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Volumn 7, Issue APR, 2016, Pages

Heat shock protein-Peptide and HSP-based immunotherapies for the treatment of cancer

Author keywords

Adaptive immunity; Cancer vaccine; HSP70 heat shock proteins; HSP90 heat shock proteins; Innate immunity

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90;

EID: 84966714463     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00171     Document Type: Short Survey
Times cited : (147)

References (86)
  • 1
    • 0022534393 scopus 로고
    • Tumor rejection antigens of chemically induced sarcomas of inbred mice
    • Srivastava PK, DeLeo AB, Old LJ. Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci U S A (1986) 83:3407-11. doi: 10.1073/pnas.83.10.3407
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 3407-3411
    • Srivastava, P.K.1    DeLeo, A.B.2    Old, L.J.3
  • 3
    • 0036214288 scopus 로고    scopus 로고
    • Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses
    • Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol (2002) 20:395-425. doi:10.1146/annurev.immunol.20.100301.064801
    • (2002) Annu Rev Immunol , vol.20 , pp. 395-425
    • Srivastava, P.1
  • 4
    • 0034252620 scopus 로고    scopus 로고
    • CD91: a receptor for heat shock protein gp96
    • Binder RJ, Han DK, Srivastava PK. CD91: a receptor for heat shock protein gp96. Nat Immunol (2000) 1:151-5. doi:10.1038/77835
    • (2000) Nat Immunol , vol.1 , pp. 151-155
    • Binder, R.J.1    Han, D.K.2    Srivastava, P.K.3
  • 5
    • 70349235599 scopus 로고    scopus 로고
    • T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1
    • Gong J, Zhu B, Murshid A, Adachi H, Song B, Lee A, et al. T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1. J Immunol (2009) 183:3092-8. doi:10.4049/jimmunol.0901235
    • (2009) J Immunol , vol.183 , pp. 3092-3098
    • Gong, J.1    Zhu, B.2    Murshid, A.3    Adachi, H.4    Song, B.5    Lee, A.6
  • 6
    • 84902194486 scopus 로고    scopus 로고
    • Heat-shock proteins-based immunotherapy for advanced melanoma in the era of target therapies and immunomodulating agents
    • Tosti G, Cocorocchio E, Pennacchioli E, Ferrucci PF, Testori A, Martinoli C. Heat-shock proteins-based immunotherapy for advanced melanoma in the era of target therapies and immunomodulating agents. Expert Opin Biol Ther (2014) 14:955-67. doi:10.1517/14712598.2014.902928
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 955-967
    • Tosti, G.1    Cocorocchio, E.2    Pennacchioli, E.3    Ferrucci, P.F.4    Testori, A.5    Martinoli, C.6
  • 7
    • 0345305789 scopus 로고    scopus 로고
    • Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells
    • Berwin B, Hart JP, Rice S, Gass C, Pizzo SV, Post SR, et al. Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBO J (2003) 22:6127-36. doi:10.1093/emboj/cdg572
    • (2003) EMBO J , vol.22 , pp. 6127-6136
    • Berwin, B.1    Hart, J.P.2    Rice, S.3    Gass, C.4    Pizzo, S.V.5    Post, S.R.6
  • 8
    • 33847260278 scopus 로고    scopus 로고
    • Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
    • Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrancois L, et al. Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 26:215-26. doi:10.1016/j.immuni.2006.12.005
    • (2007) Immunity , vol.26 , pp. 215-226
    • Yang, Y.1    Liu, B.2    Dai, J.3    Srivastava, P.K.4    Zammit, D.J.5    Lefrancois, L.6
  • 9
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest (2010) 120:457-71. doi:10.1172/JCI40483
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Remy-Martin, J.P.6
  • 10
  • 11
    • 0034113617 scopus 로고    scopus 로고
    • HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    • Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med (2000) 6:435-42. doi:10.1038/74697
    • (2000) Nat Med , vol.6 , pp. 435-442
    • Asea, A.1    Kraeft, S.K.2    Kurt-Jones, E.A.3    Stevenson, M.A.4    Chen, L.B.5    Finberg, R.W.6
  • 12
  • 13
    • 0037144808 scopus 로고    scopus 로고
    • CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes
    • Becker T, Hartl FU, Wieland F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol (2002) 158:1277-85. doi:10.1083/jcb.200208083
    • (2002) J Cell Biol , vol.158 , pp. 1277-1285
    • Becker, T.1    Hartl, F.U.2    Wieland, F.3
  • 14
