메뉴 건너뛰기




Volumn 36, Issue 47, 2016, Pages 11837-11850

Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment

Author keywords

Calcium; Channels; Dendrites; Hippocampus; Imaging; Synapse

Indexed keywords

CALCIUM CHANNEL; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; LENTIVIRUS VECTOR; PRESENILIN; STROMAL INTERACTION MOLECULE 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; CALCIUM; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 2; ORAI2 PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, MOUSE;

EID: 84997285813     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1188-16.2016     Document Type: Article
Times cited : (123)

References (82)
  • 1
    • 84876393414 scopus 로고    scopus 로고
    • Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1DeltaE9 mice
    • CrossRef Medline
    • Abbott AC, Calderon Toledo C, Aranguiz FC, Inestrosa NC, Varela-Nallar L (2013) Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1DeltaE9 mice. J Alzheimers Dis 34:873-885. CrossRef Medline
    • (2013) J Alzheimers Dis , vol.34 , pp. 873-885
    • Abbott, A.C.1    Calderon Toledo, C.2    Aranguiz, F.C.3    Inestrosa, N.C.4    Varela-Nallar, L.5
  • 2
    • 77149133728 scopus 로고    scopus 로고
    • Progressive age-related impairment of the late long-term potentiation in Alzheimer’s disease presenilin-1 mutant knock-in mice
    • CrossRef Medline
    • Auffret A, Gautheron V, Mattson MP, Mariani J, Rovira C (2010) Progressive age-related impairment of the late long-term potentiation in Alzheimer’s disease presenilin-1 mutant knock-in mice. J Alzheimers Dis 19: 1021-1033. CrossRef Medline
    • (2010) J Alzheimers Dis , vol.19 , pp. 1021-1033
    • Auffret, A.1    Gautheron, V.2    Mattson, M.P.3    Mariani, J.4    Rovira, C.5
  • 4
    • 84879813477 scopus 로고    scopus 로고
    • The synaptic maintenance problem: Membrane recycling, Ca2+ homeostasis and late onset degeneration
    • CrossRef Medline
    • Bezprozvanny I, Hiesinger PR (2013) The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration. Mol Neurodegener 8:23. CrossRef Medline
    • (2013) Mol Neurodegener , vol.8 , pp. 23
    • Bezprozvanny, I.1    Hiesinger, P.R.2
  • 5
    • 34249933982 scopus 로고    scopus 로고
    • Do thin spines learn to be mushroom spines that remember?
    • CrossRef Medline
    • Bourne J, Harris KM (2007) Do thin spines learn to be mushroom spines that remember? Curr Opin Neurobiol 17:381-386. CrossRef Medline
    • (2007) Curr Opin Neurobiol , vol.17 , pp. 381-386
    • Bourne, J.1    Harris, K.M.2
  • 6
    • 43449117577 scopus 로고    scopus 로고
    • Balancing structure and function at hippocampal dendritic spines
    • CrossRef Medline
    • Bourne JN, Harris KM (2008) Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci 31:47-67. CrossRef Medline
    • (2008) Annu Rev Neurosci , vol.31 , pp. 47-67
    • Bourne, J.N.1    Harris, K.M.2
  • 7
    • 84878834027 scopus 로고    scopus 로고
    • Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-beta plaques, 4-hydroxynonenal formation, and caspase-3 activation in AbetaPP/PS1 mice
    • CrossRef Medline
    • Carvajal FJ, Zolezzi JM, Tapia-Rojas C, Godoy JA, Inestrosa NC (2013) Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-beta plaques, 4-hydroxynonenal formation, and caspase-3 activation in AbetaPP/PS1 mice. J Alzheimers Dis 36:99-118. CrossRef Medline
    • (2013) J Alzheimers Dis , vol.36 , pp. 99-118
    • Carvajal, F.J.1    Zolezzi, J.M.2    Tapia-Rojas, C.3    Godoy, J.A.4    Inestrosa, N.C.5
  • 9
    • 77949746346 scopus 로고    scopus 로고
    • The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer’s mouse model
