메뉴 건너뛰기




Volumn 49, Issue 12, 2016, Pages

Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages

Author keywords

Adipose inflammation; Diabetes; Glucagon like peptide; Insulin resistance; Macrophage infiltration

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LYMPHOTOXIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; AUTACOID; GLUCAGON LIKE PEPTIDE 1; PEPTIDE; VENOM;

EID: 84996542208     PISSN: None     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20165826     Document Type: Article
Times cited : (70)

References (40)
  • 1
    • 84918563183 scopus 로고    scopus 로고
    • Macrophage polarization in obesity and type 2 diabetes: Weighing down our understanding of macrophage function?
    • Kraakman MJ, Murphy AJ, Jandeleit-Dahm K, Kammoun HL. Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function? Front Immunol 2014; 5: 470, doi: 10.3389/fimmu.2014.00470.
    • (2014) Front Immunol , vol.5 , pp. 470
    • Kraakman, M.J.1    Murphy, A.J.2    Jandeleit-Dahm, K.3    Kammoun, H.L.4
  • 3
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome - An allostatic perspective
    • Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome - an allostatic perspective. Biochim Biophys Acta 2010; 1801: 338-349, doi: 10.1016/j.bbalip.2009.12.006.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 4
    • 84858280061 scopus 로고    scopus 로고
    • Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine
    • Brown BN, Ratner BD, Goodman SB, Amar S, Badylak SF. Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials 2012; 33: 3792-3802, doi: 10.1016/j.biomaterials. 2012.02.034.
    • (2012) Biomaterials , vol.33 , pp. 3792-3802
    • Brown, B.N.1    Ratner, B.D.2    Goodman, S.B.3    Amar, S.4    Badylak, S.F.5
  • 5
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25: 677-686, doi: 10.1016/j.it.2004.09.015.
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 6
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 5: 953-964, doi: 10.1038/nri1733.
    • (2005) Nat Rev Immunol , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 7
    • 70350560546 scopus 로고    scopus 로고
    • Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    • Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 2009; 58: 2574-2582, doi: 10.2337/db08-1475.
    • (2009) Diabetes , vol.58 , pp. 2574-2582
    • Fujisaka, S.1    Usui, I.2    Bukhari, A.3    Ikutani, M.4    Oya, T.5    Kanatani, Y.6
  • 8
    • 79955438066 scopus 로고    scopus 로고
    • Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice
    • Fujisaka S, Usui I, Kanatani Y, Ikutani M, Takasaki I, Tsuneyama K, et al. Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice. Endocrinology 2011; 152: 1789-1799, doi: 10.1210/en.2010-1312.
    • (2011) Endocrinology , vol.152 , pp. 1789-1799
    • Fujisaka, S.1    Usui, I.2    Kanatani, Y.3    Ikutani, M.4    Takasaki, I.5    Tsuneyama, K.6
  • 9
    • 84964662010 scopus 로고    scopus 로고
    • Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review
    • Manna P, Kalita J. Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review. Nutrition 2016; 32: 732-739, doi: 10.1016/j.nut.2016.01.011.
    • (2016) Nutrition , vol.32 , pp. 732-739
    • Manna, P.1    Kalita, J.2
  • 10
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117: 175-184, doi: 10.1172/JCI29881.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 11
    • 79957916782 scopus 로고    scopus 로고
    • Adipose tissue remodeling and obesity
    • Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest 2011; 121: 2094-2101, doi: 10.1172/JCI45887.
    • (2011) J Clin Invest , vol.121 , pp. 2094-2101
    • Sun, K.1    Kusminski, C.M.2    Scherer, P.E.3
  • 12
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-683, doi: 10.1146/annurev.immunol.14.1.649.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 13
    • 84976870688 scopus 로고    scopus 로고
    • The NF-kappaB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma
    • Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, et al. The NF-kappaB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene 2016; 35: 3476-3484, doi: 10.1038/onc.2015.399.
    • (2016) Oncogene , vol.35 , pp. 3476-3484
    • Hunter, J.E.1    Butterworth, J.A.2    Zhao, B.3    Sellier, H.4    Campbell, K.J.5    Thomas, H.D.6
  • 14
    • 0034746919 scopus 로고    scopus 로고
    • NF-kappaB: A key role in inflammatory diseases
    • Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001; 107: 7-11, doi: 10.1172/JCI11830.
    • (2001) J Clin Invest , vol.107 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 16
    • 84896080822 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus
    • Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O’Connell J, et al. Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia 2014; 57: 781-784, doi: 10.1007/s00125-013-3145-0.