    • 0031945664 scopus 로고    scopus 로고
    • Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response
    • Botzler C, Li G, Issels RD, Multhoff G. Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response. Cell Stress Chaperones (1998) 3:6-11. doi:10.1379/1466-1268(1998)003<0006:DOELEO>2.3.CO;2
    • (1998) Cell Stress Chaperones , vol.3 , pp. 6-11
    • Botzler, C.1    Li, G.2    Issels, R.D.3    Multhoff, G.4
  • 15
    • 0032727033 scopus 로고    scopus 로고
    • Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells
    • Multhoff G, Mizzen L, Winchester CC, Milner CM, Wenk S, Eissner G, et al. Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol (1999) 27:1627-36. doi:10.1016/S0301-472X(99)00104-6
    • (1999) Exp Hematol , vol.27 , pp. 1627-1636
    • Multhoff, G.1    Mizzen, L.2    Winchester, C.C.3    Milner, C.M.4    Wenk, S.5    Eissner, G.6
  • 16
    • 0037298742 scopus 로고    scopus 로고
    • Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94
    • Gross C, Hansch D, Gastpar R, Multhoff G. Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94. Biol Chem (2003) 384:267-79. doi:10.1515/BC.2003.030
    • (2003) Biol Chem , vol.384 , pp. 267-279
    • Gross, C.1    Hansch, D.2    Gastpar, R.3    Multhoff, G.4
  • 17
    • 84906274976 scopus 로고    scopus 로고
    • Effective immunotherapy of rat glioblastoma with prolonged intra-tumoral delivery of exogenous heat shock protein Hsp70
    • Shevtsov MA, Pozdnyakov AV, Mikhrina AL, Yakovleva LY, Nikolaev BP, Dobrodumov AV, et al. Effective immunotherapy of rat glioblastoma with prolonged intra-tumoral delivery of exogenous heat shock protein Hsp70. Int J Cancer (2014) 135:2118-28. doi:10.1002/ijc.28858
    • (2014) Int J Cancer , vol.135 , pp. 2118-2128
    • Shevtsov, M.A.1    Pozdnyakov, A.V.2    Mikhrina, A.L.3    Yakovleva, L.Y.4    Nikolaev, B.P.5    Dobrodumov, A.V.6
  • 18
    • 84902985997 scopus 로고    scopus 로고
    • Pilot study of intra-tumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children
    • Shevtsov MA, Kim AV, Samochernych KA, Romanova IV, Margulis BA, Guzhova IV, et al. Pilot study of intra-tumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children. Onco Targets Ther (2014) 7:1071-81. doi:10.2147/OTT.S62764
    • (2014) Onco Targets Ther , vol.7 , pp. 1071-1081
    • Shevtsov, M.A.1    Kim, A.V.2    Samochernych, K.A.3    Romanova, I.V.4    Margulis, B.A.5    Guzhova, I.V.6
  • 19
    • 0027208741 scopus 로고
    • Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation
    • Li Z, Srivastava PK. Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation. EMBO J (1993) 12:3143-51
    • (1993) EMBO J , vol.12 , pp. 3143-3151
    • Li, Z.1    Srivastava, P.K.2
  • 20
    • 0027260585 scopus 로고
    • Heat shock protein 70-associated peptides elicit specific cancer immunity
    • Udono H, Srivastava PK. Heat shock protein 70-associated peptides elicit specific cancer immunity. J Exp Med (1993) 178:1391-6. doi:10.1084/jem.178.4.1391
    • (1993) J Exp Med , vol.178 , pp. 1391-1396
    • Udono, H.1    Srivastava, P.K.2
  • 21
    • 0028261389 scopus 로고
    • Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo
    • Udono H, Levey DL, Srivastava PK. Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo. Proc Natl Acad Sci U S A (1994) 91:3077-81. doi:10.1073/pnas.91.8.3077
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3077-3081
    • Udono, H.1    Levey, D.L.2    Srivastava, P.K.3
  • 22
    • 0031172626 scopus 로고    scopus 로고
    • Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens
    • Srivastava PK. Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogens. Methods (1997) 12:165-71. doi:10.1006/meth.1997.0464
    • (1997) Methods , vol.12 , pp. 165-171
    • Srivastava, P.K.1
  • 23
    • 0342547302 scopus 로고    scopus 로고
    • Purification of immunogenic heat shock protein 70-peptide complexes by ADP-affinity chromatography
    • Peng P, Menoret A, Srivastava PK. Purification of immunogenic heat shock protein 70-peptide complexes by ADP-affinity chromatography. J Immunol Methods (1997) 204:13-21. doi:10.1016/S0022-1759(97)00017-3
    • (1997) J Immunol Methods , vol.204 , pp. 13-21
    • Peng, P.1    Menoret, A.2    Srivastava, P.K.3
  • 24
    • 0028000105 scopus 로고
    • Heat shock proteins in immune response to cancer: the fourth paradigm