    • CrossRef Medline
    • Cerpa W, Hancke JL, Morazzoni P, Bombardelli E, Riva A, Marin PP, Inestrosa NC (2010) The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer’s mouse model. Curr Alzheimer Res 7:126-133. CrossRef Medline
    • (2010) Curr Alzheimer Res , vol.7 , pp. 126-133
    • Cerpa, W.1    Hancke, J.L.2    Morazzoni, P.3    Bombardelli, E.4    Riva, A.5    Marin, P.P.6    Inestrosa, N.C.7
  • 10
    • 68049134265 scopus 로고    scopus 로고
    • Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice
    • CrossRef Medline
    • Chakroborty S, Goussakov I, Miller MB, Stutzmann GE (2009) Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. J Neurosci 29:9458-9470. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 9458-9470
    • Chakroborty, S.1    Goussakov, I.2    Miller, M.B.3    Stutzmann, G.E.4
  • 12
    • 79953709412 scopus 로고    scopus 로고
    • Local Ca(2)+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca(2)+ signals required for specific cell functions
    • CrossRef Medline
    • Cheng KT, Liu X, Ong HL, Swaim W, Ambudkar IS (2011) Local Ca(2)+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca(2)+ signals required for specific cell functions. PLoS Biol 9:e1001025. CrossRef Medline
    • (2011) Plos Biol , vol.9
    • Cheng, K.T.1    Liu, X.2    Ong, H.L.3    Swaim, W.4    Ambudkar, I.S.5
  • 13
    • 45149098247 scopus 로고    scopus 로고
    • Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels
    • CrossRef Medline
    • Cheng KT, Liu X, Ong HL, Ambudkar IS (2008) Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J Biol Chem 283: 12935-12940. CrossRef Medline
    • (2008) J Biol Chem , vol.283 , pp. 12935-12940
    • Cheng, K.T.1    Liu, X.2    Ong, H.L.3    Ambudkar, I.S.4
  • 14
    • 84880710197 scopus 로고    scopus 로고
    • Contribution and regulation of TRPC channels in store-operated Ca2+ entry
    • CrossRef Medline
    • Cheng KT, Ong HL, Liu X, Ambudkar IS (2013) Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr Top Membr 71:149-179. CrossRef Medline
    • (2013) Curr Top Membr , vol.71 , pp. 149-179
    • Cheng, K.T.1    Ong, H.L.2    Liu, X.3    Ambudkar, I.S.4
  • 16
    • 77952919805 scopus 로고    scopus 로고
    • Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1
    • CrossRef Medline
    • Covington ED, Wu MM, Lewis RS (2010) Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1. Mol Biol Cell 21:1897-1907. CrossRef Medline
    • (2010) Mol Biol Cell , vol.21 , pp. 1897-1907
    • Covington, E.D.1    Wu, M.M.2    Lewis, R.S.3
  • 17
    • 33750284656 scopus 로고    scopus 로고
    • Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer’s amyloid-beta-deposits
    • CrossRef Medline
    • Dinamarca MC, Cerpa W, Garrido J, Hancke JL, Inestrosa NC (2006) Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer’s amyloid-beta-deposits. Mol Psychiatry 11:1032-1048. CrossRef Medline
    • (2006) Mol Psychiatry , vol.11 , pp. 1032-1048
    • Dinamarca, M.C.1    Cerpa, W.2    Garrido, J.3    Hancke, J.L.4    Inestrosa, N.C.5
  • 18
    • 77951119463 scopus 로고    scopus 로고
    • Targeting TRPC6 channels in oesophageal carcinoma growth
    • CrossRef Medline
    • Ding X, He Z, Shi Y, Wang Q, Wang Y (2010a) Targeting TRPC6 channels in oesophageal carcinoma growth. Expert Opin Ther Targets 14:513-527. CrossRef Medline
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 513-527
    • Ding, X.1    He, Z.2    Shi, Y.3    Wang, Q.4    Wang, Y.5
  • 22
    • 69249152563 scopus 로고    scopus 로고
    • Molecular determinants of the coupling between STIM1 and Orai channels: Differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant
    • CrossRef Medline
    • Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C (2009) Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant. J Biol Chem 284:21696-21706. CrossRef Medline
    • (2009) J Biol Chem , vol.284 , pp. 21696-21706
    • Frischauf, I.1    Muik, M.2    Derler, I.3    Bergsmann, J.4    Fahrner, M.5    Schindl, R.6    Groschner, K.7    Romanin, C.8
  • 23
    • 84946489377 scopus 로고    scopus 로고
    • Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
    • CrossRef Medline
    • Griesi-Oliveira K et al. (2015) Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry 20:1350-1365. CrossRef Medline
    • (2015) Mol Psychiatry , vol.20 , pp. 1350-1365
    • Griesi-Oliveira, K.1
  • 24
    • 84883739485 scopus 로고    scopus 로고
    • Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons
    • CrossRef Medline
    • Gruszczynska-Biegala J, Kuznicki J (2013) Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons. J Neurochem 126:727-738. CrossRef Medline
    • (2013) J Neurochem , vol.126 , pp. 727-738
    • Gruszczynska-Biegala, J.1    Kuznicki, J.2
  • 25
    • 0033016172 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
    • CrossRef Medline
    • Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP (1999) Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 5:101-106. CrossRef Medline
    • (1999) Nat Med , vol.5 , pp. 101-106
    • Guo, Q.1    Fu, W.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6    Mattson, M.P.7
  • 26
    • 84886020200 scopus 로고    scopus 로고
    • TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling
    • CrossRef Medline
    • Heiser JH, Schuwald AM, Sillani G, Ye L, Müller WE, Leuner K (2013) TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem 127:303-313. CrossRef Medline
    • (2013) J Neurochem , vol.127 , pp. 303-313
    • Heiser, J.H.1    Schuwald, A.M.2    Sillani, G.3    Ye, L.4    Müller, W.E.5    Leuner, K.6
  • 27
    • 80051959475 scopus 로고    scopus 로고
    • Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1)
    • CrossRef Medline
    • Hoover PJ, Lewis RS (2011) Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A 108:13299-13304. CrossRef Medline
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13299-13304
    • Hoover, P.J.1    Lewis, R.S.2
  • 28
    • 84880743513 scopus 로고    scopus 로고
    • The neglected CRAC proteins: Orai2, Orai3, and STIM2
    • CrossRef Medline
    • Hoth M, Niemeyer BA (2013) The neglected CRAC proteins: Orai2, Orai3, and STIM2. Curr Top Membr 71:237-271. CrossRef Medline
    • (2013) Curr Top Membr , vol.71 , pp. 237-271
    • Hoth, M.1    Niemeyer, B.A.2
  • 29
    • 33748136477 scopus 로고    scopus 로고
    • STIM1 carboxyl-terminus activates native SOC, I(Crac) and TRPC1 channels
    • CrossRef Medline
    • Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF (2006) STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol 8:1003-1010. CrossRef Medline
    • (2006) Nat Cell Biol , vol.8 , pp. 1003-1010
    • Huang, G.N.1    Zeng, W.2    Kim, J.Y.3    Yuan, J.P.4    Han, L.5    Muallem, S.6    Worley, P.F.7
  • 32
    • 66549127486 scopus 로고    scopus 로고
    • Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways
    • CrossRef Medline
    • Jardin I, Gómez LJ, Salido GM, Rosado JA (2009) Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways. Biochem J 420: 267-276. CrossRef Medline
    • (2009) Biochem J , vol.420 , pp. 267-276
    • Jardin, I.1    Gómez, L.J.2    Salido, G.M.3    Rosado, J.A.4
  • 33
    • 0038015543 scopus 로고    scopus 로고
    • Structure-stability-function relationships of dendritic spines
    • CrossRef Medline
