Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

Biochemical and Biophysical Research Communications

Volumn 478, Issue 2, 2016, Pages 765-771

  Akihara, Ryusuke ^a   Homma, Takujiro ^a   Lee, Jaeyong ^a   Yamada, Ken ichi ^b,c   Miyata, Satoshi ^d   Fujii, Junichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OSAKA KOSEI NENKIN HOSPITAL   (Japan)

Author keywords

Ascorbic acid; Carbon tetrachloride; ER stress; Oxidative stress; Steatosis

Indexed keywords

ALDEHYDE REDUCTASE; ALDEHYDE REDUCTASE 1A; ASCORBIC ACID; CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; UNCLASSIFIED DRUG; ADIPOPHILIN; ANTIOXIDANT; BIOLOGICAL MARKER; CYTOCHROME P-450 2E1, MOUSE; GLUTATHIONE; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PEROXIREDOXIN; PLIN2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FATTY LIVER; HOMEOSTASIS; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION; AGONISTS; ANIMAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER; METABOLISM; PATHOLOGY;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOMARKERS; CARBON TETRACHLORIDE; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOCHROME P-450 CYP2E1; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; GENE EXPRESSION; GLUTATHIONE; HEAT-SHOCK PROTEINS; LIPID PEROXIDATION; LIVER; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PERILIPIN-2; PEROXIREDOXINS;

EID: 84995680360     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.08.022     Document Type: Article

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