Conformational Changes of Enzymes and Aptamers Immobilized on Electrodes

Bioconjugate Chemistry

Volumn 27, Issue 11, 2016, Pages 2581-2591

  Tello, Alejandra ^a   Cao, Roberto ^b   Marchant, María José ^b   Gomez, Humberto ^b  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUEL CELLS; BIOMOLECULES; ELECTRODES; ENZYME ELECTRODES; IONIC STRENGTH;

APTAMERS; BIOELECTROCHEMICAL DEVICES; CONFORMATIONAL CHANGE; ELECTRODE SURFACES; MOLECULAR-RECOGNITION ABILITY; PROPERTY; SURROUNDING ENVIRONMENT;

ENZYMES;

APTAMER; BIOFUEL; ENZYME; IMMOBILIZED ENZYME;

BIOSENSOR; CONFORMATIONAL TRANSITION; ELECTRODE; ENVIRONMENT; IONIC STRENGTH; PH; REVIEW; TEMPERATURE; CHEMISTRY; CONFORMATION; GENETIC PROCEDURES; METABOLISM; MOLECULAR MODEL; OSMOLARITY; PROTEIN CONFORMATION;

APTAMERS, NUCLEOTIDE; BIOSENSING TECHNIQUES; ELECTRODES; ENZYMES, IMMOBILIZED; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OSMOLAR CONCENTRATION; PROTEIN CONFORMATION; TEMPERATURE;

EID: 84996865544     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/acs.bioconjchem.6b00553     Document Type: Review

References (170)

1. Lawrence, C., Vallée-Bélisle, A., Pfeil, S. H., de Mornay, D., Lipman, E. A., and Plaxco, K. W. (2014) A comparison of the folding kinetics of a small, artificially selected DNA aptamer with those of equivalently simple naturally occurring proteins Protein Sci. 23, 56-66 10.1002/pro.2390
2. Küchler, A., Yoshimoto, M., Luginbühl, S., Mavelli, F., and Walde, P. (2016) Enzymatic reactions in confined environments Nat. Nanotechnol. 11, 409-420 10.1038/nnano.2016.54
3. Zhang, Y., Ge, J., and Liu, Z. (2015) Enhanced activity of immobilized or chemically modified enzymes ACS Catal. 5, 4503-4513 10.1021/acscatal.5b00996
4. Barbosa, O., Torres, R., Ortiz, C., Berenguer-Murcia, A., Rodrígues, R. C., and Fernández-Lafuente, R. (2013) Heterofunctional supports in enzyme immobilization: from traditional immobilization protocols to opportunities in tuning enzyme properties Biomacromolecules 14, 2433-2462 10.1021/bm400762h
5. Coad, B. R., Jasieniak, M., Griesser, S. S., and Griesser, H. J. (2013) Controlled covalent surface immobilisation of proteins and peptides using plasma methods Surf. Coat. Technol. 233, 169-177 10.1016/j.surfcoat.2013.05.019
6. Secundo, F. (2013) Conformational changes of enzymes upon immobilization Chem. Soc. Rev. 42, 6250-6261 10.1039/c3cs35495d
7. Samanta, D. and Sarkar, A. (2011) Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications Chem. Soc. Rev. 40, 2567-2592 10.1039/c0cs00056f
8. Lubin, A. A. and Plaxco, K. W. (2010) Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures Acc. Chem. Res. 43, 496-505 10.1021/ar900165x
9. Vallée-Bélisle, A. and Plaxco, K. W. (2010) Structure-switching biosensors: inspired by Nature Curr. Opin. Struct. Biol. 20, 518-526 10.1016/j.sbi.2010.05.001
10. Xu, Y., Cheng, G., He, P., and Fang, Y. (2009) A review: electrochemical aptasensors with various detection strategies Electroanalysis 21, 1251-1259 10.1002/elan.200804561
11. Sassolas, A., Blum, L. J., and Leca-Bouvier, B. D. (2009) Electrochemical aptasensors Electroanalysis 21, 1237-1250 10.1002/elan.200804554
12. Hianik, T. and Wang, J. (2009) Electrochemical aptasensors-recent achievements and perspectives Electroanalysis 21, 1223-1235 10.1002/elan.200904566
13. Iliuk, A. B., Hu, L., and Tao, W. A. (2011) Aptamers in bioanalytical applications Anal. Chem. 83, 4440-4452 10.1021/ac201057w
14. Mairal, T., Özalp, V. C., Sánchez, P. L., Mir, M., Katakis, I., and O'Sullivan, C. K. (2008) Aptamers: molecular tools for analytical applications Anal. Bioanal. Chem. 390, 989-1007 10.1007/s00216-007-1346-4
15. Mokhtarzadeh, A., Dolatabadi, J. E. N., Abnous, K., de la Guardia, M., and Ramezani, M. (2015) Nanomaterial-based cocaine aptasensors Biosens. Bioelectron. 68, 95-106 10.1016/j.bios.2014.12.052
16. Prieto-Simón, B., Campàs, M., and Marty, J.-L. (2010) Electrochemical aptamer-based sensors Bioanal. Rev. 1, 141-157 10.1007/s12566-010-0010-1
17. Rusmini, F., Zhong, Z., and Feijen, J. (2007) Protein immobilization strategies for protein biochips Biomacromolecules 8, 1775-1789 10.1021/bm061197b
18. Ronkainen, N. J., Halsall, H. B., and Heineman, W. R. (2010) Electrochemical biosensors Chem. Soc. Rev. 39, 1747-1763 10.1039/b714449k
19. Holzinger, M., Le Goff, A., and Cosnier, S. (2014) Supramolecular immobilization of bio-entities for bioelectrochemical applications New J. Chem. 38, 5173-5180 10.1039/C4NJ00755G