    • Kasai H, Matsuzaki M, Noguchi J, Yasumatsu N, Nakahara H (2003) Structure-stability-function relationships of dendritic spines. Trends Neurosci 26:360-368. CrossRef Medline
    • (2003) Trends Neurosci , vol.26 , pp. 360-368
    • Kasai, H.1    Matsuzaki, M.2    Noguchi, J.3    Yasumatsu, N.4    Nakahara, H.5
  • 34
    • 77953697547 scopus 로고    scopus 로고
    • Better tolerability of St. John’s wort extract WS 5570 compared to treatment with SSRIs: A reanalysis of data from controlled clinical trials in acute major depression
    • CrossRef Medline
    • Kasper S, Gastpar M, Möller HJ, Müller WE, Volz HP, Dienel A, Kieser M (2010) Better tolerability of St. John’s wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression. Int Clin Psychopharmacol 25:204-213. CrossRef Medline
    • (2010) Int Clin Psychopharmacol , vol.25 , pp. 204-213
    • Kasper, S.1    Gastpar, M.2    Möller, H.J.3    Müller, W.E.4    Volz, H.P.5    Dienel, A.6    Kieser, M.7
  • 37
    • 85007147418 scopus 로고    scopus 로고
    • The role of the store-operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity
    • CrossRef Medline
    • Korkotian E, Oni-Biton E, Segal M (2016) The role of the store-operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity. J Physiol. In press. CrossRef Medline
    • (2016) J Physiol
    • Korkotian, E.1    Oni-Biton, E.2    Segal, M.3
  • 42
    • 42949155291 scopus 로고    scopus 로고
    • Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels
    • CrossRef Medline
    • Liao Y, Erxleben C, Abramowitz J, Flockerzi V, Zhu MX, Armstrong DL, Birnbaumer L (2008) Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad SciU S A 105:2895-2900. CrossRef Medline
    • (2008) Proc Natl Acad Sciu S A , vol.105 , pp. 2895-2900
    • Liao, Y.1    Erxleben, C.2    Abramowitz, J.3    Flockerzi, V.4    Zhu, M.X.5    Armstrong, D.L.6    Birnbaumer, L.7
  • 43
    • 62549126542 scopus 로고    scopus 로고
    • A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry
    • CrossRef Medline
    • Liao Y, Plummer NW, George MD, Abramowitz J, Zhu MX, Birnbaumer L (2009) A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry. Proc Natl Acad Sci U S A 106:3202-3206. CrossRef Medline
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3202-3206
    • Liao, Y.1    Plummer, N.W.2    George, M.D.3    Abramowitz, J.4    Zhu, M.X.5    Birnbaumer, L.6
  • 45
    • 84952629974 scopus 로고    scopus 로고
    • SOCE in neurons: Signaling or just refilling?
    • Medline
    • Majewski L, Kuznicki J 2015 SOCE in neurons: signaling or just refilling? Biochim Biophys Acta 1853:1940-1952. Medline
    • (2015) Biochim Biophys Acta , vol.1853 , pp. 1940-1952
    • Majewski, L.1    Kuznicki, J.2
  • 46
    • 33747643506 scopus 로고    scopus 로고
    • Large store-operated calcium selective currents due to coexpression of Orai1 or Orai2 with the intracellular calcium sensor
    • CrossRef Medline
    • Mercer JC, Dehaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS, Putney JW Jr (2006) Large store-operated calcium selective currents due to coexpression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem 281:24979-24990. CrossRef Medline
    • (2006) Stim1. J Biol Chem , vol.281 , pp. 24979-24990
    • Mercer, J.C.1    Dehaven, W.I.2    Smyth, J.T.3    Wedel, B.4    Boyles, R.R.5    Bird, G.S.6    Putney, J.W.7
  • 47
    • 84865754533 scopus 로고    scopus 로고
    • STIM1 is necessary for store-operated calcium entry in turning growth cones
    • CrossRef Medline
    • Mitchell CB, Gasperini RJ, Small DH, Foa L (2012) STIM1 is necessary for store-operated calcium entry in turning growth cones. J Neurochem 122: 1155-1166. CrossRef Medline