    • (2014) Diabetologia , vol.57 , pp. 781-784
    • Hogan, A.E.1    Gaoatswe, G.2    Lynch, L.3    Corrigan, M.A.4    Woods, C.5    O’Connell, J.6
  • 17
    • 0037902984 scopus 로고    scopus 로고
    • Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    • Vilsboll T, Krarup T, Sonne J, Madsbad S, Volund A, Juul AG, et al. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab 2003; 88: 2706-2713, doi: 10.1210/jc.2002-021873.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2706-2713
    • Vilsboll, T.1    Krarup, T.2    Sonne, J.3    Madsbad, S.4    Volund, A.5    Juul, A.G.6
  • 18
    • 84954306378 scopus 로고    scopus 로고
    • Exenatide (A GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner
    • Buldak L, Machnik G, Buldak RJ, Labuzek K, Boldys A, Belowski D, et al. Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner. Pharmacol Rep 2016; 68: 329-337, doi: 10.1016/j.pharep.2015.10.008.
    • (2016) Pharmacol Rep , vol.68 , pp. 329-337
    • Buldak, L.1    Machnik, G.2    Buldak, R.J.3    Labuzek, K.4    Boldys, A.5    Belowski, D.6
  • 19
    • 84866055251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes
    • Lee YS, Park MS, Choung JS, Kim SS, Oh HH, Choi CS, et al. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia 2012; 55: 2456-2468, doi: 10.1007/s00125-012-2592-3.
    • (2012) Diabetologia , vol.55 , pp. 2456-2468
    • Lee, Y.S.1    Park, M.S.2    Choung, J.S.3    Kim, S.S.4    Oh, H.H.5    Choi, C.S.6
  • 20
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, et al. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 2010; 59: 1030-1037, doi: 10.2337/db09-1694[pii].
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1    Mita, T.2    Azuma, K.3    Ebato, C.4    Goto, H.5    Nomiyama, T.6
  • 21
    • 84889564748 scopus 로고    scopus 로고
    • Activation of PPARbeta/delta protects pancreatic beta cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor
    • Yang Y, Tong Y, Gong M, Lu Y, Wang C, Zhou M, et al. Activation of PPARbeta/delta protects pancreatic beta cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor. Cell Signal 2014; 26: 268- 278, doi: 10.1016/j.cellsig.2013.11.019.
    • (2014) Cell Signal , vol.26
    • Yang, Y.1    Tong, Y.2    Gong, M.3    Lu, Y.4    Wang, C.5    Zhou, M.6
  • 22
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta NA, Mells J, Dunham RM, Grakoui A, Handy J, Saxena NK, et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010; 51: 1584-1592, doi: 10.1002/hep.23569.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6
  • 23
    • 84875660786 scopus 로고    scopus 로고
    • TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I
    • Wang H, Wang L, Song L, Zhang YW, Ye J, Xu RX, et al. TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I. Braz J Med Biol Res 2013; 46: 128-137, doi: 10.1590/1414-431X20122515.
    • (2013) Braz J Med Biol Res , vol.46 , pp. 128-137
    • Wang, H.1    Wang, L.2    Song, L.3    Zhang, Y.W.4    Ye, J.5    Xu, R.X.6
  • 24
    • 79953043643 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy
    • Wang L, Wang H, Ye J, Xu RX, Song L, Shi N, et al. Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy. Clin Exp Pharmacol Physiol 2011; 38: 278-284, doi: 10.1111/j.1440-1681.2011.05499.x.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 278-284
    • Wang, L.1    Wang, H.2    Ye, J.3    Xu, R.X.4    Song, L.5    Shi, N.6
  • 25
    • 84962109166 scopus 로고    scopus 로고
    • Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis
    • Wang H, Chen Y, Lu XA, Liu G, Fu Y, Luo Y. Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis. Diabetes 2015; 64: 2442-2456, doi: 10.2337/db14-0528.
    • (2015) Diabetes , vol.64 , pp. 2442-2456
    • Wang, H.1    Chen, Y.2    Lu, X.A.3    Liu, G.4    Fu, Y.5    Luo, Y.6
  • 26
    • 84864656836 scopus 로고    scopus 로고
    • Platyconic acid, a saponin from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo
    • Kwon DY, Kim YS, Ryu SY, Choi YH, Cha MR, Yang HJ, et al. Platyconic acid, a saponin from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo. Eur J Nutr 2012; 51: 529-540, doi: 10.1007/s00394-011-0236-x.
    • (2012) Eur J Nutr , vol.51 , pp. 529-540
    • Kwon, D.Y.1    Kim, Y.S.2    Ryu, S.Y.3    Choi, Y.H.4    Cha, M.R.5    Yang, H.J.6
  • 27
    • 44449124672 scopus 로고    scopus 로고
    • The secretory function of adipocytes in the physiology of white adipose tissue
    • Wang P, Mariman E, Renes J, Keijer J. The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol 2008; 216: 3-13, doi: 10.1002/jcp.21386.
    • (2008) J Cell Physiol , vol.216 , pp. 3-13
    • Wang, P.1    Mariman, E.2    Renes, J.3    Keijer, J.4
  • 28
    • 0034814047 scopus 로고    scopus 로고
    • Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
    • 0193-1849/01