20. Villalonga, R., Cao, R., and Fragoso, A. (2007) Supramolecular chemistry of cyclodextrins in enzyme technology Chem. Rev. 107, 3088-3116 10.1021/cr050253g
21. Das, P., Das, M., Chinnadayyala, S. R., Singha, I. M., and Goswami, P. (2016) Recent advances on developing 3rd generation enzyme electrode for biosensor applications Biosens. Bioelectron. 79, 386-397 10.1016/j.bios.2015.12.055
22. Rathee, K., Dhull, V., Dhull, R., and Singh, S. (2016) Biosensors based on electrochemical lactate detection: A comprehensive review Biochem. Biophys. Rep. 5, 35-54 10.1016/j.bbrep.2015.11.010
23. Yoetz-Kopelman, T., Ram, Y., Freeman, A., and Shacham-Diamand, Y. (2015) Faradaic impedance spectroscopy for detection of small molecules binding using the avidin-biotin model Electrochim. Acta 173, 630-635 10.1016/j.electacta.2015.05.114
24. Chung, D.-J., Kim, K.-C., and Choi, S.-H. (2011) Electrochemical DNA biosensor based on avidin-biotin conjugation for influenza virus (type A) detection Appl. Surf. Sci. 257, 9390-9396 10.1016/j.apsusc.2011.06.015
25. Walper, S. A., Turner, K. B., and Medintz, I. L. (2015) Enzymatic bioconjugation of nanoparticles: developing specificity and control Curr. Opin. Biotechnol. 34, 232-241 10.1016/j.copbio.2015.04.003
26. Wong, L. S., Khan, F., and Micklefield, J. (2009) Selective covalent protein immobilization: strategies and applications Chem. Rev. 109, 4025-4053 10.1021/cr8004668
27. López-Alonso, J. P., Diez-García, F., Font, J., Ribó, M., Vilanova, M., Scholtz, J. M., González, C., Vottariello, F., Gotte, G., and Libonati, M. et al. 2009, Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity Bioconjugate Chem. 20, 1459-1473 10.1021/bc9001486
28. Esteban Fernández de ávila, B., Watkins, H. M., Pingarrón, J. M., Plaxco, K. W., Palleschi, G., and Ricci, F. (2013) Determinants of the detection limit and specificity of surface-based biosensors Anal. Chem. 85, 6593-6597 10.1021/ac4012123
29. Yu, Z. and Lai, R. Y. (2013) Effect of signaling probe conformation on sensor performance of a displacement-based electrochemical DNA sensor Anal. Chem. 85, 3340-3346 10.1021/ac3037987
30. Mecheri, B., D'Epifanio, A., Geracitano, A., Campana, P. T., and Licoccia, S. (2013) Development of glucose oxidase bioanodes and polymer electrolyte membranes for enzymatic fuel cell applications J. Appl. Electrochem. 43, 181-190 10.1007/s10800-012-0489-y
31. Rasmussen, M., Abdellaoui, S., and Minteer, S. D. (2016) Enzymatic biofuel cells: 30 years of critical advancements Biosens. Bioelectron. 76, 91-102 10.1016/j.bios.2015.06.029
32. Akanda, Md. R., Sohail, M., Aziz, Md. A., and Kawde, A. N. (2016) Recent advances in nanomaterial-modified pencil graphite electrodes for electroanalysis Electroanalysis 28, 408-424 10.1002/elan.201500374
33. Schoukroun-Barnes, L. R., Macazo, F. C., Gutierrez, B., Lottermoser, J., Liu, J., and White, R. J. (2016) Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors Annu. Rev. Anal. Chem. 9, 163-81 10.1146/annurev-anchem-071015-041446
34. Love, J., Estroff, L., Kriebel, J., Nuzzo, R., and Whitesides, G. (2005) Self-assembled monolayers of thiolates on metals as a form of nanotechnology Chem. Rev. 105, 1103-1169 10.1021/cr0300789
35. Gooding, J. J., Mearns, F., Yang, W., and Liu, J. (2003) Self-Assembled Monolayers into the 21st Century: Recent Advances and Applications Electroanalysis 15, 81-96 10.1002/elan.200390017
36. Chaki, N. K. and Vijayamohanan, K. (2002) Self-assembled monolayers as a tunable platform for biosensor applications Biosens. Bioelectron. 17, 1-12 10.1016/S0956-5663(01)00277-9
37. Gurzȩda, B., Florczak, P., Kempiński, M., Peplińska, B., Krawczyk, P., and Jurga, S. (2016) Carbon 100, 540-545 10.1016/j.carbon.2016.01.044
38. Pavlidis, I. V., Patila, M., Bornscheuer, U. T., Gournis, D., and Stamatis, H. (2014) Graphene-based nanobiocatalytic systems: recent advances and future prospects Trends Biotechnol. 32, 312-320 10.1016/j.tibtech.2014.04.004
39. Keskin, O., Gursoy, A., Ma, B., and Nussinov, B. (2008) Principles of protein-protein interactions: What are the preferred ways for proteins to interact? Chem. Rev. 108, 1225-1244 10.1021/cr040409x
40. Koshland, D. E., Jr. (1958) Application of a Theory of Enzyme Specificity to Protein Synthesis Proc. Natl. Acad. Sci. U. S. A. 44, 98-104 10.1073/pnas.44.2.98
