Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Gorska, Magdalena ^a   Marino Gammazza, Antonella ^b,c   Zmijewski, Michal Aleksander ^a   Campanella, Claudia ^b,c   Cappello, Francesco ^b,c   Wasiewicz, Tomasz ^a   Kuban Jankowska, Alicja ^a   Daca, Agnieszka ^a   Sielicka, Alicja ^a   Popowska, Urszula ^a,d   Knap, Narcyz ^a   Antoniewicz, Jakub ^a   Wakabayashi, Takashi ^a,e   Wozniak, Michal ^a,d  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF PALERMO   (Italy)

^c Euro Mediterranean Institute of Science and Technology   (Italy)

^d Faculty in Gdynia   (Poland)

^e NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONIN 60; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PLACEBO;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CARCINOGENESIS; CELL SURVIVAL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG PROTEIN BINDING; DRUG TARGETING; GENE EXPRESSION; HUMAN; HUMAN CELL; OSTEOSARCOMA; PROTEIN DEPLETION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLATION; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BENZOQUINONES; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHAPERONIN 60; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTAMS, MACROCYCLIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OSTEOSARCOMA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 84883144703     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071135     Document Type: Article

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