and banked blood transfusion. Am J Surg 190:3 (2005), 456–462.
108. 108 Lozano, M.L., Rivera, J., Gonzalez-Conejero, R., et al. Loss of high-affinity thrombin receptors during platelet concentrate storage impairs the reactivity of platelets to thrombin. Transfusion 37:4 (1997), 368–375.
109. 109 Inaba, K., Lustenberger, T., Rhee, P., et al. The impact of platelet transfusion in massively transfused trauma patients. J Am Coll Surg 211:5 (2010), 573–579.
110. 110 Spinella, P.C., Carroll, C.L., Staff, I., et al. Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Crit Care, 13(5), 2009, R151.
111. 111 Weinberg, J.A., McGwin, G. Jr., Vandromme, M.J., et al. Duration of red cell storage influences mortality after trauma. J Trauma 69:6 (2010), 1427–1431.
112. 112 Chandler, M.H., Roberts, M., Sawyer, M., et al. The US military experience with fresh whole blood during the conflicts in Iraq and Afghanistan. Semin Cardiothorac Vasc Anesth 16:3 (2012), 153–159.
113. 113 Spinella, P.C., Perkins, J.G., Grathwohl, K.W., et al. Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma 66:4 Suppl (2009), S69–S76.
114. 114 Nessen, S.C., Eastridge, B.J., Cronk, D., et al. Fresh whole blood use by forward surgical teams in Afghanistan is associated with improved survival compared to component therapy without platelets. Transfusion 53:Suppl 1 (2013), 107S–113S.
115. 115 Strandenes, G., Berséus, O., Cap, A.P., et al. Low titer group O whole blood in emergency situations. Shock 41:Suppl 1 (2014), 70–75.
116. 116 Cotton, B.A., Podbielski, J., Camp, E., et al. A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Ann Surg 258:4 (2013), 527–532.
117. 117 Wang, S.C., Shieh, J.F., Chang, K.Y., et al. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proc 42:7 (2010), 2590–2593.
118. 118 Weber, C.F., Gorlinger, K., Meininger, D., et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 117:3 (2012), 531–547.
119. 119 Kelly, J.M., Callum, J.L., Rizoli, S.B., 1:1:1-warranted or wasteful? even where appropriate, high ratio transfusion protocols are costly: early transition to individualized care benefits patients and transfusion services. Expert Rev Hematol 6:6 (2013), 631–633.
120. 120 Kashuk, J.L., Moore, E.E., Sawyer, M., et al. Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography. Ann Surg 251:4 (2010), 604–614.
121. 121 Nascimento, B., Callum, J., Tien, H., et al. Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-results-guided transfusion in patients with severe trauma: a randomized feasibility trial. CMAJ 185:12 (2013), 583–589.
122. 122 Tapia, N.M., Chang, A., Norman, M., et al. TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients. J Trauma Acute Care Surg 74:2 (2013), 378–385.
123. 123 Ho, A.M., Holcomb, J.B., Ng, C.S., et al. The traditional vs “1:1:1”approach debate on massive transfusion in trauma should not be treated as a dichotomy. Am J Emerg Med 33:10 (2015), 1501–1504.
124. 124 Charbit, B., Mandelbrot, L., Samain, E., et al. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 5:2 (2007), 266–273.
125. 125 Karlsson, M., Ternstrom, L., Hyllner, M., et al. Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. Thromb Haemost 102:1 (2009), 137–144.
126. 126 Rossaint, R., Bouillon, B., Cerny, V., et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care, 20(1), 2016, 100.
127. 127 Chambers, L.A., Chow, S.J., Shaffer, L.E., Frequency and characteristics of coagulopathy in trauma patients treated with a low- or high-plasma-content massive transfusion protocol. Am J Clin Pathol 136:3 (2011), 364–370.
128. 128 Morrison, J.J., Ross, J.D., Dubose, J.J., et al. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. JAMA Surg 148:3 (2013), 218–225.
129. 129 Maegele, M., Zinser, M., Schlimp, C., et al. Injectable hemostatic adjuncts in trauma: fibrinogen and the FIinTIC study. J Trauma Acute Care Surg 78:6 Suppl 1 (2015), S76–S82.
130. 130 Bux, J., Sachs, U.J., The pathogenesis of transfusion-related acute lung injury (TRALI). Br J Haematol 136:6 (2007), 788–799.
131. 131 National Institute for Health and Care Excellence. Major trauma: assessment and initial management, NICE guideline: short version, draft for consultation, August 2015. London, UK: 2016. p. 9. Available at: https://www.nice.org.uk/guidance/ng39/resources/major-trauma-assessment-and-initial-management-1837400761285. Accessed September 15, 2016.