    • Edwards CM, Stanley SA, Davis R, Brynes AE, Frost GS, Seal LJ, et al. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab 2001; 281: E155-E161, doi: 0193-1849/01.
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , pp. E155-E161
    • Edwards, C.M.1    Stanley, S.A.2    Davis, R.3    Brynes, A.E.4    Frost, G.S.5    Seal, L.J.6
  • 29
    • 0036278738 scopus 로고    scopus 로고
    • Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes
    • S002604950242029X
    • Temelkova-Kurktschiev T, Siegert G, Bergmann S, Henkel E, Koehler C, Jaross W, et al. Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes. Metabolism 2002; 51: 743-749, doi: S002604950242029X.
    • (2002) Metabolism , vol.51 , pp. 743-749
    • Temelkova-Kurktschiev, T.1    Siegert, G.2    Bergmann, S.3    Henkel, E.4    Koehler, C.5    Jaross, W.6
  • 30
    • 0142053961 scopus 로고    scopus 로고
    • Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion
    • Festa A, Hanley AJ, Tracy RP, D’Agostino R Jr, Haffner SM. Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation 2003; 108: 1822-1830, doi: 10.1161/01.CIR.000 0091339.70120.53.
    • (2003) Circulation , vol.108 , pp. 1822-1830
    • Festa, A.1    Hanley, A.J.2    Tracy, R.P.3    D’Agostino, R.4    Haffner, S.M.5
  • 31
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350, doi: 10.1056/NEJM200105033441801.
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.G.3    Valle, T.T.4    Hamalainen, H.5    Ilanne-Parikka, P.6
  • 32
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue: From lipid storage compartment to endocrine organ
    • Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 2006; 55: 1537-1545, doi: 10.2337/db06-0263.
    • (2006) Diabetes , vol.55 , pp. 1537-1545
    • Scherer, P.E.1
  • 33
    • 77956342883 scopus 로고    scopus 로고
    • TNF-alpha induces mitochondrial dysfunction in 3T3-L1 adipocytes
    • Chen XH, Zhao YP, Xue M, Ji CB, Gao CL, Zhu JG, et al. TNF-alpha induces mitochondrial dysfunction in 3T3-L1 adipocytes. Mol Cell Endocrinol 2010; 328: 63-69, doi: 10.1016/j.mce.2010.07.005.
    • (2010) Mol Cell Endocrinol , vol.328 , pp. 63-69
    • Chen, X.H.1    Zhao, Y.P.2    Xue, M.3    Ji, C.B.4    Gao, C.L.5    Zhu, J.G.6
  • 34
    • 84892402412 scopus 로고    scopus 로고
    • Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration
    • Wang Y, Parlevliet ET, Geerling JJ, van der Tuin SJ, Zhang H, Bieghs V, et al. Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration. Br J Pharmacol 2014; 171: 723-734, doi: 10.1111/bph.12490.
    • (2014) Br J Pharmacol , vol.171 , pp. 723-734
    • Wang, Y.1    Parlevliet, E.T.2    Geerling, J.J.3    Van Der Tuin, S.J.4    Zhang, H.5    Bieghs, V.6
  • 35
    • 84935009269 scopus 로고    scopus 로고
    • Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix
    • Robinson E, Cassidy RS, Tate M, Zhao Y, Lockhart S, Calderwood D, et al. Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix. Basic Res Cardiol 2015; 110: 20, doi: 10.1007/s00395-015-0476-7.
    • (2015) Basic Res Cardiol , vol.110 , pp. 20
    • Robinson, E.1    Cassidy, R.S.2    Tate, M.3    Zhao, Y.4    Lockhart, S.5    Calderwood, D.6
  • 36
    • 0033556082 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
    • Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 1999; 259: 3-17, doi: 10.1046/j.1432-1327.1999.00043.
    • (1999) Eur J Biochem , vol.259 , pp. 3-17
    • Lang, J.1
  • 37
    • 34247253249 scopus 로고    scopus 로고
    • MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance
    • Bouzakri K, Zierath JR. MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem 2007; 282: 7783-7789, doi: 10.1074/jbc.M608602200.
    • (2007) J Biol Chem , vol.282 , pp. 7783-7789
    • Bouzakri, K.1    Zierath, J.R.2
  • 38
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004; 145: 2653-2659, doi: 10.1210/en.2004-0015[pii].
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 39
    • 11844252117 scopus 로고    scopus 로고
    • Cutting edge: Macrophage inhibition by cyclic AMP (cAMP): Differential roles of protein kinase A and exchange protein directly activated by cAMP-1
    • 174-2/595 [pii]
    • Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M. Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J Immunol 2005; 174: 595-599, doi: 174-2/595 [pii].
    • (2005) J Immunol , vol.174 , pp. 595-599
    • Aronoff, D.M.1    Canetti, C.2    Serezani, C.H.3    Luo, M.4    Peters-Golden, M.5
  • 40
    • 64849099960 scopus 로고    scopus 로고
    • Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages
    • Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, et al. Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. J Immunol 2009; 182: 3243-3251, doi: 10.4049/jimmunol.0803466182/5/3243 [pii].
    • (2009) J Immunol , vol.182 , pp. 3243-3251
    • Mogi, C.1    Tobo, M.2    Tomura, H.3    Murata, N.4    He, X.D.5    Sato, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.