41. Nelson, D. L. and Cox, M. M. (2005) Lehninger Principles of Biochemistry, 4 th ed., p 55, W.H. Freeman, New York.
42. Bellissent-Funel, M.-C., Hassanali, A., Havenith, M., Henchman, R., Pohl, P., Sterpone, F., van der Spoel, D., Xu, Y., and Garcia, A. E. (2016) Water Determines the Structure and Dynamics of Proteins Chem. Rev. 116, 7673-7697 10.1021/acs.chemrev.5b00664
43. Antuch, M., Abradelo, D. G., and Cao, R. (2014) Bioelectrocatalytic reduction of O2 at a supramolecularly associated laccase electrode New J. Chem. 38, 386-390 10.1039/C3NJ01143G
44. Araci, Z. O., Runge, A. F., Doherty, W. J., III, and Saavedra, S. S. (2008) Correlating molecular orientation distributions and electrochemical kinetics in subpopulations of an immobilized protein film J. Am. Chem. Soc. 130, 1572-1573 10.1021/ja710156d
45. Shao, Y., Jing, T., Tian, J., and Zheng, Y. (2015) Graphene oxide-based Fe3O4 nanoparticles as a novel scaffold for the immobilization of porcine pancreatic lipase RSC Adv. 5, 103943-103955 10.1039/C5RA19276E
46. Dervisevic, M., Çevik, E., and Şenel, M. (2015) Development of glucose biosensor based on reconstitution of glucoseoxidase onto polymeric redox mediator coated pencil graphite electrodes Enzyme Microb. Technol. 68, 69-76 10.1016/j.enzmictec.2014.09.007
47. Bahadlr, E. B. and Sezgintürk, M. K. (2015) Applications of commercial biosensors in clinical, food, environmental, and biothreat/biowarfare analyses Anal. Biochem. 478, 107-120 10.1016/j.ab.2015.03.011
48. Heller, A. and Feldman, B. (2008) Electrochemical glucose sensors and their applications in diabetes management Chem. Rev. 108, 2482-2505 10.1021/cr068069y
49. Fernández-Fernández, M., Sanromán, A., and Moldes, D. (2013) Recent developments and applications of immobilized laccase Biotechnol. Adv. 31, 1808-1825 10.1016/j.biotechadv.2012.02.013
50. Mecheri, B., De Porcellinis, D., Campana, P. T., Rainer, S., Trombetta, M., Marletta, A., Oliveira, O. N., and Licoccia, S. (2015) Tuning structural changes in glucose oxidase for enzyme fuel cell applications ACS Appl. Mater. Interfaces 7, 28311-28318 10.1021/acsami.5b08610
51. Romero, M. R., Ahumada, F., Garay, F., and Baruzzi, A. M. (2010) Amperometric biosensor for direct blood lactate detection Anal. Chem. 82, 5568-5572 10.1021/ac1004426
52. 4 nanoparticles as a novel scaffold for the immobilization of porcine pancreatic lipase RSC Adv. 5, 103943-103955 10.1039/C5RA19276E
53. Itoh, T., Shimomura, T., Hayashi, A., Yamaguchi, A., Teramae, N., Ono, M., Tsunoda, T., Mizukami, F., Stucky, G. D., and Hanaoka, T. (2014) Electrochemical enzymatic biosensor with long-term stability using hybrid mesoporous membrane Analyst 139, 4654-4660 10.1039/C4AN00975D
54. Şenel, M., Dervisevic, M., and Çevik, E. (2013) A novel amperometric glucose biosensor based on reconstitution of glucose oxidase on thiophene-3-boronic acid polymer layer Curr. Appl. Phys. 13, 1199-1204 10.1016/j.cap.2013.03.004
55. Kavitha, A. L., Prabu, H. G., Babu, S. A., and Suja, S. K. (2013) Magnetite nanoparticles-chitosan composite containing carbon paste electrode for glucose biosensor application J. Nanosci. Nanotechnol. 13, 98-104 10.1166/jnn.2013.6720
56. Hernández-Cancel, G., Suazo-Dávila, D., Medina-Guzmán, J., Rosado-Gonzalez, M., Diaz-Vázquez, L., and Griebenow, K. (2015) Chemically glycosylation improves the stability of an amperometric horseradish peroxidase biosensor Anal. Chim. Acta 854, 129-139 10.1016/j.aca.2014.11.008
57. Nesakumar, N., Thandavan, K., Sethuraman, S., Krishnan, U. M., and Rayappan, J. B. B. (2014) An electrochemical biosensor with nanointerface for lactate detection based on lactate dehydrogenase immobilized on zinc oxide nanorods J. Colloid Interface Sci. 414, 90-96 10.1016/j.jcis.2013.09.052
58. Dervisevic, M., Çevik, E., and Şenel, M. (2015) Development of glucose biosensor based on reconstitution of glucoseoxidase onto polymeric redox mediator coated pencil graphite electrodes Enzyme Microb. Technol. 68, 69-76 10.1016/j.enzmictec.2014.09.007
59. Wang, L., Wei, L., Chen, Y., and Jiang, R. (2010) Specific and reversible immobilization of NADH oxidase on functionalized carbon nanotubes J. Biotechnol. 150, 57-63 10.1016/j.jbiotec.2010.07.005
60. Wang, L., Xu, R., Chen, Y., and Jiang, R. (2011) Activity and stability comparison of immobilized NADH oxidase on multi-walled carbon nanotubes, carbon nanospheres, and single-walled carbon nanotubes J. Mol. Catal. B: Enzym. 69, 120-126 10.1016/j.molcatb.2011.01.005
61. Jasti, L. S., Dola, S. R., Fadnavis, N. W., Addepally, U., Daniels, S., and Ponrathnam, S. (2014) Co-immobilized glucose oxidase and galactosidase on bovine serum albumin coated allyl glycidyl ether (AGE)-ethylene glycoldimethacrylate (EGDM) copolymer as a biosensor for lactose determination in milk Enzyme Microb. Technol. 64-65, 67-73 10.1016/j.enzmictec.2014.07.005
