Prehospital resuscitation of traumatic hemorrhagic shock with hypertonic solutions worsens hypocoagulation and hyperfibrinolysis

Shock

Volumn 44, Issue 1, 2015, Pages 25-31

  Delano, Matthew J ^a,h   Rizoli, Sandro B ^c   Rhind, Shawn G ^d   Cuschieri, Joseph ^e   Junger, Wolfgang ^a   Baker, Andrew J ^f   Dubick, Michael A ^g   Hoyt, David B ^b   Bulger, Eileen M ^e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c St Michael's Hospital   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF WASHINGTON   (United States)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^h UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

Author keywords

coagulopathy; d dimers; hemostasis; Hypertonic saline; physiopathology; thrombin activatable fibrinolysis inhibitor; thrombomodulin; tissue factor; tissue factor pathway inhibitor; tissue plasminogen activator; underlying mechanisms

Indexed keywords

DEXTRAN 70; HYPERTONIC SOLUTION; LACTIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; SODIUM CHLORIDE; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR; THROMBOPLASTIN; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; BLOOD CLOTTING DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; EMERGENCY CARE; FEMALE; FIBRINOLYSIS; FLUID RESUSCITATION; HEMOGLOBIN BLOOD LEVEL; HEMORRHAGIC SHOCK; HUMAN; HYPERFIBRINOLYSIS; HYPOCOAGULABILITY; HYPOVOLEMIC SHOCK; INTERNATIONAL NORMALIZED RATIO; MALE; OBSERVATIONAL STUDY; OSMOLARITY; PROSPECTIVE STUDY; SYSTOLIC BLOOD PRESSURE; ADVERSE EFFECTS; AGED; BLOOD; CHEMICALLY INDUCED; CLINICAL TRIAL; EMERGENCY HEALTH SERVICE; HEMORRHAGE; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; RESUSCITATION; WOUNDS AND INJURIES;

ADULT; AGED; BLOOD COAGULATION DISORDERS; EMERGENCY MEDICAL SERVICES; FEMALE; HEMORRHAGE; HUMANS; HYPERTONIC SOLUTIONS; MALE; MIDDLE AGED; RESUSCITATION; WOUNDS AND INJURIES;

EID: 84930903977     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000368     Document Type: Article

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