Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-results-guided transfusion in patients with severe trauma: A randomized feasibility trial

CMAJ. Canadian Medical Association Journal

Volumn 185, Issue 12, 2013, Pages

  Nascimento, Bartolomeu ^a   Callum, Jeannie ^b,c   Tien, Homer ^a,d   Rubenfeld, Gordon ^a   Pinto, Ruxandra ^a   Lin, Yulia ^b,c   Rizoli, Sandro ^d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANISOCORIA; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BRAIN INJURY; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE SEVERITY; ERYTHROCYTE TRANSFUSION; FEASIBILITY STUDY; FEMALE; GLASGOW COMA SCALE; HUMAN; HYPOTENSION; INJURY; INTERMETHOD COMPARISON; LABORATORY RESULT GUIDED TRANSFUSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PARALLEL DESIGN; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; TERTIARY HEALTH CARE; TRANSFUSION;

EID: 84883486566     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.121986     Document Type: Article

References (25)

1. Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion 2006;46:685-6.
2. Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma 2007;62:307-10.
3. Zink KA, Sambasivan CN, Holcomb JB, et al. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg 2009;197:565-70.
4. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007; 63:805-13. (Pubitemid 350287298)
5. Cotton BA, Gunter OL, Isbell J, et al. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma 2008;64:1177-82. (Pubitemid 351671208)
6. Maegele M, Lefering R, Paffrath T, et al. Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 2008;95:112-9. (Pubitemid 351951900)
7. Snyder CW, Weinberg JA, McGwin G Jr, et al. The relationship of blood product ratio to mortality: Survival benefit or survival bias? J Trauma 2009;66:358-62.
8. Ho AM, Dion PW, Yeung JH, et al. Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion. Anesthesiology 2012; 116: 716-28.
9. Nascimento B, Callum J, Rubenfeld G, et al. Clinical review: fresh frozen plasma in massive bleedings - more questions than answers. Crit Care 2010;14:202.
10. Dzik WH, Blajchman MA, Fergusson D, et al. Clinical review: Canadian National Advisory Committee on Blood and Blood Products - massive transfusion consensus conference 2011: report of the panel. Crit Care 2011;15:242.
11. Young PP, Cotton BA, Goodnough LT. Massive transfusion protocols for patients with substantial hemorrhage. Transfus Med Rev 2011;25:293-303.
12. Levi M, Fries D, Gombotz H, et al. Prevention and treatment of coagulopathy in patients receiving massive transfusions. Vox Sang 2011;101:154-74.
13. Smoot D, Park M, Osborn J, et al. Pre-hospital thawed plasma: a preliminary report. Proceedings of the 41st annual meeting of Western Trauma Association; 2011 Feb. 27-Mar. 4; Big Sky (MT). Paper 36:116.
14. Forcione DG, Alam HB, Kalva SP, et al. Case records of the Massachusetts General Hospital. Case 9-2009. An 81-year-old man with massive rectal bleeding. N Engl J Med 2009; 360: 1239-48.
15. Saule I, Hawkins N. Transfusion practice in major obstetric haemorrhage: lessons from trauma. Int J Obstet Anesth 2012; 21: 79-83.
16. Petrides M, Stack G, Cooling L, et al. Carbohydrate blood group antigens and collections. In: Practical guide to transfusion medicine. 2nd ed. Bethesda (MD): AABB Press; 2007. p. 59-91.
17. Inaba K, Branco BC, Rhee P, et al. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg 2010;210:957-65.
18. Nascimento B, Rizoli S, Rubenfeld G, et al. Design and preliminary results of a pilot randomized controlled trial on a 1:1:1 transfusion strategy: the trauma formula-driven versus laboratory- guided study. J Trauma 2011;71(Suppl 1):S418-26.
19. Tri-Council policy statement: ethical conduct for research involving humans [article 3.8]. Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, and Social Sciences and Humanities Research Council of Canada; 2010. Available: www.pre.ethics.gc.ca/pdf/eng/tcps2/ TCPS-2-FINAL-Web.pdf (accessed 2012 June 12).
20. Ranieri VM, Rubenfeld GD, Thompson BT, et al.; ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307:2526-33.
21. Bulger EM, Jurkovich GJ, Nathens AB, et al. Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg 2008;143:139-48, discussion 149.
22. Transfusion Transmitted Injuries Surveillance System: user's manual, version 3.0. Ottawa (ON): Public Health Agency of Canada; 2007. Available: www.phac-aspc.gc.ca/hcai-iamss/tti-it/pdf/users-manual 07-e.pdf (accessed 2012 June 12).
23. Blood and blood components [Table 2]. Mississauga (ON): Canadian Standards Association; 2010. p. 98.
24. Eder AF, Herron RM Jr, Strupp A, et al. Effective reduction of transfusion-related acute lung injury risk with male-predominant plasma strategy in the American Red Cross (2006-2008). Transfusion 2010;50:1732-42.
25. Arnold DM, Burns KE, Adhikari NK, et al.; McMaster Critical Care Interest Group. The design and interpretation of pilot trials in clinical research in critical care. Crit Care Med 2009; 37 (Suppl 1): S69-74.