    • (2012) J Neurochem , vol.122 , pp. 1155-1166
    • Mitchell, C.B.1    Gasperini, R.J.2    Small, D.H.3    Foa, L.4
  • 48
    • 84926308403 scopus 로고    scopus 로고
    • Effects of tetrahydrohyperforin in mouse hippocampal slices: Neuroprotection, long-term potentiation and TRPC channels
    • CrossRef Medline
    • Montecinos-Oliva C, Schuller A, Parodi J, Melo F, Inestrosa NC (2014) Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and TRPC channels. Curr Med Chem 21: 3494-3506. CrossRef Medline
    • (2014) Curr Med Chem , vol.21 , pp. 3494-3506
    • Montecinos-Oliva, C.1    Schuller, A.2    Parodi, J.3    Melo, F.4    Inestrosa, N.C.5
  • 49
    • 66749085475 scopus 로고    scopus 로고
    • A Cytosolic homomerization and a modulatory domain within STIM1 C terminus determine coupling to ORAI1 channels
    • CrossRef Medline
    • Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C (2009) A Cytosolic homomerization and a modulatory domain within STIM1 C terminus determine coupling to ORAI1 channels. J Biol Chem 284:8421-8426. CrossRef Medline
    • (2009) J Biol Chem , vol.284 , pp. 8421-8426
    • Muik, M.1    Fahrner, M.2    Derler, I.3    Schindl, R.4    Bergsmann, J.5    Frischauf, I.6    Groschner, K.7    Romanin, C.8
  • 51
    • 34247898911 scopus 로고    scopus 로고
    • Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in storeoperated and calcium release-activated calcium channel components
    • CrossRef Medline
    • Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS (2007) Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in storeoperated and calcium release-activated calcium channel components. J Biol Chem 282:9105-9116. CrossRef Medline
    • (2007) J Biol Chem , vol.282 , pp. 9105-9116
    • Ong, H.L.1    Cheng, K.T.2    Liu, X.3    Bandyopadhyay, B.C.4    Paria, B.C.5    Soboloff, J.6    Pani, B.7    Gwack, Y.8    Srikanth, S.9    Singh, B.B.10    Gill, D.L.11    Gill, D.12    Ambudkar, I.S.13
  • 53
    • 84885072179 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease
    • CrossRef Medline
    • Popugaeva E, Bezprozvanny I (2013) Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease. Front Mol Neurosci 6:29. CrossRef Medline
    • (2013) Front Mol Neurosci , vol.6 , pp. 29
    • Popugaeva, E.1    Bezprozvanny, I.2
  • 54
    • 84880139689 scopus 로고    scopus 로고
    • Presenilins, deranged calcium homeostasis, synaptic loss and dysfunction in Alzheimer’s disease
    • CrossRef
    • Popugaeva E, C. Supnet, and I. Bezprozvanny (2012) Presenilins, deranged calcium homeostasis, synaptic loss and dysfunction in Alzheimer’s disease. Messenger 1:53-62. CrossRef
    • (2012) Messenger , vol.1 , pp. 53-62
    • Popugaeva, E.1    Supnet, C.2    Bezprozvanny, I.3
  • 57
    • 44349154735 scopus 로고    scopus 로고
    • Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images
    • CrossRef Medline
    • Rodriguez A, Ehlenberger DB, Dickstein DL, Hof PR, Wearne SL (2008) Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images. PLoS One 3:e1997. CrossRef Medline
    • (2008) Plos One , vol.3
    • Rodriguez, A.1    Ehlenberger, D.B.2    Dickstein, D.L.3    Hof, P.R.4    Wearne, S.L.5
  • 59
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer’s disease is a synaptic failure
    • CrossRef Medline
    • Selkoe DJ (2002) Alzheimer’s disease is a synaptic failure. Science 298:789-791. CrossRef Medline
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 60
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • CrossRef Medline
    • Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27:2866-2875. CrossRef Medline