62. Min, K., Kim, J., Park, K., and Yoo, Y. J. (2012) Enzyme immobilization on carbon nanomaterials: Loading density investigation and zeta potential analysis J. Mol. Catal. B: Enzym. 83, 87-93 10.1016/j.molcatb.2012.07.009
63. Zhang, G., Ma, J., Wang, J., Li, Y., Zhang, G., Zhang, F., and Fan, X. (2014) Lipase immobilized on graphene oxide as reusable biocatalyst Ind. Eng. Chem. Res. 53, 19878-19883 10.1021/ie503596j
64. Jemli, S., Ayadi-Zouari, D., Hlima, H. B., and Bejar, S. (2016) Biocatalysts: application and engineering for industrial purposes Crit. Rev. Biotechnol. 36, 246-258 10.3109/07388551.2014.950550
65. Mauritz, K. A. and Moore, R. B. (2004) State of understanding of Nafion Chem. Rev. 104, 4535-4585 10.1021/cr0207123
66. Wooten, M., Karra, S., Zhang, M., and Gorski, W. (2014) On the direct electron transfer, sensing, and enzyme activity in the glucose oxidase/carbon nanotubes system Anal. Chem. 86, 752-757 10.1021/ac403250w
67. Díez, P., Piuleac, C.-G., Martínez-Ruiz, P., Romano, S., Gamella, M., Villalonga, R., and Pingarrón, J. M. (2013) Supramolecular immobilization of glucose oxidase on gold coated with cyclodextrin-modified cysteamine core PAMAM G-4 dendron/Pt nanoparticles for mediatorless biosensor design Anal. Bioanal. Chem. 405, 3773-3781 10.1007/s00216-012-6491-8
68. Rodrigues, R. C., Ortiz, C., Berenguer-Murcia, A., Torres, R., and Fernández-Lafuente, R. (2013) Modifying enzyme activity and selectivity by immobilization Chem. Soc. Rev. 42, 6290-6307 10.1039/C2CS35231A
69. Sezer, M., Kielb, P., Kuhlmann, U., Mohrmann, H., Schulz, C., Heinrich, D., Schlesinger, R., Heberle, J., and Weidinger, I. (2015) Surface enhanced Raman spectroscopy reveals potential induced redox and conformational changes of cytochrome c oxidase on electrodes J. Phys. Chem. B 119, 9586-9591 10.1021/acs.jpcb.5b03206
70. Kielb, P., Sezer, M., Katz, S., Lopez, F., Gorton, L., Ludwig, R., Wollenberger, U., Zebger, I., and Weidinger, I. M. (2015) Spectroscopic observation of calcium-induced reorientation of cellobiose dehydrogenase immobilized on electrodes and its effect on electrocatalytic activity ChemPhysChem 16, 1960-1968 10.1002/cphc.201500112
71. Yin, X. B. (2012) Functional nucleic acids for electrochemical and electrochemiluminescent sensing applications. TrAC-Trends TrAC, Trends Anal. Chem. 33, 81-94 10.1016/j.trac.2011.09.012
72. Xiao, Y., Lai, R. Y., and Plaxco, K. W. (2007) Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing Nat. Protoc. 2, 2875-2880 10.1038/nprot.2007.413
73. Liu, B., Lu, L. S., Hua, E. H., Jiang, S. T., and Xie, G. M. (2012) Detection of the human prostate-specific antigen using an aptasensor with gold nanoparticles encapsulated by graphitized mesoporous carbon Microchim. Acta 178, 163-170 10.1007/s00604-012-0822-5
74. Wu, L., Xiong, E., Zhang, X., Zhang, X., and Chen, J. (2014) Nanomaterials as signal amplification elements in DNA-based electrochemical sensing Nano Today 9, 197-211 10.1016/j.nantod.2014.04.002
75. Plaxco, K. W. and Soh, H. T. (2011) Switch based biosensors: a new approach towards real-time, in vivo molecular detection Trends Biotechnol. 29, 1-5 10.1016/j.tibtech.2010.10.005
76. Jarczewska, M., Gorski, L., and Malinowska, E. (2016) Electrochemical aptamer-based biosensors as potential tools for clinical diagnostics Anal. Methods 8, 3861-3877 10.1039/C6AY00499G
77. Watkins, H. M., Vallée-Bélisle, A., Ricci, F., Makarov, D. E., and Plaxco, K. W. (2012) Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study J. Am. Chem. Soc. 134, 2120-2126 10.1021/ja208436p
78. Wu, Z. S., Zheng, F., Shen, G. L., and Yu, R. Q. (2009) A hairpin aptamer-based electrochemical biosensing platform for the sensitive detection of proteins Biomaterials 30, 2950-2955 10.1016/j.biomaterials.2009.02.017
79. Chiorcea-Paquim, A. M. and Oliveira-Brett, A. M. (2014) Redox behaviour of G-quadruplexes Electrochim. Acta 126, 162-170 10.1016/j.electacta.2013.07.150
80. Qiu, L., Qiu, L., Wu, Z.-S., Shen, G., and Yu, R.-Q. (2013) Cooperative amplification-based electrochemical sensor for the zeptomole detection of nucleic acids Anal. Chem. 85, 8225-8231 10.1021/ac401300a
81. Jiang, B., Li, F., Yang, C., Xie, J., Xiang, Y., and Yuan, R. (2015) Aptamer pseudoknot-functionalized electronic sensor for reagentless and single-step detection of immunoglobulin e in human serum Anal. Chem. 87, 3094-3098 10.1021/acs.analchem.5b00041
82. Walter, J.-G., Stahl, F., and Scheper, T. (2012) Aptamers as affinity ligands for downstream processing Eng. Life Sci. 12, 496-506 10.1002/elsc.201100197
83. Prieto-Simón, B. and Samitier, J. (2014) Signal off" aptasensor based on enzyme inhibition induced by conformational switch Anal. Chem. 86, 1437-1444 10.1021/ac402258x
84. Wu, M., Kempaiah, R., Huang, P.-J. J., Maheshwari, V., and Liu, J. (2011) Adsorption and desorption of DNA on graphene oxide studied by fluorescently labeled oligonucleotides Langmuir 27, 2731-2738 10.1021/la1037926
