Platyconic acid, a saponin from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo

European Journal of Nutrition

Volumn 51, Issue 5, 2012, Pages 529-540

  Kwon, Dae Young ^a   Kim, Young Seob ^b   Ryu, Shi Yong ^b   Choi, Yeon Hee ^b   Cha, Mi Ran ^b   Yang, Hye Jeong ^a   Park, Sunmin ^c  

^a Korea Food Research Institute   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Hoseo University   (South Korea)

Author keywords

Liver; Platycodi radix; Platycodine D; Platyconic acid; PPAR

Indexed keywords

DEAPIOPLAYCOSIDE E; DIMETHYL SULFOXIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOGEN; INSULIN; INSULIN SENSITIZING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PLATYCODINE D; PLATYCODINE D2; PLATYCODINE D3; PLATYCODINE E; PLATYCONIC ACID; ROSIGLITAZONE; SAPONIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INSULINOMA; LIPID DIET; LIVER; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANT ROOT; PLATYCODI GRANDIFLORUM; PLATYCODI RADIX; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES;

3T3-L1 CELLS; ADIPOCYTES; ADIPONECTIN; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; PPAR GAMMA; PROTEIN TRANSPORT; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES;

ANIMALIA; MUS;

EID: 84864656836     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-011-0236-x     Document Type: Article

References (39)