    • (2007) J Neurosci , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 63
    • 84865223570 scopus 로고    scopus 로고
    • Phosphoregulation of STIM1 leads to exclusion of the endoplasmic reticulum from the mitotic spindle
    • Medline
    • Smyth JT, Beg AM, Wu S, Putney JW Jr, Rusan NM 2012 Phosphoregulation of STIM1 leads to exclusion of the endoplasmic reticulum from the mitotic spindle. Curr Biol 22:1487-1493. Medline
    • (2012) Curr Biol , vol.22 , pp. 1487-1493
    • Smyth, J.T.1    Beg, A.M.2    Wu, S.3    Putney, J.W.4    Rusan, N.M.5
  • 64
    • 84880754162 scopus 로고    scopus 로고
    • Structure and function of endoplasmic reticulum STIM calcium sensors
    • CrossRef Medline
    • Stathopulos PB, Ikura M (2013) Structure and function of endoplasmic reticulum STIM calcium sensors. Curr Top Membr 71:59-93. CrossRef Medline
    • (2013) Curr Top Membr , vol.71 , pp. 59-93
    • Stathopulos, P.B.1    Ikura, M.2
  • 65
    • 84897463426 scopus 로고    scopus 로고
    • Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice
    • CrossRef Medline
    • Sun S, Zhang H, Liu J, Popugaeva E, Xu NJ, Feske S, White CL 3rd, Bezprozvanny I (2014a) Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron 82:79-93. CrossRef Medline
    • (2014) Neuron , vol.82 , pp. 79-93
    • Sun, S.1    Zhang, H.2    Liu, J.3    Popugaeva, E.4    Xu, N.J.5    Feske, S.6    White, C.L.7    Bezprozvanny, I.8
  • 66
    • 84924910859 scopus 로고    scopus 로고
    • Physiological function and characterization of TRPCs in neurons
    • CrossRef Medline
    • Sun Y, Sukumaran P, Bandyopadhyay BC, Singh BB (2014b) Physiological function and characterization of TRPCs in neurons. Cells 3:455-475. CrossRef Medline
    • (2014) Cells , vol.3 , pp. 455-475
    • Sun, Y.1    Sukumaran, P.2    Bandyopadhyay, B.C.3    Singh, B.B.4
  • 67
    • 67149099836 scopus 로고    scopus 로고
    • Thin, stubby or mushroom: Spine pathology in Alzheimer’s disease
    • CrossRef Medline
    • Tackenberg C, Ghori A, Brandt R (2009) Thin, stubby or mushroom: spine pathology in Alzheimer’s disease. Curr Alzheimer Res 6:261-268. CrossRef Medline
    • (2009) Curr Alzheimer Res , vol.6 , pp. 261-268
    • Tackenberg, C.1    Ghori, A.2    Brandt, R.3
  • 68
    • 49649088696 scopus 로고    scopus 로고
    • TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
    • CrossRef Medline
    • Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, Wang Y (2008) TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 121:2301-2307. CrossRef Medline
    • (2008) J Cell Sci , vol.121 , pp. 2301-2307
    • Tai, Y.1    Feng, S.2    Ge, R.3    Du, W.4    Zhang, X.5    He, Z.6    Wang, Y.7
  • 70
    • 84920842347 scopus 로고    scopus 로고
    • Oligomeric Abeta-induced synaptic dysfunction in Alzheimer’s disease
    • CrossRef Medline
    • Tu S, Okamoto S, Lipton SA, Xu H (2014) Oligomeric Abeta-induced synaptic dysfunction in Alzheimer’s disease. Mol Neurodegener 9:48. CrossRef Medline
    • (2014) Mol Neurodegener , vol.9 , pp. 48
    • Tu, S.1    Okamoto, S.2    Lipton, S.A.3    Xu, H.4
  • 71
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • CrossRef Medline
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539. CrossRef Medline
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 72
    • 84947604855 scopus 로고    scopus 로고
    • TRPC6 specifically interacts with APP to inhibit its cleavage by gamma-secretase and reduce Abeta production
    • CrossRef Medline
    • Wang J, Lu R, Yang J, Li H, He Z, Jing N, Wang X, Wang Y (2015) TRPC6 specifically interacts with APP to inhibit its cleavage by gamma-secretase and reduce Abeta production. Nat Commun 6:8876. CrossRef Medline