85. Ranganathan, S. V., Halvorsen, K., Myers, C. S., Robertson, N. M., Yigit, M. V., and Chen, A. A. (2016) Complex thermodynamic behavior of single-stranded nucleic acid adsorption to graphene surfaces Langmuir 32, 6028-6034 10.1021/acs.langmuir.6b00456
86. Park, J. S., Goo, N.-I., and Kim, D.-E. (2014) Mechanism of dna adsorption and desorption on graphene oxide Langmuir 30, 12587-12595 10.1021/la503401d
87. Roushani, M. and Shahdost-fard, F. (2015) A novel ultrasensitive aptasensor based on silver nanoparticles measured via enhanced voltammetric response of electrochemical reduction of riboflavin as redox probe for cocaine detection Sens. Actuators, B 207, 764-771 10.1016/j.snb.2014.10.131
88. Ravalli, L., Rivas, A., De la Escosura-Muniz, J., Pons, A., Merkoci, G., and Marrazza, A. (2015) DNA aptasensor for electrochemical detection of vascular endothelial growth factor J. Nanosci. Nanotechnol. 15, 3411-3416 10.1166/jnn.2015.10037
89. Ferapontova, E. E. and Gothelf, K. V. (2011) Recent advances in electrochemical aptamer-based sensors Curr. Org. Chem. 15, 498-505 10.2174/138527211794474483
90. Catanante, G., Mishra, R. K., Hayat, A., and Marty, J. L. (2016) Sensitive analytical performance of folding based biosensor using methylene blue tagged aptamers Talanta 153, 138-144 10.1016/j.talanta.2016.03.004
91. Josephs, E. and Ye, T. (2012) A single-molecule view of conformational switching of DNA tethered to a gold electrode J. Am. Chem. Soc. 134, 10021-10030 10.1021/ja3010946
92. Fan, C. H., Plaxco, K. W., and Heeger, A. J. (2003) Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA Proc. Natl. Acad. Sci. U. S. A. 100, 9134-9137 10.1073/pnas.1633515100
93. Xiao, Y., Uzawa, T., White, R. J., DeMartini, D., and Plaxco, K. W. (2009) On the signaling of electrochemical aptamer-based sensors: collision- and folding-based mechanisms Electroanalysis 21, 1267-1271 10.1002/elan.200804564
94. Bai, H.-Y., Del Campo, F. J., and Tsai, Y.-C. (2013) Sensitive electrochemical thrombin aptasensor based on gold disk microelectrode arrays Biosens. Bioelectron. 42, 17-22 10.1016/j.bios.2012.10.063
95. Liu, X., Li, Y., Zheng, J., Zhang, J., and Sheng, Q. (2010) Carbon nanotube-enhanced electro-chemical aptasensor for the detection of thrombin Talanta 81, 1619-1624 10.1016/j.talanta.2010.03.013
96. Chen, J. H., Zhang, J., Li, J., Yang, H. H., Fu, F. F., and Chen, G. N. (2010) An ultrasensitive signal-on electrochemical aptasensor via target-induced conjunction of split aptamer fragments Biosens. Bioelectron. 25, 996-1000 10.1016/j.bios.2009.09.015
97. Kang, D., White, R. J., Xia, F., Zuo, X., Vallee-Belisle, A., and Plaxco, K. W. (2012) DNA biomolecular-electronic encoder and decoder devices constructed by multiplex biosensors NPG Asia Mater. 4, 1-6 10.1038/am.2012.1
98. Hsieh, K., Ferguson, B. S., Eisenstein, M., Plaxco, K. W., and Soh, H. T. (2015) Integrated electrochemical microsystems for genetic detection of pathogens at the point of care Acc. Chem. Res. 48, 911-920 10.1021/ar500456w
99. White, R. J., Rowe, A. A., and Plaxco, K. W. (2010) Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors Analyst 135, 589-594 10.1039/b921253a
100. Wang, X., Dong, P., He, P., and Fang, Y. (2010) A solid-state electrochemiluminescence sensing platform for detection of adenosine based on ferrocene-labeled structure-switching signaling aptamer Anal. Chim. Acta 658, 128-132 10.1016/j.aca.2009.11.007
101. Wang, L., Xu, M., Han, L., Zhou, M., Zhu, C., and Dong, S. (2012) Graphene enhanced electron transfer at aptamer modified electrode and its application in biosensing Anal. Chem. 84, 7301-7307 10.1021/ac300521d
102. Labib, M., Zamay, A. S., Muharemagic, D., Chechik, A., Bell, J. C., and Berezovski, M. V. (2012) Electrochemical sensing of aptamer-facilitated virus immunoshielding Anal. Chem. 84, 1677-1686 10.1021/ac202978r
103. Jolly, P., Formisano, N., Tkáč, J., Kasák, P., Frost, C. G., and Estrela, P. (2015) Label-free impedimetric aptasensor with antifouling surfacechemistry: A prostate specific antigen case study Sens. Actuators, B 209, 306-312 10.1016/j.snb.2014.11.083
104. Zaitouna, A. J., Maben, A. J., and Lai, R. Y. (2015) Incorporation of extra amino acids in peptide recognition probe to improve specificity and selectivity of an electrochemical peptide based sensor Anal. Chim. Acta 886, 157-164 10.1016/j.aca.2015.05.037
105. Cui, L., Wu, J., and Ju, H. (2016) Label-free signal-on aptasensor for sensitive electrochemical detection of arsenite Biosens. Bioelectron. 79, 861-865 10.1016/j.bios.2016.01.010
106. Wang, J., Shan, Y., Zhao, W. W., Xu, J. J., and Chen, H. Y. (2011) Gold nanoparticle enhanced electrochemiluminescence of CdS thin films for ultrasensitive thrombin detection Anal. Chem. 83, 4004-4011 10.1021/ac200616g
