Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation

Shock

Volumn 38, Issue 4, 2012, Pages 341-350

  Junger, Wolfgang G ^a   Rhind, Shawn G ^b   Rizoli, Sandro B ^c   Cuschieri, Joseph ^d   Shiu, Maria Y ^c   Baker, Andrew J ^e   Li, Linglin ^a   Shek, Pang N ^b   Hoyt, David B ^f   Bulger, Eileen M ^d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF WASHINGTON   (United States)

^e ST MICHAEL'S HOSPITAL   (Canada)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

adhesion molecules; hemorrhage; Hypertonic saline; inflammation; matrix metalloproteinase; multiorgan failure; myeloperoxidase; neutrophils; resuscitation fluids; shock

Indexed keywords

CD11B ANTIGEN; CD63 ANTIGEN; CD64 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; DEXTRAN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; MYELOPEROXIDASE; PADGEM PROTEIN; SODIUM CHLORIDE; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL ADHESION; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEGRANULATION; DOUBLE BLIND PROCEDURE; EMERGENCY CARE; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; FLUID RESUSCITATION; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; HYPOVOLEMIC SHOCK; IMMUNOASSAY; INFLAMMATION; INJURY; LEUKOCYTE ACTIVATION; LEUKOCYTOSIS; MALE; MORTALITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; NEUTROPHIL; OXIDATIVE STRESS; UPREGULATION;

ADOLESCENT; ADULT; AGED; ANIMALS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; HUMANS; HYPOVOLEMIA; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; NEUTROPHIL ACTIVATION; NEUTROPHILS; RESUSCITATION; SALINE SOLUTION, HYPERTONIC; SHOCK, HEMORRHAGIC; WOUNDS AND INJURIES;

EID: 84866631204     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182635aca     Document Type: Article

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