    • Srivastava PK. Heat shock proteins in immune response to cancer: the fourth paradigm. Experientia (1994) 50:1054-60. doi:10.1007/BF01923461
    • (1994) Experientia , vol.50 , pp. 1054-1060
    • Srivastava, P.K.1
  • 25
    • 0037389073 scopus 로고    scopus 로고
    • Gene vaccines
    • Srivastava IK, Liu MA. Gene vaccines. Ann Intern Med (2003) 138:550-9. doi:10.7326/0003-4819-138-7-200304010-00011
    • (2003) Ann Intern Med , vol.138 , pp. 550-559
    • Srivastava, I.K.1    Liu, M.A.2
  • 26
    • 3242811091 scopus 로고    scopus 로고
    • Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II
    • SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, et al. Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II. J Immunol (2004) 173:1987-93. doi:10.4049/jimmunol.173.3.1987
    • (2004) J Immunol , vol.173 , pp. 1987-1993
    • SenGupta, D.1    Norris, P.J.2    Suscovich, T.J.3    Hassan-Zahraee, M.4    Moffett, H.F.5    Trocha, A.6
  • 27
    • 0030775140 scopus 로고    scopus 로고
    • Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
    • Blachere NE, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, et al. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med (1997) 186:1315-22. doi:10.1084/jem.186.8.1315
    • (1997) J Exp Med , vol.186 , pp. 1315-1322
    • Blachere, N.E.1    Li, Z.2    Chandawarkar, R.Y.3    Suto, R.4    Jaikaria, N.S.5    Basu, S.6
  • 28
    • 0037108696 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings
    • Belli F, Testori A, Rivoltini L, Maio M, Andreola G, Sertoli MR, et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol (2002) 20:4169-80. doi:10.1200/JCO.2002.09.134
    • (2002) J Clin Oncol , vol.20 , pp. 4169-4180
    • Belli, F.1    Testori, A.2    Rivoltini, L.3    Maio, M.4    Andreola, G.5    Sertoli, M.R.6
  • 29
    • 0028979675 scopus 로고
    • A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
    • Suto R, Srivastava PK. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science (1995) 269:1585-8. doi:10.1126/science.7545313
    • (1995) Science , vol.269 , pp. 1585-1588
    • Suto, R.1    Srivastava, P.K.2
  • 30
    • 0037111218 scopus 로고    scopus 로고
    • Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells
    • Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJ, Kuppner MC, et al. Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J Immunol (2002) 169:5424-32. doi:10.4049/jimmunol.169.10.5424
    • (2002) J Immunol , vol.169 , pp. 5424-5432
    • Noessner, E.1    Gastpar, R.2    Milani, V.3    Brandl, A.4    Hutzler, P.J.5    Kuppner, M.C.6
  • 31
    • 84865175386 scopus 로고    scopus 로고
    • The role of heat shock proteins in antigen cross presentation
    • Murshid A, Gong J, Calderwood SK. The role of heat shock proteins in antigen cross presentation. Front Immunol (2012) 3:63. doi:10.3389/fimmu.2012.00063
    • (2012) Front Immunol , vol.3 , pp. 63
    • Murshid, A.1    Gong, J.2    Calderwood, S.K.3
  • 32
    • 0034284227 scopus 로고    scopus 로고
    • Saturation, competition, and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ cells
    • Binder RJ, Harris ML, Menoret A, Srivastava PK. Saturation, competition, and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ cells. J Immunol (2000) 165:2582-7. doi:10.4049/jimmunol.165.5.2582
    • (2000) J Immunol , vol.165 , pp. 2582-2587
    • Binder, R.J.1    Harris, M.L.2    Menoret, A.3    Srivastava, P.K.4
  • 33
    • 0035070198 scopus 로고    scopus 로고
    • CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
    • Basu S, Binder RJ, Ramalingam T, Srivastava PK. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity (2001) 14:303-13. doi:10.1016/S1074-7613(01)00111-X
    • (2001) Immunity , vol.14 , pp. 303-313
    • Basu, S.1    Binder, R.J.2    Ramalingam, T.3    Srivastava, P.K.4
  • 34
    • 80054761699 scopus 로고    scopus 로고
    • Investigating receptors for extracellular heat shock proteins
    • Murshid A, Theriault J, Gong J, Calderwood SK. Investigating receptors for extracellular heat shock proteins. Methods Mol Biol (2011) 787:289-302. doi:10.1007/978-1-61779-295-3_22
    • (2011) Methods Mol Biol , vol.787 , pp. 289-302
    • Murshid, A.1    Theriault, J.2    Gong, J.3    Calderwood, S.K.4
  • 35
    • 84939777720 scopus 로고    scopus 로고
    • Emerging roles for scavenger receptor SREC-I in immunity