107. Shahdost-fard, F. and Roushani, M. (2016) Conformation switching of an aptamer based on cocaine enhancement on a surface of modified GCE Talanta 154, 7-14 10.1016/j.talanta.2016.03.055
108. Cunningham, J. C., Brenes, N. J., and Crooks, R. M. (2014) Paper electrochemical device for detection of DNA and thrombin by target-induced conformational switching Anal. Chem. 86, 6166-6170 10.1021/ac501438y
109. Li, D., Song, S., and Fan, C. (2010) Target-responsive structural switching for nucleic acid-based sensors Acc. Chem. Res. 43, 631-641 10.1021/ar900245u
110. Elshafey, R., Siaj, M., and Zourob, M. (2015) DNA aptamers selection and characterization for development of label- free impedimetric aptasensor for neurotoxin anatoxin-a Biosens. Bioelectron. 68, 295-302 10.1016/j.bios.2015.01.002
111. Hua, M., Tao, M., Wang, P., Zhang, Y., Wu, Z., Chang, Y., and Yang, Y. (2010) Label-free electrochemical cocaine aptasensor based on a target-inducing aptamer switching conformation Anal. Sci. 26, 1265-1270 10.2116/analsci.26.1265
112. Pilehvar, S., Dierckx, T., Blust, R., Breugelmans, T., and De Wael, K. (2014) An electrochemical impedimetric aptasensing platform for sensitive and selective detection of small molecules such as chloramphenicol Sensors 14, 12059-12069 10.3390/s140712059
113. Eissa, S., Ng, A., Siaj, M., and Zourob, M. (2014) Label-free voltammetric aptasensor for the sensitive detection of microcystin-LR using graphene-modified electrodes Anal. Chem. 86, 7551-7557 10.1021/ac501335k
114. Roushani, M. and Shahdost-fard, F. (2016) An aptasensor for voltammetric and impedimetric determination of cocaine based on a glassy carbon electrode modified with platinum nanoparticles and using rutin as a redox probe Microchim. Acta 183, 185-193 10.1007/s00604-015-1604-7
115. Rosy, Goyal, R. N., and Shim, Y.-B. (2015) Glutaraldehyde sandwiched amino functionalized polymer based aptasensor for the determination and quantification of chloramphenicol RSC Adv. 5, 69356-69364 10.1039/C5RA11131E
116. Liu, Y., Liu, Y., Matharu, Z., Rahimian, A., and Revzin, A. (2015) Detecting multiple cell-secreted cytokines from the same aptamer-functionalized electrode Biosens. Bioelectron. 64, 43-50 10.1016/j.bios.2014.08.034
117. Eissa, S., Siaj, M., and Zourob, M. (2015) Aptamer-based competitive electrochemical biosensor for brevetoxin-2 Biosens. Bioelectron. 69, 148-154 10.1016/j.bios.2015.01.055
118. Yu, P., Liu, Y., Zhang, X., Zhou, J., Xiong, E., Li, X., and Chen, J. (2016) Biosens. Bioelectron. 79, 22-28 10.1016/j.bios.2015.12.007
119. Eissa, S., Ng, A., Siaj, M., Tavares, A. C., and Zourob, M. (2013) Selection and identification of DNA aptamers against okadaic acid for biosensing application Anal. Chem. 85, 11794-11801 10.1021/ac402220k
120. Kuang, H., Chen, W., Xu, D., Xu, L., Zhu, Y., Liu, L., Chu, H., Peng, C., Xu, C., and Zhu, S. (2010) Fabricated aptamer-based electrochemical "signal-off" sensor of ochratoxin A Biosens. Bioelectron. 26, 710-716 10.1016/j.bios.2010.06.058
121. Bulbul, G., Hayat, A., and Andreescu, S. (2015) A generic amplification strategy for electrochemical aptasensors using a non-enzymatic nanoceria tag Nanoscale 7, 13230-13238 10.1039/C5NR02628H
122. Fetter, L., Richards, J., Daniel, J., Roon, L., Rowland, T. J., and Bonham, A. J. (2015) Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins Chem. Commun. 51, 15137-15140 10.1039/C5CC05933J
123. Yang, Z., Kasprzyk-Hordern, B., Goggins, S., Frost, C., and Estrela, P. (2015) A novel immobilization strategy for electrochemical detection of cancer biomarkers: DNA-directed immobilization of aptamer sensors for sensitive detection of prostate specific antigens Analyst 140, 2628-2633 10.1039/C4AN02277G
124. Jia, J., Feng, J., Chen, H. G., Luo, H. Q., and Li, N. B. (2016) A simple electrochemical method for the detection of ATP using target-induced conformational change of dual-hairpin DNA structure Sens. Actuators, B 222, 1090-1095 10.1016/j.snb.2015.08.045
125. He, X. P., Wang, G. F., Xu, G., Zhu, Y. H., Chen, L., and Zhang, X. J. (2013) A simple, fast, and sensitive assay for the detection of DNA, thrombin, and adenosine triphosphate based on dual-hairpin DNA structure Langmuir 29, 14328-14334 10.1021/la403192p
126. Pang, J., Zhang, Z., and Jin, H. (2016) Effect of structure variation of the aptamer-DNA duplex probe on the performance of displacement-based electrochemical aptamer sensors Biosens. Bioelectron. 77, 174-181 10.1016/j.bios.2015.09.035
127. Goda, T. and Miyahara, Y. (2012) A hairpin DNA aptamer coupled with groove binders as a smart switch for a field-effect transistor biosensor Biosens. Bioelectron. 32, 244-249 10.1016/j.bios.2011.12.022
128. Yu, Z.-G., Zaitouna, A. J., and Lai, R. Y. (2014) Effect of redox label tether length and flexibility on sensorperformance of displacement-based electrochemical DNA sensors Anal. Chim. Acta 812, 176-183 10.1016/j.aca.2013.12.040