    • (2015) Nat Commun , vol.6 , pp. 8876
    • Wang, J.1    Lu, R.2    Yang, J.3    Li, H.4    He, Z.5    Jing, N.6    Wang, X.7    Wang, Y.8
  • 74
    • 61849107063 scopus 로고    scopus 로고
    • SOAR and the polybasic STIM1 domains gate and regulate Orai channels
    • CrossRef Medline
    • Yuan JP, Zeng W, Dorwart MR, Choi YJ, Worley PF, Muallem S (2009) SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol 11:337-343. CrossRef Medline
    • (2009) Nat Cell Biol , vol.11 , pp. 337-343
    • Yuan, J.P.1    Zeng, W.2    Dorwart, M.R.3    Choi, Y.J.4    Worley, P.F.5    Muallem, S.6
  • 75
    • 55049099696 scopus 로고    scopus 로고
    • STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction
    • CrossRef Medline
    • Zeng W, Yuan JP, Kim MS, Choi YJ, Huang GN, Worley PF, Muallem S (2008) STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell 32:439-448. CrossRef Medline
    • (2008) Mol Cell , vol.32 , pp. 439-448
    • Zeng, W.1    Yuan, J.P.2    Kim, M.S.3    Choi, Y.J.4    Huang, G.N.5    Worley, P.F.6    Muallem, S.7
  • 77
    • 77954123379 scopus 로고    scopus 로고
    • Role of presenilins in neuronal calcium homeostasis
    • CrossRef Medline
    • Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I (2010) Role of presenilins in neuronal calcium homeostasis. J Neurosci 30:8566-8580. CrossRef Medline
    • (2010) J Neurosci , vol.30 , pp. 8566-8580
    • Zhang, H.1    Sun, S.2    Herreman, A.3    De Strooper, B.4    Bezprozvanny, I.5
  • 78
    • 84925366380 scopus 로고    scopus 로고
    • Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer’s disease
    • CrossRef Medline
    • Zhang H, Liu J, Sun S, Pchitskaya E, Popugaeva E, Bezprozvanny I (2015a) Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer’s disease. J Alzheimers Dis 45:561-580. CrossRef Medline
    • (2015) J Alzheimers Dis , vol.45 , pp. 561-580
    • Zhang, H.1    Liu, J.2    Sun, S.3    Pchitskaya, E.4    Popugaeva, E.5    Bezprozvanny, I.6
  • 79
    • 84942863993 scopus 로고    scopus 로고
    • Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-inmousemodel of Alzheimer’s disease
    • CrossRef Medline
    • Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, Bezprozvanny I (2015b) Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-inmousemodel of Alzheimer’s disease. J Neurosci 35:13275-13286. CrossRef Medline
    • (2015) J Neurosci , vol.35 , pp. 13275-13286
    • Zhang, H.1    Wu, L.2    Pchitskaya, E.3    Zakharova, O.4    Saito, T.5    Saido, T.6    Bezprozvanny, I.7
  • 81
    • 46049112457 scopus 로고    scopus 로고
    • Critical role of TRPC6 channels in the formation of excitatory synapses
    • CrossRef Medline
    • Zhou J, Du W, Zhou K, Tai Y, Yao H, Jia Y, Ding Y, Wang Y (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci 11:741-743. CrossRef Medline
    • (2008) Nat Neurosci , vol.11 , pp. 741-743
    • Zhou, J.1    Du, W.2    Zhou, K.3    Tai, Y.4    Yao, H.5    Jia, Y.6    Ding, Y.7    Wang, Y.8
  • 82
    • 84892756265 scopus 로고    scopus 로고
    • Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Abeta and Abeta-AChE complex challenge in rat hippocampal neurons
    • CrossRef Medline
    • Zolezzi JM, Carvajal FJ, Ríos JA, Ordenes D, Silva-Alvarez C, Godoy JA, Inestrosa NC (2013) Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Abeta and Abeta-AChE complex challenge in rat hippocampal neurons. J Alzheimers Dis 37:735-746. CrossRef Medline
    • (2013) J Alzheimers Dis , vol.37 , pp. 735-746
    • Zolezzi, J.M.1    Carvajal, F.J.2    Ríos, J.A.3    Ordenes, D.4    Silva-Alvarez, C.5    Godoy, J.A.6    Inestrosa, N.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.