Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus

Diabetologia

Volumn 57, Issue 4, 2014, Pages 781-784

  Hogan, Andrew E ^a,b   Gaoatswe, Gadintshware ^a   Lynch, Lydia ^c,e   Corrigan, Michelle A ^a   Woods, Conor ^a   O'Connell, Jean ^a   O'Shea, Donal ^a,d  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^c HARVARD MEDICAL SCHOOL   (United States)

^d St Columcille s Hospital   (Ireland)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

GLP 1; Inflammation; Macrophage; Obesity

Indexed keywords

ADIPONECTIN; CD163 ANTIGEN; FRUCTOSAMINE; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; HEMOGLOBIN A1C; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; TREATMENT DURATION;

BODY WEIGHT; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED;

EID: 84896080822     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3145-0     Document Type: Article

References (12)

1. Dalmas E, Clément K, Guerre-Millo M (2011) Defining macrophage phenotype and function in adipose tissue. Trends Immunol 32:307-314
2. Fujisaka S, Usui I, Bukhari A et al (2009) Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58:2574-2582
3. Parkner T, Sørensen LP, Nielsen AR et al (2012) Soluble CD163: a biomarker linking macrophages and insulin resistance. Diabetologia 55:1856-1862
4. Ridaura VK, Faith JJ, Rey FE et al (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214
5. Wu JD, Xu XH, Zhu J et al (2011) Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus. Diabetes Technol Ther 13:143-148
6. Hattori Y, Jojima T, Tomizawa A et al (2010) A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells. Diabetologia 53:2256-2263
7. Lee YS, Park MS, Choung JS et al (2012) Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia 55:2456-2468
8. Chaudhuri A, Ghanim H, Vora M et al (2012) Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab 97:198-207
9. Hogan AE, Tobin AM, Ahern T et al (2011) Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia 54:2745-2754
10. Lynch L, Nowak M, Varghese B et al (2012) Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 37:574-587
11. Feingold KR, Soued M, Adi S et al (1991) Effect of interleukin-1 on lipid metabolismin the rat. Similarities to and differences from tumor necrosis factor. Arterioscler Thromb 11:495-500
12. Wisse BE (2004) The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15:2792-2800