129. Yu, Z.-G. and Lai, R. Y. (2012) A reagentless and reusable electrochemical DNA sensor based on target hybridization-induced stem-loop probe formation Chem. Commun. 48, 10523-10525 10.1039/c2cc35985e
130. Li, Y., Bao, J., Han, M., Dai, Z., and Wang, H. (2011) A simple assay to amplify the electrochemical signal by the aptamer based biosensor modified with CdS hollow nanospheres Biosens. Bioelectron. 26, 3531-3535 10.1016/j.bios.2011.01.039
131. Pilehvar, S., Mehta, J., Dardenne, F., Robbens, J., Blust, R., and De Wael, K. (2012) Aptasensing of chloramphenicol in the presence of its analogues: Reaching the maximum residue limit Anal. Chem. 84, 6753-6758 10.1021/ac3012522
132. Wang, R., Xiang, Y., Zhou, X., Liu, L. H., and Shi, H. (2015) A reusable aptamer-based evanescent wave all-fiber biosensor for highly sensitive detection of Ochratoxin A Biosens. Bioelectron. 66, 11-18 10.1016/j.bios.2014.10.079
133. 2+-thymine structure Anal. Chim. Acta 853, 242-248 10.1016/j.aca.2014.10.015
134. 3+ and an elongated thrombin binding aptamer G-quadruplex Electrochim. Acta 179, 84-92 10.1016/j.electacta.2015.05.023
135. Shi, S.-S., Jia, L.-P., Ma, R.-N., Jia, W.-L., and Wang, H.-S. (2015) A label-free electrochemical aptasensor for 8-hydroxy-2′-deoxyguanosine detection J. Electroanal. Chem. 759, 107-112 10.1016/j.jelechem.2015.10.040
136. Kazemi, S. H., Shanehsaz, M., and Ghaemmaghami, M. (2015) Non-Faradaic electrochemical impedance spectroscopy as a reliable and facile method: Determination of the potassium ion concentration using a guanine rich aptasensor Mater. Sci. Eng., C 52, 151-154 10.1016/j.msec.2015.03.058
137. Zhang, S., Hu, X., Yang, X., Sun, Q., Xu, X., Liu, X., Shen, G., Lu, J., Shen, G., and Yu, R. (2015) Background eliminated signal-on electrochemical aptasensing plat- form for highly sensitive detection of protein Biosens. Bioelectron. 66, 363-369 10.1016/j.bios.2014.11.044
138. Ferguson, B. S., Hoggarth, D. A., Maliniak, D., Ploense, K., White, R. J., Woodward, N., Hsieh, K., Bonham, A. J., Eisenstein, M., and Kippin et al. 2013, Real-time, aptamer-based tracking of circulating therapeutic agents in living animals Sci. Transl. Med. 5, 1-9
139. Gao, F., Qian, Y., Zhang, L., Dai, S., Lan, Y., Zhang, Y., Du, L., and Tang, D. (2015) Target catalyzed hairpin assembly for constructing a ratiometric electrochemical aptasensor Biosens. Bioelectron. 71, 158-163 10.1016/j.bios.2015.04.040
140. Wu, L., Xiong, E., Yao, Y., Zhang, X., Zhang, X., and Chen, J. (2015) A new electrochemical aptasensor based on electrocatalytic property of graphene toward ascorbic acid oxidation Talanta 134, 699-704 10.1016/j.talanta.2014.12.011
141. Zheng, W., Teng, J., Cheng, L., Ye, Y., Pan, D., Wu, J., Xue, F., Liu, G., and Chen, W. (2016) Hetero-enzyme-based two-round signal amplification strategy for trace detection of aflatoxin B1 using an electrochemical aptasensor Biosens. Bioelectron. 80, 574-581 10.1016/j.bios.2016.01.091
142. Zhang, J., Chen, J., Zhang, X., Zeng, Z., Chen, M., and Wang, S. (2012) An electrochemical biosensor based on hairpin-DNA aptamer probe and restriction endonuclease for ochratoxin A detection Electrochem. Commun. 25, 5-7 10.1016/j.elecom.2012.09.006
143. Vallée-Bélisle, A., Ricci, F., Uzawa, T., Xia, F., and Plaxco, K. W. (2012) Bioelectrochemical switches for the quantitative detection of antibodies directly in whole blood J. Am. Chem. Soc. 134, 15197-15200 10.1021/ja305720w
144. Hayat, A., Andreescu, S., and Marty, J. L. (2013) Design of PEG-aptamer two piece macro-molecules as convenient and integrated sensing platform: application to the label free detection of small size molecules Biosens. Bioelectron. 45, 168-172 10.1016/j.bios.2013.01.059
145. Hayat, A., Haider, W., Rolland, M., and Marty, J. L. (2013) Electrochemical grafting of long spacer arms of hexamethyldiamine on a screen printed carbon electrode surface: application in target induced ochratoxin A electrochemical aptasensor Analyst 138, 2951-2957 10.1039/c3an00158j
146. Xia, Y., Gan, S., Xu, Q., Qiu, X., Gao, P., and Huang, S. (2013) A three-way junction aptasensor for lysozyme detection Biosens. Bioelectron. 39, 250-254 10.1016/j.bios.2012.07.053
147. Li, W., Wu, P., Zhang, H., and Cai, C. (2012) Catalytic signal amplification of gold nanoparticles combining with conformation-switched hairpin DNA probe for hepatitis C virus quantification Chem. Commun. 48, 7877-7879 10.1039/c2cc33635a
148. Shen, W.-J., Zhuo, Y., Chai, Y.-Q., and Yuan, R. (2015) Cu-based metal-organic frameworks as a catalyst to construct a ratiometric electrochemical aptasensor for sensitive lipopolysaccharide detection Anal. Chem. 87, 11345-11352 10.1021/acs.analchem.5b02694