    • Murshid A, Borges TJ, Calderwood SK. Emerging roles for scavenger receptor SREC-I in immunity. Cytokine (2015) 75:256-60. doi:10.1016/j.cyto.2015.02.009
    • (2015) Cytokine , vol.75 , pp. 256-260
    • Murshid, A.1    Borges, T.J.2    Calderwood, S.K.3
  • 36
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: role of TLR2 and TLR4
    • Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, et al. Novel signal transduction pathway utilized by extracellular HSP70: role of TLR2 and TLR4. J Biol Chem (2002) 277:15028-34. doi:10.1074/jbc.M200497200
    • (2002) J Biol Chem , vol.277 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3    Boch, J.A.4    Bare, O.5    Auron, P.E.6
  • 37
    • 0033120990 scopus 로고    scopus 로고
    • Cutting edge: receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
    • Arnold-Schild D, Hanau D, Spehner D, Schmid C, Rammensee HG, de la SH, et al. Cutting edge: receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells. J Immunol (1999) 162:3757-60
    • (1999) J Immunol , vol.162 , pp. 3757-3760
    • Arnold-Schild, D.1    Hanau, D.2    Spehner, D.3    Schmid, C.4    Rammensee, H.G.5    de la, S.H.6
  • 38
    • 0345299172 scopus 로고    scopus 로고
    • The dual nature of specific immunological activity of tumor-derived gp96 preparations
    • Chandawarkar RY, Wagh MS, Srivastava PK. The dual nature of specific immunological activity of tumor-derived gp96 preparations. J Exp Med (1999) 189:1437-42. doi:10.1084/jem.189.9.1437
    • (1999) J Exp Med , vol.189 , pp. 1437-1442
    • Chandawarkar, R.Y.1    Wagh, M.S.2    Srivastava, P.K.3
  • 39
    • 1842854683 scopus 로고    scopus 로고
    • Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis
    • Chandawarkar RY, Wagh MS, Kovalchin JT, Srivastava P. Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis. Int Immunol (2004) 16:615-24. doi:10.1093/intimm/dxh063
    • (2004) Int Immunol , vol.16 , pp. 615-624
    • Chandawarkar, R.Y.1    Wagh, M.S.2    Kovalchin, J.T.3    Srivastava, P.4
  • 40
    • 84871397752 scopus 로고    scopus 로고
    • CD91-dependent modulation of immune responses by heat shock proteins: a role in autoimmunity
    • Binder RJ, Zhou YJ, Messmer MN, Pawaria S. CD91-dependent modulation of immune responses by heat shock proteins: a role in autoimmunity. Autoimmune Dis (2012) 2012:863041. doi:10.1155/2012/863041
    • (2012) Autoimmune Dis , vol.2012
    • Binder, R.J.1    Zhou, Y.J.2    Messmer, M.N.3    Pawaria, S.4
  • 41
    • 4043126112 scopus 로고    scopus 로고
    • Heat shock protein-based cancer vaccines
    • Oki Y, Younes A. Heat shock protein-based cancer vaccines. Expert Rev Vaccines (2004) 3:403-11. doi:10.1586/14760584.3.4.403
    • (2004) Expert Rev Vaccines , vol.3 , pp. 403-411
    • Oki, Y.1    Younes, A.2
  • 42
    • 0033819308 scopus 로고    scopus 로고
    • Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot study
    • Janetzki S, Palla D, Rosenhauer V, Lochs H, Lewis JJ, Srivastava PK. Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot study. Int J Cancer (2000) 88:232-8. doi:10.1002/1097-0215(20001015)88:2<232::AID-IJC14>3.0.CO;2-8
    • (2000) Int J Cancer , vol.88 , pp. 232-238
    • Janetzki, S.1    Palla, D.2    Rosenhauer, V.3    Lochs, H.4    Lewis, J.J.5    Srivastava, P.K.6
  • 43
    • 33644636996 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines
    • Srivastava PK. Therapeutic cancer vaccines. Curr Opin Immunol (2006) 18:201-5. doi:10.1016/j.coi.2006.01.009
    • (2006) Curr Opin Immunol , vol.18 , pp. 201-205
    • Srivastava, P.K.1
  • 44
    • 12144290005 scopus 로고    scopus 로고
    • Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer
    • Castelli C, Rivoltini L, Rini F, Belli F, Testori A, Maio M, et al. Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer. Cancer Immunol Immunother (2004) 53:227-33. doi:10.1007/s00262-003-0481-9
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 227-233
    • Castelli, C.1    Rivoltini, L.2    Rini, F.3    Belli, F.4    Testori, A.5    Maio, M.6
  • 45
    • 33646348754 scopus 로고    scopus 로고
    • A Phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes Gp96, in combination with GM-CSF and interferon-alpha in metastatic melanoma patients