1. DeFronzo RA, Ferrannini E (2001) Regulation of intermediary metabolism during fasting and feeding. In: DeGroot LJ, Jameson JL (eds) Endocrinology. W. B. Saunders Co., Philadelphia, pp 737-775
2. Taylor SI (1999) Deconstructing type 2 diabetes. Cell 97:9-12
3. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, Zimmet P, Son HY (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet 368:1681-1688
4. Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB (2009) Diabetes in Asia: epidemiology, risk factors and pathophysiology. JAMA 301:2129-2140
5. Hui H, Tang G, Go VLW (2009) Hypoglycemic herbs and their action mechanisms. Chin Med 4:11
6. Han LK, Xu BJ, Kimura Y, Zheng Y, Okuda H (2000) Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. J Nutr 130:2760-2764
7. Kim KS, Seo EK, Lee YC, Lee TK, Cho YW, Ezaki O, Kim CH (2000) Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese zucker rats. J Nutr Biochem 11:420-424
8. Kwon DY, Kim YS, Hong SM, Park S (2009) Long-term consumption of saponins derived from Platycodi radix (22 years old) enhances hepatic insulin sensitivity and glucose-stimulated insulin secretion in 90% pancreatectomized diabetic rats fed a high-fat diet. Br J Nutr 101:358-366
9. Kim HK, Choi JS, Yoo DS, Choi YH, Yeon KH, Hong KS, Lee BH, Kim HJ, Kim EJ, Roh SW, Jeong YC, Kim YS, Ryu SY (2007) HPLC analysis of saponins in Platycodi radix. Kr J Pharm 38:1-18
10. Choi JH, Yoo KY, Park OK, Lee CH, Won MH, Hwang IK, Ryu SY, Kim YS, Yi JS, Bae YS, Kang IJ (2009) Platycodin D and 200-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus. Brain Res 1279:197-208
11. Chung JW, Noh EJ, Zhao HL, Sim JS, Ha YW, Shin EM, Lee EB, Cheong CS, Kim YS (2008) Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factorkappa B pathway inhibition. Biol Pharm Bull 31:2114-2120
12. Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS, Kim YS (2005) Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappa B activation in RAW 264.7 cells. Life Sci 76:2315-2328
13. Choi YH, Yoo DS, Choi CW, Cha MR, Kim YS, Lee HS, Lee KR, Ryu SY (2008) Platyconic acid A, a genuine triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules 13:2871-2879
14. Shimaya A, Kovacina KS, Roth RA (2004) On the mechanism for neomycin reversal of wortmannin inhibition of insulin stimulation of glucose uptake. J Biol Chem 279:55277-55282
15. Park S, Ahn IS, Kwon DY, Ko BS, Jun. WK (2008) Ginsenoside Rb1 and Rg1 suppress triacylglycerol accumulation in 3T3-L1 adipocytes and enhance β-cell insulin secretion and viability in Min6 cells via PKA dependent pathways. Biosci Biotechnol Biochem 72:2815-2823
16. Letter EH (1982) Multiple low-dose streptozotocin-induced hyperglycemia and insulinitis in C57BL mice: influence of inbred background, sex, and thymus. Proc Natl Acad Sci USA 79:630-634
17. Mu J, Petrov A, Eiermann GJ, Woods J et al (2009) Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Eur J Pharmacol 623:148-154
18. Kusakabe T, Tanioka H, Ebihara K et al (2009) Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet. Diabetologia 52:675-683
19. American Institute of Nutrition (1993) AIN-93 purified diets for laboratory rodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951
20. Frontoni S, Choi SB, Banduch D, Rossetti L (1991) In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle. Diabetes 40:568-573
21. Sebokova E, Klimes I, Moss R, Stolba P, Wiersma MM, Mitková A (1993) Muscle GLUT 4 protein levels and impaired triglyceride metabolism in streptozotocin diabetic rats. Effect of a high sucrose diet and fish oil supplementation. Ann NY Acad Sci 683:218-227
22. Zanquetta MM, Nascimento ME, Mori RC, D'Agord Schaan B, Young ME, Machado UF (2006) Participation of beta-adrenergic activity in modulation of GLUT4 expression during fasting and refeeding in rats. Metabolism 55:1538-1545
23. Hallakou S, Doaré L, Foufelle F, Kergoat M, Guerre-Millo M, Berthault MF, Dugail I, Morin J, Auwerx J, Ferré P (1997) Pioglitazone induces in vivo adipocyte differentiation in the obese zucker fa/fa rat. Diabetes 46:1393-1399
24. Kim JY, Moon KD, Seo KI, Park KW, Choi MS, Do GM, Jeong YK, Cho YS, Lee MK (2009) Supplementation of SK1 from Platycodi radix ameliorates obesity and glucose intolerance in mice fed a high-fat diet. J Med Food 12:629-636
25. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, Reaven GM (2000) A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 49:1390-1394
26. Zhang F, Ye C, Li G (2003) The rat model of type 2 diabetic mellitus and its glycometabolism characters. Exp Anim 52:401-407
27. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P (2005) Combination of high-fat diet-fed and low-dose streptozotocintreated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:313-320
28. Han LK, Zheng YN, Xu BJ, Okuda H, Kimura Y (2002) Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice. J Nutr 132:2241-2245
29. Lee H, Kang R, Kim YS, Chung SI, Yoon Y (2010) Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma. Phytother Res 24:S161-S167
30. DeFronzo RA (2004) Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 88:787-835
31. Ide T, Shimano H, Yahagi N, Matsuzaka T et al (2004) SREBPs suppress IRS-2-mediated insulin signaling in the liver. Nat Cell Biol 6:351-357
32. Kwon DY, Jang JS, Hong SM, Lee JE, Sung SR, Park HR, Park S (2007) Long-term consumption of fermented soybean-derived chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. Eur J Nutr 46:44-52
33. Dong X, Park S, Lin X, Copps K, Yi X, White MF (2006) Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 116:101-1014
34. Ribon V, Johnson JH, Camp HS, Saltiel AR (1998) Thiazolidinediones and insulin resistance: peroxisome proliferator-activated receptor gamma activation stimulates expression of the CAP gene. Proc Natl Acad Sci USA 95:14751-14756
35. Huang TH, Kota BP, Razmovski V, Roufogalis BD (2005) Herbal or natural medicines as modulators of peroxisome proliferator-activated receptors and related nuclear receptors for therapy of metabolic syndrome. Basic Clin Pharmacol Toxicol 96:13-14
36. Rangwala SM, Lazar MA (2004) Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol Sci 25:331-336
37. Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106:467-472
38. Ratziu V, Giral P, Jacqueminet S, Charlotte F, Hartemann-Heurtier A, Serfaty L, Podevin P, Lacorte JM, Bernhardt C, Bruckert E, Grimaldi A, Poynard T, LIDO Study Group (2008) Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) Trial. Gastroenterology 135:100-110
39. Wu CW, Chu ES, Lam CN, Cheng AS, Lee CW, Wong VW, Sung JJ, Yu J (2010) PPAR gamma is essential for protection against nonalcoholic steatohepatitis. Gene Ther 17:790-798