149. Zhou, L., Wang, J., Li, D., and Li, Y. (2014) An electrochemical aptasensor based on gold nanoparticles dotted graphene modified glassy carbon electrode for label-free detection of bisphenol A in milk samples Food Chem. 162, 34-40 10.1016/j.foodchem.2014.04.058
150. Wu, X., Chai, Y., Yuan, R., Zhuo, Y., and Chen, Y. (2014) Dual signal amplification strategy for enzyme-free electrochemical detection of microRNAs Sens. Actuators, B 203, 296-302 10.1016/j.snb.2014.06.131
151. Chen, Z., Zhang, C., Li, X., Ma, H., Wan, C., Li, K., and Lin, Y. (2015) Aptasensor for electrochemical sensing of angiogenin based on electrode modified by cationic polyelectrolyte-functionalized graphene/gold nanoparticles composites Biosens. Bioelectron. 65, 232-237 10.1016/j.bios.2014.10.046
152. Sun, C., Han, Q., Wang, D., Xu, W., Wang, W., Zhao, W., and Zhou, M. (2014) A label-free and high sensitive aptamer biosensor based on hyperbranched polyester microspheres for thrombin detection Anal. Chim. Acta 850, 33-40 10.1016/j.aca.2014.08.010
153. Chrouda, A., Sbartai, A., Baraket, A., Renaud, L., Maaref, A., and Jaffrezic-Renault, N. (2015) An aptasensor for ochratoxin A based on grafting of polyethylene glycol on a boron-doped diamond microcell Anal. Biochem. 488, 36-44 10.1016/j.ab.2015.07.012
154. Kwon, O. S., Park, S. J., Hong, J. Y., Han, A. R., Lee, J. S., Oh, J. H., Jang, J., and Lee, J. S. (2012) Flexible FET-type VEGF aptasensor based on nitrogen-doped graphene converted from conducting polymer ACS Nano 6, 1486-1493 10.1021/nn204395n
155. Zhao, S., Yang, W., and Lai, R. Y. (2011) A folding-based electrochemical aptasensor for detection of vascular endothelial growth factor in human whole blood Biosens. Bioelectron. 26, 2442-2447 10.1016/j.bios.2010.10.029
156. Ocaña, C., Pacios, M., and del Valle, M. (2012) A reusable impedimetric aptasensor for detection of thrombin employing a graphite-epoxy composite electrode Sensors 12, 3037-3048 10.3390/s120303037
157. Sun, D., Lu, J., Chen, Z., Yu, Y., and Mo, M. (2015) A repeatable assembling and disassembling electrochemical aptamer cytosensor for ultrasensitive and highly selective detection of human liver cancer cells Anal. Chim. Acta 885, 166-173 10.1016/j.aca.2015.05.027
158. Thu, V. V., Dung, P. T., Tam, L. T., and Tam, P. D. (2014) Biosensor based on nanocomposite material for pathogenic virus detection Colloids Surf., B 115, 176-181 10.1016/j.colsurfb.2013.11.016
159. Wang, R., Xiang, Y., Zhou, X., Liu, L. H., and Shi, H. (2015) A reusable aptamer-based evanescent wave all-fiber biosensor for highly sensitive detection of Ochratoxin A Biosens. Bioelectron. 66, 11-18 10.1016/j.bios.2014.10.079
160. Shen, H., Yang, J., Chen, Z., Chen, X., Wang, L., Hu, J., Ji, F., Xie, G., and Feng, W. (2016) A novel label-free and reusable electrochemical cytosensor for highly sensitive detection and specific collection of CTCs Biosens. Bioelectron. 81, 495-502 10.1016/j.bios.2016.03.048
161. Chang, C. C., Lin, S., Lee, C. H., Chuang, T. L., Hsueh, P. R., Lai, H. C., and Lin, C. W. (2012) Amplified surface plasmon resonance immunosensor for interferon-Gamma based on a streptavidin-incorporated aptamer Biosens. Bioelectron. 37, 68-74 10.1016/j.bios.2012.04.038
162. Qiu, H., Sun, Y., Huang, X., and Qu, Y. (2010) A sensitive nanoporous gold-based electrochemical aptasensor for thrombin detection Colloids Surf., B 79, 304-308 10.1016/j.colsurfb.2010.04.017
163. Liu, Y., Tuleouva, N., Ramanculov, E., and Revzin, A. (2010) Aptamer-based electrochemical biosensor for interferon gamma detection Anal. Chem. 82, 8131-8136 10.1021/ac101409t
164. Wu, Z. S., Guo, M. M., Zhang, S. B., Chen, C. R., Jiang, J. H., Shen, G. L., and Yu, R. Q. (2007) Reusable electrochemical sensing platform for highly sensitive detection of small molecules based on structure-switching signaling aptamers Anal. Chem. 79, 2933-2939 10.1021/ac0622936
165. Rogers, J. K., Taylor, N. D., and Church, G. M. (2016) Biosensor-based engineering of biosynthetic pathways Curr. Opin. Biotechnol. 42, 84-91 10.1016/j.copbio.2016.03.005
166. Mross, S., Pierrat, S., Zimmermann, T., and Kraft, M. (2015) Microfluidic enzymatic biosensing systems: A review Biosens. Bioelectron. 70, 376-391 10.1016/j.bios.2015.03.049
167. Rocchitta, G., Spanu, A., Babudieri, S., Latte, G., Madeddu, G., Galleri, G., Nuvoli, S., Bagella, P., Demartis, M. I., and Fiore, V. et al. 2016, Enzyme biosensors for biomedical applications: strategies for safeguarding analytical performances in biological fluids Sensors 16, 780-801 10.3390/s16060780
168. Sassolas, A., Blum, L. J., and Leca-Bouvier, B. D. (2012) Immobilization strategies to develop enzymatic biosensors Biotechnol. Adv. 30, 489-511 10.1016/j.biotechadv.2011.09.003
169. + sensor: process of aptamer transforming into G-quadruplex J. Phys. Chem. B 120, 6606-6611 10.1021/acs.jpcb.6b05002
170. Walt, D. R. (2009) Ubiquitous sensors: when will they be here? ACS Nano 3, 2876-2880 10.1021/nn901295n