    • Pilla L, Patuzzo R, Rivoltini L, Maio M, Pennacchioli E, Lamaj E, et al. A Phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes Gp96, in combination with GM-CSF and interferon-alpha in metastatic melanoma patients. Cancer Immunol Immunother (2006) 55:958-68. doi:10.1007/s00262-005-0084-8
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 958-968
    • Pilla, L.1    Patuzzo, R.2    Rivoltini, L.3    Maio, M.4    Pennacchioli, E.5    Lamaj, E.6
  • 46
    • 39749186213 scopus 로고    scopus 로고
    • Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group
    • Testori A, Richards J, Whitman E, Mann GB, Lutzky J, Camacho L, et al. Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group. J Clin Oncol (2008) 26:955-62. doi:10.1200/JCO.2007.11.9941
    • (2008) J Clin Oncol , vol.26 , pp. 955-962
    • Testori, A.1    Richards, J.2    Whitman, E.3    Mann, G.B.4    Lutzky, J.5    Camacho, L.6
  • 47
    • 33645325115 scopus 로고    scopus 로고
    • Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized Phase III trial of the DC study group of the DeCOG
    • Schadendorf D, Ugurel S, Schuler-Thurner B, Nestle FO, Enk A, Brocker EB, et al. Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized Phase III trial of the DC study group of the DeCOG. Ann Oncol (2006) 17:563-70. doi:10.1093/annonc/mdj138
    • (2006) Ann Oncol , vol.17 , pp. 563-570
    • Schadendorf, D.1    Ugurel, S.2    Schuler-Thurner, B.3    Nestle, F.O.4    Enk, A.5    Brocker, E.B.6
  • 48
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
    • Nestle FO, Alijagic S, Gilliet M, Sun Y, Grabbe S, Dummer R, et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med (1998) 4:328-32. doi:10.1038/nm0398-328
    • (1998) Nat Med , vol.4 , pp. 328-332
    • Nestle, F.O.1    Alijagic, S.2    Gilliet, M.3    Sun, Y.4    Grabbe, S.5    Dummer, R.6
  • 49
    • 10744233222 scopus 로고    scopus 로고
    • Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer
    • Mazzaferro V, Coppa J, Carrabba MG, Rivoltini L, Schiavo M, Regalia E, et al. Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. Clin Cancer Res (2003) 9:3235-45
    • (2003) Clin Cancer Res , vol.9 , pp. 3235-3245
    • Mazzaferro, V.1    Coppa, J.2    Carrabba, M.G.3    Rivoltini, L.4    Schiavo, M.5    Regalia, E.6
  • 50
    • 54149097564 scopus 로고    scopus 로고
    • A vaccine for renal cancer
    • Wood C. A vaccine for renal cancer. Lancet (2008) 372:1460-1. doi:10.1016/S0140-6736(08)61615-3
    • (2008) Lancet , vol.372 , pp. 1460-1461
    • Wood, C.1
  • 51
    • 33645272083 scopus 로고    scopus 로고
    • Phase I trial of vaccination with autologous tumor-derived gp96 in patients after surgery for gastric cancer
    • Hertkorn C, Lehr A, Wölfel T, Junginger T, Dippold WG, Galle PR, et al. Phase I trial of vaccination with autologous tumor-derived gp96 in patients after surgery for gastric cancer. Proc Am Soc Clin Oncol (2002) 21:30a
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 30a
    • Hertkorn, C.1    Lehr, A.2    Wölfel, T.3    Junginger, T.4    Dippold, W.G.5    Galle, P.R.6
  • 52
    • 0038357724 scopus 로고    scopus 로고
    • Pilot trial of vaccination with autologous tumor-derived GP96 heat shock protein-peptide complex (HSPPC-96) in patients after surgery for gastric carcinoma
    • Heike M, Hertkorn C, Reitsma DJ, Kommoss F, Simiantonaki N, Woelfel T, et al. Pilot trial of vaccination with autologous tumor-derived GP96 heat shock protein-peptide complex (HSPPC-96) in patients after surgery for gastric carcinoma. Proc Am Soc Clin Oncol (2000) 19:1825
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 1825
    • Heike, M.1    Hertkorn, C.2    Reitsma, D.J.3    Kommoss, F.4    Simiantonaki, N.5    Woelfel, T.6
  • 53
    • 34347380750 scopus 로고    scopus 로고
    • A Phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinoma
    • Maki RG, Livingston PO, Lewis JJ, Janetzki S, Klimstra D, Desantis D, et al. A Phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinoma. Dig Dis Sci (2007) 52:1964-72. doi:10.1007/s10620-006-9205-2
    • (2007) Dig Dis Sci , vol.52 , pp. 1964-1972
    • Maki, R.G.1    Livingston, P.O.2    Lewis, J.J.3    Janetzki, S.4    Klimstra, D.5    Desantis, D.6
  • 54
    • 2942679464 scopus 로고    scopus 로고
    • What ASCO does for its members
    • Hammond DB. What ASCO does for its members. J Clin Oncol (2004) 22:2251-2. doi:10.1200/JCO.2004.99.075
