Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis

Diabetes

Volumn 64, Issue 7, 2015, Pages 2442-2456

  Hui, Wang ^a   Chen, Yang ^a   Lu, Xin An ^a   Liu, Guanghua ^a   Fu, Yan ^a   Luo, Yongzhang ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; AP2 PROTEIN; BETA ACTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CD36 ANTIGEN; ENDOSTATIN; FIBROBLAST GROWTH FACTOR 2; GLUCOSE TRANSPORTER 4; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PLACENTAL GROWTH FACTOR; PROTEIN; PROTEIN SAM68; RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; KHDRBS1 PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MTOR PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ADIPOGENESIS; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET INDUCED OBESITY; FATTY LIVER; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MALE; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENETICS; INTRON; LIPID DIET; MOUSE; OBESITY; PHYSIOLOGY;

3T3-L1 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOGENESIS; ANGIOGENESIS INHIBITORS; ANIMALS; DIET, HIGH-FAT; ENDOSTATINS; INTRONS; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; OBESITY; RNA-BINDING PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84962109166     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0528     Document Type: Article

References (50)

1. Finucane MM, Stevens GA, Cowan MJ, et al.; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index). National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9$1 million participants. Lancet 2011;377: 557-567
2. Malik VS, Willett WC, Hu FB. Global obesity: Trends, risk factors and policy implications. Nat Rev Endocrinol 2013;9:13-27
3. Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: Implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 2012;97:745-755
4. Cristancho AG, Lazar MA. Forming functional fat: A growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011;12:722-734
5. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev 2000;14:1293-1307
6. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 1991;5:1538-1552
7. Yeh WC, Cao Z, Classon M, McKnight SL. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 1995;9:168-181
8. Tang QQ, Lane MD. Adipogenesis: From stem cell to adipocyte. Annu Rev Biochem 2012;81:715-736
9. Tontonoz P, Spiegelman BM. Fat and beyond: The diverse biology of PPARgamma. Annu Rev Biochem 2008;77:289-312
10. Huot ME, Vogel G, Zabarauskas A, et al. The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis. Mol Cell 2012; 46:187-199
11. Richard S. Reaching for the stars: Linking RNA binding proteins to diseases. Adv Exp Med Biol 2010;693:142-157
12. Daquinag AC, Zhang Y, Kolonin MG. Vascular targeting of adipose tissue as an anti-obesity approach. Trends Pharmacol Sci 2011;32:300-307
13. Rupnick MA, Panigrahy D, Zhang CY, et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A 2002;99:10730-10735
14. Kim MY, Park BY, Lee HS, et al. The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice. Int J Obes (Lond) 2010;34: 820-830
15. Wabitsch M. The acquisition of obesity: Insights from cellular and genetic research. Proc Nutr Soc 2000;59:325-330
16. Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/-mice. Mol Cell Biol 2004;24:5080-5087
17. Sun Y, Ma YC, Huang J, Chen KY, McGarrigle DK, Huang XY. Requirement of SRC-family tyrosine kinases in fat accumulation. Biochemistry 2005;44:14455-14462
18. Ding Y, Song N, Liu C, et al. Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin. Arterioscler Thromb Vasc Biol 2012;32:e126-e134
19. Wang X, Song X, Zhuo W, et al. The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. Proc Natl Acad Sci U S A 2009; 106:21288-21293
20. Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood 2011;117:6392-6403
21. Guo S. Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms. J Endocrinol 2014;220:T1-T23
22. Avruch J, Hara K, Lin Y, et al. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 2006;25: 6361-6372
23. Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-293
24. Wang L, Lawrence JC Jr, Sturgill TW, Harris TE. Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J Biol Chem 2009;284:14693-14697
25. Julien LA, Carriere A, Moreau J, Roux PP. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 2010;30:908-921
26. Treins C, Warne PH, Magnuson MA, Pende M, Downward J. Rictor is a novel target of p70 S6 kinase-1. Oncogene 2010;29:1003-1016
27. Bhaskar PT, Hay N. The two TORCs and Akt. Dev Cell 2007;12:487-502
28. Lamming DW, Ye L, Katajisto P, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012;335: 1638-1643
29. Shi H, Huang Y, Zhou H, et al. Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin. Blood 2007;110:2899-2906
30. Yuan S, Fu Y, Wang X, et al. Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis. FASEB J 2008;22:2809-2820
31. Aoki N, Yokoyama R, Asai N, et al. Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro [retracted in: Endocrinology 2013;154:4437]. Endocrinology 2010;151: 2567-2576
32. Huang Y, Shi H, Zhou H, Song X, Yuan S, Luo Y. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. Blood 2006;107:3564-3571
33. Song N, Ding Y, Zhuo W, et al. The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells. Angiogenesis 2012;15: 697-711
34. Rovira J, Marcelo Arellano E, Burke JT, et al. Effect of mTOR inhibitor on body weight: From an experimental rat model to human transplant patients. Transpl Int 2008;21:992-998
35. Kim JE, Chen J. regulation of peroxisome proliferator-activated receptorgamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 2004;53:2748-2756
36. Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA, Hall MN. Adiposespecific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 2008;8:399-410
37. Lemoine AY, Ledoux S, Quéguiner I, et al. Link between adipose tissue angiogenesis and fat accumulation in severely obese subjects. J Clin Endocrinol Metab 2012;97:E775-E780
38. Tran KV, Gealekman O, Frontini A, et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab 2012;15: 222-229
39. Sung HK, Doh KO, Son JE, et al. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab 2013;17:61-72
40. Fukumura D, Ushiyama A, Duda DG, et al. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res 2003; 93:e88-e97
41. Lijnen HR, Maquoi E, Hansen LB, Van Hoef B, Frederix L, Collen D. Matrix metalloproteinase inhibition impairs adipose tissue development in mice. Arterioscler Thromb Vasc Biol 2002;22:374-379
42. Bouloumié A, Sengenès C, Portolan G, Galitzky J, Lafontan M. Adipocyte produces matrix metalloproteinases 2 and 9: Involvement in adipose differentiation. Diabetes 2001;50:2080-2086
43. Pende M, Fisher TL, Simpson PB, Russell JT, Blenis J, Gallo V. Neurotransmitter-and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: Role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway. J Neurosci 1997;17:1291-1301
44. Pardo OE, Arcaro A, Salerno G, et al. Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells. Oncogene 2001;20:7658-7667
45. Um SH, Frigerio F, Watanabe M, et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200-205
46. Ramdas M, Harel C, Armoni M, Karnieli E. AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant. Horm Metab Res 2015;47: 265-272
47. Koren-Gluzer M, Aviram M, Hayek T. Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway. Atherosclerosis 2013;229:71-78
48. Fu Y, Tang H, Huang Y, Song N, Luo Y. Unraveling the mysteries of endostatin. IUBMB Life 2009;61:613-626
49. Brixius K, Schoenberger S, Ladage D, et al. Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50-60 years. Br J Sports Med 2008;42:126-129; discussion 129
50. Seida A, Wada J, Kunitomi M, et al. Serum bFGF levels are reduced in Japanese overweight men and restored by a 6-month exercise education. Int J Obes Relat Metab Disord 2003;27:1325-1331