    • (2004) J Clin Oncol , vol.22 , pp. 2251-2252
    • Hammond, D.B.1
  • 55
    • 84893073441 scopus 로고    scopus 로고
    • Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a Phase II, single-arm trial
    • Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, et al. Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a Phase II, single-arm trial. Neuro Oncol (2014) 16:274-9. doi:10.1093/neuonc/not203
    • (2014) Neuro Oncol , vol.16 , pp. 274-279
    • Bloch, O.1    Crane, C.A.2    Fuks, Y.3    Kaur, R.4    Aghi, M.K.5    Berger, M.S.6
  • 56
    • 0038712092 scopus 로고    scopus 로고
    • Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells
    • Gehrmann M, Schmetzer H, Eissner G, Haferlach T, Hiddemann W, Multhoff G. Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells. Haematologica (2003) 88:474-6
    • (2003) Haematologica , vol.88 , pp. 474-476
    • Gehrmann, M.1    Schmetzer, H.2    Eissner, G.3    Haferlach, T.4    Hiddemann, W.5    Multhoff, G.6
  • 57
    • 0031132876 scopus 로고    scopus 로고
    • Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells
    • Multhoff G, Botzler C, Jennen L, Schmidt J, Ellwart J, Issels R. Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. J Immunol (1997) 158:4341-50
    • (1997) J Immunol , vol.158 , pp. 4341-4350
    • Multhoff, G.1    Botzler, C.2    Jennen, L.3    Schmidt, J.4    Ellwart, J.5    Issels, R.6
  • 58
    • 0028953056 scopus 로고
    • A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells
    • Multhoff G, Botzler C, Wiesnet M, Muller E, Meier T, Wilmanns W, et al. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer (1995) 61:272-9. doi:10.1002/ijc.2910610222
    • (1995) Int J Cancer , vol.61 , pp. 272-279
    • Multhoff, G.1    Botzler, C.2    Wiesnet, M.3    Muller, E.4    Meier, T.5    Wilmanns, W.6
  • 59
    • 0037470247 scopus 로고    scopus 로고
    • Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function
    • Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem (2003) 278:7607-16. doi:10.1074/jbc.M210455200
    • (2003) J Biol Chem , vol.278 , pp. 7607-7616
    • Shin, B.K.1    Wang, H.2    Yim, A.M.3    Le Naour, F.4    Brichory, F.5    Jang, J.H.6
  • 60
    • 79551657031 scopus 로고    scopus 로고
    • Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody
    • Stangl S, Gehrmann M, Riegger J, Kuhs K, Riederer I, Sievert W, et al. Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A (2011) 108:733-8. doi:10.1073/pnas.1016065108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 733-738
    • Stangl, S.1    Gehrmann, M.2    Riegger, J.3    Kuhs, K.4    Riederer, I.5    Sievert, W.6
  • 61
    • 84943355161 scopus 로고    scopus 로고
    • Quantitative analysis of liposomal heat shock protein 70 (Hsp70) in the blood of tumor patients using an novel lipHsp70 ELISA
    • Breuninger S, Erl J, Knape C, Gunther S, Regel I, Rodel F, et al. Quantitative analysis of liposomal heat shock protein 70 (Hsp70) in the blood of tumor patients using an novel lipHsp70 ELISA. J Clin Cell Immunol (2014) 5:2-10. doi:10.4172/2155-9899.1000264
    • (2014) J Clin Cell Immunol , vol.5 , pp. 2-10
    • Breuninger, S.1    Erl, J.2    Knape, C.3    Gunther, S.4    Regel, I.5    Rodel, F.6
  • 62
    • 21744445069 scopus 로고    scopus 로고
    • Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
    • Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones (2005) 10:86-103. doi:10.1379/CSC-99r.1
    • (2005) Cell Stress Chaperones , vol.10 , pp. 86-103
    • Ciocca, D.R.1    Calderwood, S.K.2
  • 63
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res (2005) 65:5238-47. doi:10.1158/0008-5472.CAN-04-3804
    • (2005) Cancer Res , vol.65 , pp. 5238-5247
    • Gastpar, R.1    Gehrmann, M.2    Bausero, M.A.3    Asea, A.4    Gross, C.5    Schroeder, J.A.6
  • 66
    • 61849086864 scopus 로고    scopus 로고
    • Human natural killer receptors, co-receptors, and their ligands
    • Unit14.10
    • Biassoni R. Human natural killer receptors, co-receptors, and their ligands. Curr Protoc Immunol (2009) Chapter 14:Unit14.10. doi:10.1002/0471142735.im1410s84
    • (2009) Curr Protoc Immunol , Issue.14
    • Biassoni, R.1
  • 68
    • 37149026664 scopus 로고    scopus 로고
    • The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition
    • Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, et al. The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity (2007) 27:900-11. doi:10.1016/j.immuni.2007.10.013
    • (2007) Immunity , vol.27 , pp. 900-911
    • Sullivan, L.C.1    Clements, C.S.2    Beddoe, T.3    Johnson, D.4    Hoare, H.L.5    Lin, J.6
  • 69
    • 33845878827 scopus 로고    scopus 로고
    • The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance
    • Borrego F, Masilamani M, Marusina AI, Tang X, Coligan JE. The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance. Immunol Res (2006) 35:263-78. doi:10.1385/IR:35:3:263
    • (2006) Immunol Res , vol.35 , pp. 263-278
    • Borrego, F.1    Masilamani, M.2    Marusina, A.I.3    Tang, X.4    Coligan, J.E.5
  • 70
    • 1242314233 scopus 로고    scopus 로고
    • Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells
    • Gross C, Schmidt-Wolf IG, Nagaraj S, Gastpar R, Ellwart J, Kunz-Schughart LA, et al. Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells. Cell Stress Chaperones (2003) 8:348-60. doi:10.1379/1466-1268(2003)008<0348:HSPRIA>2.0.CO;2
    • (2003) Cell Stress Chaperones , vol.8 , pp. 348-360
    • Gross, C.1    Schmidt-Wolf, I.G.2    Nagaraj, S.3    Gastpar, R.4    Ellwart, J.5    Kunz-Schughart, L.A.6
  • 71
    • 0142103373 scopus 로고    scopus 로고
    • Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B
    • Gross C, Koelch W, DeMaio A, Arispe N, Multhoff G. Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem (2003) 278:41173-81. doi:10.1074/jbc.M302644200
    • (2003) J Biol Chem , vol.278 , pp. 41173-41181
    • Gross, C.1    Koelch, W.2    DeMaio, A.3    Arispe, N.4    Multhoff, G.5
  • 72
    • 2542558307 scopus 로고    scopus 로고
    • Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical Phase I trial
    • Krause SW, Gastpar R, Andreesen R, Gross C, Ullrich H, Thonigs G, et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical Phase I trial. Clin Cancer Res (2004) 10:3699-707. doi:10.1158/1078-0432.CCR-03-0683
    • (2004) Clin Cancer Res , vol.10 , pp. 3699-3707
    • Krause, S.W.1    Gastpar, R.2    Andreesen, R.3    Gross, C.4    Ullrich, H.5    Thonigs, G.6
  • 73
    • 84926683486 scopus 로고    scopus 로고
    • Heat shock protein 70 (Hsp70) peptide activated natural killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx)-from preclinical studies to a clinical Phase II trial
    • Specht HM, Ahrens N, Blankenstein C, Duell T, Fietkau R, Gaipl US, et al. Heat shock protein 70 (Hsp70) peptide activated natural killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx)-from preclinical studies to a clinical Phase II trial. Front Immunol (2015) 6:162. doi:10.3389/fimmu.2015.00162
    • (2015) Front Immunol , vol.6 , pp. 162
    • Specht, H.M.1    Ahrens, N.2    Blankenstein, C.3    Duell, T.4    Fietkau, R.5    Gaipl, U.S.6
  • 74
    • 38449103605 scopus 로고    scopus 로고
    • The heat shock protein Hsp70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands
    • Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeboller H, et al. The heat shock protein Hsp70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands. J Immunol (2007) 179:5523-33. doi:10.4049/jimmunol.179.8.5523
    • (2007) J Immunol , vol.179 , pp. 5523-5533
    • Elsner, L.1    Muppala, V.2    Gehrmann, M.3    Lozano, J.4    Malzahn, D.5    Bickeboller, H.6
  • 75
    • 77957723884 scopus 로고    scopus 로고
    • Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8(+) T cell and CD4(+) T cell epitopes
    • Takemoto S, Nishikawa M, Guan X, Ohno Y, Yata T, Takakura Y. Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8(+) T cell and CD4(+) T cell epitopes. Mol Pharm (2010) 7:1715-23. doi:10.1021/mp1001069
    • (2010) Mol Pharm , vol.7 , pp. 1715-1723
    • Takemoto, S.1    Nishikawa, M.2    Guan, X.3    Ohno, Y.4    Yata, T.5    Takakura, Y.6
  • 77
    • 33747224323 scopus 로고    scopus 로고
    • Initiation of the immune response by extracellular Hsp72: chaperokine activity of Hsp72
    • Asea A. Initiation of the immune response by extracellular Hsp72: chaperokine activity of Hsp72. Curr Immunol Rev (2006) 2:209-15. doi:10.2174/157339506778018514
    • (2006) Curr Immunol Rev , vol.2 , pp. 209-215
    • Asea, A.1
  • 78
    • 33646345848 scopus 로고    scopus 로고
    • HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma
    • Geng H, Zhang GM, Xiao H, Yuan Y, Li D, Zhang H, et al. HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma. Int J Cancer (2006) 118:2657-64. doi:10.1002/ijc.21795
    • (2006) Int J Cancer , vol.118 , pp. 2657-2664
    • Geng, H.1    Zhang, G.M.2    Xiao, H.3    Yuan, Y.4    Li, D.5    Zhang, H.6
  • 79
    • 0035209979 scopus 로고    scopus 로고
    • Induction of systemic anti-tumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situ
    • Rafiee M, Kanwar JR, Berg RW, Lehnert K, Lisowska K, Krissansen GW. Induction of systemic anti-tumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situ. Cancer Gene Ther (2001) 8:974-81. doi:10.1038/sj.cgt.7700395
    • (2001) Cancer Gene Ther , vol.8 , pp. 974-981
    • Rafiee, M.1    Kanwar, J.R.2    Berg, R.W.3    Lehnert, K.4    Lisowska, K.5    Krissansen, G.W.6
  • 80
    • 76349106683 scopus 로고    scopus 로고
    • Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice
    • Nishikawa M, Otsuki T, Ota A, Guan X, Takemoto S, Takahashi Y, et al. Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice. Mol Ther (2010) 18:421-8. doi:10.1038/mt.2009.203
    • (2010) Mol Ther , vol.18 , pp. 421-428
    • Nishikawa, M.1    Otsuki, T.2    Ota, A.3    Guan, X.4    Takemoto, S.5    Takahashi, Y.6
  • 81
    • 0742269451 scopus 로고    scopus 로고
    • Anti-tumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
    • Ito A, Matsuoka F, Honda H, Kobayashi T. Anti-tumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma. Cancer Immunol Immunother (2004) 53:26-32. doi:10.1007/s00262-003-0416-5
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 26-32
    • Ito, A.1    Matsuoka, F.2    Honda, H.3    Kobayashi, T.4
  • 82
    • 84902089965 scopus 로고    scopus 로고
    • Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity
    • Shevtsov MA, Komarova EY, Meshalkina DA, Bychkova NV, Aksenov ND, Abkin SV, et al. Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity. Oncotarget (2014) 5:3101-14. doi:10.18632/oncotarget.1820
    • (2014) Oncotarget , vol.5 , pp. 3101-3114
    • Shevtsov, M.A.1    Komarova, E.Y.2    Meshalkina, D.A.3    Bychkova, N.V.4    Aksenov, N.D.5    Abkin, S.V.6
  • 83
    • 84946559449 scopus 로고    scopus 로고
    • 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma
    • Shevtsov MA, Nikolaev BP, Yakovleva LY, Parr MA, Marchenko YY, Eliseev I, et al. 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma. J Control Release (2015) 220:329-40. doi:10.1016/j.jconrel.2015.10.051
    • (2015) J Control Release , vol.220 , pp. 329-340
    • Shevtsov, M.A.1    Nikolaev, B.P.2    Yakovleva, L.Y.3    Parr, M.A.4    Marchenko, Y.Y.5    Eliseev, I.6
  • 84
    • 62549085594 scopus 로고    scopus 로고
    • A Phase I trial of intra-tumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients
    • Li JL, Liu HL, Zhang XR, Xu JP, Hu WK, Liang M, et al. A Phase I trial of intra-tumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther (2009) 16:376-82. doi:10.1038/gt.2008.179
    • (2009) Gene Ther , vol.16 , pp. 376-382
    • Li, J.L.1    Liu, H.L.2    Zhang, X.R.3    Xu, J.P.4    Hu, W.K.5    Liang, M.6
  • 85
    • 84937969182 scopus 로고    scopus 로고
    • Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a Phase I dose escalation clinical trial
    • Maeda Y, Yoshimura K, Matsui H, Shindo Y, Tamesa T, Tokumitsu Y, et al. Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a Phase I dose escalation clinical trial. Cancer Immunol Immunother (2015) 64:1047-56. doi:10.1007/s00262-015-1709-1
    • (2015) Cancer Immunol Immunother , vol.64 , pp. 1047-1056
    • Maeda, Y.1    Yoshimura, K.2    Matsui, H.3    Shindo, Y.4    Tamesa, T.5    Tokumitsu, Y.6
  • 86
    • 80655127833 scopus 로고    scopus 로고
    • Radiation combined with hyperthermia induces Hsp70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages
    • Schildkopf P, Frey B, Ott OJ, Rubner Y, Multhoff G, Sauer R, et al. Radiation combined with hyperthermia induces Hsp70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages. Radiother Oncol (2011) 101:109-15. doi:10.1016/j.radonc.2011.05.056
    • (2011) Radiother Oncol , vol.101 , pp. 109-115
    • Schildkopf, P.1    Frey, B.2    Ott, O.J.3    Rubner, Y.4    Multhoff, G.5    Sauer, R.6


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